Hub : Genes

CPED1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1020	0.0350	2.1e-04	0.016	NA	0.036	NA	0.032	1.6e-02	NA	6.2e-04	NA	1.1e-03
2	GTEx	Adrenal Gland	0.1831	0.0755	6.5e-03	0.012	NA	-0.006	NA	-0.008	1.2e-01	NA	6.5e-01	NA	9.8e-01
3	GTEx	Artery Tibial	0.0797	0.0375	4.1e-03	0.001	NA	-0.002	NA	0.004	2.5e-01	NA	4.5e-01	NA	1.4e-01
4	GTEx	Cells Transformed fibroblasts	0.1980	0.0510	3.1e-09	0.117	NA	0.136	NA	0.157	4.4e-09	NA	2.4e-10	NA	7.6e-12
5	GTEx	Esophagus Muscularis	0.2120	0.0690	4.1e-06	0.064	NA	0.013	NA	0.029	9.4e-05	NA	5.4e-02	NA	7.0e-03
6	GTEx	Muscle Skeletal	0.0365	0.0174	7.3e-03	0.061	NA	0.043	NA	0.053	1.3e-06	NA	4.0e-05	NA	6.5e-06
7	GTEx	Nerve Tibial	0.0855	0.0372	3.3e-03	0.026	NA	0.021	NA	0.058	5.6e-03	NA	1.2e-02	NA	6.4e-05
8	GTEx	Skin Sun Exposed Lower leg	0.0540	0.0250	4.1e-03	0.008	NA	0.015	NA	0.017	6.3e-02	NA	1.8e-02	NA	1.3e-02
9	METSIM	Adipose	0.0458	0.0212	2.6e-03	0.043	0.032	0.040	0.038	0.041	3.7e-07	1.3e-05	9.6e-07	1.8e-06	7.1e-07
10	ROSMAP	Brain Pre-frontal Cortex	0.0509	0.0197	1.3e-03	0.011	0.031	0.030	0.031	0.023	1.2e-02	6.1e-05	8.5e-05	6.9e-05	4.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	5.1	2.3	-0.3	-0.2	0.9	-0.5	-0.5	0.7	1.9	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	3.6	1.9	-0.1	-0.4	1.1	-1.8	0.2	1.4	-0.1	-0.0	0.2
Depressed Affect (Nagel 2018)	1.3	2.7	10.8	-1.8	-0.3	-1.3	-3.3	-2.0	1.3	-1.0	-1.4	-0.0	1.4
Depression (Nagel 2018)	1.0	1.6	6.1	-1.8	-0.6	-0.0	-2.5	-1.6	0.8	-1.2	-1.0	-0.4	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.4	-0.4	-1.0	1.0	0.2	0.5	-1.6	-0.1	1.8	-1.1	-1.0
Neuroticism (Nagel 2018)	1.5	3.6	12.3	-1.5	1.1	-1.1	-3.5	-2.5	2.1	-0.3	-1.1	1.4	2.2
Schizophrenia (2018)	0.5	1.0	3.6	0.6	0.1	-0.3	0.8	-1.9	0.7	1.3	-1.6	0.2	0.7
Schizophrenia vs Biploar Disorder	3.9	5.2	10.9	-0.5	3.2	0.2	0.8	-3.0	2.4	2.9	-2.2	3.3	1.3
Worry (Nagel 2018)	2.1	4.5	9.6	-0.1	2.7	-0.2	-2.2	-2.7	3.1	0.9	-1.2	2.9	2.3
Alzheimer’s Disease (in mother)	0.6	0.7	4.6	1.0	0.7	0.2	0.2	0.4	0.2	0.3	2.2	0.7	-0.6
Alzheimer’s Disease (in father)	0.4	0.5	1.9	-0.5	0.7	0.5	-0.4	-1.4	0.7	0.5	0.2	0.7	0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	6.2	1.1	-0.2	1.1	0.5	-0.3	0.4	0.7	2.5	-0.4	-1.4
Crohns Disease (2017)	0.9	2.1	4.9	0.5	-1.8	0.8	-0.4	1.5	-2.2	-1.4	-0.6	-1.7	-2.0
Irritable Bowel Disease (IBD)	0.7	1.8	4.2	0.9	-1.7	1.2	-0.4	1.1	-2.1	-1.3	-0.7	-1.6	-1.4
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.4	-1.1	0.8	-0.9	0.4	-0.8	-1.0	-1.2	-0.9	-0.0
Major Depression (MDD)	2.0	2.4	5.2	-0.9	1.5	-1.0	-1.4	-2.3	2.1	0.4	-2.1	1.7	1.3
Reaction Time	0.7	1.2	3.4	1.4	0.9	0.6	1.9	-0.1	-1.3	0.4	1.7	0.5	0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.5	-2.1	-0.4	-0.6	-1.3	-0.8	-0.5	-0.8	0.5	-0.4	0.1
Breast Cancer	0.5	1.1	2.3	-0.3	-1.5	0.0	0.8	0.8	-1.0	-0.0	1.4	-1.5	-1.5
Ovarian Cancer	1.1	1.5	5.6	-2.1	0.5	-0.5	-2.4	-0.5	0.7	-0.7	-1.4	0.7	0.7
Prostate Cancer	0.3	0.4	2.6	0.7	-0.1	-0.6	0.2	-0.2	0.7	0.6	0.1	0.0	1.6
Age at First Birth	1.3	1.9	8.5	1.5	0.1	1.8	1.1	0.8	-1.6	-0.5	2.9	-0.0	-0.8
Bipolar Disorder (2011)	0.6	0.6	1.7	1.0	-1.0	0.6	-0.2	0.2	0.6	-0.1	1.0	-0.8	-1.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.7	0.1	0.7	-0.4	0.6	-0.6	-1.0	0.5	0.1	-0.9
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.3	0.7	-0.0	-0.0	-0.3	0.1	-0.2	-0.9	0.7	-0.4
Crohns Disease (2012)	0.4	0.7	1.3	0.8	-0.7	-0.8	-0.2	0.7	-1.1	-1.1	-0.3	-0.7	-1.1
Mean Putamen Volume	0.2	0.2	0.9	-0.4	-0.1	0.1	-0.4	0.4	-0.4	-0.4	-0.6	-0.1	-0.9
