Hub : Traits :

Ever unenthusiastic/disinterested for a whole week

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 139323257 141087689 3 1 8.2e-08 2.1e-06 0.78 100 ZMAT2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 5.55 1 0 0 0 1 ZMAT2
Reaction Time 5.19 1 0 0 0 1 ZMAT2
Verbal and Numeric Reasoning (VNR) 15.50 1 1 3 0 1 ZMAT2
Bipolar Disorder 8.66 1 0 0 0 1 ZMAT2
Schizophrenia 5.16 1 0 0 0 1 ZMAT2
Blood White Count 1.35 1 0 0 0 1 ZMAT2
BMI 4.46 1 1 3 0 1 ZMAT2
Height 0.46 1 0 0 0 1 ZMAT2
Waist Hip Ratio (WHR) 2.13 1 0 0 0 1 ZMAT2
Systolic Blood Pressure 9.58 1 1 3 0 1 ZMAT2
Allergy or Eczema 2.60 1 0 0 0 1 ZMAT2
Respiratory disease 8.16 1 0 0 0 1 ZMAT2
Lung FVC 6.91 1 1 3 0 1 ZMAT2
Neuroticism 6.92 1 0 0 0 1 ZMAT2
Frequency of depressed mood in last 2 weeks 4.98 1 0 0 0 1 ZMAT2
Impedance of leg (right) 2.36 1 0 0 0 1 ZMAT2
Leg fat-free mass (left) 3.40 1 0 0 0 1 ZMAT2
Trunk fat percentage 2.39 1 0 0 0 1 ZMAT2
Age when periods started (menarche) 2.77 1 0 0 0 1 ZMAT2
Sitting height 1.83 1 0 0 0 1 ZMAT2
Body mass index (BMI) 3.48 1 0 0 0 1 ZMAT2
Impedance of leg (left) 2.24 1 0 0 0 1 ZMAT2
Leg predicted mass (left) 3.43 1 0 0 0 1 ZMAT2
Trunk fat mass 3.24 1 0 0 0 1 ZMAT2
Waist circumference 2.81 1 0 0 0 1 ZMAT2
Past tobacco smoking 4.30 1 0 0 0 1 ZMAT2
Frequency of tenseness / restlessness in last 2 weeks 4.81 1 0 0 0 1 ZMAT2
Forced vital capacity (FVC) 5.06 1 0 0 0 1 ZMAT2
Qualifications: None of the above 4.30 1 0 0 0 1 ZMAT2
Allergy 3.93 1 0 0 0 1 ZMAT2
Fluid intelligence score 7.41 1 0 0 0 1 ZMAT2
Neuroticism score 4.27 1 0 0 0 1 ZMAT2
Weight 4.24 1 0 0 0 1 ZMAT2
Impedance of arm (right) 2.06 1 0 0 0 1 ZMAT2
Arm fat percentage (right) 2.43 1 0 0 0 1 ZMAT2
Trunk fat-free mass 3.31 1 0 0 0 1 ZMAT2
Hip circumference 4.86 1 0 0 0 1 ZMAT2
Frequency of tiredness / lethargy in last 2 weeks 4.89 1 0 0 0 1 ZMAT2
Forced expiratory volume in 1-second (FEV1) 3.83 1 0 0 0 1 ZMAT2
Asthma 5.92 1 0 0 0 1 ZMAT2
Forced expiratory volume in 1-second (FEV1), Best measure 6.66 1 0 0 0 1 ZMAT2
Impedance of arm (left) 1.44 1 0 0 0 1 ZMAT2
Arm fat mass (right) 4.05 1 0 0 0 1 ZMAT2
Trunk predicted mass 3.28 1 0 0 0 1 ZMAT2
Mouth/teeth dental problems: Bleeding gums 6.18 1 0 0 0 1 ZMAT2
Birth weight 3.60 1 0 0 0 1 ZMAT2
Forced vital capacity (FVC), Best measure 6.66 1 0 0 0 1 ZMAT2
Body fat percentage 2.30 1 0 0 0 1 ZMAT2
Arm fat-free mass (right) 3.72 1 0 0 0 1 ZMAT2
Worry too long after embarrassment 4.29 1 0 0 0 1 ZMAT2
Qualifications: College or University degree 4.92 1 0 0 0 1 ZMAT2
Eye problems/disorders: None of the above 5.93 1 0 0 0 1 ZMAT2
Medication: Seretide 50 evohaler 7.16 1 0 0 0 1 ZMAT2
Mean time to correctly identify matches 5.27 1 0 0 0 1 ZMAT2
Whole body fat mass 2.94 1 0 0 0 1 ZMAT2
Leg fat mass (right) 2.69 1 0 0 0 1 ZMAT2
Arm predicted mass (right) 3.70 1 0 0 0 1 ZMAT2
Chest pain or discomfort 5.29 1 0 0 0 1 ZMAT2
Family relationship satisfaction 8.23 1 0 0 0 1 ZMAT2
