Hub : Traits :

Alzheimer’s Disease (in mother)

15 significantly associated models · 10 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 127113672 128561279 1 1 1.5e-09 1.4e-11 2.8e-06 52 BIN1
2 19 44190626 46267534 9 13 2.0e-39 5.5e-89 NaN NaN BCAM CEACAM19 CLPTM1 PVRL2 SFRS16 TOMM40 ZNF180 ZNF229 ZNF285

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 23.27 6 3 9.1 0.99 7.9e-08 CEACAM19 PVRL2 TOMM40 ZNF180 ZNF229 ZNF285
Alzheimer’s Disease (including proxy) 112.08 10 10 30.3 1.00 1.2e-14 BCAM BIN1 CEACAM19 CLPTM1 PVRL2 SFRS16 TOMM40 ZNF180 ZNF229 ZNF285
Crohns Disease (2017) 1.40 1 0 0.0 0.00 1.0e+00 BIN1
Ulcerative Colitis (UC) 1.07 1 0 0.0 0.00 1.0e+00 BCAM
Verbal and Numeric Reasoning (VNR) 0.75 1 0 0.0 0.00 1.0e+00 PVRL2
Breast Cancer 0.61 1 0 0.0 0.00 1.0e+00 PVRL2
Coronary Artery Disease (CAD) 2.89 1 0 0.0 0.00 1.0e+00 BCAM
HDL Cholesterol 2.91 3 0 0.0 0.00 1.0e+00 CLPTM1 TOMM40 ZNF229
LDL Cholesterol 25.84 5 5 15.2 0.89 3.0e-03 BCAM CEACAM19 TOMM40 ZNF229 ZNF285
Triglycerides 1.59 2 0 0.0 0.00 1.0e+00 CLPTM1 ZNF285
Ulcerative Colitis 1.07 1 0 0.0 0.00 1.0e+00 BCAM
Blood Eosinophil Count 0.79 3 1 3.0 0.00 1.0e+00 BCAM CLPTM1 TOMM40
Blood Platelet Count 1.18 6 1 3.0 -0.41 4.2e-01 BIN1 CEACAM19 CLPTM1 SFRS16 TOMM40 ZNF285
Blood White Count 0.36 1 0 0.0 0.00 1.0e+00 CLPTM1
Heel T-Score 0.54 2 0 0.0 0.00 1.0e+00 TOMM40 ZNF285
BMI 0.96 4 0 0.0 -0.96 4.3e-02 CEACAM19 CLPTM1 ZNF229 ZNF285
Height 0.42 4 1 3.0 -0.64 3.6e-01 CEACAM19 CLPTM1 TOMM40 ZNF229
Systolic Blood Pressure 0.96 3 0 0.0 0.00 1.0e+00 BIN1 CLPTM1 TOMM40
Cardiovascular Disease 2.85 4 2 6.1 0.84 1.6e-01 BCAM TOMM40 ZNF229 ZNF285
Hypothyroidism (self reported) 0.81 1 0 0.0 0.00 1.0e+00 TOMM40
Respiratory disease 1.12 1 0 0.0 0.00 1.0e+00 PVRL2
Lung FEV1/FVC ratio 0.89 1 1 3.0 0.00 1.0e+00 SFRS16
Lung FVC 0.35 1 0 0.0 0.00 1.0e+00 PVRL2
Chronotype (morning person) 1.51 1 0 0.0 0.00 1.0e+00 ZNF285
Hand grip strength (left) 0.82 1 0 0.0 0.00 1.0e+00 PVRL2
Number of treatments/medications taken 1.62 1 0 0.0 0.00 1.0e+00 TOMM40
Systolic blood pressure, automated reading 0.72 1 0 0.0 0.00 1.0e+00 BIN1
Leg fat-free mass (left) 0.56 1 0 0.0 0.00 1.0e+00 CLPTM1
Trunk fat percentage 0.66 1 0 0.0 0.00 1.0e+00 BCAM
Hand grip strength (right) 0.65 1 0 0.0 0.00 1.0e+00 PVRL2
Maternal smoking around birth 1.04 1 0 0.0 0.00 1.0e+00 PVRL2
Hayfever, allergic rhinitis or eczema 0.95 1 0 0.0 0.00 1.0e+00 BIN1
Medication: Atenolol 1.20 1 0 0.0 0.00 1.0e+00 TOMM40
Sitting height 0.27 1 0 0.0 0.00 1.0e+00 CLPTM1
Body mass index (BMI) 0.78 1 0 0.0 0.00 1.0e+00 BCAM
Leg predicted mass (left) 0.57 1 0 0.0 0.00 1.0e+00 CLPTM1
Trunk fat mass 0.80 3 0 0.0 0.00 1.0e+00 BCAM CLPTM1 ZNF229
Waist circumference 0.81 1 0 0.0 0.00 1.0e+00 BCAM
Forced vital capacity (FVC) 0.33 1 0 0.0 0.00 1.0e+00 PVRL2