Fasting Glucose	0.1	0.2	0.5	-0.5	-0.3	0.0	-0.3	-0.2	0.7	0.3	0.5	-0.3	0.4
HbA1C	0.4	0.4	1.3	0.9	0.7	-0.2	0.7	0.6	-1.2	0.1	0.6	0.4	0.4
HDL Cholesterol	0.7	1.1	3.1	-1.0	-0.9	0.4	-0.4	1.5	-0.9	-0.9	1.0	-0.9	-1.8
LDL Cholesterol	0.4	0.7	2.4	-0.3	-0.1	-1.6	0.8	-0.4	-0.4	0.5	-1.0	-0.0	1.4
Lupus	1.6	2.5	4.7	-1.2	2.0	-1.7	-2.1	-1.1	1.0	-0.2	-0.8	2.2	2.0
Neuroticism (2016)	2.6	3.7	9.4	-1.6	1.7	-2.2	-1.7	-2.0	3.1	0.7	-1.7	2.0	1.7
Primary Biliary Cirrhosis	0.8	1.1	2.8	1.6	1.6	-0.1	0.5	-1.1	0.7	1.0	-0.1	1.7	0.8
Rheumatoid Arthritis	1.7	2.4	4.8	-1.0	-2.0	-0.5	-1.3	1.7	-0.6	-1.4	2.2	-1.8	-1.8
Schizophrenia (2014)	1.6	3.6	10.9	1.4	1.8	0.3	1.4	-3.3	2.1	2.5	-1.9	1.9	0.6
Triglycerides	0.3	0.5	1.5	-0.5	-0.8	0.3	-0.4	-0.7	-0.1	-0.4	1.2	-0.9	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.0	-0.4	0.6	-0.3	-0.7	-1.0	1.7	0.4	-0.1	1.4	-0.2
Ulcerative Colitis	0.7	1.0	2.6	1.0	-1.6	-0.5	-0.7	0.4	-1.0	-1.2	0.6	-1.3	-1.1
Blood Eosinophil Count	0.0	0.3	0.7	0.3	-0.8	-0.7	0.1	0.1	0.8	0.6	-0.5	-0.7	-0.1
Blood Platelet Count	0.3	3.3	10.8	-1.4	1.3	-3.3	-0.3	-1.5	2.2	1.0	-2.4	1.4	1.6
Blood Red Count	0.2	2.0	5.4	-0.8	2.3	-1.4	0.1	-1.5	1.7	0.8	-0.1	2.3	0.9
Blood White Count	0.3	2.0	4.4	-1.8	1.8	-0.7	0.4	-2.1	0.7	1.3	-0.9	1.6	1.8
Heel T-Score	173.0	1376.0	5446.4	50.9	-0.2	73.8	46.1	5.9	2.5	30.6	15.3	-2.0	-48.8
BMI	0.4	2.2	9.1	1.1	1.1	3.0	-0.4	-1.7	1.0	0.5	-2.0	1.1	-1.1
Height	0.7	13.9	59.9	-6.3	-0.7	1.9	-7.7	-1.7	1.1	-4.1	-3.9	-0.0	-0.0
Waist Hip Ratio (WHR)	4.3	19.4	57.3	-7.0	-1.3	-5.2	-7.6	1.1	-0.7	-6.4	-3.3	-0.9	2.1
Systolic Blood Pressure	1.3	6.6	17.7	-2.2	4.0	-2.6	-1.4	-0.9	0.8	-0.1	-0.6	4.1	4.2
Smoking Status	0.6	1.3	3.1	-1.1	1.8	-1.1	-0.7	0.2	-0.1	-1.1	-0.9	1.5	1.6
Allergy or Eczema	0.6	1.5	5.1	2.3	1.1	0.5	0.8	-0.9	1.4	2.0	0.2	1.3	0.0
Cardiovascular Disease	1.9	6.4	17.6	-1.1	3.1	-3.0	-1.9	-2.8	2.0	0.5	-0.6	3.2	4.2
Hypothyroidism (self reported)	0.2	0.4	0.9	0.4	-1.0	-0.5	-0.2	0.0	-0.8	-0.6	-0.7	-1.0	-0.1
Respiratory disease	0.3	0.6	2.3	1.5	-0.4	-0.0	1.2	-0.8	-0.6	0.8	0.5	-0.4	0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.0	8.7	-2.9	1.2	-1.0	-2.1	-0.8	1.1	-0.3	-0.5	1.3	0.7
Lung FEV1/FVC ratio	0.4	2.1	9.1	-0.8	1.3	-3.0	-1.3	-1.4	1.9	-0.2	-0.9	1.4	0.4
Lung FVC	0.1	0.7	2.0	-0.6	-1.0	-0.9	0.3	-0.8	1.4	1.1	0.5	-0.8	-0.7
Neuroticism	1.6	3.8	7.1	-1.4	1.9	-1.1	-2.6	-2.6	2.0	-0.0	-1.6	2.1	2.7
Chronotype (morning person)	0.3	0.7	2.4	-0.9	0.4	-1.1	-0.1	-0.9	0.1	0.5	-1.5	0.4	1.1
Hair Pigment	0.3	7.6	16.9	0.9	-3.9	-0.8	-1.2	3.2	-3.5	-3.1	2.5	-4.1	-1.5
Tanning	0.1	0.8	2.8	-1.7	-0.6	-0.8	-0.7	-0.1	-0.8	-0.4	-1.6	-0.6	0.2
Hand grip strength (left)	2.0	5.3	14.0	-2.1	-3.5	-0.1	-3.7	-0.8	1.8	-2.2	-0.2	-3.1	-2.0
Number of treatments/medications taken	2.8	4.9	14.4	-0.7	2.3	-2.9	-1.1	-2.2	1.6	0.5	-2.5	2.4	3.8
Average weekly spirits intake	0.3	0.3	1.0	0.2	-0.6	-0.8	0.2	1.0	-0.3	-0.3	0.0	-0.6	-0.8
Sensitivity / hurt feelings	0.8	1.4	4.1	-0.9	1.1	-1.2	-1.9	-0.0	0.1	-0.5	-1.0	1.1	2.0
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.7	-1.0	-0.4	0.6	-1.2	-1.3	0.8	-0.7	-0.6	-0.4	0.2
Hearing difficulty/problems: Yes	1.2	1.8	4.6	-0.2	2.2	-0.4	1.0	-1.1	0.8	1.9	-1.1	2.0	1.3
Relative age of first facial hair	0.8	1.6	6.2	-0.5	0.0	-2.5	-1.1	1.0	-0.9	-1.4	1.6	-0.1	1.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.7	0.2	1.3	-1.1	-1.0	-1.9	0.8	0.4	-1.3	1.2	1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	0.9	1.0	-0.3	0.4	0.0	0.1	0.6	-1.4	1.0	-0.0
