Hub : Traits :

Breast cancer (self-reported)

13 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 26460080 28211713 2 2 3.3e-10 1.2e-13 1.6e-03 82 NEK10 SLC4A7
2 5 44120236 45516364 2 1 1.5e-09 3.5e-08 3.3e-01 97 RP11-53O19.3
3 5 55524108 56923759 1 1 3.3e-08 3.6e-16 1.5e-09 45 CTD-2310F14.1
4 8 128107136 129812343 1 1 8.1e-09 1.7e-12 6.2e-06 59 PVT1
5 16 51773126 53271249 1 1 2.1e-34 1.3e-35 1.0e+00 100 TOX3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Reaction Time 1.10 1 0 0.0 0.00 1.00000 SLC4A7
Breast Cancer 132.08 6 6 18.2 0.98 0.00037 CTD-2310F14.1 NEK10 PVT1 RP11-53O19.3 SLC4A7 TOX3
Prostate Cancer 2.15 1 0 0.0 0.00 1.00000 PVT1
LDL Cholesterol 1.93 1 0 0.0 0.00 1.00000 NEK10
Schizophrenia 1.77 1 0 0.0 0.00 1.00000 RP11-53O19.3
Blood Platelet Count 0.76 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Blood Red Count 0.34 1 0 0.0 0.00 1.00000 PVT1
Blood White Count 0.81 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Heel T-Score 0.85 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
BMI 0.74 2 0 0.0 0.00 1.00000 CTD-2310F14.1 NEK10
Height 1.29 5 1 3.0 -0.15 0.81500 CTD-2310F14.1 NEK10 PVT1 RP11-53O19.3 SLC4A7
Waist Hip Ratio (WHR) 1.62 3 0 0.0 0.00 1.00000 PVT1 RP11-53O19.3 TOX3
Systolic Blood Pressure 7.53 3 3 9.1 0.00 1.00000 NEK10 SLC4A7 TOX3
Smoking Status 0.96 1 0 0.0 0.00 1.00000 RP11-53O19.3
Cardiovascular Disease 4.16 3 1 3.0 0.00 1.00000 CTD-2310F14.1 NEK10 SLC4A7
Type 2 Diabetes (T2D) 0.87 1 0 0.0 0.00 1.00000 RP11-53O19.3
Lung FEV1/FVC ratio 0.40 1 0 0.0 0.00 1.00000 RP11-53O19.3
Neuroticism 1.29 1 0 0.0 0.00 1.00000 TOX3
Chronotype (morning person) 1.51 1 0 0.0 0.00 1.00000 TOX3
Hair Pigment 0.61 2 2 6.1 0.00 1.00000 CTD-2310F14.1 TOX3
Sensitivity / hurt feelings 2.15 1 0 0.0 0.00 1.00000 TOX3
Systolic blood pressure, automated reading 2.66 2 0 0.0 0.00 1.00000 SLC4A7 TOX3
Supplements: Zinc 2.91 1 0 0.0 0.00 1.00000 CTD-2310F14.1
Medication: Metformin 2.67 1 0 0.0 0.00 1.00000 RP11-53O19.3
Impedance of leg (right) 1.18 2 0 0.0 0.00 1.00000 CTD-2310F14.1 SLC4A7
Leg fat-free mass (left) 0.40 1 0 0.0 0.00 1.00000 SLC4A7
Trunk fat percentage 1.28 1 0 0.0 0.00 1.00000 NEK10
Fed-up feelings 1.50 1 0 0.0 0.00 1.00000 RP11-53O19.3
Heel bone mineral density (BMD) T-score, automated (left) 1.74 1 0 0.0 0.00 1.00000 NEK10
High blood pressure 5.30 2 1 3.0 0.00 1.00000 NEK10 SLC4A7
Sitting height 1.29 3 0 0.0 0.00 1.00000 CTD-2310F14.1 PVT1 SLC4A7
High blood pressure (mother) 3.44 1 0 0.0 0.00 1.00000 SLC4A7
Impedance of leg (left) 1.27 2 0 0.0 0.00 1.00000 CTD-2310F14.1 SLC4A7
Leg predicted mass (left) 0.40 1 0 0.0 0.00 1.00000 SLC4A7
Forced vital capacity (FVC) 1.41 1 0 0.0 0.00 1.00000 NEK10
