Hub : Genes

MAP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1340	0.0500	2.6e-04	0.000	NA	0.018	NA	-0.001	3.1e-01	NA	1.2e-02	NA	4.0e-01
2	GTEx	Cells Transformed fibroblasts	0.1010	0.0360	7.2e-05	0.062	NA	0.075	NA	0.078	2.1e-05	NA	2.9e-06	NA	1.7e-06
3	GTEx	Esophagus Muscularis	0.1500	0.0730	4.5e-03	0.113	NA	0.081	NA	0.102	2.3e-07	NA	1.2e-05	NA	9.6e-07
4	GTEx	Lung	0.0909	0.0328	5.7e-05	0.043	NA	0.058	NA	0.055	3.2e-04	NA	3.0e-05	NA	4.5e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.2373	0.0531	0.0e+00	0.142	0.17	0.158	0.169	0.144	7.6e-18	3.0e-21	7.7e-20	3.9e-21	5.0e-18
6	TCGA	Thyroid Carcinoma	0.0740	0.0400	2.7e-03	0.020	0.02	0.003	NA	0.013	4.2e-03	3.9e-03	1.6e-01	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.8	6.1	15.3	-0.5	2.8	3.5	3.9	-0.1	1.1
Bipolar Disorder or Schizophrenia	3.5	8.5	20.0	-0.7	3.5	3.7	4.5	1.3	1.7
Depressed Affect (Nagel 2018)	1.1	2.2	5.7	1.2	-2.4	-1.3	-2.0	0.3	-0.6
Depression (Nagel 2018)	2.4	3.5	7.0	1.5	-1.8	-1.2	-2.6	1.4	-2.3
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.4	-0.3	-0.9	-1.3	-1.8	0.6	-1.2
Neuroticism (Nagel 2018)	1.6	3.8	8.6	0.8	-2.9	-1.6	-2.7	2.0	-0.1
Schizophrenia (2018)	1.6	3.3	6.7	-0.1	2.2	2.0	2.6	1.7	1.2
Schizophrenia vs Biploar Disorder	1.5	1.9	3.6	0.4	-1.6	-1.9	-1.9	1.1	-0.1
Worry (Nagel 2018)	1.6	3.4	7.2	0.8	-2.7	-1.3	-2.2	2.3	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	1.6	0.1	-0.4	-0.4	0.3	-1.3	-0.6
Alzheimer’s Disease (in father)	0.7	0.7	1.6	-0.1	-0.4	0.1	-1.2	-1.1	-1.2
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	0.5	0.5	0.9	0.6	-1.5	-0.7
Crohns Disease (2017)	1.0	2.1	10.3	-0.8	0.7	0.4	0.3	-3.2	-1.0
Irritable Bowel Disease (IBD)	0.2	0.5	2.4	-0.7	-0.2	-0.0	-0.4	-1.6	0.4
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.3	-0.6	-0.2	-0.6	0.2	0.9
Major Depression (MDD)	0.4	0.5	1.3	-0.9	-0.6	-0.5	-0.5	1.2	-0.5
Reaction Time	0.4	0.7	2.8	-1.1	-0.3	-0.4	-0.0	-1.7	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.8	-0.9	-0.0	-0.2	-0.8	2.0	-0.7
Breast Cancer	0.4	1.0	2.3	-1.1	-0.7	-1.0	-1.0	-0.1	-1.5
Ovarian Cancer	0.5	0.6	1.4	0.6	1.2	0.8	0.9	0.5	-0.6
Prostate Cancer	0.3	0.5	1.4	-0.3	-0.1	-1.1	-0.4	-0.2	-1.2
Age at First Birth	0.2	0.3	1.8	0.0	-0.3	-0.1	0.4	-0.0	1.3
Bipolar Disorder (2011)	3.1	3.0	7.7	0.4	2.0	2.8	2.4	0.2	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	0.1	0.9	0.6	0.5	-0.0	-0.7
Coronary Artery Disease (CAD)	1.1	1.3	5.5	0.7	0.1	-0.4	-0.2	-1.2	-2.4
Crohns Disease (2012)	1.8	2.9	11.6	-1.3	0.5	0.3	0.4	-3.4	-1.9
Mean Putamen Volume	0.4	0.5	1.8	-1.3	0.2	0.0	0.1	0.0	-1.0
Fasting Glucose	0.2	0.3	0.8	0.2	-0.4	-0.9	-0.6	0.1	-0.2
HbA1C	0.6	0.6	1.2	-1.0	-0.8	-0.6	-1.1	-0.7	-0.6
HDL Cholesterol	1.3	2.2	4.5	-1.2	1.1	0.7	1.9	1.2	2.1
LDL Cholesterol	0.4	0.7	1.9	-1.2	0.7	0.3	-0.2	0.3	-1.4
Lupus	0.9	1.4	3.9	1.4	-0.2	-2.0	-0.8	-1.0	-0.9
Neuroticism (2016)	0.6	0.8	2.5	0.3	-0.5	0.1	0.3	1.6	1.5
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.3	-0.7	-0.3	0.1	-0.7	0.1
Rheumatoid Arthritis	1.2	1.7	3.0	-1.6	-1.4	-1.7	-1.1	1.2	-0.5
Schizophrenia (2014)	2.0	4.3	8.7	-0.6	2.3	2.2	3.0	2.2	1.4
