Hub : Traits :

Supplements: Glucosamine

10 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 45423943 46809419 1 1 3.5e-07 2.3e-05 0.82100 100 RP11-767N6.2
2 4 41297430 42786141 1 1 2.5e-07 2.2e-06 0.17200 92 SLC30A9
3 9 32275256 33721935 1 1 4.8e-08 1.3e-07 0.40300 98 APTX
4 10 64195778 65606229 1 1 2.1e-07 1.6e-08 0.00017 56 NRBF2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 2.99 1 0 0.0 0 1 SLC30A9
Breast Cancer 3.60 1 1 3.0 0 1 RP11-767N6.2
Age at First Birth 2.91 1 0 0.0 0 1 RP11-767N6.2
HDL Cholesterol 2.29 1 0 0.0 0 1 NRBF2
Triglycerides 3.94 1 0 0.0 0 1 NRBF2
Blood Platelet Count 15.58 2 2 6.1 0 1 NRBF2 RP11-767N6.2
Blood Red Count 6.23 2 1 3.0 0 1 APTX RP11-767N6.2
Blood White Count 2.09 1 1 3.0 0 1 NRBF2
Heel T-Score 0.68 2 0 0.0 0 1 NRBF2 RP11-767N6.2
BMI 2.47 2 1 3.0 0 1 NRBF2 RP11-767N6.2
Height 1.23 3 2 6.1 0 1 APTX RP11-767N6.2 SLC30A9
Waist Hip Ratio (WHR) 1.29 1 0 0.0 0 1 SLC30A9
Systolic Blood Pressure 4.83 3 1 3.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Smoking Status 1.40 1 0 0.0 0 1 RP11-767N6.2
Allergy or Eczema 4.91 2 0 0.0 0 1 NRBF2 SLC30A9
Cardiovascular Disease 5.93 2 1 3.0 0 1 NRBF2 SLC30A9
Hypothyroidism (self reported) 1.02 1 0 0.0 0 1 RP11-767N6.2
Lung FEV1/FVC ratio 5.92 2 2 6.1 0 1 NRBF2 RP11-767N6.2
Lung FVC 1.00 1 0 0.0 0 1 NRBF2
Neuroticism 3.73 2 0 0.0 0 1 RP11-767N6.2 SLC30A9
Hair Pigment 0.17 1 0 0.0 0 1 APTX
Tanning 1.03 1 1 3.0 0 1 NRBF2
Frequency of depressed mood in last 2 weeks 3.45 1 0 0.0 0 1 SLC30A9
Hearing difficulty/problems: Yes 4.72 1 0 0.0 0 1 RP11-767N6.2
Ever had hysterectomy (womb removed) 2.93 1 0 0.0 0 1 RP11-767N6.2
Systolic blood pressure, automated reading 5.50 2 1 3.0 0 1 NRBF2 RP11-767N6.2
Vitamin and mineral supplements 5.51 1 0 0.0 0 1 SLC30A9
Supplements: Zinc 5.37 2 0 0.0 0 1 RP11-767N6.2 SLC30A9
Impedance of leg (right) 0.88 1 0 0.0 0 1 SLC30A9
Leg fat-free mass (left) 0.41 1 0 0.0 0 1 NRBF2
Trunk fat percentage 2.11 2 0 0.0 0 1 RP11-767N6.2 SLC30A9
Current tobacco smoking 1.81 1 0 0.0 0 1 RP11-767N6.2
Maternal smoking around birth 2.90 1 0 0.0 0 1 RP11-767N6.2
Heel bone mineral density (BMD) T-score, automated (left) 1.04 1 0 0.0 0 1 NRBF2
Serious illness, injury or assault to yourself 2.38 1 0 0.0 0 1 SLC30A9
High blood pressure 5.40 2 1 3.0 0 1 NRBF2 SLC30A9
Hayfever, allergic rhinitis or eczema 4.22 2 0 0.0 0 1 NRBF2 SLC30A9
Multivitamins +/- minerals 6.58 2 0 0.0 0 1 NRBF2 SLC30A9
Sitting height 2.84 2 1 3.0 0 1 RP11-767N6.2 SLC30A9
High blood pressure (mother) 4.11 1 0 0.0 0 1 NRBF2
Body mass index (BMI) 2.67 2 1 3.0 0 1 NRBF2 RP11-767N6.2
Impedance of leg (left) 0.88 1 0 0.0 0 1 SLC30A9
Leg predicted mass (left) 0.41 1 0 0.0 0 1 NRBF2
Trunk fat mass 2.02 2 0 0.0 0 1 RP11-767N6.2 SLC30A9
Waist circumference 2.27 2 0 0.0 0 1 NRBF2 RP11-767N6.2
Past tobacco smoking 1.28 1 0 0.0 0 1 RP11-767N6.2
Alcohol usually taken with meals 5.89 1 0 0.0 0 1 SLC30A9
Hearing difficulty/problems with background noise 3.24 1 0 0.0 0 1 RP11-767N6.2
Had other major operations 5.49 2 0 0.0 0 1 NRBF2 SLC30A9
Qualifications: None of the above 3.33 2 0 0.0 0 1 APTX NRBF2
Allergy 4.13 3 0 0.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Illnesses of siblings 3.11 1 0 0.0 0 1 NRBF2
Neuroticism score 2.90 1 0 0.0 0 1 SLC30A9
Weight 1.37 1 0 0.0 0 1 NRBF2