Medication: Simvastatin 6.71 4 2 6.1 -0.91 9.3e-02 BCAM CEACAM19 TOMM40 ZNF229
Weight 0.88 3 0 0.0 0.00 1.0e+00 BCAM CLPTM1 ZNF229
Arm fat percentage (right) 0.74 1 0 0.0 0.00 1.0e+00 BCAM
Trunk fat-free mass 0.58 1 0 0.0 0.00 1.0e+00 CLPTM1
Hip circumference 0.58 2 0 0.0 0.00 1.0e+00 BCAM CLPTM1
Worrier / anxious feelings 0.71 1 0 0.0 0.00 1.0e+00 CLPTM1
Medication: Cholesterol lowering 6.59 5 3 9.1 -0.90 3.9e-02 BCAM CEACAM19 TOMM40 ZNF229 ZNF285
Illnesses of mother 4.20 2 0 0.0 0.00 1.0e+00 ZNF229 ZNF285
Forced expiratory volume in 1-second (FEV1), Best measure 0.41 1 0 0.0 0.00 1.0e+00 SFRS16
Pulse wave Arterial Stiffness index 1.44 1 0 0.0 0.00 1.0e+00 TOMM40
Arm fat mass (right) 0.87 2 0 0.0 0.00 1.0e+00 BCAM CLPTM1
Trunk predicted mass 0.58 1 0 0.0 0.00 1.0e+00 CLPTM1
Standing height 0.54 2 0 0.0 0.00 1.0e+00 CEACAM19 CLPTM1
Medication for cholesterol, blood pressure or diabetes 2.11 3 0 0.0 0.00 1.0e+00 BCAM TOMM40 ZNF229
Birth weight 1.19 1 0 0.0 0.00 1.0e+00 PVRL2
Chronic bronchitis/emphysema (mother) 2.15 1 0 0.0 0.00 1.0e+00 BCAM
High blood pressure (siblings) 2.11 1 0 0.0 0.00 1.0e+00 BIN1
Body fat percentage 0.74 1 0 0.0 0.00 1.0e+00 BCAM
Leg fat percentage (right) 0.84 1 0 0.0 0.00 1.0e+00 BCAM
Arm fat-free mass (right) 0.48 1 0 0.0 0.00 1.0e+00 CLPTM1
Pulse wave peak to peak time 1.34 1 0 0.0 0.00 1.0e+00 TOMM40
Shortness of breath walking on level ground 1.95 1 0 0.0 0.00 1.0e+00 ZNF285
Qualifications: College or University degree 0.47 1 0 0.0 0.00 1.0e+00 BIN1
Angina (self-reported) 1.30 1 0 0.0 0.00 1.0e+00 TOMM40
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.56 1 0 0.0 0.00 1.0e+00 CEACAM19
Whole body fat mass 0.80 1 0 0.0 0.00 1.0e+00 BCAM
Leg fat mass (right) 0.93 1 0 0.0 0.00 1.0e+00 BCAM
Arm predicted mass (right) 0.45 1 0 0.0 0.00 1.0e+00 CLPTM1
Pulse rate, automated reading 0.61 1 0 0.0 0.00 1.0e+00 BCAM
Alcohol intake frequency. 0.67 1 0 0.0 0.00 1.0e+00 PVRL2
Comparative height size at age 10 0.65 1 0 0.0 0.00 1.0e+00 CLPTM1
Medication: Aspirin 2.17 1 0 0.0 0.00 1.0e+00 TOMM40
Forced expiratory volume in 1-second (FEV1), predicted 1.76 1 0 0.0 0.00 1.0e+00 CEACAM19
Whole body fat-free mass 0.57 1 0 0.0 0.00 1.0e+00 CLPTM1
Leg fat-free mass (right) 0.55 1 0 0.0 0.00 1.0e+00 CLPTM1
Arm fat percentage (left) 0.66 1 0 0.0 0.00 1.0e+00 BCAM
Diabetes diagnosed by doctor 2.00 1 0 0.0 0.00 1.0e+00 PVRL2
Medication for cholesterol 1.85 1 0 0.0 0.00 1.0e+00 TOMM40
Medication: Aspirin 2.18 1 0 0.0 0.00 1.0e+00 TOMM40
Whole body water mass 0.55 1 0 0.0 0.00 1.0e+00 CLPTM1
Leg predicted mass (right) 0.55 1 0 0.0 0.00 1.0e+00 CLPTM1
Arm fat mass (left) 0.76 1 0 0.0 0.00 1.0e+00 BCAM
Number of self-reported non-cancer illnesses 1.55 1 0 0.0 0.00 1.0e+00 TOMM40
