Hub : Traits :

Illnesses of father: High blood pressure

25 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 46723603 48128751 1 1 6.4e-08 6.3e-08 1.00 100 RP11-750H9.5
2 15 90730363 92135418 1 1 8.8e-14 2.2e-11 0.81 100 FES
3 16 89037130 90172696 2 1 9.8e-08 9.8e-08 0.20 94 CHMP1A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 5.70 2 0 0.0 0 1 CHMP1A FES
Bipolar Disorder or Schizophrenia 11.77 2 1 2.2 0 1 CHMP1A FES
Depressed Affect (Nagel 2018) 7.66 1 1 2.2 0 1 RP11-750H9.5
Neuroticism (Nagel 2018) 6.86 2 1 2.2 0 1 FES RP11-750H9.5
Schizophrenia (2018) 10.21 1 1 2.2 0 1 FES
Worry (Nagel 2018) 5.02 1 1 2.2 0 1 RP11-750H9.5
Alzheimer’s Disease (including proxy) 6.72 1 0 0.0 0 1 RP11-750H9.5
Crohns Disease (2017) 1.64 1 0 0.0 0 1 FES
Irritable Bowel Disease (IBD) 1.48 1 0 0.0 0 1 FES
Breast Cancer 4.96 2 0 0.0 0 1 FES RP11-750H9.5
Ovarian Cancer 3.88 1 0 0.0 0 1 FES
Prostate Cancer 3.94 1 0 0.0 0 1 RP11-750H9.5
Body Mass Index (BMI) (2010) 3.97 1 0 0.0 0 1 RP11-750H9.5
Crohns Disease (2012) 2.18 1 0 0.0 0 1 FES
Fasting Glucose 6.89 1 0 0.0 0 1 RP11-750H9.5
Neuroticism (2016) 5.79 1 0 0.0 0 1 RP11-750H9.5
Schizophrenia (2014) 10.63 2 1 2.2 0 1 CHMP1A FES
Blood Eosinophil Count 1.45 1 1 2.2 0 1 RP11-750H9.5
Blood Red Count 2.51 3 1 2.2 0 1 CHMP1A FES RP11-750H9.5
Blood White Count 2.45 1 1 2.2 0 1 FES
BMI 2.89 1 1 2.2 0 1 RP11-750H9.5
Height 0.74 2 1 2.2 0 1 CHMP1A FES
Waist Hip Ratio (WHR) 1.46 1 0 0.0 0 1 RP11-750H9.5
Systolic Blood Pressure 28.25 3 2 4.4 0 1 CHMP1A FES RP11-750H9.5
Smoking Status 3.30 1 0 0.0 0 1 FES
Allergy or Eczema 2.78 1 0 0.0 0 1 FES
Cardiovascular Disease 22.87 3 3 6.7 0 1 CHMP1A FES RP11-750H9.5
Hypothyroidism (self reported) 2.12 1 0 0.0 0 1 RP11-750H9.5
Respiratory disease 2.86 1 0 0.0 0 1 FES
Neuroticism 5.12 2 0 0.0 0 1 FES RP11-750H9.5
Hair Pigment 28.18 2 2 4.4 0 1 CHMP1A FES
Tanning 61.68 2 1 2.2 0 1 CHMP1A RP11-750H9.5
Hand grip strength (left) 4.79 3 0 0.0 0 1 CHMP1A FES RP11-750H9.5
Number of treatments/medications taken 3.38 1 0 0.0 0 1 FES
Sensitivity / hurt feelings 5.87 1 1 2.2 0 1 FES
Frequency of depressed mood in last 2 weeks 5.21 1 0 0.0 0 1 RP11-750H9.5
Systolic blood pressure, automated reading 19.55 2 1 2.2 0 1 FES RP11-750H9.5
Angina 12.01 1 1 2.2 0 1 FES
Medication: Metformin 3.23 1 0 0.0 0 1 RP11-750H9.5
Severe depression (siblings) 6.14 1 0 0.0 0 1 CHMP1A
Impedance of leg (right) 4.48 2 2 4.4 0 1 FES RP11-750H9.5
Leg fat-free mass (left) 2.70 2 0 0.0 0 1 FES RP11-750H9.5
Trunk fat percentage 3.68 1 1 2.2 0 1 RP11-750H9.5
Hand grip strength (right) 3.11 1 0 0.0 0 1 RP11-750H9.5
Current tobacco smoking 3.18 1 0 0.0 0 1 FES
Fed-up feelings 3.87 1 0 0.0 0 1 RP11-750H9.5
Age when periods started (menarche) 1.68 1 0 0.0 0 1 RP11-750H9.5
High blood pressure 31.85 3 3 6.7 0 1 CHMP1A FES RP11-750H9.5
Hayfever, allergic rhinitis or eczema 3.11 1 0 0.0 0 1 FES
Medication: Atenolol 16.48 1 1 2.2 0 1 FES
Sitting height 1.47 2 0 0.0 0 1 FES RP11-750H9.5