Impedance of arm (right) 1.90 2 0 0.0 0 1 NRBF2 SLC30A9
Arm fat percentage (right) 2.22 1 0 0.0 0 1 RP11-767N6.2
Trunk fat-free mass 0.52 1 0 0.0 0 1 NRBF2
Hip circumference 1.83 2 0 0.0 0 1 NRBF2 RP11-767N6.2
Frequency of tiredness / lethargy in last 2 weeks 3.57 1 0 0.0 0 1 SLC30A9
Number of live births 2.00 1 0 0.0 0 1 NRBF2
Forced expiratory volume in 1-second (FEV1) 1.73 1 0 0.0 0 1 NRBF2
Pulse rate 2.47 1 0 0.0 0 1 APTX
Qualifications: A levels/AS levels or equivalent 3.27 2 0 0.0 0 1 APTX NRBF2
Forced expiratory volume in 1-second (FEV1), Best measure 2.49 1 1 3.0 0 1 NRBF2
Impedance of arm (left) 1.90 1 0 0.0 0 1 NRBF2
Arm fat mass (right) 2.19 2 0 0.0 0 1 NRBF2 RP11-767N6.2
Trunk predicted mass 0.50 1 0 0.0 0 1 NRBF2
Standing height 1.12 2 1 3.0 0 1 RP11-767N6.2 SLC30A9
Medication for cholesterol, blood pressure or diabetes 2.36 1 0 0.0 0 1 SLC30A9
Gout (self-reported) 3.34 1 0 0.0 0 1 NRBF2
Medication: Amlodipine 2.18 1 0 0.0 0 1 NRBF2
Medication: Ventolin 100micrograms inhaler 2.88 1 0 0.0 0 1 NRBF2
High blood pressure (siblings) 6.48 1 1 3.0 0 1 NRBF2
Forced vital capacity (FVC), Best measure 1.15 1 0 0.0 0 1 NRBF2
Body fat percentage 2.58 2 0 0.0 0 1 RP11-767N6.2 SLC30A9
Leg fat percentage (right) 3.97 3 1 3.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Arm fat-free mass (right) 0.78 1 0 0.0 0 1 NRBF2
Comparative body size at age 10 2.74 3 0 0.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Worry too long after embarrassment 3.67 1 0 0.0 0 1 RP11-767N6.2
Wheeze or whistling in the chest in last year 3.06 1 0 0.0 0 1 RP11-767N6.2
Age at first live birth 2.08 1 0 0.0 0 1 NRBF2
Qualifications: College or University degree 1.97 2 0 0.0 0 1 APTX RP11-767N6.2
Medication: Blood pressure 2.40 2 0 0.0 0 1 NRBF2 SLC30A9
Medication: Allopurinol 3.43 1 0 0.0 0 1 SLC30A9
Mean time to correctly identify matches 2.31 1 0 0.0 0 1 RP11-767N6.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.20 1 0 0.0 0 1 RP11-767N6.2
Whole body fat mass 2.16 3 0 0.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Leg fat mass (right) 2.94 2 0 0.0 0 1 NRBF2 RP11-767N6.2
Arm predicted mass (right) 0.72 1 0 0.0 0 1 NRBF2
Pulse rate, automated reading 2.16 2 0 0.0 0 1 RP11-767N6.2 SLC30A9
Alcohol intake frequency. 0.92 1 0 0.0 0 1 SLC30A9
Comparative height size at age 10 1.61 1 0 0.0 0 1 RP11-767N6.2
Number of full sisters 5.32 1 0 0.0 0 1 NRBF2
Overall health rating 2.98 2 0 0.0 0 1 APTX NRBF2
Had major operations 3.56 1 0 0.0 0 1 RP11-767N6.2
Leg pain on walking 1.91 1 0 0.0 0 1 RP11-767N6.2
Knee pain experienced in last month 2.31 1 0 0.0 0 1 RP11-767N6.2
Hypertension (Self-reported) 5.04 2 1 3.0 0 1 NRBF2 SLC30A9
Whole body fat-free mass 0.47 1 0 0.0 0 1 NRBF2
Arm fat percentage (left) 2.10 1 0 0.0 0 1 RP11-767N6.2
Average weekly red wine intake 4.41 1 0 0.0 0 1 NRBF2
Mood swings 3.35 1 0 0.0 0 1 SLC30A9
Long-standing illness, disability or infirmity 2.38 1 0 0.0 0 1 SLC30A9
Medication for cholesterol 2.70 1 0 0.0 0 1 NRBF2
Mineral and other dietary supplements 12.65 3 1 3.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Osteoarthritis (self-reported) 2.12 1 0 0.0 0 1 RP11-767N6.2
Smoking status: Current 1.84 1 0 0.0 0 1 RP11-767N6.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.74 1 0 0.0 0 1 NRBF2
Whole body water mass 0.46 1 0 0.0 0 1 NRBF2