Heel bone mineral density (BMD) T-score, automated (right) 1.39 1 0 0.0 0.00 1.00000 PVT1
Ever unenthusiastic/disinterested for a whole week 2.36 1 0 0.0 0.00 1.00000 RP11-53O19.3
Illnesses of siblings 2.34 1 0 0.0 0.00 1.00000 SLC4A7
Neuroticism score 1.81 1 0 0.0 0.00 1.00000 TOX3
Impedance of arm (right) 1.25 1 0 0.0 0.00 1.00000 SLC4A7
Arm fat percentage (right) 1.42 1 0 0.0 0.00 1.00000 NEK10
Trunk fat-free mass 0.93 1 0 0.0 0.00 1.00000 SLC4A7
Illnesses of mother 1.85 1 0 0.0 0.00 1.00000 SLC4A7
Impedance of arm (left) 1.22 2 0 0.0 0.00 1.00000 CTD-2310F14.1 SLC4A7
Trunk predicted mass 0.89 1 0 0.0 0.00 1.00000 SLC4A7
Standing height 1.22 3 1 3.0 0.00 1.00000 CTD-2310F14.1 PVT1 SLC4A7
Tense / 'highly strung' 1.65 1 0 0.0 0.00 1.00000 TOX3
Medication for cholesterol, blood pressure or diabetes 3.38 1 0 0.0 0.00 1.00000 SLC4A7
Medication: Amlodipine 4.39 1 1 3.0 0.00 1.00000 SLC4A7
High blood pressure (siblings) 3.48 1 0 0.0 0.00 1.00000 SLC4A7
Forced vital capacity (FVC), Best measure 1.37 1 0 0.0 0.00 1.00000 PVT1
Body fat percentage 1.53 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Leg fat percentage (right) 1.69 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Arm fat-free mass (right) 0.72 1 0 0.0 0.00 1.00000 SLC4A7
Comparative body size at age 10 0.77 1 0 0.0 0.00 1.00000 NEK10
Worry too long after embarrassment 1.61 1 0 0.0 0.00 1.00000 TOX3
Medication: Blood pressure 7.37 2 1 3.0 0.00 1.00000 NEK10 SLC4A7
Mean time to correctly identify matches 1.20 1 0 0.0 0.00 1.00000 SLC4A7
Heart disease (mother) 2.44 1 0 0.0 0.00 1.00000 SLC4A7
Arm predicted mass (right) 0.72 1 0 0.0 0.00 1.00000 SLC4A7
Pulse rate, automated reading 2.56 3 0 0.0 0.00 1.00000 NEK10 RP11-53O19.3 SLC4A7
Alcohol intake frequency. 1.05 1 0 0.0 0.00 1.00000 CTD-2310F14.1
Comparative height size at age 10 0.74 1 0 0.0 0.00 1.00000 CTD-2310F14.1
Hypertension (Self-reported) 5.05 2 1 3.0 0.00 1.00000 NEK10 SLC4A7
Whole body fat-free mass 0.72 1 0 0.0 0.00 1.00000 SLC4A7
Leg fat-free mass (right) 0.49 1 0 0.0 0.00 1.00000 SLC4A7
Arm fat percentage (left) 1.35 1 0 0.0 0.00 1.00000 NEK10
Mouth/teeth dental problems: Mouth ulcers 3.16 1 0 0.0 0.00 1.00000 RP11-53O19.3
Whole body water mass 0.67 1 0 0.0 0.00 1.00000 SLC4A7
Leg predicted mass (right) 0.50 1 0 0.0 0.00 1.00000 SLC4A7
Mother's age at death 3.73 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Medication: Blood pressure 3.36 1 0 0.0 0.00 1.00000 SLC4A7
Medication: Bendroflumethiazide 3.97 1 1 3.0 0.00 1.00000 SLC4A7
Medication: Lisinopril 2.62 1 0 0.0 0.00 1.00000 SLC4A7
Illnesses of father: High blood pressure 4.37 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Basal metabolic rate 0.50 1 0 0.0 0.00 1.00000 SLC4A7