High blood pressure (mother) 28.21 2 1 2.2 0 1 CHMP1A FES
Body mass index (BMI) 2.71 1 1 2.2 0 1 RP11-750H9.5
Impedance of leg (left) 4.43 2 2 4.4 0 1 FES RP11-750H9.5
Leg predicted mass (left) 2.73 2 0 0.0 0 1 FES RP11-750H9.5
Trunk fat mass 3.22 1 1 2.2 0 1 RP11-750H9.5
Waist circumference 3.87 1 1 2.2 0 1 RP11-750H9.5
Number of incorrect matches in round 5.48 1 0 0.0 0 1 FES
Past tobacco smoking 2.57 1 0 0.0 0 1 FES
Alcohol usually taken with meals 3.79 1 0 0.0 0 1 FES
Nervous feelings 4.14 1 0 0.0 0 1 RP11-750H9.5
Frequency of tenseness / restlessness in last 2 weeks 3.59 1 0 0.0 0 1 RP11-750H9.5
Forced vital capacity (FVC) 1.09 1 0 0.0 0 1 CHMP1A
Heart attack 8.01 1 1 2.2 0 1 FES
Allergy 3.81 1 0 0.0 0 1 FES
Medication: Ramipril 9.58 2 0 0.0 0 1 FES RP11-750H9.5
Medication: Simvastatin 7.56 1 1 2.2 0 1 FES
Illnesses of siblings 7.06 1 1 2.2 0 1 FES
Neuroticism score 6.20 1 1 2.2 0 1 RP11-750H9.5
Weight 2.17 1 0 0.0 0 1 RP11-750H9.5
Arm fat percentage (right) 4.58 1 1 2.2 0 1 RP11-750H9.5
Trunk fat-free mass 1.08 1 0 0.0 0 1 FES
Hip circumference 1.62 1 0 0.0 0 1 RP11-750H9.5
Father's age at death 7.27 1 1 2.2 0 1 FES
Number of live births 3.97 1 0 0.0 0 1 FES
Forced expiratory volume in 1-second (FEV1) 1.65 1 0 0.0 0 1 CHMP1A
Asthma 2.77 1 0 0.0 0 1 FES
Medication: Cholesterol lowering 8.14 1 1 2.2 0 1 FES
Lung cancer (father) 4.22 1 0 0.0 0 1 FES
Illnesses of mother 14.90 2 1 2.2 0 1 FES RP11-750H9.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.42 1 0 0.0 0 1 CHMP1A
Pulse wave Arterial Stiffness index 4.29 1 0 0.0 0 1 FES
Arm fat mass (right) 3.40 1 1 2.2 0 1 RP11-750H9.5
Trunk predicted mass 1.08 1 0 0.0 0 1 FES
Standing height 0.64 1 0 0.0 0 1 CHMP1A
Breastfed as a baby 4.43 1 0 0.0 0 1 FES
Tense / 'highly strung' 4.11 1 0 0.0 0 1 RP11-750H9.5
Hair/balding pattern: Pattern 4 4.27 2 0 0.0 0 1 CHMP1A FES
Birth weight of first child 12.08 1 1 2.2 0 1 FES
Peak expiratory flow (PEF) 2.37 1 0 0.0 0 1 CHMP1A
Mouth/teeth dental problems: Bleeding gums 3.68 1 0 0.0 0 1 RP11-750H9.5
Headache pain in last month 3.57 1 0 0.0 0 1 FES
Medication for cholesterol, blood pressure or diabetes 17.50 1 1 2.2 0 1 FES
Medication: Amlodipine 14.31 2 1 2.2 0 1 CHMP1A FES
Birth weight 6.03 1 1 2.2 0 1 FES
High blood pressure (siblings) 13.70 2 1 2.2 0 1 FES RP11-750H9.5
Forced vital capacity (FVC), Best measure 1.12 1 0 0.0 0 1 CHMP1A
Body fat percentage 2.84 1 1 2.2 0 1 RP11-750H9.5
Comparative body size at age 10 3.92 1 1 2.2 0 1 RP11-750H9.5
Pulse wave peak to peak time 4.79 1 0 0.0 0 1 FES
Medication: Blood pressure 24.64 3 1 2.2 0 1 CHMP1A FES RP11-750H9.5
Angina (self-reported) 12.43 1 1 2.2 0 1 FES
Mean time to correctly identify matches 2.84 1 0 0.0 0 1 FES
Heart disease (mother) 5.04 1 0 0.0 0 1 FES
Whole body fat mass 2.69 1 1 2.2 0 1 RP11-750H9.5
Leg fat mass (right) 1.61 1 0 0.0 0 1 RP11-750H9.5
Pulse rate, automated reading 2.43 1 0 0.0 0 1 RP11-750H9.5
