Hub : Traits :

Illnesses of father: High blood pressure

25 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	46723603	48128751	1	1	6.4e-08	6.3e-08	1.00	100	RP11-750H9.5
2	15	90730363	92135418	1	1	8.8e-14	2.2e-11	0.81	100	FES
3	16	89037130	90172696	2	1	9.8e-08	9.8e-08	0.20	94	CHMP1A

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Tanning	61.68	2	1	2.2	1	CHMP1A RP11-750H9.5
Hypertension (Self-reported)	32.90	3	3	6.7	1	CHMP1A FES RP11-750H9.5
Vascular/heart problems diagnosed by doctor	32.74	3	3	6.7	1	CHMP1A FES RP11-750H9.5
High blood pressure	31.85	3	3	6.7	1	CHMP1A FES RP11-750H9.5
Systolic Blood Pressure	28.25	3	2	4.4	1	CHMP1A FES RP11-750H9.5
High blood pressure (mother)	28.21	2	1	2.2	1	CHMP1A FES
Hair Pigment	28.18	2	2	4.4	1	CHMP1A FES
Medication: Blood pressure	25.52	3	2	4.4	1	CHMP1A FES RP11-750H9.5
Medication: Blood pressure	24.64	3	1	2.2	1	CHMP1A FES RP11-750H9.5
Cardiovascular Disease	22.87	3	3	6.7	1	CHMP1A FES RP11-750H9.5
Systolic blood pressure, automated reading	19.55	2	1	2.2	1	FES RP11-750H9.5
Medication for cholesterol, blood pressure or diabetes	17.50	1	1	2.2	1	FES
Diastolic blood pressure, automated reading	17.06	3	2	4.4	1	CHMP1A FES RP11-750H9.5
Medication: Atenolol	16.48	1	1	2.2	1	FES
Illnesses of mother	14.90	2	1	2.2	1	FES RP11-750H9.5
Illnesses of father: None of the above (group 1)	14.37	1	1	2.2	1	FES
Medication: Amlodipine	14.31	2	1	2.2	1	CHMP1A FES
Illnesses of father: Heart disease	14.00	1	1	2.2	1	FES
Medication: Bendroflumethiazide	13.92	3	1	2.2	1	CHMP1A FES RP11-750H9.5
High blood pressure (siblings)	13.70	2	1	2.2	1	FES RP11-750H9.5
Angina (self-reported)	12.43	1	1	2.2	1	FES
Birth weight of first child	12.08	1	1	2.2	1	FES
Angina	12.01	1	1	2.2	1	FES
Bipolar Disorder or Schizophrenia	11.77	2	1	2.2	1	CHMP1A FES
Schizophrenia (2014)	10.63	2	1	2.2	1	CHMP1A FES
Medication: Aspirin	10.43	1	1	2.2	1	FES
Schizophrenia (2018)	10.21	1	1	2.2	1	FES
Mood swings	10.12	1	1	2.2	1	RP11-750H9.5
Medication: Ramipril	9.58	2	0	0.0	1	FES RP11-750H9.5
Medication: Aspirin	9.23	1	1	2.2	1	FES
Medication for cholesterol	8.63	2	0	0.0	1	CHMP1A FES
Medication: Cholesterol lowering	8.14	1	1	2.2	1	FES
Heart attack	8.01	1	1	2.2	1	FES
Heart attack/myocardial infarction (self-reported)	7.96	1	1	2.2	1	FES
Medication: Lisinopril	7.92	2	0	0.0	1	CHMP1A FES
Depressed Affect (Nagel 2018)	7.66	1	1	2.2	1	RP11-750H9.5
Medication: Simvastatin	7.56	1	1	2.2	1	FES
Miserableness	7.54	1	1	2.2	1	RP11-750H9.5
Father's age at death	7.27	1	1	2.2	1	FES
Illnesses of siblings	7.06	1	1	2.2	1	FES
Fasting Glucose	6.89	1	0	0.0	1	RP11-750H9.5
Neuroticism (Nagel 2018)	6.86	2	1	2.2	1	FES RP11-750H9.5
Alzheimer’s Disease (including proxy)	6.72	1	0	0.0	1	RP11-750H9.5
Heart disease (siblings)	6.50	1	0	0.0	1	FES
Neuroticism score	6.20	1	1	2.2	1	RP11-750H9.5
Severe depression (siblings)	6.14	1	0	0.0	1	CHMP1A
Birth weight	6.03	1	1	2.2	1	FES
Sensitivity / hurt feelings	5.87	1	1	2.2	1	FES
