Hub : Traits :

Qualifications: CSEs or equivalent

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 150008790 151435941 1 1 2.4e-07 1.1e-05 0.073 83 CTSS

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.09 1 0 0 0 1 CTSS
Breast Cancer 2.47 1 0 0 0 1 CTSS
Body Mass Index (BMI) (2010) 4.32 1 0 0 0 1 CTSS
Coronary Artery Disease (CAD) 5.25 1 0 0 0 1 CTSS
Crohns Disease (2012) 5.31 1 0 0 0 1 CTSS
Mean Putamen Volume 3.50 1 0 0 0 1 CTSS
Lupus 3.57 1 0 0 0 1 CTSS
Schizophrenia 5.65 1 0 0 0 1 CTSS
Blood Eosinophil Count 1.21 1 0 0 0 1 CTSS
Blood Platelet Count 4.12 1 1 3 0 1 CTSS
Heel T-Score 2.19 1 0 0 0 1 CTSS
BMI 2.39 1 0 0 0 1 CTSS
Height 0.77 1 0 0 0 1 CTSS
Allergy or Eczema 6.46 1 0 0 0 1 CTSS
Lung FEV1/FVC ratio 1.38 1 0 0 0 1 CTSS
Lung FVC 8.33 1 1 3 0 1 CTSS
Hair Pigment 0.30 1 0 0 0 1 CTSS
Tanning 1.12 1 0 0 0 1 CTSS
Eye problems/disorders: Diabetes related eye disease 3.75 1 0 0 0 1 CTSS
Impedance of leg (right) 2.17 1 0 0 0 1 CTSS
Trunk fat percentage 4.10 1 0 0 0 1 CTSS
Townsend deprivation index at recruitment 2.89 1 0 0 0 1 CTSS
Frequency of unenthusiasm / disinterest in last 2 weeks 3.03 1 0 0 0 1 CTSS
Age when periods started (menarche) 3.25 1 0 0 0 1 CTSS
Serious illness, injury or assault to yourself 5.85 1 0 0 0 1 CTSS
Hayfever, allergic rhinitis or eczema 3.97 1 0 0 0 1 CTSS
Supplements: Glucosamine 3.77 1 0 0 0 1 CTSS
Body mass index (BMI) 1.83 1 0 0 0 1 CTSS
Impedance of leg (left) 1.54 1 0 0 0 1 CTSS
Trunk fat mass 2.60 1 0 0 0 1 CTSS
Waist circumference 1.21 1 0 0 0 1 CTSS
Alcohol usually taken with meals 6.48 1 0 0 0 1 CTSS
Frequency of tenseness / restlessness in last 2 weeks 3.32 1 0 0 0 1 CTSS
Forced vital capacity (FVC) 7.44 1 1 3 0 1 CTSS
Arm fat percentage (right) 3.29 1 0 0 0 1 CTSS
Hip circumference 1.67 1 0 0 0 1 CTSS
Father's age at death 2.94 1 0 0 0 1 CTSS
Forced expiratory volume in 1-second (FEV1) 5.64 1 0 0 0 1 CTSS
Noisy workplace 4.41 1 0 0 0 1 CTSS
Medication: Cholesterol lowering 3.48 1 0 0 0 1 CTSS
Medication: Lansoprazole 3.88 1 0 0 0 1 CTSS
Lung cancer (father) 4.64 1 0 0 0 1 CTSS
Forced expiratory volume in 1-second (FEV1), Best measure 4.74 1 0 0 0 1 CTSS
Pulse wave Arterial Stiffness index 4.82 1 0 0 0 1 CTSS
Arm fat mass (right) 2.00 1 0 0 0 1 CTSS
Standing height 0.71 1 0 0 0 1 CTSS
Breastfed as a baby 3.61 1 0 0 0 1 CTSS
Birth weight of first child 5.23 1 0 0 0 1 CTSS
Peak expiratory flow (PEF) 2.65 1 0 0 0 1 CTSS
Forced vital capacity (FVC), Best measure 7.57 1 1 3 0 1 CTSS
Body fat percentage 5.29 1 0 0 0 1 CTSS
Leg fat percentage (right) 6.77 1 0 0 0 1 CTSS
Exposure to tobacco smoke outside home 3.82 1 0 0 0 1 CTSS
Worry too long after embarrassment 2.45 1 0 0 0 1 CTSS
Qualifications: College or University degree 3.76 1 0 0 0 1 CTSS
Medication: Blood pressure 4.13 1 0 0 0 1 CTSS
Medication: Allopurinol 4.91 1 0 0 0 1 CTSS
Medication: Seretide 50 evohaler 3.44 1 0 0 0 1 CTSS
Whole body fat mass 2.86 1 0 0 0 1 CTSS
Leg fat mass (right) 3.94 1 0 0 0 1 CTSS
Commuting to job workplace: Car/motor vehicle 3.42 1 0 0 0 1 CTSS
Arm fat percentage (left) 3.33 1 0 0 0 1 CTSS
Average weekly red wine intake 2.86 1 0 0 0 1 CTSS
Mouth/teeth dental problems: Mouth ulcers 6.74 1 0 0 0 1 CTSS
Osteoarthritis (self-reported) 3.37 1 0 0 0 1 CTSS
Forced expiratory volume in 1-second (FEV1), predicted percentage 7.90 1 0 0 0 1 CTSS
Arm fat mass (left) 1.92 1 0 0 0 1 CTSS
Average weekly champagne plus white wine intake 6.00 1 0 0 0 1 CTSS
Miserableness 2.78 1 0 0 0 1 CTSS
Guilty feelings 3.86 1 0 0 0 1 CTSS
Pain type(s) experienced in last month: Hip pain 5.22 1 0 0 0 1 CTSS
Leg fat percentage (left) 5.50 1 0 0 0 1 CTSS
Number of operations (self-reported) 2.87 1 0 0 0 1 CTSS
Commuting to job workplace: Cycle 3.55 1 0 0 0 1 CTSS
Myopia 8.39 1 0 0 0 1 CTSS
Basal cell carcinoma (self-reported) 4.42 1 0 0 0 1 CTSS
Impedance of whole body 0.75 1 0 0 0 1 CTSS
Leg fat mass (left) 3.07 1 0 0 0 1 CTSS

