Hub : Traits :

Mineral and other dietary supplements

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 41297430 42786141 1 1 4.1e-08 5.8e-08 0.043 86 SLC30A9
2 10 64195778 66034105 2 1 2.6e-08 3.4e-08 0.180 94 NRBF2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 6.32 1 0 0.0 0 1 SLC30A9
Body Mass Index (BMI) (2010) 4.86 1 0 0.0 0 1 NRBF2
Fasting Glucose 5.33 1 0 0.0 0 1 SLC30A9
HDL Cholesterol 2.75 1 0 0.0 0 1 NRBF2
Schizophrenia 1.99 1 0 0.0 0 1 NRBF2
Triglycerides 5.79 1 0 0.0 0 1 NRBF2
Blood Platelet Count 34.65 1 1 3.0 0 1 NRBF2
Blood Red Count 1.63 1 1 3.0 0 1 NRBF2
Blood White Count 11.05 1 1 3.0 0 1 NRBF2
Heel T-Score 0.49 1 0 0.0 0 1 NRBF2
BMI 2.98 1 1 3.0 0 1 NRBF2
Height 2.71 2 2 6.1 0 1 NRBF2 SLC30A9
Waist Hip Ratio (WHR) 1.87 1 0 0.0 0 1 SLC30A9
Systolic Blood Pressure 2.29 2 0 0.0 0 1 NRBF2 SLC30A9
Allergy or Eczema 6.44 2 0 0.0 0 1 NRBF2 SLC30A9
Cardiovascular Disease 3.96 2 0 0.0 0 1 NRBF2 SLC30A9
Respiratory disease 3.00 1 0 0.0 0 1 NRBF2
Type 2 Diabetes (T2D) 2.65 1 0 0.0 0 1 NRBF2
Lung FEV1/FVC ratio 4.04 1 1 3.0 0 1 NRBF2
Neuroticism 4.16 1 0 0.0 0 1 SLC30A9
Frequency of depressed mood in last 2 weeks 6.49 1 0 0.0 0 1 SLC30A9
Relative age of first facial hair 7.02 1 1 3.0 0 1 NRBF2
Other serious medical condition/disability diagnosed by doctor 3.14 1 0 0.0 0 1 SLC30A9
Systolic blood pressure, automated reading 1.95 1 0 0.0 0 1 NRBF2
Vitamin and mineral supplements 13.92 2 0 0.0 0 1 NRBF2 SLC30A9
Supplements: Zinc 11.04 2 0 0.0 0 1 NRBF2 SLC30A9
Impedance of leg (right) 1.41 1 0 0.0 0 1 SLC30A9
Trunk fat percentage 1.78 1 0 0.0 0 1 SLC30A9
Frequency of unenthusiasm / disinterest in last 2 weeks 3.47 1 0 0.0 0 1 SLC30A9
Relative age voice broke 5.06 1 0 0.0 0 1 NRBF2
Taking other prescription medications 3.04 1 0 0.0 0 1 NRBF2
Age when periods started (menarche) 4.71 1 0 0.0 0 1 NRBF2
Serious illness, injury or assault to yourself 3.77 1 0 0.0 0 1 SLC30A9
High blood pressure 4.76 2 0 0.0 0 1 NRBF2 SLC30A9
Hayfever, allergic rhinitis or eczema 6.61 2 0 0.0 0 1 NRBF2 SLC30A9
Multivitamins +/- minerals 14.94 2 1 3.0 0 1 NRBF2 SLC30A9
Stomach or abdominal pain in last month 4.17 1 0 0.0 0 1 NRBF2
Supplements: Glucosamine 19.16 2 1 3.0 0 1 NRBF2 SLC30A9
Sitting height 1.46 2 0 0.0 0 1 NRBF2 SLC30A9
High blood pressure (mother) 3.71 1 0 0.0 0 1 NRBF2
Body mass index (BMI) 3.10 1 1 3.0 0 1 NRBF2
Impedance of leg (left) 1.38 1 0 0.0 0 1 SLC30A9
Trunk fat mass 1.65 1 0 0.0 0 1 SLC30A9
Waist circumference 1.24 1 0 0.0 0 1 NRBF2
Alcohol usually taken with meals 12.42 2 0 0.0 0 1 NRBF2 SLC30A9
Nervous feelings 2.30 1 0 0.0 0 1 SLC30A9
Had other major operations 3.82 1 0 0.0 0 1 SLC30A9
Qualifications: None of the above 4.84 2 0 0.0 0 1 NRBF2 SLC30A9