Triglycerides	1.7	2.8	6.1	-2.5	1.7	1.7	0.9	-1.3	-1.7
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.8	0.6	-1.2	-0.3	-0.8	-2.0	-1.1
Ulcerative Colitis	0.2	0.3	0.7	-0.8	-0.3	0.2	-0.3	0.4	0.8
Blood Eosinophil Count	0.4	3.3	8.7	0.0	-1.5	-1.7	-3.0	-0.5	-2.4
Blood Platelet Count	0.2	1.9	7.5	-2.7	1.3	0.0	0.4	-0.4	-1.4
Blood Red Count	0.3	2.9	6.9	-1.5	1.8	1.0	2.6	-0.2	2.0
Blood White Count	0.1	0.7	3.2	-1.8	-0.1	0.4	0.4	1.0	-0.0
Heel T-Score	0.1	0.9	2.1	-0.4	1.4	1.2	1.0	-0.8	-0.3
BMI	0.1	0.3	0.9	-0.5	0.2	0.9	0.4	-0.6	-0.6
Height	0.2	3.5	7.7	-2.2	-1.8	-2.0	-2.8	-0.0	-0.9
Waist Hip Ratio (WHR)	0.9	3.9	6.7	-1.9	-2.6	-2.6	-2.2	-0.9	-1.1
Systolic Blood Pressure	0.4	2.2	3.8	-1.9	-1.1	-1.1	-1.7	1.6	-1.2
Smoking Status	1.1	2.7	4.9	1.5	-1.2	-1.3	-1.8	1.6	-2.2
Allergy or Eczema	0.7	1.9	4.7	-1.5	-0.8	-0.8	-1.4	-1.2	-2.2
Cardiovascular Disease	0.2	0.6	1.6	-0.6	-0.9	-0.2	-1.3	-0.1	-0.9
Hypothyroidism (self reported)	0.2	0.5	0.8	-0.2	-0.9	-0.6	-0.4	0.8	0.9
Respiratory disease	0.5	1.2	3.3	-1.8	-0.6	-1.4	-1.0	-0.7	-0.2
Type 2 Diabetes (T2D) (2018)	2.2	4.2	7.5	0.2	-2.6	-2.3	-2.7	-1.6	-1.7
Lung FEV1/FVC ratio	0.7	3.5	6.8	1.9	-2.6	-2.6	-1.9	-0.7	0.2
Lung FVC	8.0	40.6	83.9	1.2	8.5	9.2	8.5	-0.8	3.5
Neuroticism	1.9	4.6	12.1	1.5	-3.5	-2.0	-2.6	1.4	0.5
Chronotype (morning person)	1.3	3.0	5.5	-0.1	-1.8	-2.1	-2.2	-0.1	-2.3
Hair Pigment	0.0	0.8	2.8	0.3	0.9	1.7	0.9	-0.1	-0.3
Tanning	0.2	1.9	4.0	0.6	1.2	1.8	2.0	1.1	1.0
Hand grip strength (left)	1.4	3.7	7.5	0.0	2.7	2.5	2.3	-1.2	1.1
Number of treatments/medications taken	0.6	1.0	1.8	0.3	-1.0	-1.1	-1.2	0.6	-1.3
Average weekly spirits intake	1.2	1.5	2.8	0.5	-1.4	-1.3	-1.4	-0.5	-1.7
Sensitivity / hurt feelings	0.2	0.4	1.3	-0.6	-0.2	-0.1	-1.1	-0.1	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.5	1.2	-0.3	0.5	-1.2	0.1	-1.1
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.6	-0.2	-0.2	0.2	0.7	0.3
Relative age of first facial hair	0.4	0.9	2.7	1.0	0.0	-0.8	-1.0	1.6	0.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	4.5	-2.1	-0.7	-0.6	-0.4	-0.9	-0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.1	0.2	-1.0	-0.9	-0.7	0.9	-1.1
Ever had hysterectomy (womb removed)	1.6	1.8	7.2	-1.1	-0.5	-1.1	-1.1	-0.0	-2.7
Systolic blood pressure, automated reading	0.6	1.7	7.6	-1.3	-0.5	-0.8	-0.4	2.8	-0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	0.3	-0.3	-0.6	0.4	0.1	1.3
Angina	0.4	0.6	2.6	0.4	-0.7	0.1	-0.3	-1.6	-0.0
Medication for hormone replacement therapy	0.6	0.7	2.4	0.6	-0.4	-0.0	0.2	1.6	1.0
Vitamin and mineral supplements	1.7	2.3	3.2	-0.3	-1.7	-1.7	-1.7	-1.8	-1.4
Supplements: Zinc	0.9	1.0	1.9	0.3	1.4	0.7	0.6	-1.2	-1.2
Medication: Co-codamol	0.3	0.3	0.5	-0.4	-0.3	-0.7	-0.4	0.6	-0.6
Medication: Metformin	2.7	3.7	7.1	0.3	-2.5	-2.7	-2.5	-1.2	-1.2
Diabetes (father)	0.3	0.4	0.8	0.9	-0.4	0.1	-0.8	-0.2	-0.9
Diabetes (mother)	0.7	0.9	3.0	1.7	-0.1	-1.0	-0.4	0.1	-1.2
Severe depression (siblings)	1.8	2.0	5.8	1.4	-2.4	-1.2	-1.4	-0.4	0.6
Pack years adult smoking proportion	0.0	0.1	0.1	-0.3	0.2	0.1	0.1	0.3	0.2
