Hub : Traits :

Handedness (chirality/laterality): Left-handed

271 significantly associated models · 21 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 209599808 211264173 1 1 1.5e-07 2.8e-09 0.005 78 MAP2
2 17 42774693 45796313 20 1 1.8e-12 2.5e-08 0.202 95 ARL17B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Reaction Time 10.8 1 1 3.0 0 1 ARL17B
Verbal and Numeric Reasoning (VNR) 3.7 1 0 0.0 0 1 ARL17B
Breast Cancer 3.9 1 0 0.0 0 1 ARL17B
Neuroticism 7.9 1 0 0.0 0 1 ARL17B
Blood Eosinophil Count 5.4 1 1 3.0 0 1 ARL17B
Blood Red Count 6.3 1 1 3.0 0 1 ARL17B
Heel T-Score 3.9 1 1 3.0 0 1 ARL17B
Height 3.1 1 1 3.0 0 1 ARL17B
Waist Hip Ratio (WHR) 2.5 1 0 0.0 0 1 ARL17B
Systolic Blood Pressure 3.3 1 1 3.0 0 1 ARL17B
Lung FVC 27.6 2 2 6.1 0 1 ARL17B MAP2
Neuroticism 20.1 1 1 3.0 0 1 ARL17B
Hand grip strength (left) 8.4 1 1 3.0 0 1 ARL17B
Sensitivity / hurt feelings 18.6 1 1 3.0 0 1 ARL17B
Frequency of depressed mood in last 2 weeks 9.0 1 0 0.0 0 1 ARL17B
Relative age of first facial hair 12.9 1 1 3.0 0 1 ARL17B
Systolic blood pressure, automated reading 4.5 1 1 3.0 0 1 ARL17B
Trunk fat percentage 5.3 1 1 3.0 0 1 ARL17B
Hand grip strength (right) 9.1 1 1 3.0 0 1 ARL17B
Fed-up feelings 5.2 1 0 0.0 0 1 ARL17B
Relative age voice broke 6.8 1 0 0.0 0 1 ARL17B
Age when periods started (menarche) 3.3 1 0 0.0 0 1 ARL17B
Sitting height 6.4 1 1 3.0 0 1 ARL17B
Trunk fat mass 3.9 1 1 3.0 0 1 ARL17B
Nervous feelings 10.3 1 1 3.0 0 1 ARL17B
Frequency of tenseness / restlessness in last 2 weeks 15.8 1 1 3.0 0 1 ARL17B
Hearing difficulty/problems with background noise 6.3 1 0 0.0 0 1 ARL17B
Hair/balding pattern: Pattern 2 13.0 1 1 3.0 0 1 ARL17B
Forced vital capacity (FVC) 24.7 2 1 3.0 0 1 ARL17B MAP2
Mouth/teeth dental problems 6.5 1 0 0.0 0 1 ARL17B
Fluid intelligence score 4.4 1 0 0.0 0 1 ARL17B
Neuroticism score 17.6 1 1 3.0 0 1 ARL17B
Impedance of arm (right) 8.8 2 1 3.0 0 1 ARL17B MAP2
Time employed in main current job 8.8 1 0 0.0 0 1 ARL17B
Worrier / anxious feelings 9.8 1 1 3.0 0 1 ARL17B
Hair/balding pattern: Pattern 3 21.1 1 1 3.0 0 1 ARL17B
Forced expiratory volume in 1-second (FEV1) 23.9 2 1 3.0 0 1 ARL17B MAP2
Forced expiratory volume in 1-second (FEV1), Best measure 21.5 2 1 3.0 0 1 ARL17B MAP2
Impedance of arm (left) 7.6 1 1 3.0 0 1 ARL17B
Standing height 3.2 1 1 3.0 0 1 ARL17B
Tense / 'highly strung' 6.1 1 0 0.0 0 1 ARL17B
Hair/balding pattern: Pattern 4 24.8 1 1 3.0 0 1 ARL17B
Peak expiratory flow (PEF) 10.8 1 1 3.0 0 1 ARL17B
Medication: Paracetamol 6.6 1 0 0.0 0 1 ARL17B
Headache pain in last month 16.3 1 1 3.0 0 1 ARL17B
Forced vital capacity (FVC), Best measure 23.2 2 1 3.0 0 1 ARL17B MAP2
Body fat percentage 3.0 1 0 0.0 0 1 ARL17B
Exposure to tobacco smoke outside home 6.1 1 0 0.0 0 1 ARL17B
Number of full brothers 8.9 1 0 0.0 0 1 ARL17B
Worry too long after embarrassment 9.6 1 1 3.0 0 1 ARL17B
Qualifications: College or University degree 3.1 1 0 0.0 0 1 ARL17B
Emphysema/chronic bronchitis 8.4 1 0 0.0 0 1 ARL17B
Mean time to correctly identify matches 8.5 1 1 3.0 0 1 ARL17B
Reproduciblity of spirometry measurement using ERS/ATS criteria 7.3 1 0 0.0 0 1 ARL17B
Whole body fat mass 2.1 1 0 0.0 0 1 ARL17B
Alcohol intake frequency. 4.6 1 0 0.0 0 1 ARL17B
Comparative height size at age 10 3.6 1 1 3.0 0 1 ARL17B
Suffer from 'nerves' 7.9 1 0 0.0 0 1 ARL17B
Mood swings 14.2 1 1 3.0 0 1 ARL17B
Mouth/teeth dental problems: Mouth ulcers 6.6 1 0 0.0 0 1 ARL17B
Forced expiratory volume in 1-second (FEV1), predicted percentage 19.2 2 1 3.0 0 1 ARL17B MAP2
Miserableness 5.1 1 0 0.0 0 1 ARL17B
Guilty feelings 5.9 1 0 0.0 0 1 ARL17B
Medication: Paracetamol 6.5 1 0 0.0 0 1 ARL17B
Irritability 8.2 1 1 3.0 0 1 ARL17B
Risk taking 5.0 1 0 0.0 0 1 MAP2
Fractured/broken bones in last 5 years 5.8 1 0 0.0 0 1 ARL17B
Pain experienced in last month 5.8 1 0 0.0 0 1 ARL17B
Impedance of whole body 5.8 1 1 3.0 0 1 ARL17B