Ever had hysterectomy (womb removed)	1.3	1.5	9.9	3.1	-0.8	0.9	0.6	-0.5	0.1	0.3	1.0	-0.7	-1.1
Systolic blood pressure, automated reading	1.7	4.8	10.5	-2.2	3.2	-2.3	-1.9	-1.2	0.8	-0.0	-1.7	3.2	3.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.6	-1.9	-1.7	0.8	-1.5	1.2	-1.0	-1.7	-1.1	-1.6	-0.6
Angina	1.8	2.4	5.1	-0.3	0.9	-2.2	-1.6	-1.7	1.8	0.0	-1.7	1.1	2.3
Medication for hormone replacement therapy	1.5	1.7	6.2	2.5	0.2	1.2	2.0	-0.2	1.0	1.5	0.2	0.2	-1.5
Vitamin and mineral supplements	0.5	0.6	1.4	-0.5	0.7	-0.7	-0.8	0.1	1.0	-0.3	-1.2	0.8	1.1
Supplements: Zinc	0.2	0.3	1.8	-1.3	-0.3	-0.2	-0.2	-0.7	-0.1	0.3	0.3	-0.3	-0.2
Medication: Co-codamol	0.7	0.8	1.9	-0.6	0.3	-1.4	-1.0	0.5	0.7	-1.0	-1.1	0.3	1.3
Medication: Metformin	0.3	0.5	1.3	-1.2	-0.1	0.5	-0.7	1.0	-0.7	-0.6	0.9	-0.1	-0.1
Diabetes (father)	0.9	1.1	4.2	-0.5	-0.3	-1.3	-1.2	0.5	-1.0	-0.7	-1.3	-0.2	2.0
Diabetes (mother)	2.1	2.6	8.0	-2.8	-1.0	-0.4	-2.6	-0.6	0.5	-2.2	-2.1	-0.9	0.2
Severe depression (siblings)	0.5	0.6	2.1	-1.4	0.3	-1.3	-0.8	-0.7	-0.1	-0.6	-0.3	0.1	0.5
Pack years adult smoking proportion	0.7	1.0	4.0	-1.0	-0.1	2.0	-0.1	0.6	-0.8	-0.8	-1.3	-0.2	-1.3
Impedance of leg (right)	1.0	4.9	8.5	-1.7	-2.5	-2.8	-2.2	2.5	-2.1	-2.9	-0.0	-2.5	1.1
Leg fat-free mass (left)	0.6	3.0	14.5	-0.1	1.3	3.8	-0.9	-2.5	1.1	0.5	-1.6	1.4	-1.0
Trunk fat percentage	1.1	4.5	16.8	-1.7	1.6	1.1	-3.6	-1.8	0.6	-1.4	-4.1	1.7	0.8
Hand grip strength (right)	2.8	7.5	19.5	-2.9	-4.1	-0.1	-4.4	-0.4	0.8	-3.3	-0.8	-3.7	-2.2
Townsend deprivation index at recruitment	0.6	0.8	2.0	0.7	0.8	1.4	1.2	1.2	-1.4	-0.4	-0.2	0.4	0.3
Current tobacco smoking	0.2	0.4	1.3	-0.1	0.1	0.4	0.4	0.2	-1.2	-0.7	1.1	-0.1	-0.2
Average weekly fortified wine intake	0.2	0.2	1.0	0.4	0.2	0.1	0.4	1.0	-0.4	0.2	-0.6	0.1	-0.6
Maternal smoking around birth	0.7	1.0	3.0	-1.5	-0.3	-1.0	-1.7	-1.1	0.4	-0.6	-1.1	-0.3	0.4
Fed-up feelings	1.0	1.8	5.8	-2.0	-0.1	-1.4	-2.4	-0.4	-0.2	-1.7	-0.8	-0.0	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.2	-0.6	-2.0	0.9	-1.3	-0.1	-0.5	-1.3	-0.3	-2.0	-0.2
Relative age voice broke	0.4	0.7	4.0	-0.4	0.2	-1.2	-0.3	0.4	-0.2	-0.7	2.0	0.1	0.4
Taking other prescription medications	1.8	2.8	9.2	-1.3	0.3	-3.0	-2.8	-0.5	0.4	-1.4	-1.6	0.5	1.9
Age when periods started (menarche)	0.5	1.2	3.5	-1.9	-0.4	-1.1	-1.6	-0.3	0.6	-1.1	-1.6	-0.2	0.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.6	1.8	-1.2	1.7	1.1	-0.6	1.6	0.7	0.2	-1.2	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	119.1	270.1	1089.0	22.2	0.5	33.0	20.3	0.8	2.4	14.8	5.3	-0.2	-21.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.3	0.9	-1.2	0.1	-1.5	1.4	-0.7	-1.5	-1.0	-1.2	-0.1
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.1	1.3	1.0	1.0	-1.3	0.5	0.6	-0.7	1.2	0.8
Serious illness, injury or assault to yourself	0.1	0.1	0.6	-0.1	0.1	-0.4	-0.2	-0.8	-0.1	0.2	0.4	0.1	0.0
High blood pressure	2.0	5.6	12.1	-0.4	3.5	-1.2	-0.2	-3.2	2.1	2.1	-1.4	3.5	3.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	5.5	2.3	0.5	0.5	0.6	-0.5	1.1	1.2	0.6	0.7	-0.5
Multivitamins +/- minerals	0.8	1.0	2.8	1.7	0.3	1.5	1.2	-0.9	-0.3	1.0	0.9	0.2	-0.5
Stomach or abdominal pain in last month	0.4	0.5	1.8	0.3	0.5	0.6	1.3	0.7	0.3	0.6	0.3	0.3	-1.0
Supplements: Glucosamine	2.2	2.9	7.3	-1.1	-2.7	-1.7	-1.8	0.8	-1.5	-2.1	-0.1	-2.5	-0.4
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	6.0	1.1	-2.1	-0.7	0.4	1.8	-2.5	-1.0	1.5	-2.2	-0.1
Medication: Atenolol	1.3	1.7	7.7	-0.2	1.0	-1.8	-0.4	-1.6	-0.0	0.3	-0.8	1.0	2.8