Impedance of leg (right)	1.6	8.0	13.5	-1.7	-3.2	-3.5	-3.7	-0.6	-3.0
Leg fat-free mass (left)	0.0	0.1	0.4	-0.1	0.7	0.3	0.1	-0.4	0.1
Trunk fat percentage	1.5	5.9	9.5	-1.6	-2.5	-2.6	-3.1	-0.7	-3.1
Hand grip strength (right)	1.4	3.8	8.6	-0.1	2.9	2.9	2.3	-0.1	0.8
Townsend deprivation index at recruitment	1.3	1.8	4.0	-0.2	1.8	1.3	1.1	0.7	2.0
Current tobacco smoking	0.7	1.1	1.9	0.7	-1.3	-1.0	-1.2	-0.0	-1.4
Average weekly fortified wine intake	0.4	0.5	2.5	-1.6	-0.1	-0.4	-0.4	-0.1	-0.2
Maternal smoking around birth	0.3	0.4	1.1	-1.0	-0.5	-0.1	-0.7	0.4	-0.8
Fed-up feelings	0.9	1.7	3.5	0.3	-1.9	-1.0	-1.3	1.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.7	1.5	-0.9	-0.3	-1.6	1.6	-1.6
Relative age voice broke	0.1	0.1	0.3	0.6	0.2	-0.1	0.2	-0.1	-0.2
Taking other prescription medications	2.3	3.6	4.9	-1.6	-2.2	-2.2	-1.6	-1.8	-1.8
Age when periods started (menarche)	0.6	1.5	3.0	-0.7	1.7	0.9	1.7	-1.3	-0.6
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.5	1.2	1.1	0.5	1.5	2.4	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	0.5	0.7	0.9	0.5	-0.4	-1.2
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	4.8	-0.8	-2.1	-1.8	-2.2	-0.8	-1.5
Qualifications: CSEs or equivalent	0.2	0.3	1.0	1.0	-0.3	0.3	0.2	-0.4	-0.4
Serious illness, injury or assault to yourself	1.1	1.3	4.0	-2.0	-0.8	-0.9	-0.7	0.2	-1.4
High blood pressure	0.8	2.3	4.8	0.2	-2.0	-2.0	-2.2	0.5	-1.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.0	-1.0	0.1	-0.0	-1.0	-2.6	-2.6
Multivitamins +/- minerals	2.2	2.8	3.5	1.3	1.9	1.7	1.6	1.8	1.7
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.9	-0.1	0.0	0.1	-0.4	-0.3
Supplements: Glucosamine	1.9	2.5	4.9	-0.6	2.2	1.6	1.6	1.9	1.0
Diverticular disease/diverticulitis (self-reported)	3.8	4.5	9.2	-1.0	-2.3	-2.4	-3.0	-0.6	-2.3
Medication: Atenolol	0.2	0.3	0.9	-0.3	-0.1	-0.2	-0.7	0.4	-1.0
Medication: Levothyroxine sodium	0.1	0.2	0.8	0.4	-0.1	0.1	0.1	0.6	0.9
Sitting height	0.1	0.5	1.0	-0.7	-0.1	-1.0	-0.4	-0.7	0.9
Chronic bronchitis/emphysema (father)	1.8	2.2	11.6	-3.4	0.0	0.7	0.4	0.1	-0.9
High blood pressure (mother)	1.2	1.7	2.9	0.8	1.2	1.7	1.7	1.4	0.8
Body mass index (BMI)	0.1	0.3	1.6	-0.2	0.1	0.1	-0.3	0.1	-1.3
Impedance of leg (left)	1.5	7.1	10.2	-1.9	-3.2	-3.2	-3.2	-0.9	-2.7
Leg predicted mass (left)	0.0	0.1	0.3	-0.0	0.5	0.3	0.1	-0.4	0.2
Trunk fat mass	1.0	4.4	7.7	-1.7	-2.0	-2.1	-2.6	-0.8	-2.8
Waist circumference	0.9	3.2	5.6	-0.7	-2.2	-2.2	-2.4	-0.4	-1.9
Number of incorrect matches in round	0.1	0.2	0.7	0.8	-0.2	0.7	-0.0	-0.1	-0.6
Past tobacco smoking	0.7	1.3	6.7	-0.2	-0.4	0.8	0.5	-0.5	2.6
Alcohol usually taken with meals	0.4	0.7	3.0	1.7	0.2	0.8	-0.2	-0.7	-0.1
Nervous feelings	1.2	2.2	7.9	-0.0	-0.9	-0.3	0.2	2.2	2.8
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.3	7.4	0.5	-2.5	-2.1	-2.7	0.2	-1.5
Hearing difficulty/problems with background noise	0.7	1.1	3.3	-1.0	-1.1	-0.2	-0.6	1.8	0.5
Hair/balding pattern: Pattern 2	1.2	1.5	2.3	0.8	-1.2	-1.4	-1.5	-1.5	-0.8
Had menopause	1.0	1.2	2.0	-0.8	-1.3	-1.3	-1.4	0.9	-0.8
Had other major operations	0.3	0.4	1.0	-0.4	1.0	0.2	0.1	-0.8	-0.7
