Hub : Traits :

Shortness of breath walking on level ground

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 16 71234989 71768500 1 1 1.2e-07 1.6e-06 0.066 85 ZNF23

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 5.63 1 0 0.0 0 1 ZNF23
Depression (Nagel 2018) 7.88 1 0 0.0 0 1 ZNF23
Intelligence (Savage-Jansen 2018) 5.85 1 0 0.0 0 1 ZNF23
Neuroticism (Nagel 2018) 3.03 1 0 0.0 0 1 ZNF23
Schizophrenia vs Biploar Disorder 6.99 1 0 0.0 0 1 ZNF23
Verbal and Numeric Reasoning (VNR) 4.35 1 0 0.0 0 1 ZNF23
Breast Cancer 7.09 1 0 0.0 0 1 ZNF23
Age at First Birth 5.78 1 0 0.0 0 1 ZNF23
Body Mass Index (BMI) (2010) 4.70 1 0 0.0 0 1 ZNF23
LDL Cholesterol 2.77 1 0 0.0 0 1 ZNF23
Blood Eosinophil Count 2.36 1 0 0.0 0 1 ZNF23
Blood Platelet Count 0.77 1 0 0.0 0 1 ZNF23
Blood Red Count 0.59 1 0 0.0 0 1 ZNF23
BMI 1.25 1 0 0.0 0 1 ZNF23
Height 1.05 1 0 0.0 0 1 ZNF23
Waist Hip Ratio (WHR) 1.49 1 0 0.0 0 1 ZNF23
Systolic Blood Pressure 7.33 1 1 2.2 0 1 ZNF23
Respiratory disease 2.95 1 0 0.0 0 1 ZNF23
Neuroticism 3.16 1 0 0.0 0 1 ZNF23
Other serious medical condition/disability diagnosed by doctor 3.28 1 0 0.0 0 1 ZNF23
Systolic blood pressure, automated reading 6.34 1 0 0.0 0 1 ZNF23
Leg fat-free mass (left) 3.28 1 0 0.0 0 1 ZNF23
Trunk fat percentage 2.08 1 0 0.0 0 1 ZNF23
Fed-up feelings 3.07 1 0 0.0 0 1 ZNF23
Frequency of unenthusiasm / disinterest in last 2 weeks 9.67 1 0 0.0 0 1 ZNF23
Relative age voice broke 3.45 1 0 0.0 0 1 ZNF23
Heel bone mineral density (BMD) T-score, automated (left) 3.78 1 0 0.0 0 1 ZNF23
Qualifications: CSEs or equivalent 3.07 1 0 0.0 0 1 ZNF23
Sitting height 1.08 1 0 0.0 0 1 ZNF23
Body mass index (BMI) 2.15 1 0 0.0 0 1 ZNF23
Leg predicted mass (left) 3.31 1 0 0.0 0 1 ZNF23
Trunk fat mass 3.31 1 0 0.0 0 1 ZNF23
Waist circumference 4.28 1 0 0.0 0 1 ZNF23
Heel bone mineral density (BMD) T-score, automated (right) 4.11 1 0 0.0 0 1 ZNF23
Qualifications: None of the above 2.89 1 0 0.0 0 1 ZNF23
Fluid intelligence score 4.08 1 0 0.0 0 1 ZNF23
Weight 3.81 1 0 0.0 0 1 ZNF23
Impedance of arm (right) 1.06 1 0 0.0 0 1 ZNF23
Arm fat percentage (right) 1.04 1 0 0.0 0 1 ZNF23
Trunk fat-free mass 3.09 1 0 0.0 0 1 ZNF23
Hip circumference 2.29 1 0 0.0 0 1 ZNF23
Worrier / anxious feelings 3.27 1 0 0.0 0 1 ZNF23
Frequency of tiredness / lethargy in last 2 weeks 5.20 1 0 0.0 0 1 ZNF23
Number of live births 2.82 1 0 0.0 0 1 ZNF23
Prospective memory result 4.76 1 0 0.0 0 1 ZNF23
Impedance of arm (left) 0.83 1 0 0.0 0 1 ZNF23
Arm fat mass (right) 2.78 1 0 0.0 0 1 ZNF23
Trunk predicted mass 3.10 1 0 0.0 0 1 ZNF23