Medication: Levothyroxine sodium	0.6	0.9	5.1	-0.6	-0.2	0.3	-0.3	-1.4	1.0	0.7	-2.3	-0.0	-0.3
Sitting height	0.5	3.6	10.0	-1.0	-2.3	3.2	-2.3	-0.5	-0.5	-2.1	-1.0	-2.0	-2.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-1.0	0.8	-1.3	-1.1	0.2	-0.2	-0.9	0.7	0.7	0.6
High blood pressure (mother)	0.4	0.5	1.6	-0.9	-0.1	1.1	-0.1	-0.7	-0.6	-0.3	-1.3	-0.0	0.9
Body mass index (BMI)	0.4	1.9	4.7	0.7	1.6	2.2	-0.7	-1.9	0.8	0.5	-1.9	1.6	-0.5
Impedance of leg (left)	1.2	6.0	13.3	-1.9	-2.5	-3.6	-2.7	2.4	-2.1	-3.2	0.1	-2.5	1.5
Leg predicted mass (left)	0.6	3.0	14.7	-0.1	1.3	3.8	-0.8	-2.5	1.1	0.5	-1.6	1.4	-0.9
Trunk fat mass	1.1	4.7	14.8	-1.8	1.2	2.1	-3.7	-2.2	0.8	-1.4	-3.9	1.4	0.2
Waist circumference	0.8	3.1	12.5	-1.9	0.9	1.0	-3.5	-1.1	-0.2	-2.1	-2.4	1.0	0.4
Number of incorrect matches in round	0.5	0.8	2.9	-0.1	0.8	-1.7	0.1	-0.1	-1.2	-0.2	-0.0	0.7	1.7
Past tobacco smoking	0.5	0.9	2.4	1.0	-0.1	0.9	1.2	-0.5	0.5	1.6	0.9	-0.0	-1.2
Alcohol usually taken with meals	1.5	2.4	6.1	-0.4	1.4	-1.4	-0.1	-2.5	1.7	1.8	-0.5	1.6	2.2
Nervous feelings	2.2	4.0	7.6	-1.0	2.4	-0.7	-2.2	-2.4	2.8	0.4	-2.0	2.6	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.7	-0.9	1.6	-0.2	-1.6	-2.4	1.8	0.5	-1.6	1.9	2.1
Hearing difficulty/problems with background noise	5.0	8.0	21.9	0.5	4.7	-0.9	1.1	-2.8	2.7	2.9	-1.3	4.6	3.2
Hair/balding pattern: Pattern 2	0.3	0.4	2.4	0.6	0.4	1.5	-0.2	0.2	0.5	-0.5	0.1	0.4	0.1
Had menopause	0.9	1.1	3.3	0.2	1.7	-0.4	-0.5	-0.6	0.3	0.5	-1.8	1.7	0.8
Had other major operations	0.5	0.6	2.3	-0.2	-0.5	-0.9	-0.8	-0.9	0.9	0.6	-1.5	-0.2	0.2
Forced vital capacity (FVC)	0.4	1.7	4.7	-0.4	-2.2	1.4	-1.3	-1.1	1.2	-0.5	-0.8	-1.8	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	116.2	266.2	1075.8	21.9	0.2	32.8	19.7	1.2	2.3	14.1	6.1	-0.5	-21.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.1	-0.7	-0.5	-1.8	-1.2	-0.9	0.6	-0.4	-0.1	-0.3	0.7
Qualifications: None of the above	1.2	2.5	6.9	-0.7	1.9	-2.6	-1.3	-0.8	1.3	0.1	-1.9	2.0	1.6
Financial difficulties in last 2 years	1.5	2.0	7.0	-1.6	-1.4	0.6	-1.2	1.0	-1.7	-2.6	-0.1	-1.5	-0.0
Mouth/teeth dental problems	0.3	0.5	2.0	0.2	-0.2	-1.0	-0.2	1.4	-1.2	-0.5	0.5	-0.3	0.5
Heart attack	0.7	0.9	4.5	0.5	-0.6	0.1	-0.9	1.1	-0.8	-0.7	-2.1	-0.5	0.5
Allergy	0.4	1.0	3.5	-1.9	-0.1	-1.1	-1.2	0.4	-0.6	-1.2	-0.5	-0.3	1.2
Pain all over the body in last month	0.7	0.7	3.1	-1.8	-0.8	0.7	-1.1	-0.3	-0.1	-0.5	-0.1	-0.6	-1.1
Diabetes (self-reported)	1.2	1.8	9.3	-3.0	0.1	-0.5	-2.2	0.8	-0.9	-1.4	-0.3	0.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.9	0.3	-1.3	0.4	0.2	-0.6	1.1	1.2	0.6	-1.1	-2.0
Medication: Ramipril	0.4	0.5	2.2	-0.3	-0.4	-0.2	-0.9	0.3	-1.5	-1.2	-0.4	-0.4	-0.1
Medication: Simvastatin	3.3	4.9	10.5	-1.9	2.3	-3.2	-2.1	-2.0	1.6	0.4	-1.2	2.6	3.2
Fluid intelligence score	0.6	1.3	3.9	-1.9	-0.3	-0.4	-2.0	-0.0	-1.1	-1.7	0.5	-0.3	0.8
Illnesses of siblings	0.4	0.6	2.7	-1.6	-0.4	-0.2	-0.4	-0.5	0.5	-0.0	-1.7	-0.3	0.3
Neuroticism score	1.8	3.7	15.6	-2.1	0.6	-1.1	-4.0	-1.8	1.3	-1.5	-1.9	0.8	2.1
Weight	0.7	3.3	8.9	-1.1	0.7	3.0	-2.8	-2.2	0.6	-0.9	-2.7	0.8	-0.6
Impedance of arm (right)	0.3	1.3	3.7	-1.2	0.3	-1.5	-0.7	1.4	-0.4	-0.7	-1.5	0.2	1.9
Arm fat percentage (right)	0.9	3.6	10.3	0.0	2.4	1.9	-1.4	-2.2	1.5	0.6	-3.2	2.4	0.4
Trunk fat-free mass	0.4	2.2	9.4	-0.7	0.2	3.1	-1.4	-2.6	1.4	0.1	-0.5	0.4	-1.2
Hip circumference	0.4	1.8	10.5	1.2	1.0	3.2	-0.1	-1.7	0.1	0.5	-1.0	0.9	-0.9