Forced vital capacity (FVC)	3.0	11.6	23.3	-0.6	4.7	4.8	4.5	-1.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.1	-0.6	-0.6	-0.6	0.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	0.6	-0.4	0.3	0.4	-0.7	0.9
Qualifications: None of the above	0.1	0.1	0.4	-0.1	0.4	0.2	0.4	-0.1	-0.7
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.5	-0.1	-0.5	-0.3	0.6	-0.8
Mouth/teeth dental problems	0.9	1.4	6.1	2.5	-0.8	0.0	-0.5	-1.2	0.1
Heart attack	0.7	0.9	2.1	0.1	1.5	1.4	0.8	0.3	-0.7
Allergy	1.3	2.9	6.4	1.9	-0.4	0.0	1.1	2.5	2.5
Pain all over the body in last month	0.3	0.3	0.7	-0.2	-0.8	-0.8	-0.5	-0.0	-0.3
Diabetes (self-reported)	1.9	2.9	5.2	0.5	-1.9	-2.1	-2.3	-1.6	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	4.1	-0.2	-0.1	-0.3	-0.6	-2.0	-1.1
Medication: Ramipril	0.6	0.8	3.7	1.9	-0.2	-0.7	-0.3	-0.1	-0.6
Medication: Simvastatin	0.3	0.4	1.7	0.6	-0.2	0.2	-0.5	-0.2	-1.3
Fluid intelligence score	0.7	1.5	3.4	-0.5	-0.3	-0.9	-1.7	1.9	-1.2
Illnesses of siblings	0.7	0.9	3.2	0.5	0.5	0.6	1.2	-0.1	1.8
Neuroticism score	1.5	3.2	7.7	0.7	-2.8	-1.4	-2.6	1.3	0.1
Weight	0.2	1.0	2.3	-1.0	-0.4	-0.8	-1.2	-0.5	-1.5
Impedance of arm (right)	2.1	9.9	20.0	-0.9	-4.2	-4.2	-4.5	-0.2	-1.9
Arm fat percentage (right)	0.8	3.2	6.1	-1.0	-1.8	-1.8	-2.5	-0.2	-2.4
Trunk fat-free mass	0.1	0.5	1.6	-0.6	1.3	0.7	0.6	-0.4	0.3
Hip circumference	0.3	1.4	3.5	0.1	-1.5	-1.3	-1.9	-0.1	-1.0
Time employed in main current job	0.8	0.9	2.2	-1.5	0.5	0.2	1.0	0.1	1.5
Alcohol intake versus 10 years previously	0.7	1.0	2.0	-0.9	-1.3	-1.4	-1.3	0.5	0.2
Father’s age at death	0.2	0.3	1.0	0.6	-0.1	-0.1	-0.8	0.1	-1.0
Worrier / anxious feelings	3.7	7.1	14.9	0.7	-3.7	-3.1	-3.9	1.7	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.9	-0.4	-1.4	-2.0	-1.6	1.4	-1.0
Falls in the last year	0.2	0.3	0.6	0.4	-0.3	-0.7	-0.7	0.1	-0.8
Hair/balding pattern: Pattern 3	1.1	1.7	6.4	-2.5	0.8	0.9	0.5	0.3	-1.3
Number of live births	0.3	0.4	1.6	0.0	0.6	0.1	-0.5	1.3	-0.4
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	16.5	0.6	4.0	4.1	4.0	-1.7	1.9
Pulse rate	0.7	1.1	4.9	0.0	-0.1	0.1	0.4	2.2	1.3
Happiness	1.5	1.8	4.2	0.2	-2.0	-0.8	-1.4	-1.9	-0.7
Noisy workplace	1.1	1.4	6.8	-2.6	-0.1	-1.0	-0.3	0.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.7	-0.6	0.2	-0.1	-0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.0	-1.5	0.5	0.2	-0.4	-1.2	-2.5
Mouth/teeth dental problems: Dentures	0.6	1.0	2.6	-1.5	-0.4	-0.8	-0.3	1.6	-0.4
Asthma	0.7	1.4	6.2	-2.5	-0.2	-0.6	-0.9	-0.8	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.6	0.5	-0.4	-0.3	-0.8	-1.6	-1.2
Medication: Cholesterol lowering	0.3	0.5	2.4	0.2	-0.0	0.4	0.0	-0.5	-1.6
Depression (self-reported)	0.9	1.1	3.5	0.4	1.0	1.9	0.6	-0.8	-1.0
Medication: Lansoprazole	0.2	0.2	0.8	-0.1	-0.4	-0.2	-0.1	-0.3	-0.9
Prospective memory result	0.7	0.9	3.4	-1.8	-0.1	0.3	0.5	1.2	0.5
Lung cancer (father)	0.6	0.7	2.2	-1.5	-0.0	-0.1	-0.2	0.2	1.4
Illnesses of mother	0.8	1.0	2.5	-1.2	-1.0	-1.6	-1.0	-0.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	14.1	0.6	3.7	3.8	3.6	-1.8	2.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.0	-0.7	-0.8	-0.7	-0.5	1.4	1.1