Neuroticism (2016)	5.79	1	0	0.0	1	RP11-750H9.5
Bipolar Disorder (2018)	5.70	2	0	0.0	1	CHMP1A FES
Handedness (chirality/laterality): Left-handed	5.51	1	0	0.0	1	FES
Number of incorrect matches in round	5.48	1	0	0.0	1	FES
Loneliness, isolation	5.30	1	0	0.0	1	RP11-750H9.5
Frequency of depressed mood in last 2 weeks	5.21	1	0	0.0	1	RP11-750H9.5
Suffer from 'nerves'	5.14	1	0	0.0	1	RP11-750H9.5
Neuroticism	5.12	2	0	0.0	1	FES RP11-750H9.5
Heart disease (mother)	5.04	1	0	0.0	1	FES
Worry (Nagel 2018)	5.02	1	1	2.2	1	RP11-750H9.5
Breast Cancer	4.96	2	0	0.0	1	FES RP11-750H9.5
Arm fat percentage (left)	4.82	1	1	2.2	1	RP11-750H9.5
Hand grip strength (left)	4.79	3	0	0.0	1	CHMP1A FES RP11-750H9.5
Pulse wave peak to peak time	4.79	1	0	0.0	1	FES
Arm fat percentage (right)	4.58	1	1	2.2	1	RP11-750H9.5
Impedance of leg (right)	4.48	2	2	4.4	1	FES RP11-750H9.5
Impedance of leg (left)	4.43	2	2	4.4	1	FES RP11-750H9.5
Breastfed as a baby	4.43	1	0	0.0	1	FES
Risk taking	4.40	1	0	0.0	1	FES
Pulse wave Arterial Stiffness index	4.29	1	0	0.0	1	FES
Hair/balding pattern: Pattern 4	4.27	2	0	0.0	1	CHMP1A FES
Lung cancer (father)	4.22	1	0	0.0	1	FES
Nervous feelings	4.14	1	0	0.0	1	RP11-750H9.5
Tense / 'highly strung'	4.11	1	0	0.0	1	RP11-750H9.5
Body Mass Index (BMI) (2010)	3.97	1	0	0.0	1	RP11-750H9.5
Number of live births	3.97	1	0	0.0	1	FES
Guilty feelings	3.96	1	0	0.0	1	RP11-750H9.5
Prostate Cancer	3.94	1	0	0.0	1	RP11-750H9.5
Comparative body size at age 10	3.92	1	1	2.2	1	RP11-750H9.5
Ovarian Cancer	3.88	1	0	0.0	1	FES
Fed-up feelings	3.87	1	0	0.0	1	RP11-750H9.5
Waist circumference	3.87	1	1	2.2	1	RP11-750H9.5
Allergy	3.81	1	0	0.0	1	FES
Alcohol usually taken with meals	3.79	1	0	0.0	1	FES
Arm fat mass (left)	3.73	1	1	2.2	1	RP11-750H9.5
Trunk fat percentage	3.68	1	1	2.2	1	RP11-750H9.5
Mouth/teeth dental problems: Bleeding gums	3.68	1	0	0.0	1	RP11-750H9.5
Frequency of tenseness / restlessness in last 2 weeks	3.59	1	0	0.0	1	RP11-750H9.5
Headache pain in last month	3.57	1	0	0.0	1	FES
Mineral and other dietary supplements	3.53	1	0	0.0	1	FES
Supplements: Fish oil (including cod liver oil)	3.45	1	0	0.0	1	FES
Arm fat mass (right)	3.40	1	1	2.2	1	RP11-750H9.5
Number of treatments/medications taken	3.38	1	0	0.0	1	FES
Age started oral contraceptive pill	3.37	1	0	0.0	1	FES
Osteoarthritis (self-reported)	3.34	1	0	0.0	1	CHMP1A
Smoking Status	3.30	1	0	0.0	1	FES
Medication: Metformin	3.23	1	0	0.0	1	RP11-750H9.5
Illness, injury, bereavement, stress in last 2 years	3.23	1	0	0.0	1	RP11-750H9.5
Trunk fat mass	3.22	1	1	2.2	1	RP11-750H9.5
Current tobacco smoking	3.18	1	0	0.0	1	FES
Hand grip strength (right)	3.11	1	0	0.0	1	RP11-750H9.5
Hayfever, allergic rhinitis or eczema	3.11	1	0	0.0	1	FES
Alcohol drinker status: Previous	3.03	1	0	0.0	1	CHMP1A
Basal cell carcinoma (self-reported)	2.99	1	0	0.0	1	CHMP1A
Ever smoked	2.98	1	0	0.0	1	FES
Leg predicted mass (right)	2.91	2	0	0.0	1	FES RP11-750H9.5