Standing height 1.29 1 0 0.0 0 1 ZNF23
Ever highly irritable/argumentative for 2 days 3.30 1 0 0.0 0 1 ZNF23
Qualifications: O levels/GCSEs or equivalent 3.62 1 0 0.0 0 1 ZNF23
Medication: Paracetamol 2.37 1 0 0.0 0 1 ZNF23
Birth weight 2.52 1 0 0.0 0 1 ZNF23
Body fat percentage 1.99 1 0 0.0 0 1 ZNF23
Leg fat percentage (right) 1.93 1 0 0.0 0 1 ZNF23
Arm fat-free mass (right) 4.29 1 0 0.0 0 1 ZNF23
Wheeze or whistling in the chest in last year 3.37 1 0 0.0 0 1 ZNF23
Number of children fathered 5.77 1 0 0.0 0 1 ZNF23
Age at first live birth 6.83 1 0 0.0 0 1 ZNF23
Health satisfaction 8.02 1 0 0.0 0 1 ZNF23
Emphysema/chronic bronchitis 6.29 1 0 0.0 0 1 ZNF23
Neck or shoulder pain in last month 6.13 1 0 0.0 0 1 ZNF23
Medication: Seretide 50 evohaler 6.28 1 0 0.0 0 1 ZNF23
Whole body fat mass 3.14 1 0 0.0 0 1 ZNF23
Leg fat mass (right) 3.21 1 0 0.0 0 1 ZNF23
Arm predicted mass (right) 4.12 1 0 0.0 0 1 ZNF23
Comparative height size at age 10 0.98 1 0 0.0 0 1 ZNF23
Number of full sisters 3.65 1 0 0.0 0 1 ZNF23
Overall health rating 9.89 1 0 0.0 0 1 ZNF23
Chest pain or discomfort 6.16 1 0 0.0 0 1 ZNF23
Had major operations 3.31 1 0 0.0 0 1 ZNF23
Commuting to job workplace: Car/motor vehicle 5.79 1 0 0.0 0 1 ZNF23
Knee pain experienced in last month 3.46 1 0 0.0 0 1 ZNF23
Whole body fat-free mass 3.33 1 0 0.0 0 1 ZNF23
Leg fat-free mass (right) 3.18 1 0 0.0 0 1 ZNF23
Arm fat percentage (left) 1.28 1 0 0.0 0 1 ZNF23
Mood swings 5.81 1 0 0.0 0 1 ZNF23
Loneliness, isolation 5.76 1 0 0.0 0 1 ZNF23
Commuting to job workplace: Walk 5.34 1 0 0.0 0 1 ZNF23
Back pain experienced in last month 3.08 1 0 0.0 0 1 ZNF23
Breast cancer (self-reported) 9.98 1 0 0.0 0 1 ZNF23
Whole body water mass 3.41 1 0 0.0 0 1 ZNF23
Leg predicted mass (right) 3.24 1 0 0.0 0 1 ZNF23
Arm fat mass (left) 2.78 1 0 0.0 0 1 ZNF23
Pain type(s) experienced in last month: Hip pain 6.32 1 0 0.0 0 1 ZNF23
Medication: Paracetamol 2.84 1 0 0.0 0 1 ZNF23
Basal metabolic rate 3.64 1 0 0.0 0 1 ZNF23
Leg fat percentage (left) 1.93 1 0 0.0 0 1 ZNF23
Arm fat-free mass (left) 3.63 1 0 0.0 0 1 ZNF23
Average weekly beer plus cider intake 3.02 1 0 0.0 0 1 ZNF23
Irritability 5.59 1 0 0.0 0 1 ZNF23
Risk taking 5.44 1 0 0.0 0 1 ZNF23
Fractured/broken bones in last 5 years 6.52 1 0 0.0 0 1 ZNF23
Diastolic blood pressure, automated reading 1.64 1 0 0.0 0 1 ZNF23
Pain experienced in last month 5.03 1 0 0.0 0 1 ZNF23
Leg fat mass (left) 3.41 1 0 0.0 0 1 ZNF23
Arm predicted mass (left) 3.29 1 0 0.0 0 1 ZNF23

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.1
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2