Impedance of arm (left)	1.3	6.0	11.7	-0.7	-3.3	-3.3	-3.4	-0.1	-1.4
Arm fat mass (right)	0.5	1.9	3.7	-0.8	-1.3	-1.5	-1.9	-0.2	-1.8
Trunk predicted mass	0.1	0.5	1.7	-0.5	1.3	0.8	0.6	-0.3	0.4
Standing height	0.3	2.9	5.2	-1.7	-1.4	-2.2	-2.3	-1.2	-0.9
Length of working week for main job	0.1	0.2	0.8	0.1	-0.4	-0.0	0.2	-0.9	-0.2
Exposure to tobacco smoke at home	0.3	0.4	1.1	-0.3	-0.4	-0.8	-0.1	1.0	0.5
Breastfed as a baby	3.3	4.1	9.3	1.3	3.1	2.3	2.9	0.2	0.5
Tense / ‘highly strung’	0.3	0.4	0.9	-0.8	-0.7	0.5	-0.4	0.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	0.4	-0.9	0.4	-0.7	1.3	-0.3
Hair/balding pattern: Pattern 4	0.7	1.7	3.9	2.0	0.1	1.0	1.3	0.2	1.8
Birth weight of first child	1.1	1.9	3.8	0.4	-1.4	-1.5	-2.0	-0.9	-1.6
Peak expiratory flow (PEF)	0.6	1.4	2.2	0.1	1.4	1.5	1.3	-0.8	1.4
Pulse wave reflection index	2.7	3.3	6.7	0.1	2.4	2.2	2.6	0.4	1.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.9	0.2	0.8	0.1	-0.6	-0.1
Loud music exposure frequency	0.7	0.8	1.4	-0.0	-1.2	-1.0	-0.9	0.1	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	0.6	-1.2	-0.3	-0.6	0.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	-0.2	0.9	1.4	0.6	-1.0	-0.2
Blood clot in the leg (DVT)	1.9	2.5	5.4	1.5	1.8	2.3	1.8	-0.8	0.6
Medication: Paracetamol	0.1	0.2	1.0	0.0	-0.3	-0.4	-0.2	-1.0	0.2
Headache pain in last month	1.1	1.9	4.7	1.0	-1.3	-1.8	-0.6	2.2	0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.9	-0.9	0.2	0.0	0.1	0.9	1.0
Glaucoma (self-reported)	4.1	4.8	15.0	-0.1	-3.9	-3.2	-1.8	-0.2	0.8
Gout (self-reported)	1.3	1.8	5.1	-0.6	1.7	1.1	2.3	0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.6	-0.6	-0.4	-0.2	0.7	1.1
Medication: Amlodipine	0.9	1.3	2.7	1.6	-1.5	-1.5	-0.6	0.6	0.2
Medication: Ventolin 100micrograms inhaler	2.2	2.8	6.7	-0.6	-2.0	-2.6	-2.1	-0.3	-1.1
Birth weight	0.1	0.3	0.7	0.4	-0.6	-0.2	-0.6	-0.8	-0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	0.1	0.6	0.9	-0.0	-1.3	-1.1
High blood pressure (siblings)	1.4	2.1	6.2	-1.9	-0.6	-0.5	-1.4	0.2	-2.5
Forced vital capacity (FVC), Best measure	2.6	9.4	17.4	0.2	4.1	4.2	4.1	-1.2	2.1
Body fat percentage	1.2	4.9	8.8	-1.6	-2.2	-2.3	-2.7	-0.6	-3.0
Leg fat percentage (right)	1.4	5.1	13.3	-1.6	-1.7	-2.1	-2.7	-0.3	-3.6
Arm fat-free mass (right)	0.1	0.5	1.2	-0.6	1.1	0.8	0.8	-0.6	0.1
Exposure to tobacco smoke outside home	0.9	1.2	2.3	0.8	-1.1	-1.5	-1.1	1.3	-0.3
Comparative body size at age 10	0.4	1.1	3.6	0.5	-0.8	-0.4	-1.3	-0.3	-1.9
Number of full brothers	0.4	0.6	1.8	-0.8	-0.0	-0.0	-0.8	0.5	-1.4
Worry too long after embarrassment	1.6	2.6	7.4	0.0	-1.7	-1.8	-1.3	2.7	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.0	0.1	-1.6	-0.2	-1.7	-1.3	-1.3
Wheeze or whistling in the chest in last year	1.9	3.4	12.2	-3.5	-0.8	-1.3	-1.6	-0.3	-1.9
Number of children fathered	0.5	0.5	2.2	0.6	0.1	0.8	-0.1	1.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	6.4	-0.6	2.5	2.3	1.9	-0.6	-0.4
Age at first live birth	0.8	1.4	3.6	1.9	0.4	0.5	0.6	-1.5	1.4