Miserableness 0.66 1 0 0.0 0.00 1.0e+00 CLPTM1
High cholesterol (Self-reported) 13.41 5 4 12.1 -0.95 3.9e-04 BCAM CEACAM19 TOMM40 ZNF229 ZNF285
Medication: Paracetamol 0.95 1 0 0.0 0.00 1.0e+00 BIN1
Medication: Atorvastatin 6.87 4 1 3.0 -0.96 4.1e-02 BCAM TOMM40 ZNF229 ZNF285
Basal metabolic rate 0.64 1 0 0.0 0.00 1.0e+00 CLPTM1
Leg fat percentage (left) 0.92 1 0 0.0 0.00 1.0e+00 BCAM
Arm fat-free mass (left) 0.56 1 0 0.0 0.00 1.0e+00 CLPTM1
Diastolic blood pressure, automated reading 0.57 1 0 0.0 0.00 1.0e+00 BIN1
Cholesterol lowering medication 7.15 5 2 6.1 -0.93 2.3e-02 BCAM CEACAM19 TOMM40 ZNF229 ZNF285
Leg fat mass (left) 0.99 1 0 0.0 0.00 1.0e+00 BCAM
Arm predicted mass (left) 0.60 1 0 0.0 0.00 1.0e+00 CLPTM1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.17
GTEx Adipose Visceral Omentum 1 0.0490 1.25
GTEx Adrenal Gland 0 0.0000 1.14
GTEx Artery Aorta 0 0.0000 1.19
GTEx Artery Coronary 0 0.0000 1.08
GTEx Artery Tibial 0 0.0000 1.17
GTEx Brain Caudate basal ganglia 0 0.0000 1.20
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.12
GTEx Brain Cerebellum 0 0.0000 1.16
GTEx Brain Cortex 0 0.0000 1.08
GTEx Brain Frontal Cortex BA9 0 0.0000 1.07
GTEx Brain Hippocampus 0 0.0000 1.05
GTEx Brain Hypothalamus 0 0.0000 1.01
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.15
GTEx Brain Putamen basal ganglia 0 0.0000 1.17
GTEx Breast Mammary Tissue 0 0.0000 1.15
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.08
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.14
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.20
GTEx Cells Transformed fibroblasts 1 0.0238 1.19
GTEx Colon Sigmoid 0 0.0000 1.09
GTEx Colon Transverse 1 0.0484 1.13
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.15
GTEx Esophagus Mucosa 0 0.0000 1.17
GTEx Esophagus Muscularis 0 0.0000 1.18
GTEx Heart Atrial Appendage 0 0.0000 1.13
GTEx Heart Left Ventricle 0 0.0000 1.14
GTEx Liver 1 0.1393 1.25
GTEx Lung 0 0.0000 1.20
GTEx Muscle Skeletal 0 0.0000 1.11
GTEx Nerve Tibial 0 0.0000 1.16
GTEx Ovary 0 0.0000 1.25
GTEx Pancreas 0 0.0000 1.08
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.16
GTEx Skin Not Sun Exposed Suprapubic 1 0.0406 1.21
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.15
GTEx Small Intestine Terminal Ileum 0 0.0000 1.13
GTEx Spleen 0 0.0000 1.13
GTEx Stomach 1 0.0687 1.18
GTEx Testis 0 0.0000 1.14
GTEx Thyroid 1 0.0250 1.18
GTEx Uterus 0 0.0000 1.08
GTEx Vagina 0 0.0000 1.08
GTEx Whole Blood 0 0.0000 1.22
METSIM Adipose 0 0.0000 1.12
NTR Blood 1 0.0416 1.23
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.20
YFS Blood 2 0.0433 1.16
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.19
TCGA Breast Tumor 0 0.0000 1.09
TCGA Breast Normal 1 0.0238 1.16
TCGA Ovarian Tumor 1 0.0342 1.11
TCGA Prostate Tumor 0 0.0000 1.12