Hub : Traits :

Ever had hysterectomy (womb removed)

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 48072855 49519654 1 1 7.7e-09 5.9e-05 0.0018 39 STON1
2 11 29646947 31048683 1 1 2.7e-07 1.6e-06 1.0000 100 ARL14EP

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 3.71 1 0 0 0 1 STON1
Age at First Birth 3.52 1 0 0 0 1 ARL14EP
Schizophrenia 2.21 1 0 0 0 1 STON1
Triglycerides 4.55 2 0 0 0 1 ARL14EP STON1
Blood Platelet Count 1.41 1 1 3 0 1 STON1
Blood Red Count 0.62 1 0 0 0 1 ARL14EP
Blood White Count 1.51 1 0 0 0 1 STON1
Heel T-Score 3.02 1 1 3 0 1 ARL14EP
BMI 1.19 1 0 0 0 1 STON1
Height 2.04 2 1 3 0 1 ARL14EP STON1
Waist Hip Ratio (WHR) 1.55 2 0 0 0 1 ARL14EP STON1
Systolic Blood Pressure 0.99 1 0 0 0 1 ARL14EP
Cardiovascular Disease 3.07 2 0 0 0 1 ARL14EP STON1
Type 2 Diabetes (T2D) 2.45 1 0 0 0 1 ARL14EP
Lung FEV1/FVC ratio 3.80 2 1 3 0 1 ARL14EP STON1
Lung FVC 1.24 1 0 0 0 1 ARL14EP
Relative age of first facial hair 1.69 1 0 0 0 1 STON1
Other serious medical condition/disability diagnosed by doctor 2.16 1 0 0 0 1 ARL14EP
Ever used hormone-replacement therapy (HRT) 7.55 1 0 0 0 1 ARL14EP
Leg fat-free mass (left) 0.87 1 0 0 0 1 ARL14EP
Frequency of unenthusiasm / disinterest in last 2 weeks 3.81 1 0 0 0 1 ARL14EP
Age when periods started (menarche) 5.87 1 0 0 0 1 ARL14EP
Bilateral oophorectomy (both ovaries removed) 20.41 2 1 3 0 1 ARL14EP STON1
Heel bone mineral density (BMD) T-score, automated (left) 4.79 2 0 0 0 1 ARL14EP STON1
High blood pressure 2.50 1 0 0 0 1 ARL14EP
Stomach or abdominal pain in last month 4.47 1 0 0 0 1 STON1
Sitting height 1.33 1 0 0 0 1 ARL14EP
High blood pressure (mother) 2.11 1 0 0 0 1 ARL14EP
Body mass index (BMI) 0.76 1 0 0 0 1 STON1
Leg predicted mass (left) 0.90 1 0 0 0 1 ARL14EP
Had menopause 4.59 1 0 0 0 1 ARL14EP
Had other major operations 5.41 1 0 0 0 1 STON1
Forced vital capacity (FVC) 2.51 1 0 0 0 1 ARL14EP
Heel bone mineral density (BMD) T-score, automated (right) 5.09 1 0 0 0 1 ARL14EP
Medication: Simvastatin 5.91 2 0 0 0 1 ARL14EP STON1
Impedance of arm (right) 0.84 1 0 0 0 1 STON1
Trunk fat-free mass 0.57 1 0 0 0 1 ARL14EP
Time employed in main current job 3.29 1 0 0 0 1 STON1
Alcohol intake versus 10 years previously 1.70 1 0 0 0 1 ARL14EP
Worrier / anxious feelings 2.75 1 0 0 0 1 STON1
Forced expiratory volume in 1-second (FEV1) 1.21 1 0 0 0 1 ARL14EP
Pulse rate 4.52 2 0 0 0 1 ARL14EP STON1
Happiness 4.31 1 0 0 0 1 STON1
Noisy workplace 2.46 1 0 0 0 1 STON1
Forced expiratory volume in 1-second (FEV1), Best measure 1.53 1 0 0 0 1 ARL14EP
Pulse wave Arterial Stiffness index 3.40 1 0 0 0 1 STON1
Impedance of arm (left) 1.08 1 0 0 0 1 STON1
Trunk predicted mass 0.57 1 0 0 0 1 ARL14EP
Standing height 1.29 1 0 0 0 1 ARL14EP
Peak expiratory flow (PEF) 1.82 1 0 0 0 1 ARL14EP
Ever highly irritable/argumentative for 2 days 2.39 1 0 0 0 1 ARL14EP
Medication: Paracetamol 1.69 1 0 0 0 1 STON1
Headache pain in last month 3.05 1 0 0 0 1 ARL14EP
Forced vital capacity (FVC), Best measure 2.91 1 0 0 0 1 ARL14EP
Number of children fathered 3.34 1 0 0 0 1 STON1
Age at first live birth 7.67 2 0 0 0 1 ARL14EP STON1
Pulse wave peak to peak time 4.00 1 0 0 0 1 STON1