Arm fat mass (left) 1.97 2 0 0.0 0 1 NRBF2 RP11-767N6.2
Number of self-reported non-cancer illnesses 2.63 1 0 0.0 0 1 RP11-767N6.2
Guilty feelings 3.08 1 0 0.0 0 1 SLC30A9
Financial situation satisfaction 2.80 1 0 0.0 0 1 RP11-767N6.2
Medication: Blood pressure 3.64 1 0 0.0 0 1 NRBF2
Supplements: Fish oil (including cod liver oil) 7.30 3 0 0.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Medication: Bendroflumethiazide 3.93 1 0 0.0 0 1 NRBF2
Medication: Lisinopril 5.77 1 0 0.0 0 1 NRBF2
Illnesses of father: High blood pressure 2.24 1 0 0.0 0 1 NRBF2
Ever smoked 2.29 1 0 0.0 0 1 RP11-767N6.2
Basal metabolic rate 0.62 1 0 0.0 0 1 NRBF2
Leg fat percentage (left) 3.95 3 1 3.0 0 1 NRBF2 RP11-767N6.2 SLC30A9
Arm fat-free mass (left) 0.87 1 0 0.0 0 1 NRBF2
Number of operations (self-reported) 3.33 1 0 0.0 0 1 NRBF2
Age started oral contraceptive pill 3.08 1 0 0.0 0 1 RP11-767N6.2
Diastolic blood pressure, automated reading 7.59 1 1 3.0 0 1 NRBF2
Vascular/heart problems diagnosed by doctor 5.10 1 1 3.0 0 1 NRBF2
Cholesterol lowering medication 1.64 1 0 0.0 0 1 NRBF2
Pain experienced in last month 2.03 1 0 0.0 0 1 RP11-767N6.2
Impedance of whole body 1.43 2 0 0.0 0 1 NRBF2 SLC30A9
Leg fat mass (left) 2.92 2 0 0.0 0 1 NRBF2 RP11-767N6.2
Arm predicted mass (left) 0.84 1 0 0.0 0 1 NRBF2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.35
GTEx Adipose Visceral Omentum 0 0.0000 1.36
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 1 0.0336 1.32
GTEx Artery Coronary 0 0.0000 1.26
GTEx Artery Tibial 0 0.0000 1.33
GTEx Brain Caudate basal ganglia 0 0.0000 1.30
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.35
GTEx Brain Cerebellum 0 0.0000 1.30
GTEx Brain Cortex 0 0.0000 1.26
GTEx Brain Frontal Cortex BA9 0 0.0000 1.24
GTEx Brain Hippocampus 0 0.0000 1.35
GTEx Brain Hypothalamus 0 0.0000 1.28
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.34
GTEx Brain Putamen basal ganglia 0 0.0000 1.34
GTEx Breast Mammary Tissue 0 0.0000 1.38
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.33
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.37
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.29
GTEx Cells Transformed fibroblasts 1 0.0238 1.33
GTEx Colon Sigmoid 1 0.0684 1.31
GTEx Colon Transverse 0 0.0000 1.34
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 0 0.0000 1.34
GTEx Esophagus Muscularis 0 0.0000 1.36
GTEx Heart Atrial Appendage 0 0.0000 1.27
GTEx Heart Left Ventricle 0 0.0000 1.25
GTEx Liver 0 0.0000 1.23
GTEx Lung 0 0.0000 1.32
GTEx Muscle Skeletal 0 0.0000 1.32
GTEx Nerve Tibial 0 0.0000 1.33
GTEx Ovary 0 0.0000 1.30
GTEx Pancreas 1 0.0613 1.32
GTEx Pituitary 0 0.0000 1.29
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.30
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.35
GTEx Small Intestine Terminal Ileum 0 0.0000 1.17
GTEx Spleen 0 0.0000 1.27
GTEx Stomach 0 0.0000 1.36
GTEx Testis 0 0.0000 1.32
GTEx Thyroid 1 0.0250 1.32
GTEx Uterus 0 0.0000 1.27
GTEx Vagina 1 0.1575 1.39
GTEx Whole Blood 0 0.0000 1.30
METSIM Adipose 0 0.0000 1.30
NTR Blood 0 0.0000 1.24
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.33
YFS Blood 0 0.0000 1.29
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.27
TCGA Breast Tumor 0 0.0000 1.32
TCGA Breast Normal 1 0.0238 1.25
TCGA Ovarian Tumor 0 0.0000 1.25
TCGA Prostate Tumor 0 0.0000 1.33