Hub : Traits :

Back pain experienced in last month

12 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 73027892 74809596 4 1 1.3e-11 7.5e-12 1.00 100 CHST3
2 12 5860179 6956462 2 1 2.8e-08 1.8e-08 0.12 92 MRPL51
3 15 66662107 68183665 1 1 1.5e-07 2.2e-07 1.00 100 SMAD3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 3.10 1 0 0.0 0 1 SMAD3
Heel T-Score 3.65 2 1 3.0 0 1 MRPL51 SMAD3
BMI 0.55 1 0 0.0 0 1 CHST3
Height 1.67 2 2 6.1 0 1 CHST3 SMAD3
Allergy or Eczema 1.77 1 0 0.0 0 1 SMAD3
Lung FVC 2.09 1 0 0.0 0 1 SMAD3
Hand grip strength (left) 2.83 1 0 0.0 0 1 SMAD3
Impedance of leg (right) 2.23 1 1 3.0 0 1 SMAD3
Trunk fat percentage 4.38 1 1 3.0 0 1 SMAD3
Hand grip strength (right) 2.35 1 0 0.0 0 1 SMAD3
Age when periods started (menarche) 2.87 1 0 0.0 0 1 CHST3
Heel bone mineral density (BMD) T-score, automated (left) 1.78 1 0 0.0 0 1 SMAD3
Sitting height 0.97 2 0 0.0 0 1 CHST3 SMAD3
Body mass index (BMI) 0.84 1 0 0.0 0 1 CHST3
Impedance of leg (left) 2.20 1 1 3.0 0 1 SMAD3
Trunk fat mass 2.74 1 1 3.0 0 1 SMAD3
Waist circumference 1.60 1 0 0.0 0 1 CHST3
Frequency of tenseness / restlessness in last 2 weeks 2.09 1 0 0.0 0 1 SMAD3
Forced vital capacity (FVC) 1.95 1 0 0.0 0 1 CHST3
Heel bone mineral density (BMD) T-score, automated (right) 1.62 1 0 0.0 0 1 SMAD3
Fluid intelligence score 2.28 1 0 0.0 0 1 SMAD3
Impedance of arm (right) 4.82 1 1 3.0 0 1 SMAD3
Arm fat percentage (right) 2.87 2 0 0.0 0 1 CHST3 SMAD3
Impedance of arm (left) 4.47 1 1 3.0 0 1 SMAD3
Standing height 1.27 2 0 0.0 0 1 CHST3 SMAD3
Hair/balding pattern: Pattern 4 1.96 1 0 0.0 0 1 SMAD3
Peak expiratory flow (PEF) 2.98 1 0 0.0 0 1 SMAD3
Forced vital capacity (FVC), Best measure 1.41 1 0 0.0 0 1 SMAD3
Body fat percentage 3.64 1 1 3.0 0 1 SMAD3
Leg fat percentage (right) 1.55 1 0 0.0 0 1 SMAD3
Comparative body size at age 10 1.79 1 0 0.0 0 1 SMAD3
Whole body fat mass 2.06 1 0 0.0 0 1 SMAD3
Leg fat mass (right) 1.15 1 0 0.0 0 1 SMAD3
Comparative height size at age 10 2.67 2 1 3.0 0 1 CHST3 SMAD3
Knee pain experienced in last month 1.92 1 0 0.0 0 1 CHST3
Arm fat percentage (left) 2.65 2 0 0.0 0 1 CHST3 SMAD3
Qualifications: nursing, teaching 2.35 1 0 0.0 0 1 CHST3
Osteoporosis (self-reported) 2.59 1 0 0.0 0 1 SMAD3
Osteoarthritis (self-reported) 3.77 1 0 0.0 0 1 MRPL51
Financial situation satisfaction 2.62 1 0 0.0 0 1 MRPL51
Leg fat percentage (left) 1.62 1 0 0.0 0 1 SMAD3
Fractured/broken bones in last 5 years 2.58 1 0 0.0 0 1 SMAD3
Impedance of whole body 3.74 1 1 3.0 0 1 SMAD3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.52
GTEx Adipose Visceral Omentum 0 0.0000 1.49
GTEx Adrenal Gland 2 0.1373 1.55
GTEx Artery Aorta 0 0.0000 1.46
GTEx Artery Coronary 0 0.0000 1.46
GTEx Artery Tibial 0 0.0000 1.47
GTEx Brain Caudate basal ganglia 0 0.0000 1.45
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.55
GTEx Brain Cerebellum 0 0.0000 1.48
GTEx Brain Cortex 0 0.0000 1.53
GTEx Brain Frontal Cortex BA9 0 0.0000 1.48
GTEx Brain Hippocampus 0 0.0000 1.40
GTEx Brain Hypothalamus 0 0.0000 1.46
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.41
GTEx Brain Putamen basal ganglia 0 0.0000 1.38
GTEx Breast Mammary Tissue 0 0.0000 1.49
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.46
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.41
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.49
GTEx Cells Transformed fibroblasts 1 0.0238 1.46
GTEx Colon Sigmoid 0 0.0000 1.56
GTEx Colon Transverse 0 0.0000 1.53
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.49
GTEx Esophagus Mucosa 0 0.0000 1.45
GTEx Esophagus Muscularis 1 0.0309 1.51
GTEx Heart Atrial Appendage 0 0.0000 1.48
GTEx Heart Left Ventricle 0 0.0000 1.45
GTEx Liver 0 0.0000 1.53
GTEx Lung 0 0.0000 1.47
GTEx Muscle Skeletal 2 0.0692 1.51
GTEx Nerve Tibial 0 0.0000 1.47
GTEx Ovary 0 0.0000 1.56
GTEx Pancreas 0 0.0000 1.60
GTEx Pituitary 0 0.0000 1.53
GTEx Prostate 0 0.0000 1.58
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.53
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.48
GTEx Small Intestine Terminal Ileum 0 0.0000 1.45
GTEx Spleen 0 0.0000 1.62
GTEx Stomach 0 0.0000 1.53
GTEx Testis 0 0.0000 1.52
GTEx Thyroid 0 0.0000 1.49
GTEx Uterus 0 0.0000 1.59
GTEx Vagina 0 0.0000 1.49
GTEx Whole Blood 0 0.0000 1.39
METSIM Adipose 2 0.0434 1.46
NTR Blood 1 0.0416 1.47
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.49
YFS Blood 0 0.0000 1.40
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.45
TCGA Breast Tumor 0 0.0000 1.48
TCGA Breast Normal 0 0.0000 1.44
TCGA Ovarian Tumor 0 0.0000 1.37
TCGA Prostate Tumor 0 0.0000 1.48