BMI	2.89	1	1	2.2	1	RP11-750H9.5
Respiratory disease	2.86	1	0	0.0	1	FES
Leg fat-free mass (right)	2.86	2	0	0.0	1	FES RP11-750H9.5
Body fat percentage	2.84	1	1	2.2	1	RP11-750H9.5
Mean time to correctly identify matches	2.84	1	0	0.0	1	FES
Alcohol intake frequency.	2.82	1	0	0.0	1	RP11-750H9.5
Average weekly champagne plus white wine intake	2.82	1	0	0.0	1	RP11-750H9.5
Allergy or Eczema	2.78	1	0	0.0	1	FES
Asthma	2.77	1	0	0.0	1	FES
Asthma (self-reported)	2.77	1	0	0.0	1	FES
Medication: Omeprazole (e.g. Zanprol)	2.74	1	0	0.0	1	CHMP1A
Leg predicted mass (left)	2.73	2	0	0.0	1	FES RP11-750H9.5
Body mass index (BMI)	2.71	1	1	2.2	1	RP11-750H9.5
Leg fat-free mass (left)	2.70	2	0	0.0	1	FES RP11-750H9.5
Whole body fat mass	2.69	1	1	2.2	1	RP11-750H9.5
Past tobacco smoking	2.57	1	0	0.0	1	FES
Blood Red Count	2.51	3	1	2.2	1	CHMP1A FES RP11-750H9.5
Blood White Count	2.45	1	1	2.2	1	FES
Pulse rate, automated reading	2.43	1	0	0.0	1	RP11-750H9.5
Peak expiratory flow (PEF)	2.37	1	0	0.0	1	CHMP1A
High cholesterol (Self-reported)	2.32	1	0	0.0	1	FES
Crohns Disease (2012)	2.18	1	0	0.0	1	FES
Weight	2.17	1	0	0.0	1	RP11-750H9.5
Hypothyroidism (self reported)	2.12	1	0	0.0	1	RP11-750H9.5
Comparative height size at age 10	1.94	2	0	0.0	1	CHMP1A FES
Leg fat mass (left)	1.76	1	0	0.0	1	RP11-750H9.5
Age when periods started (menarche)	1.68	1	0	0.0	1	RP11-750H9.5
Forced expiratory volume in 1-second (FEV1)	1.65	1	0	0.0	1	CHMP1A
Crohns Disease (2017)	1.64	1	0	0.0	1	FES
Basal metabolic rate	1.63	2	0	0.0	1	FES RP11-750H9.5
Hip circumference	1.62	1	0	0.0	1	RP11-750H9.5
Leg fat mass (right)	1.61	1	0	0.0	1	RP11-750H9.5
Whole body water mass	1.55	1	0	0.0	1	FES
Irritable Bowel Disease (IBD)	1.48	1	0	0.0	1	FES
Whole body fat-free mass	1.48	1	0	0.0	1	FES
Sitting height	1.47	2	0	0.0	1	FES RP11-750H9.5
Waist Hip Ratio (WHR)	1.46	1	0	0.0	1	RP11-750H9.5
Blood Eosinophil Count	1.45	1	1	2.2	1	RP11-750H9.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.42	1	0	0.0	1	CHMP1A
Impedance of whole body	1.17	1	0	0.0	1	FES
Leg fat percentage (left)	1.16	1	0	0.0	1	RP11-750H9.5
Forced vital capacity (FVC), Best measure	1.12	1	0	0.0	1	CHMP1A
Forced vital capacity (FVC)	1.09	1	0	0.0	1	CHMP1A
Trunk fat-free mass	1.08	1	0	0.0	1	FES
Trunk predicted mass	1.08	1	0	0.0	1	FES
Height	0.74	2	1	2.2	1	CHMP1A FES
Standing height	0.64	1	0	0.0	1	CHMP1A

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Prostate	0	0.000	1.4
GTEx	Adipose Subcutaneous	1	0.029	1.3
GTEx	Adipose Visceral Omentum	2	0.098	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	1	0.027	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.3
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	1	0.022	1.2
NTR	Blood	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.2
GTEx	Brain Hypothalamus	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
GTEx	Small Intestine Terminal Ileum	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1