Allergy 6.47 2 0 0.0 0 1 NRBF2 SLC30A9
Diabetes (self-reported) 4.13 1 0 0.0 0 1 NRBF2
Hayfever/allergic rhinitis (self-reported) 2.81 1 0 0.0 0 1 NRBF2
Neuroticism score 3.90 1 0 0.0 0 1 SLC30A9
Impedance of arm (right) 4.44 2 1 3.0 0 1 NRBF2 SLC30A9
Arm fat percentage (right) 1.90 1 0 0.0 0 1 NRBF2
Worrier / anxious feelings 1.85 1 0 0.0 0 1 SLC30A9
Frequency of tiredness / lethargy in last 2 weeks 6.60 1 0 0.0 0 1 SLC30A9
Qualifications: A levels/AS levels or equivalent 4.81 2 0 0.0 0 1 NRBF2 SLC30A9
Medication: Cholesterol lowering 2.63 1 0 0.0 0 1 SLC30A9
Impedance of arm (left) 4.18 2 1 3.0 0 1 NRBF2 SLC30A9
Arm fat mass (right) 1.78 1 0 0.0 0 1 NRBF2
Standing height 2.08 2 1 3.0 0 1 NRBF2 SLC30A9
Tense / 'highly strung' 3.97 1 0 0.0 0 1 SLC30A9
Blood clot in the leg (DVT) 4.85 1 0 0.0 0 1 NRBF2
Medication for cholesterol, blood pressure or diabetes 2.45 1 0 0.0 0 1 SLC30A9
Gout (self-reported) 4.17 1 0 0.0 0 1 NRBF2
Medication: Ventolin 100micrograms inhaler 3.47 1 0 0.0 0 1 NRBF2
High blood pressure (siblings) 2.80 1 0 0.0 0 1 NRBF2
Body fat percentage 2.25 2 0 0.0 0 1 NRBF2 SLC30A9
Leg fat percentage (right) 4.17 2 0 0.0 0 1 NRBF2 SLC30A9
Exposure to tobacco smoke outside home 4.17 1 0 0.0 0 1 NRBF2
Comparative body size at age 10 3.18 2 0 0.0 0 1 NRBF2 SLC30A9
Worry too long after embarrassment 2.41 1 0 0.0 0 1 SLC30A9
Number of children fathered 3.35 1 0 0.0 0 1 SLC30A9
Age at first live birth 3.36 1 0 0.0 0 1 NRBF2
Qualifications: College or University degree 1.92 1 0 0.0 0 1 NRBF2
Medication: Blood pressure 2.23 1 0 0.0 0 1 SLC30A9
Medication: Allopurinol 6.05 1 0 0.0 0 1 SLC30A9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.66 1 0 0.0 0 1 NRBF2
Whole body fat mass 1.75 1 0 0.0 0 1 SLC30A9
Leg fat mass (right) 2.70 2 0 0.0 0 1 NRBF2 SLC30A9
Pulse rate, automated reading 1.55 1 0 0.0 0 1 SLC30A9
Alcohol intake frequency. 2.03 1 0 0.0 0 1 SLC30A9
Number of full sisters 3.81 1 0 0.0 0 1 NRBF2
Chest pain or discomfort 2.41 1 0 0.0 0 1 SLC30A9
Age at last live birth 5.56 1 0 0.0 0 1 NRBF2
Illness, injury, bereavement, stress in last 2 years 3.00 1 0 0.0 0 1 SLC30A9
Hypertension (Self-reported) 4.44 2 0 0.0 0 1 NRBF2 SLC30A9
Arm fat percentage (left) 1.79 1 0 0.0 0 1 NRBF2
Average weekly red wine intake 6.38 1 0 0.0 0 1 NRBF2
Mood swings 3.88 1 0 0.0 0 1 SLC30A9
Loneliness, isolation 2.76 1 0 0.0 0 1 SLC30A9
Long-standing illness, disability or infirmity 5.36 1 0 0.0 0 1 SLC30A9
Diabetes diagnosed by doctor 2.82 1 0 0.0 0 1 NRBF2
Medication for cholesterol 2.75 1 0 0.0 0 1 NRBF2
Breast cancer (self-reported) 3.28 1 0 0.0 0 1 SLC30A9
Arm fat mass (left) 1.84 1 0 0.0 0 1 NRBF2
Guilty feelings 3.46 1 0 0.0 0 1 SLC30A9
Mother's age at death 3.49 1 0 0.0 0 1 NRBF2