Pulse wave peak to peak time	0.6	0.8	2.2	0.6	0.8	0.4	0.3	-1.5	-1.1
Health satisfaction	1.2	1.5	3.5	-0.1	1.5	1.8	1.9	0.2	-0.3
Shortness of breath walking on level ground	0.3	0.4	1.5	-1.2	-0.7	0.1	-0.4	-0.2	-0.4
Qualifications: College or University degree	0.3	1.0	2.8	-0.6	0.8	0.7	-0.3	-1.2	-1.7
Eye problems/disorders: None of the above	1.2	1.4	3.6	0.5	1.7	1.9	1.0	-0.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.2	1.4	0.7	0.6	0.6	1.5	-0.6
Emphysema/chronic bronchitis	0.7	0.8	1.6	-0.8	1.2	0.1	1.3	-1.1	-0.2
Medication for pain relief, constipation, heartburn	1.2	2.0	2.9	-0.6	1.7	1.6	1.7	1.1	1.5
Neck or shoulder pain in last month	1.1	1.6	4.0	1.2	0.5	1.4	1.4	0.5	2.0
Medication: Blood pressure	0.4	0.7	1.5	1.2	-0.6	-0.4	-0.5	-1.2	-0.9
Angina (self-reported)	0.6	0.7	3.0	0.2	-1.0	-0.1	-0.5	-1.7	-0.3
Migraine (self-reported)	4.4	5.5	11.8	2.0	-3.3	-3.4	-2.1	0.2	-1.4
Medication: Ibuprofen	0.4	0.4	1.5	0.1	-0.1	0.1	-0.6	-0.8	-1.2
Medication: Allopurinol	0.3	0.4	1.3	0.2	-0.4	-0.3	0.5	-0.8	-1.2
Medication: Omeprazole	1.8	2.1	3.9	-0.4	-1.1	-1.8	-2.0	-1.0	-1.8
Medication: Seretide 50 evohaler	1.2	1.4	3.5	-1.9	1.1	-0.0	0.7	1.7	0.3
Mean time to correctly identify matches	0.6	1.1	2.3	-0.7	-0.8	-0.9	-0.8	-1.5	-1.4
Heart disease (mother)	0.5	0.6	2.0	0.7	-1.4	-0.8	-0.6	0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.4	-0.8	1.0	0.7	0.3	1.5	-1.0
Whole body fat mass	0.7	2.7	5.1	-1.2	-1.5	-1.6	-2.1	-0.5	-2.2
Leg fat mass (right)	0.7	2.8	7.0	-1.1	-1.4	-1.5	-2.1	-0.6	-2.6
Arm predicted mass (right)	0.1	0.7	1.9	-0.4	1.4	1.0	0.9	-0.7	0.1
Pulse rate, automated reading	0.4	1.1	4.2	-1.0	-0.7	-1.0	-0.3	2.0	-0.4
Alcohol intake frequency.	0.4	0.8	1.7	0.4	-0.9	-1.0	-0.8	-0.8	1.3
Comparative height size at age 10	0.3	1.5	2.8	-1.0	-1.5	-1.7	-1.7	-0.5	-0.2
Number of full sisters	0.4	0.4	1.0	-0.0	-0.4	-0.7	-0.9	1.0	-0.3
Suffer from ‘nerves’	1.0	1.6	2.5	1.6	-1.3	-1.0	-0.6	1.6	1.4
Overall health rating	0.2	0.3	1.0	0.3	-0.7	-0.5	0.3	1.0	-0.1
Chest pain or discomfort	1.1	1.6	3.8	-1.6	-0.9	-1.5	-0.7	-0.0	-1.9
Had major operations	1.2	1.5	5.0	0.6	2.2	1.3	0.9	0.8	-0.2
Age at last live birth	0.4	0.6	1.0	1.0	-0.4	-0.9	-0.8	-0.2	-0.8
Family relationship satisfaction	0.3	0.3	0.7	0.4	0.9	0.7	0.7	-0.5	0.1
Leg pain on walking	0.3	0.4	0.9	-1.0	0.6	0.3	0.5	0.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	0.1	-1.1	-0.5	-1.5	0.1	-0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.5	-0.0	-1.5	-0.8	-1.4	-1.6	-1.3
Illness, injury, bereavement, stress in last 2 years	2.9	3.6	7.1	1.8	1.5	2.3	1.9	0.2	2.7
Medication: Aspirin	0.4	0.5	1.2	0.4	-0.7	-0.6	-0.5	-1.1	-0.8
Supplements: Vitamin C	0.3	0.4	1.6	1.3	-0.5	0.2	0.1	-0.5	-0.2
Knee pain experienced in last month	0.7	1.1	3.9	-2.0	0.4	-0.2	0.1	1.1	-1.2
Hypertension (Self-reported)	0.7	2.0	4.3	0.2	-1.9	-1.8	-2.1	0.4	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	6.4	-1.4	-1.6	-1.9	-2.5	-0.2	-1.6
Illnesses of father: Heart disease	0.2	0.3	0.9	0.9	0.0	-0.2	0.3	-0.9	-0.1
Illnesses of siblings: Diabetes	1.6	2.0	3.4	0.4	-1.1	-1.6	-1.6	-1.4	-1.9