Time employed in main current job	1.0	1.1	2.9	0.3	1.1	-0.1	0.3	-1.6	1.7	1.5	-0.7	1.4	0.4
Alcohol intake versus 10 years previously	2.2	3.3	7.6	1.5	-2.3	0.3	0.9	1.3	-2.8	-0.5	2.4	-2.6	-1.6
Father’s age at death	0.7	0.9	2.7	-0.1	-1.6	-0.6	-0.7	0.8	-0.4	-0.5	1.1	-1.6	-0.8
Worrier / anxious feelings	0.8	1.6	5.0	-0.6	0.9	-1.1	-2.2	-1.4	1.5	-0.5	0.0	1.0	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.5	-0.3	1.2	0.2	-0.6	-1.9	1.9	0.8	-0.9	1.3	0.9
Falls in the last year	2.1	2.9	8.2	-1.1	2.0	-2.9	-1.6	-0.6	0.2	-0.6	-0.9	2.1	2.7
Hair/balding pattern: Pattern 3	0.3	0.5	2.3	1.5	0.3	-0.4	0.7	-0.2	0.9	0.8	-0.2	0.3	0.3
Number of live births	0.9	1.3	3.4	0.9	1.1	-0.9	1.8	-0.6	0.5	1.6	-0.9	1.0	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.5	-0.8	-1.6	0.4	-1.3	-1.7	2.1	-0.2	-0.6	-1.3	-1.0
Pulse rate	1.2	2.1	9.4	-3.1	-0.6	0.2	-1.9	-1.9	0.8	-0.7	-1.4	-0.5	0.7
Happiness	0.6	0.7	2.9	-1.0	0.2	0.2	-1.7	-0.8	1.2	-1.0	-0.4	0.3	0.4
Noisy workplace	0.3	0.3	1.4	-0.0	-0.2	1.1	-0.3	-0.3	0.6	-0.1	-0.3	-0.1	-1.2
Qualifications: A levels/AS levels or equivalent	1.0	2.2	7.0	-0.6	-1.3	2.5	0.5	0.7	-0.9	-0.2	1.9	-1.3	-2.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.8	1.9	1.1	0.7	1.0	-0.9	1.4	1.6	-0.6	1.1	-0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	3.0	-1.7	0.4	-0.3	-0.9	-1.3	0.6	-0.2	-1.0	0.4	0.7
Asthma	0.4	0.7	1.7	0.6	-1.0	-1.2	0.6	-0.3	-0.9	-0.0	1.3	-0.9	-0.4
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	11.1	-0.2	1.3	-0.7	0.5	-3.3	2.0	1.9	-1.8	1.4	2.0
Medication: Cholesterol lowering	0.9	1.3	5.5	-1.2	0.1	-1.7	-2.4	-0.2	0.2	-0.8	-1.2	0.3	1.1
Depression (self-reported)	1.3	1.6	5.5	0.0	1.6	0.1	-1.2	-0.5	0.5	-0.4	-2.3	1.6	1.8
Medication: Lansoprazole	0.8	0.9	3.7	0.9	-0.9	-0.8	0.2	0.8	-1.9	-0.9	0.4	-1.0	-0.0
Prospective memory result	1.0	1.2	2.5	-0.4	1.1	-1.6	-1.1	-1.0	1.6	0.2	-1.1	1.2	1.0
Lung cancer (father)	1.2	1.4	5.4	-0.8	1.0	-2.3	-0.7	-0.6	0.5	-0.5	-1.0	1.1	1.7
Illnesses of mother	0.5	0.6	2.0	0.6	0.7	-1.4	-0.0	-0.6	1.2	0.6	-0.2	0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.0	-0.3	-1.4	-0.2	-1.3	-1.0	1.4	-0.9	0.9	-1.1	-1.1
Pulse wave Arterial Stiffness index	1.3	1.5	4.2	-1.1	-1.1	-0.6	-1.1	1.5	-1.5	-2.0	-0.3	-1.2	-0.2
Impedance of arm (left)	0.4	1.9	5.4	-1.8	0.1	-1.4	-1.5	1.1	-0.2	-1.2	-2.3	0.0	1.9
Arm fat mass (right)	0.8	3.3	8.0	-0.3	1.9	2.2	-1.9	-2.6	1.6	0.2	-2.8	2.0	-0.2
Trunk predicted mass	0.4	2.2	8.6	-0.7	0.2	2.9	-1.4	-2.6	1.3	0.1	-0.4	0.4	-1.3
Standing height	0.7	6.5	25.7	-4.0	-1.8	1.9	-5.1	-1.0	-0.2	-3.2	-2.0	-1.4	-0.4
Length of working week for main job	0.1	0.1	0.8	0.9	-0.1	0.3	0.2	-0.2	0.5	0.1	-0.0	0.1	-0.1
Exposure to tobacco smoke at home	4.1	4.6	14.9	-0.3	-2.1	0.1	-1.1	3.9	-2.7	-3.1	1.2	-2.4	-1.2
Breastfed as a baby	1.8	2.2	7.0	-2.7	-1.6	-1.7	-2.2	-0.7	0.9	-1.1	0.6	-1.2	-0.6
Tense / ‘highly strung’	0.9	1.4	2.7	0.6	1.6	0.7	-1.5	-1.5	1.4	0.4	-0.8	1.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	6.9	0.8	-0.1	-0.5	-1.2	-1.6	1.9	0.1	-2.6	0.2	0.5
Hair/balding pattern: Pattern 4	0.4	1.0	4.7	-2.2	0.2	-0.7	-1.4	0.3	-1.2	-1.1	0.0	0.2	0.6
Birth weight of first child	0.3	0.6	2.3	-0.8	-0.6	-0.7	-1.1	0.4	-0.7	-1.5	-0.5	-0.6	0.1
Peak expiratory flow (PEF)	0.5	1.1	3.6	0.3	-1.9	0.6	1.0	0.1	0.5	0.7	-0.0	-1.8	-1.5
Pulse wave reflection index	0.8	1.0	2.9	0.7	-0.8	0.1	0.7	1.1	-0.9	-0.1	1.7	-0.9	-1.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	0.8	-1.0	1.4	-0.7	-1.4	0.2	-0.0	-0.2	-0.9	0.2