Alcohol intake frequency. 2.82 1 0 0.0 0 1 RP11-750H9.5
Comparative height size at age 10 1.94 2 0 0.0 0 1 CHMP1A FES
Suffer from 'nerves' 5.14 1 0 0.0 0 1 RP11-750H9.5
Illness, injury, bereavement, stress in last 2 years 3.23 1 0 0.0 0 1 RP11-750H9.5
Medication: Aspirin 9.23 1 1 2.2 0 1 FES
Hypertension (Self-reported) 32.90 3 3 6.7 0 1 CHMP1A FES RP11-750H9.5
Illnesses of father: Heart disease 14.00 1 1 2.2 0 1 FES
Whole body fat-free mass 1.48 1 0 0.0 0 1 FES
Leg fat-free mass (right) 2.86 2 0 0.0 0 1 FES RP11-750H9.5
Arm fat percentage (left) 4.82 1 1 2.2 0 1 RP11-750H9.5
Handedness (chirality/laterality): Left-handed 5.51 1 0 0.0 0 1 FES
Mood swings 10.12 1 1 2.2 0 1 RP11-750H9.5
Loneliness, isolation 5.30 1 0 0.0 0 1 RP11-750H9.5
Medication for cholesterol 8.63 2 0 0.0 0 1 CHMP1A FES
Mineral and other dietary supplements 3.53 1 0 0.0 0 1 FES
Asthma (self-reported) 2.77 1 0 0.0 0 1 FES
Osteoarthritis (self-reported) 3.34 1 0 0.0 0 1 CHMP1A
Medication: Aspirin 10.43 1 1 2.2 0 1 FES
Illnesses of father: None of the above (group 1) 14.37 1 1 2.2 0 1 FES
Whole body water mass 1.55 1 0 0.0 0 1 FES
Leg predicted mass (right) 2.91 2 0 0.0 0 1 FES RP11-750H9.5
Arm fat mass (left) 3.73 1 1 2.2 0 1 RP11-750H9.5
Average weekly champagne plus white wine intake 2.82 1 0 0.0 0 1 RP11-750H9.5
Miserableness 7.54 1 1 2.2 0 1 RP11-750H9.5
Guilty feelings 3.96 1 0 0.0 0 1 RP11-750H9.5
Medication: Blood pressure 25.52 3 2 4.4 0 1 CHMP1A FES RP11-750H9.5
Supplements: Fish oil (including cod liver oil) 3.45 1 0 0.0 0 1 FES
High cholesterol (Self-reported) 2.32 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 13.92 3 1 2.2 0 1 CHMP1A FES RP11-750H9.5
Medication: Lisinopril 7.92 2 0 0.0 0 1 CHMP1A FES
Ever smoked 2.98 1 0 0.0 0 1 FES
Basal metabolic rate 1.63 2 0 0.0 0 1 FES RP11-750H9.5
Leg fat percentage (left) 1.16 1 0 0.0 0 1 RP11-750H9.5
Risk taking 4.40 1 0 0.0 0 1 FES
Age started oral contraceptive pill 3.37 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 17.06 3 2 4.4 0 1 CHMP1A FES RP11-750H9.5
Vascular/heart problems diagnosed by doctor 32.74 3 3 6.7 0 1 CHMP1A FES RP11-750H9.5
Medication: Omeprazole (e.g. Zanprol) 2.74 1 0 0.0 0 1 CHMP1A
Basal cell carcinoma (self-reported) 2.99 1 0 0.0 0 1 CHMP1A
Heart attack/myocardial infarction (self-reported) 7.96 1 1 2.2 0 1 FES
Heart disease (siblings) 6.50 1 0 0.0 0 1 FES
Alcohol drinker status: Previous 3.03 1 0 0.0 0 1 CHMP1A
Impedance of whole body 1.17 1 0 0.0 0 1 FES
Leg fat mass (left) 1.76 1 0 0.0 0 1 RP11-750H9.5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.3
GTEx Adipose Visceral Omentum 2 0.098 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 1 0.027 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 1 0.067 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.1
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.1
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 1 0.022 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1