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.1719 1.21
GTEx Adipose Visceral Omentum 6 0.2947 1.26
GTEx Adrenal Gland 5 0.3432 1.28
GTEx Artery Aorta 9 0.3023 1.28
GTEx Artery Coronary 8 0.6762 1.45
GTEx Artery Tibial 5 0.1329 1.19
GTEx Brain Caudate basal ganglia 4 0.4348 1.26
GTEx Brain Cerebellar Hemisphere 5 0.3358 1.26
GTEx Brain Cerebellum 4 0.2018 1.27
GTEx Brain Cortex 2 0.1932 1.31
GTEx Brain Frontal Cortex BA9 4 0.4329 1.33
GTEx Brain Hippocampus 3 0.5725 1.55
GTEx Brain Hypothalamus 3 0.5085 1.36
GTEx Brain Nucleus accumbens basal ganglia 6 0.6936 1.40
GTEx Brain Putamen basal ganglia 3 0.4808 1.43
GTEx Breast Mammary Tissue 8 0.4053 1.33
GTEx Breast Mammary Tissue (Male) 6 0.5029 1.38
GTEx Breast Mammary Tissue (Female) 7 0.4258 1.33
GTEx Cells EBV-transformed lymphocytes 9 0.6325 1.39
GTEx Cells Transformed fibroblasts 6 0.1429 1.15
GTEx Colon Sigmoid 8 0.5472 1.29
GTEx Colon Transverse 6 0.2907 1.22
GTEx Esophagus Gastroesophageal Junction 8 0.5536 1.33
GTEx Esophagus Mucosa 7 0.2108 1.23
GTEx Esophagus Muscularis 10 0.3094 1.24
GTEx Heart Atrial Appendage 6 0.3800 1.27
GTEx Heart Left Ventricle 7 0.4575 1.23
GTEx Liver 3 0.4184 1.30
GTEx Lung 7 0.2436 1.26
GTEx Muscle Skeletal 5 0.1730 1.21
GTEx Nerve Tibial 6 0.1389 1.18
GTEx Ovary 7 0.7709 1.42
GTEx Pancreas 5 0.3064 1.25
GTEx Pituitary 4 0.3587 1.34
GTEx Prostate 4 0.4790 1.40
GTEx Skin Not Sun Exposed Suprapubic 7 0.2847 1.29
GTEx Skin Sun Exposed Lower leg 6 0.1648 1.24
GTEx Small Intestine Terminal Ileum 3 0.6508 1.35
GTEx Spleen 5 0.3544 1.23
GTEx Stomach 6 0.4127 1.29
GTEx Testis 10 0.3170 1.23
GTEx Thyroid 8 0.2001 1.22
GTEx Uterus 6 1.0582 1.41
GTEx Vagina 3 0.4724 1.39
GTEx Whole Blood 4 0.2007 1.19
METSIM Adipose 2 0.0434 1.12
NTR Blood 1 0.0416 1.20
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.12
YFS Blood 0 0.0000 1.13
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.16
TCGA Breast Tumor 1 0.1304 1.20
TCGA Breast Normal 0 0.0000 1.08
TCGA Ovarian Tumor 4 0.1369 1.20
TCGA Prostate Tumor 2 0.0578 1.13