Loud music exposure frequency	0.5	0.5	1.4	1.1	0.3	0.3	-0.7	0.7	-1.0	-0.5	-0.1	0.3	1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	10.1	-1.1	0.1	3.2	-0.1	0.4	-1.0	-0.2	1.0	0.0	-1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.5	1.0	0.9	0.9	1.4	-0.8	0.6	1.2	1.6	0.9	-0.3
Blood clot in the leg (DVT)	0.6	0.8	1.7	-0.4	-1.3	0.8	-1.0	-0.6	0.8	-0.6	-0.3	-1.1	-1.3
Medication: Paracetamol	3.2	5.3	10.4	-1.0	2.4	-2.2	-1.0	-3.2	3.1	1.3	-1.9	2.5	3.1
Headache pain in last month	1.3	2.2	7.6	0.5	1.5	-0.2	0.7	-1.8	2.8	1.5	-1.6	1.6	0.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.9	1.3	-0.4	2.6	2.2	1.0	-0.5	0.6	1.3	-0.6	-1.7
Glaucoma (self-reported)	0.2	0.3	1.2	0.2	0.3	-0.8	0.7	0.6	-1.1	0.1	-0.0	0.2	-0.0
Gout (self-reported)	1.1	1.5	4.3	-1.6	-0.3	-1.2	-2.1	0.4	-0.7	-1.8	-0.9	-0.1	1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	3.3	-0.4	0.1	-0.9	-0.5	-1.0	0.4	0.1	-1.8	0.3	0.6
Medication: Amlodipine	1.4	1.9	5.5	-0.3	1.3	-0.8	1.2	-1.9	1.8	2.4	-0.4	1.4	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.8	-0.6	0.1	0.9	-0.7	-0.2	0.9	-0.7	-0.6	0.4
Birth weight	0.4	0.8	4.0	-0.6	-0.5	-1.3	0.5	2.0	-0.4	-0.6	-0.3	-0.6	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.4	-0.4	-0.6	0.4	0.3	-0.3	0.1	0.7	-0.3	-0.9
High blood pressure (siblings)	0.5	0.7	2.2	1.4	0.0	0.6	0.8	0.8	-0.9	0.2	1.5	-0.1	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.4	3.6	0.1	-1.9	0.9	-1.4	-0.7	0.7	-1.1	1.0	-1.6	-1.5
Body fat percentage	1.0	3.8	13.8	-1.1	1.7	1.2	-3.2	-1.8	0.6	-1.0	-3.7	1.7	0.8
Leg fat percentage (right)	0.6	2.2	9.4	-0.7	0.9	0.9	-2.7	-1.0	-0.4	-1.2	-3.1	0.9	0.5
Arm fat-free mass (right)	0.4	2.1	6.7	-1.2	-0.1	2.1	-2.3	-2.6	1.0	-0.7	-0.9	0.2	-0.8
Exposure to tobacco smoke outside home	1.1	1.5	5.4	-1.1	0.1	-1.7	-2.3	0.8	-0.2	-2.0	-0.5	0.1	0.8
Comparative body size at age 10	0.2	0.7	4.3	2.1	0.2	-0.6	0.7	0.1	-0.4	0.3	-0.2	0.2	0.9
Number of full brothers	1.7	2.1	7.0	2.6	-0.2	2.2	1.5	0.3	-1.7	-0.1	1.9	-0.4	-0.5
Worry too long after embarrassment	1.7	2.9	4.9	-0.9	1.7	-1.5	-1.4	-1.9	2.2	1.0	-1.7	1.9	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.6	1.1	0.1	-0.0	-0.1	-0.3	-0.3	-0.2	0.9	1.1
Wheeze or whistling in the chest in last year	0.1	0.2	1.7	-0.3	-0.0	0.3	-0.3	-1.3	-0.1	0.2	-0.5	0.0	0.1
Number of children fathered	1.0	1.2	3.5	-0.4	0.6	0.3	-0.6	-1.8	1.6	0.9	-1.9	0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.5	0.6	-1.6	0.3	-1.3	1.0	-1.2	-1.6	-0.5	-1.5	0.1
Age at first live birth	0.3	0.5	2.3	-0.3	-1.5	0.6	-0.6	0.1	-0.3	-0.4	0.3	-1.4	0.2
Pulse wave peak to peak time	1.2	1.4	3.7	1.2	1.1	0.8	1.0	-1.5	1.4	1.9	0.5	1.2	0.3
Health satisfaction	0.2	0.3	1.3	-0.2	-0.0	0.2	-1.2	-0.8	0.6	-0.6	0.2	0.1	0.2
Shortness of breath walking on level ground	1.1	1.2	4.7	-2.0	0.2	-0.3	-2.2	-0.9	0.3	-1.2	-1.1	0.3	0.4
Qualifications: College or University degree	0.3	1.1	2.6	1.3	-0.6	1.0	1.5	-1.1	1.1	1.6	0.6	-0.5	-0.3
Eye problems/disorders: None of the above	1.2	1.3	5.1	-0.0	-1.4	0.7	-0.4	2.3	-1.0	-0.8	0.8	-1.4	-1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.1	-1.6	-0.4	-1.3	-1.3	1.1	-0.6	-2.0	0.1	-0.4	0.4
Emphysema/chronic bronchitis	1.0	1.1	3.5	-0.9	1.3	-1.3	-0.8	-0.8	-0.0	0.4	-0.8	1.2	1.9
Medication for pain relief, constipation, heartburn	3.9	6.7	13.2	1.4	-2.1	3.4	1.2	3.6	-2.8	-0.9	2.8	-2.3	-3.5
Neck or shoulder pain in last month	2.5	3.5	13.4	-2.4	1.3	-0.2	-3.7	0.0	0.8	-1.6	-2.3	1.5	1.7
Medication: Blood pressure	1.8	3.3	12.1	-1.4	0.9	-3.5	-2.3	-1.3	0.7	-0.8	-1.7	1.1	2.4