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.36
GTEx Adipose Visceral Omentum 0 0.0000 1.40
GTEx Adrenal Gland 0 0.0000 1.25
GTEx Artery Aorta 0 0.0000 1.36
GTEx Artery Coronary 0 0.0000 1.35
GTEx Artery Tibial 0 0.0000 1.33
GTEx Brain Caudate basal ganglia 0 0.0000 1.31
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.38
GTEx Brain Cerebellum 0 0.0000 1.40
GTEx Brain Cortex 0 0.0000 1.37
GTEx Brain Frontal Cortex BA9 0 0.0000 1.42
GTEx Brain Hippocampus 0 0.0000 1.28
GTEx Brain Hypothalamus 0 0.0000 1.42
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.40
GTEx Brain Putamen basal ganglia 0 0.0000 1.34
GTEx Breast Mammary Tissue 0 0.0000 1.38
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.30
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.31
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.41
GTEx Cells Transformed fibroblasts 0 0.0000 1.33
GTEx Colon Sigmoid 0 0.0000 1.39
GTEx Colon Transverse 0 0.0000 1.42
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.39
GTEx Esophagus Mucosa 0 0.0000 1.35
GTEx Esophagus Muscularis 0 0.0000 1.39
GTEx Heart Atrial Appendage 0 0.0000 1.38
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 0 0.0000 1.31
GTEx Lung 0 0.0000 1.36
GTEx Muscle Skeletal 0 0.0000 1.38
GTEx Nerve Tibial 0 0.0000 1.34
GTEx Ovary 0 0.0000 1.28
GTEx Pancreas 0 0.0000 1.34
GTEx Pituitary 0 0.0000 1.30
GTEx Prostate 0 0.0000 1.27
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.31
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.32
GTEx Small Intestine Terminal Ileum 0 0.0000 1.45
GTEx Spleen 0 0.0000 1.35
GTEx Stomach 0 0.0000 1.30
GTEx Testis 0 0.0000 1.36
GTEx Thyroid 0 0.0000 1.34
GTEx Uterus 0 0.0000 1.42
GTEx Vagina 0 0.0000 1.41
GTEx Whole Blood 0 0.0000 1.31
METSIM Adipose 1 0.0217 1.31
NTR Blood 0 0.0000 1.30
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.32
YFS Blood 0 0.0000 1.28
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.28
TCGA Breast Tumor 0 0.0000 1.32
TCGA Breast Normal 0 0.0000 1.30
TCGA Ovarian Tumor 0 0.0000 1.33
TCGA Prostate Tumor 0 0.0000 1.30