Whole body fat-free mass 3.50 1 0 0 0 1 ZMAT2
Leg fat-free mass (right) 3.42 1 0 0 0 1 ZMAT2
Arm fat percentage (left) 2.69 1 0 0 0 1 ZMAT2
Friendships satisfaction 14.38 1 0 0 0 1 ZMAT2
Asthma (self-reported) 6.75 1 0 0 0 1 ZMAT2
Forced expiratory volume in 1-second (FEV1), predicted percentage 7.98 1 0 0 0 1 ZMAT2
Whole body water mass 3.63 1 0 0 0 1 ZMAT2
Leg predicted mass (right) 3.49 1 0 0 0 1 ZMAT2
Arm fat mass (left) 4.08 1 0 0 0 1 ZMAT2
Miserableness 5.51 1 0 0 0 1 ZMAT2
Financial situation satisfaction 6.56 1 0 0 0 1 ZMAT2
Medication: Bendroflumethiazide 4.12 1 0 0 0 1 ZMAT2
Ever smoked 6.07 1 0 0 0 1 ZMAT2
Basal metabolic rate 3.97 1 0 0 0 1 ZMAT2
Arm fat-free mass (left) 3.46 1 0 0 0 1 ZMAT2
Ever depressed for a whole week 6.91 1 0 0 0 1 ZMAT2
Impedance of whole body 2.83 1 0 0 0 1 ZMAT2
Leg fat mass (left) 2.73 1 0 0 0 1 ZMAT2
Arm predicted mass (left) 3.85 1 0 0 0 1 ZMAT2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.21
GTEx Adipose Visceral Omentum 0 0.0000 1.28
GTEx Adrenal Gland 0 0.0000 1.21
GTEx Artery Aorta 0 0.0000 1.26
GTEx Artery Coronary 0 0.0000 1.26
GTEx Artery Tibial 0 0.0000 1.20
GTEx Brain Caudate basal ganglia 0 0.0000 1.30
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.25
GTEx Brain Cerebellum 0 0.0000 1.25
GTEx Brain Cortex 0 0.0000 1.28
GTEx Brain Frontal Cortex BA9 0 0.0000 1.36
GTEx Brain Hippocampus 0 0.0000 1.36
GTEx Brain Hypothalamus 0 0.0000 1.41
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.27
GTEx Brain Putamen basal ganglia 0 0.0000 1.34
GTEx Breast Mammary Tissue 0 0.0000 1.29
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.26
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.25
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.31
GTEx Cells Transformed fibroblasts 0 0.0000 1.22
GTEx Colon Sigmoid 0 0.0000 1.24
GTEx Colon Transverse 0 0.0000 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.25
GTEx Esophagus Mucosa 0 0.0000 1.29
GTEx Esophagus Muscularis 0 0.0000 1.28
GTEx Heart Atrial Appendage 0 0.0000 1.27
GTEx Heart Left Ventricle 0 0.0000 1.35
GTEx Liver 0 0.0000 1.22
GTEx Lung 0 0.0000 1.29
GTEx Muscle Skeletal 0 0.0000 1.27
GTEx Nerve Tibial 0 0.0000 1.23
GTEx Ovary 0 0.0000 1.32
GTEx Pancreas 0 0.0000 1.28
GTEx Pituitary 0 0.0000 1.26
GTEx Prostate 0 0.0000 1.20
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.26
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.26
GTEx Small Intestine Terminal Ileum 0 0.0000 1.37
GTEx Spleen 0 0.0000 1.29
GTEx Stomach 0 0.0000 1.29
GTEx Testis 0 0.0000 1.22
GTEx Thyroid 0 0.0000 1.26
GTEx Uterus 0 0.0000 1.34
GTEx Vagina 0 0.0000 1.33
GTEx Whole Blood 0 0.0000 1.12
METSIM Adipose 0 0.0000 1.19
NTR Blood 0 0.0000 1.20
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.23
YFS Blood 0 0.0000 1.14
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.20
TCGA Breast Tumor 1 0.1304 1.25
TCGA Breast Normal 0 0.0000 1.17
TCGA Ovarian Tumor 0 0.0000 1.17
TCGA Prostate Tumor 0 0.0000 1.18