Smoking status: Previous	0.6	0.9	2.8	-0.1	0.5	-0.8	-0.5	1.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.6	0.1	-2.0	-1.5	-1.6	-2.6	-1.0
Whole body fat-free mass	0.1	0.4	1.3	-0.4	1.1	0.7	0.6	-0.4	0.3
Leg fat-free mass (right)	0.1	0.4	0.8	0.0	0.9	0.7	0.7	-0.5	0.7
Arm fat percentage (left)	0.7	2.7	5.5	-1.1	-1.6	-1.4	-2.2	-0.4	-2.3
Average weekly red wine intake	1.7	2.5	6.1	2.5	1.5	0.9	1.3	1.8	0.9
Handedness (chirality/laterality): Left-handed	9.0	10.8	27.7	-0.2	-4.0	-5.3	-4.5	-0.2	-1.2
Mood swings	1.5	2.6	8.4	0.8	-2.9	-1.3	-1.6	1.1	1.2
Loneliness, isolation	0.8	1.1	3.9	-0.5	-0.6	-0.4	-0.8	-2.0	-1.0
Long-standing illness, disability or infirmity	0.5	0.8	1.8	0.1	-1.0	-1.4	-0.8	0.7	-0.9
Ever had bowel cancer screening	1.1	1.3	2.6	0.5	1.0	1.2	1.6	0.8	1.4
Diabetes diagnosed by doctor	1.6	2.5	5.5	0.1	-2.0	-2.3	-2.1	-1.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.2	-0.8	0.9	0.3	-0.5	1.0	-1.5
Friendships satisfaction	0.3	0.4	0.8	0.9	-0.5	0.1	-0.4	-0.9	0.4
Qualifications: nursing, teaching	0.3	0.5	1.2	0.7	0.5	0.6	0.4	-0.6	-1.1
Commuting to job workplace: Walk	1.8	2.0	4.3	1.2	1.0	0.6	2.1	-0.7	2.0
Eye problems/disorders: Cataract	0.3	0.4	1.8	0.1	0.1	-0.3	0.5	0.3	1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.5	-1.2	1.0	0.1	1.1	0.4	1.2
Medication for cholesterol	1.2	1.8	2.7	-0.9	1.5	1.6	1.7	-1.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.7	0.5	-1.5	-1.0	-0.7	2.2	0.7
Back pain experienced in last month	0.3	0.4	1.3	-0.1	-0.7	-0.6	-0.5	-0.1	-1.1
Mineral and other dietary supplements	1.4	1.8	4.5	-0.1	-2.1	-1.5	-1.5	-1.0	-0.9
Breast cancer (self-reported)	0.9	1.1	2.9	-0.2	1.7	1.0	1.3	-0.3	-0.8
Asthma (self-reported)	0.6	1.1	4.5	-2.1	-0.4	-0.6	-1.1	-0.2	-0.7
Osteoporosis (self-reported)	0.8	1.0	1.8	0.6	-1.2	-1.3	-1.3	0.4	-0.9
Osteoarthritis (self-reported)	0.4	0.5	1.5	-1.1	-0.0	-0.1	-0.2	0.7	-1.2
Medication: Aspirin	0.5	0.6	2.8	0.5	-0.3	-0.3	-0.1	-1.7	-0.8
Medication: Gliclazide	0.5	0.5	1.0	-0.9	0.0	-0.8	-0.3	-1.0	-0.9
Illnesses of father: None of the above (group 1)	0.2	0.3	1.3	-0.3	0.3	-0.3	-0.4	1.1	-0.1
Smoking status: Current	0.7	1.1	1.8	0.9	-1.4	-1.2	-1.2	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.8	10.2	19.9	-0.2	4.3	4.5	4.3	-1.3	1.7
Whole body water mass	0.1	0.4	1.3	-0.3	1.1	0.7	0.7	-0.5	0.3
Leg predicted mass (right)	0.1	0.4	0.8	0.0	0.9	0.8	0.7	-0.5	0.7
Arm fat mass (left)	0.5	1.9	3.6	-0.8	-1.3	-1.3	-1.8	-0.4	-1.9
Number of self-reported non-cancer illnesses	1.5	2.6	4.2	0.3	-1.8	-1.8	-2.0	-0.8	-2.1
Average weekly champagne plus white wine intake	1.1	1.5	3.8	-0.1	1.4	1.9	0.5	-1.2	-1.2
Miserableness	0.7	1.2	3.5	1.9	-1.3	-0.1	-1.3	0.2	-0.2
Guilty feelings	1.8	2.7	6.2	0.3	-1.5	-1.0	-2.5	2.1	-1.6
Wears glasses or contact lenses	4.1	4.8	9.1	1.6	-2.8	-3.0	-2.3	2.0	-0.4
Ever taken oral contraceptive pill	1.3	1.4	3.8	0.1	2.0	1.4	1.5	0.5	-0.5
Hearing aid user	0.2	0.2	0.4	0.2	-0.6	-0.5	0.4	0.7	-0.0
Mother’s age at death	0.1	0.1	0.4	0.6	-0.3	0.0	-0.0	0.5	0.2
Financial situation satisfaction	0.4	0.4	0.7	-0.8	0.4	0.8	0.7	-0.8	0.2