Medication: Blood pressure 4.67 1 0 0.0 0 1 NRBF2
Supplements: Fish oil (including cod liver oil) 13.75 2 0 0.0 0 1 NRBF2 SLC30A9
Medication: Bendroflumethiazide 2.56 1 0 0.0 0 1 NRBF2
Leg fat percentage (left) 3.76 2 0 0.0 0 1 NRBF2 SLC30A9
Average weekly beer plus cider intake 8.51 1 0 0.0 0 1 NRBF2
Diastolic blood pressure, automated reading 6.06 1 1 3.0 0 1 NRBF2
Vascular/heart problems diagnosed by doctor 4.26 2 0 0.0 0 1 NRBF2 SLC30A9
Supplements: Calcium 8.31 1 0 0.0 0 1 NRBF2
Deep venous thrombosis (DVT) (self-reported) 5.73 1 0 0.0 0 1 NRBF2
Impedance of whole body 2.73 2 0 0.0 0 1 NRBF2 SLC30A9
Leg fat mass (left) 2.50 2 0 0.0 0 1 NRBF2 SLC30A9

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.39
GTEx Adipose Visceral Omentum 0 0.0000 1.38
GTEx Adrenal Gland 0 0.0000 1.34
GTEx Artery Aorta 0 0.0000 1.38
GTEx Artery Coronary 0 0.0000 1.31
GTEx Artery Tibial 0 0.0000 1.36
GTEx Brain Caudate basal ganglia 0 0.0000 1.37
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.41
GTEx Brain Cerebellum 0 0.0000 1.33
GTEx Brain Cortex 0 0.0000 1.40
GTEx Brain Frontal Cortex BA9 0 0.0000 1.33
GTEx Brain Hippocampus 0 0.0000 1.30
GTEx Brain Hypothalamus 0 0.0000 1.33
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.34
GTEx Brain Putamen basal ganglia 0 0.0000 1.50
GTEx Breast Mammary Tissue 0 0.0000 1.40
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.32
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.39
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.30
GTEx Cells Transformed fibroblasts 0 0.0000 1.36
GTEx Colon Sigmoid 0 0.0000 1.42
GTEx Colon Transverse 0 0.0000 1.39
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.33
GTEx Esophagus Mucosa 0 0.0000 1.33
GTEx Esophagus Muscularis 0 0.0000 1.39
GTEx Heart Atrial Appendage 0 0.0000 1.37
GTEx Heart Left Ventricle 0 0.0000 1.36
GTEx Liver 0 0.0000 1.27
GTEx Lung 0 0.0000 1.38
GTEx Muscle Skeletal 0 0.0000 1.39
GTEx Nerve Tibial 0 0.0000 1.37
GTEx Ovary 0 0.0000 1.35
GTEx Pancreas 0 0.0000 1.31
GTEx Pituitary 0 0.0000 1.34
GTEx Prostate 0 0.0000 1.42
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.38
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.37
GTEx Small Intestine Terminal Ileum 0 0.0000 1.17
GTEx Spleen 0 0.0000 1.33
GTEx Stomach 1 0.0688 1.37
GTEx Testis 0 0.0000 1.39
GTEx Thyroid 0 0.0000 1.35
GTEx Uterus 0 0.0000 1.27
GTEx Vagina 0 0.0000 1.33
GTEx Whole Blood 0 0.0000 1.29
METSIM Adipose 0 0.0000 1.32
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.45
YFS Blood 0 0.0000 1.35
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.33
TCGA Breast Tumor 0 0.0000 1.34
TCGA Breast Normal 1 0.0238 1.30
TCGA Ovarian Tumor 0 0.0000 1.31
TCGA Prostate Tumor 0 0.0000 1.36