Angina (self-reported)	1.6	2.1	4.3	-0.1	0.7	-2.0	-1.5	-1.8	1.8	0.0	-1.8	1.0	2.1
Migraine (self-reported)	1.8	2.2	5.5	-1.6	2.3	0.2	-0.0	-1.2	1.8	1.4	-0.9	2.4	1.2
Medication: Ibuprofen	1.2	1.4	5.2	-0.5	0.5	-1.1	-0.4	-2.3	1.3	0.5	-1.5	0.6	1.5
Medication: Allopurinol	1.1	1.4	4.1	-2.0	0.0	-2.0	-1.9	-0.1	0.1	-1.0	-0.4	0.1	1.3
Medication: Omeprazole	1.7	2.0	5.4	-0.3	-0.6	-2.3	-1.2	1.9	-1.3	-2.2	1.3	-0.7	0.8
Medication: Seretide 50 evohaler	0.7	0.9	3.5	-0.1	-0.3	-1.0	-0.5	-1.9	0.8	0.4	-1.7	-0.2	0.3
Mean time to correctly identify matches	0.3	0.6	2.9	0.5	0.4	0.3	0.4	0.3	-1.4	-0.6	1.7	0.1	-0.0
Heart disease (mother)	1.3	1.5	4.9	-1.2	-0.1	-0.9	-2.2	-0.2	-0.2	-1.6	-0.9	-0.0	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.4	0.5	1.0	0.8	1.3	-0.6	0.3	1.5	-0.8	0.9	0.9
Whole body fat mass	0.9	3.9	11.2	-1.1	1.6	2.1	-3.2	-2.2	0.9	-0.8	-3.4	1.7	0.4
Leg fat mass (right)	0.6	2.4	7.4	-0.6	0.9	2.2	-2.4	-1.6	0.2	-0.8	-2.7	0.9	-0.2
Arm predicted mass (right)	0.4	2.2	6.9	-0.9	-0.0	2.3	-2.2	-2.6	1.3	-0.5	-0.9	0.3	-1.1
Pulse rate, automated reading	0.7	2.2	7.8	-2.8	-0.4	1.4	-2.1	-1.5	1.2	-0.6	-1.4	-0.1	-1.4
Alcohol intake frequency.	0.3	0.7	2.3	1.2	-0.1	0.4	1.5	0.3	-0.9	-0.2	1.1	-0.4	-0.4
Comparative height size at age 10	0.5	2.9	13.3	-2.8	-0.9	0.3	-3.6	-1.0	-0.0	-2.1	-1.2	-0.6	-0.2
Number of full sisters	0.8	1.0	2.8	0.8	-1.5	1.0	1.2	0.6	-1.1	-0.2	-0.0	-1.7	-0.4
Suffer from ‘nerves’	3.2	5.1	11.7	1.5	2.6	1.5	-0.2	-3.4	3.4	2.4	-1.1	2.8	0.9
Overall health rating	0.7	1.6	3.7	-0.4	1.5	-0.3	-1.9	-1.7	1.2	0.4	-0.5	1.6	1.5
Chest pain or discomfort	0.6	0.8	1.8	0.1	0.6	1.3	-0.5	-1.3	1.3	0.8	-1.2	0.7	-0.2
Had major operations	0.4	0.4	1.3	-0.1	-0.7	-0.9	-0.5	-1.1	-0.3	-0.5	0.8	-0.7	0.4
Age at last live birth	0.7	1.1	2.7	-0.5	-1.7	1.2	-0.4	1.2	-0.9	-1.0	-0.2	-1.6	-0.3
Family relationship satisfaction	0.3	0.3	1.8	0.6	0.4	1.4	-0.1	0.2	-0.1	-0.3	-0.8	0.3	0.3
Leg pain on walking	0.2	0.2	1.3	-0.6	0.0	-0.1	-1.1	0.3	-0.0	-0.5	-0.2	0.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.2	0.1	-1.6	2.0	0.8	1.1	-2.0	-0.1	1.2	-1.8	-1.6
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.1	-1.5	0.4	-0.4	-0.4	-1.0	0.8	0.7	-0.3	0.6	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	0.0	-0.4	-0.6	0.4	1.0	-1.0	-0.1	0.0	-0.4	0.1
Medication: Aspirin	1.9	2.6	6.2	-1.0	1.5	-1.7	-1.8	-0.9	1.0	-0.5	-2.5	1.6	2.3
Supplements: Vitamin C	0.7	0.8	2.7	-1.6	-1.1	-1.2	-1.1	0.3	-0.0	-0.3	-0.8	-0.9	0.0
Knee pain experienced in last month	0.3	0.4	1.5	0.1	0.7	0.1	-0.7	-0.8	0.1	0.4	-1.2	0.7	0.2
Hypertension (Self-reported)	2.1	6.0	11.7	-1.0	3.2	-2.3	-1.0	-3.3	2.1	1.6	-1.4	3.2	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.4	0.1	-1.4	-0.9	-0.1	0.2	-1.4	-1.1	1.6	-1.5	0.2
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.6	0.2	0.4	-1.0	0.0	0.5	-0.1	-0.8	0.3	0.2
Illnesses of siblings: Diabetes	0.5	0.6	2.0	-0.7	0.4	-1.0	-0.9	0.2	-0.5	-1.4	-0.3	0.4	0.9
Smoking status: Previous	0.6	1.0	2.6	-1.0	0.3	-0.8	-1.1	0.4	-0.3	-1.3	-1.6	0.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	5.0	-0.8	-1.4	0.7	-1.3	0.4	-1.2	-2.2	0.2	-1.6	0.2
Whole body fat-free mass	0.5	2.6	11.2	-0.5	0.8	3.3	-1.3	-2.8	1.4	0.3	-0.9	1.0	-1.0
Leg fat-free mass (right)	0.5	2.9	13.1	-0.2	1.3	3.6	-0.9	-2.6	1.3	0.5	-1.5	1.5	-0.8
Arm fat percentage (left)	0.9	3.7	12.4	-0.3	2.2	2.0	-1.9	-2.3	1.6	0.2	-3.5	2.2	0.4
Average weekly red wine intake	1.1	1.7	5.2	-0.0	1.4	-0.1	-0.6	-1.1	0.8	0.8	-2.1	1.5	2.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.3	0.3	0.1	0.2	0.5	1.1	-0.0	-0.0	0.4	-0.0	-0.1