Medication: Blood pressure 1.66 1 0 0 0 1 ARL14EP
Angina (self-reported) 3.53 1 0 0 0 1 ARL14EP
Pulse rate, automated reading 2.03 1 0 0 0 1 STON1
Chest pain or discomfort 3.04 1 0 0 0 1 ARL14EP
Age at last live birth 9.37 2 0 0 0 1 ARL14EP STON1
Qualifications: NVQ or HND or HNC or equivalent 3.33 1 0 0 0 1 ARL14EP
Hypertension (Self-reported) 2.85 1 0 0 0 1 ARL14EP
Whole body fat-free mass 0.72 1 0 0 0 1 ARL14EP
Leg fat-free mass (right) 0.95 1 0 0 0 1 ARL14EP
Average weekly red wine intake 3.66 1 0 0 0 1 ARL14EP
Ever had bowel cancer screening 2.59 1 0 0 0 1 ARL14EP
Diabetes diagnosed by doctor 2.23 1 0 0 0 1 ARL14EP
Medication for cholesterol 2.24 1 0 0 0 1 ARL14EP
Osteoporosis (self-reported) 2.64 1 0 0 0 1 STON1
Leg predicted mass (right) 0.90 1 0 0 0 1 ARL14EP
Ever taken oral contraceptive pill 3.40 1 0 0 0 1 ARL14EP
Number of operations (self-reported) 8.52 1 0 0 0 1 ARL14EP
Age started oral contraceptive pill 3.15 1 0 0 0 1 STON1
Vascular/heart problems diagnosed by doctor 3.16 1 0 0 0 1 ARL14EP
Impedance of whole body 0.65 1 0 0 0 1 STON1
Leg fat mass (left) 0.72 1 0 0 0 1 STON1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.14
GTEx Adipose Visceral Omentum 0 0.0000 1.11
GTEx Adrenal Gland 0 0.0000 1.14
GTEx Artery Aorta 0 0.0000 1.15
GTEx Artery Coronary 0 0.0000 1.11
GTEx Artery Tibial 0 0.0000 1.14
GTEx Brain Caudate basal ganglia 0 0.0000 1.14
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.12
GTEx Brain Cerebellum 0 0.0000 1.08
GTEx Brain Cortex 0 0.0000 1.19
GTEx Brain Frontal Cortex BA9 0 0.0000 1.13
GTEx Brain Hippocampus 0 0.0000 1.08
GTEx Brain Hypothalamus 0 0.0000 1.18
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.13
GTEx Brain Putamen basal ganglia 0 0.0000 1.17
GTEx Breast Mammary Tissue 0 0.0000 1.10
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.12
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.12
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.14
GTEx Cells Transformed fibroblasts 0 0.0000 1.14
GTEx Colon Sigmoid 0 0.0000 1.16
GTEx Colon Transverse 0 0.0000 1.14
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.13
GTEx Esophagus Mucosa 0 0.0000 1.14
GTEx Esophagus Muscularis 0 0.0000 1.15
GTEx Heart Atrial Appendage 0 0.0000 1.14
GTEx Heart Left Ventricle 0 0.0000 1.16
GTEx Liver 0 0.0000 1.25
GTEx Lung 0 0.0000 1.14
GTEx Muscle Skeletal 0 0.0000 1.08
GTEx Nerve Tibial 0 0.0000 1.15
GTEx Ovary 0 0.0000 1.18
GTEx Pancreas 0 0.0000 1.18
GTEx Pituitary 0 0.0000 1.10
GTEx Prostate 0 0.0000 1.14
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.12
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.13
GTEx Small Intestine Terminal Ileum 0 0.0000 1.25
GTEx Spleen 0 0.0000 1.12
GTEx Stomach 0 0.0000 1.13
GTEx Testis 1 0.0317 1.15
GTEx Thyroid 0 0.0000 1.17
GTEx Uterus 0 0.0000 1.15
GTEx Vagina 0 0.0000 1.16
GTEx Whole Blood 0 0.0000 1.13
METSIM Adipose 1 0.0217 1.13
NTR Blood 0 0.0000 1.16
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.19
YFS Blood 0 0.0000 1.08
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.15
TCGA Breast Tumor 0 0.0000 1.20
TCGA Breast Normal 0 0.0000 1.09
TCGA Ovarian Tumor 0 0.0000 1.13
TCGA Prostate Tumor 0 0.0000 1.10