Leg fat percentage (left) 1.70 2 0 0.0 0.00 1.00000 NEK10 SLC4A7
Arm fat-free mass (left) 0.69 1 0 0.0 0.00 1.00000 SLC4A7
Average weekly beer plus cider intake 1.87 1 0 0.0 0.00 1.00000 TOX3
Irritability 3.20 1 0 0.0 0.00 1.00000 TOX3
Diastolic blood pressure, automated reading 0.93 1 0 0.0 0.00 1.00000 TOX3
Ever depressed for a whole week 2.45 1 0 0.0 0.00 1.00000 RP11-53O19.3
Vascular/heart problems diagnosed by doctor 5.30 3 1 3.0 0.00 1.00000 CTD-2310F14.1 NEK10 SLC4A7
Impedance of whole body 1.34 2 0 0.0 0.00 1.00000 CTD-2310F14.1 SLC4A7
Arm predicted mass (left) 0.64 1 0 0.0 0.00 1.00000 SLC4A7

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.23
GTEx Adipose Visceral Omentum 1 0.0491 1.22
GTEx Adrenal Gland 0 0.0000 1.18
GTEx Artery Aorta 1 0.0336 1.23
GTEx Artery Coronary 0 0.0000 1.25
GTEx Artery Tibial 1 0.0266 1.22
GTEx Brain Caudate basal ganglia 0 0.0000 1.27
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.24
GTEx Brain Cerebellum 0 0.0000 1.19
GTEx Brain Cortex 0 0.0000 1.35
GTEx Brain Frontal Cortex BA9 0 0.0000 1.23
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.37
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.30
GTEx Brain Putamen basal ganglia 0 0.0000 1.31
GTEx Breast Mammary Tissue 0 0.0000 1.28
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.27
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.27
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.31
GTEx Cells Transformed fibroblasts 1 0.0238 1.21
GTEx Colon Sigmoid 0 0.0000 1.26
GTEx Colon Transverse 0 0.0000 1.22
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.24
GTEx Esophagus Mucosa 0 0.0000 1.22
GTEx Esophagus Muscularis 0 0.0000 1.21
GTEx Heart Atrial Appendage 0 0.0000 1.26
GTEx Heart Left Ventricle 0 0.0000 1.31
GTEx Liver 0 0.0000 1.26
GTEx Lung 1 0.0348 1.28
GTEx Muscle Skeletal 0 0.0000 1.23
GTEx Nerve Tibial 0 0.0000 1.23
GTEx Ovary 0 0.0000 1.30
GTEx Pancreas 0 0.0000 1.32
GTEx Pituitary 0 0.0000 1.28
GTEx Prostate 0 0.0000 1.30
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.24
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.17
GTEx Small Intestine Terminal Ileum 0 0.0000 1.30
GTEx Spleen 2 0.1417 1.25
GTEx Stomach 0 0.0000 1.20
GTEx Testis 0 0.0000 1.24
GTEx Thyroid 0 0.0000 1.24
GTEx Uterus 0 0.0000 1.37
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.23
METSIM Adipose 0 0.0000 1.14
NTR Blood 0 0.0000 1.15
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.15
YFS Blood 0 0.0000 1.12
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.18
TCGA Breast Tumor 0 0.0000 1.17
TCGA Breast Normal 3 0.0713 1.16
TCGA Ovarian Tumor 0 0.0000 1.08
TCGA Prostate Tumor 2 0.0578 1.20