Tinnitus: Yes, now most or all of the time	1.8	2.2	4.5	1.2	1.7	1.4	2.1	1.2	0.7
Commuting to job workplace: Public transport	0.3	0.4	1.1	-0.3	0.4	0.1	0.5	1.0	0.8
Eye problems/disorders: Glaucoma	4.1	4.8	11.4	-0.6	-3.4	-3.0	-1.1	1.0	2.4
Medication: Blood pressure	1.5	2.8	5.3	0.6	-2.0	-2.3	-2.3	1.1	-0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.9	-0.5	1.7	1.6	1.3	1.3	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.1	0.7	0.3	0.5	0.6	0.2
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.2	-0.9	-0.2	-0.9	1.0	-1.1
Medication: Bendroflumethiazide	0.3	0.4	2.0	0.1	0.1	-0.4	-0.5	0.2	-1.4
Medication: Paracetamol	0.3	0.5	2.0	0.3	-0.5	-0.3	-0.6	-1.4	-0.5
Medication: Lisinopril	0.9	1.1	3.3	-1.4	0.2	-0.4	-0.5	-1.1	-1.8
Medication: Atorvastatin	1.3	1.6	4.3	-0.5	-2.1	-1.8	-1.2	0.0	-0.6
Illnesses of father: High blood pressure	1.2	1.5	2.7	1.4	1.1	1.6	1.4	0.5	1.1
Alcohol drinker status: Never	0.2	0.2	0.5	-0.7	0.4	-0.3	0.6	0.6	0.3
Ever smoked	0.3	0.5	2.2	0.6	-0.0	-0.7	-0.2	0.2	-1.5
Basal metabolic rate	0.0	0.2	0.6	-0.6	0.8	0.4	0.2	-0.5	-0.1
Leg fat percentage (left)	1.1	3.8	10.2	-1.8	-1.5	-1.6	-2.1	-0.3	-3.2
Arm fat-free mass (left)	0.0	0.2	0.6	-0.4	0.8	0.3	0.4	-0.3	-0.1
Number of operations (self-reported)	0.3	0.4	1.4	-0.1	1.2	0.7	0.4	0.4	-0.2
Average weekly beer plus cider intake	1.5	2.1	5.5	-1.0	2.0	1.0	2.3	1.1	0.2
Irritability	0.8	1.4	3.9	0.3	-1.4	-0.1	-1.5	2.0	-0.1
Risk taking	3.6	5.2	14.0	-0.8	3.2	3.7	1.6	0.3	-2.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	0.9	0.4	1.2	0.4	-0.1	-0.3
Fractured/broken bones in last 5 years	0.9	1.2	4.5	-2.1	1.3	0.8	0.1	-0.2	-0.5
Age started oral contraceptive pill	0.3	0.4	0.9	-0.9	-0.4	-0.5	-0.6	0.8	0.4
Diastolic blood pressure, automated reading	0.3	1.0	3.2	-1.8	0.7	0.3	0.5	1.2	-0.7
Ever depressed for a whole week	0.9	1.1	2.6	1.6	-1.6	-0.4	-1.0	-0.6	0.1
Unable to work because of sickness or disability	0.8	1.0	3.2	-1.8	-0.3	0.1	-0.3	-0.6	-1.6
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.6	-0.2	-0.6	-0.3	-0.1	0.4
Myopia	0.1	0.1	0.3	0.2	0.4	0.4	-0.2	0.1	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.5	3.1	-0.2	1.6	1.5	1.8	-0.1	1.0
Cholesterol lowering medication	1.9	2.8	5.5	1.5	-2.3	-2.0	-2.2	0.2	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	4.7	-1.3	-1.5	-1.8	-2.2	-1.7	-2.1
Pain experienced in last month	0.4	0.6	1.7	0.5	1.3	0.8	0.5	-0.9	-0.0
Supplements: Calcium	1.5	1.7	4.2	-1.0	1.9	2.1	1.0	0.1	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	1.7	0.1	-1.2	-1.2	-1.1	1.3	-0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	0.2	1.4	1.3	0.6	-0.3	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.3	3.0	6.5	1.5	2.0	2.5	2.0	-0.8	0.7
Heart disease (siblings)	0.3	0.4	0.8	0.5	0.7	0.6	0.6	-0.9	-0.4
Alcohol drinker status: Previous	0.5	0.6	1.6	-0.1	0.7	0.9	0.7	-0.6	1.3
Pack years of smoking	0.1	0.2	0.4	-0.0	-0.3	-0.4	-0.3	0.7	0.5
Impedance of whole body	1.5	7.8	13.5	-1.5	-3.6	-3.7	-3.6	-0.6	-2.2
Leg fat mass (left)	0.6	2.2	5.2	-1.3	-1.2	-1.2	-1.7	-0.6	-2.3
Arm predicted mass (left)	0.0	0.2	0.4	-0.5	0.7	0.2	0.2	-0.3	-0.1