Mood swings	1.1	2.1	7.5	-1.4	-0.4	-0.7	-2.7	-2.0	1.9	-0.9	-0.8	-0.1	1.2
Loneliness, isolation	2.2	3.1	13.0	-2.1	-1.4	-0.7	-3.6	-0.6	0.4	-2.1	-2.1	-1.0	0.1
Long-standing illness, disability or infirmity	0.3	0.5	2.8	0.3	-0.1	-0.9	-0.8	-0.7	0.4	-0.2	1.7	0.0	-0.3
Ever had bowel cancer screening	2.6	3.0	9.7	-2.4	-0.9	-3.1	-2.6	-0.0	-1.1	-2.2	-0.9	-0.7	0.3
Diabetes diagnosed by doctor	0.9	1.5	6.9	-2.6	0.0	-0.7	-2.2	0.7	-0.4	-1.5	0.3	0.1	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.2	-0.2	-0.7	-0.8	-0.4	0.9	-0.3	-0.4	-0.1	-0.1
Friendships satisfaction	0.9	1.1	5.5	1.2	0.0	1.0	0.7	0.4	-0.4	0.3	2.3	-0.0	-1.4
Qualifications: nursing, teaching	1.1	1.8	3.8	1.2	-1.3	2.0	0.9	1.3	-1.6	-0.2	1.0	-1.2	-1.8
Commuting to job workplace: Walk	1.2	1.3	4.2	1.6	-0.8	1.0	2.0	-0.3	0.2	1.4	0.8	-0.9	-0.7
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.4	0.8	-0.7	-1.0	-1.3	0.6	-0.8	-1.4	0.9	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	0.3	0.3	1.2	-0.4	-1.3	1.2	0.1	-0.9	0.5	-0.0
Medication for cholesterol	0.7	1.1	2.3	0.5	-1.4	1.5	-0.2	1.2	-1.0	-0.8	-0.2	-1.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.5	-0.3	-1.7	-2.1	-0.4	0.0	-0.9	-0.8	0.8	-1.8	-0.1
Back pain experienced in last month	0.9	1.4	5.7	-0.8	2.3	-0.2	-0.5	-0.5	0.6	0.4	0.1	2.4	1.0
Mineral and other dietary supplements	0.9	1.2	3.8	1.0	1.2	2.0	1.1	-0.3	1.1	1.1	-0.2	1.2	-0.5
Breast cancer (self-reported)	2.3	2.7	10.2	-2.1	-0.4	-0.8	-3.2	0.5	0.1	-2.8	-1.9	-0.3	0.3
Asthma (self-reported)	0.3	0.6	1.6	0.6	-0.9	-1.3	0.7	-0.5	-0.8	0.1	1.2	-0.8	-0.2
Osteoporosis (self-reported)	6.8	8.5	41.4	-2.4	1.7	-6.4	-0.5	-2.5	0.6	0.9	-0.1	1.8	4.9
Osteoarthritis (self-reported)	0.6	0.7	3.6	1.9	0.3	0.6	0.3	-0.3	0.6	0.9	1.3	0.4	-0.1
Medication: Aspirin	2.4	3.2	6.4	-0.4	2.0	-2.1	-1.2	-1.8	1.5	0.5	-2.1	2.2	2.5
Medication: Gliclazide	0.2	0.2	1.5	-0.2	-0.1	0.1	0.0	0.8	0.0	-0.3	1.2	-0.1	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.9	0.9	-0.1	-0.2	0.2	0.2	-0.1	-0.2	-0.4	-0.1	0.3
Smoking status: Current	0.2	0.3	1.0	0.1	0.3	0.4	0.3	0.2	-1.0	-0.6	1.0	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	6.7	-0.2	0.2	-0.4	-1.2	-1.7	2.6	0.4	-0.8	0.4	0.1
Whole body water mass	0.5	2.6	10.5	-0.6	0.9	3.2	-1.4	-2.7	1.4	0.3	-0.9	1.1	-0.9
Leg predicted mass (right)	0.5	2.9	13.3	-0.1	1.4	3.6	-0.8	-2.6	1.2	0.5	-1.4	1.5	-0.8
Arm fat mass (left)	0.9	3.5	9.7	-0.8	1.6	2.2	-2.4	-2.6	1.5	-0.2	-3.1	1.7	0.0
Number of self-reported non-cancer illnesses	1.6	2.7	5.6	-0.9	1.9	-1.6	-0.8	-2.3	1.4	1.3	-0.9	2.0	2.4
Average weekly champagne plus white wine intake	0.7	1.0	3.6	-1.9	-0.4	-1.3	-1.9	-0.1	0.3	-0.6	0.3	-0.3	-0.4
Miserableness	0.6	1.1	3.5	-1.4	-1.1	0.2	-1.9	-0.1	-0.0	-1.2	-1.3	-1.0	0.2
Guilty feelings	0.7	1.1	4.2	-1.5	-0.7	-0.6	-2.1	-0.7	-0.1	-1.5	0.2	-0.6	0.9
Wears glasses or contact lenses	3.1	3.5	10.4	-2.6	1.1	-2.4	-3.2	-1.1	1.7	-0.4	-1.4	1.4	1.8
Ever taken oral contraceptive pill	1.0	1.1	2.0	-1.4	-1.2	0.5	-0.5	0.8	-0.4	-1.4	1.2	-1.2	-1.2
Hearing aid user	2.0	2.2	4.8	-1.6	2.1	0.3	-1.1	-1.8	1.8	0.4	-1.3	2.2	-0.7
Mother’s age at death	1.0	1.3	4.4	-0.3	-0.9	1.8	-0.4	1.1	-0.8	-0.9	0.8	-0.9	-2.1
Financial situation satisfaction	0.3	0.3	0.9	0.0	0.3	1.0	0.3	0.1	-0.9	-0.7	0.3	0.0	0.8
Tinnitus: Yes, now most or all of the time	4.4	5.1	11.9	0.8	2.5	0.8	2.0	-2.7	2.9	3.5	-1.5	2.6	1.7
Commuting to job workplace: Public transport	0.4	0.4	1.2	-0.8	-0.7	1.1	-0.5	0.0	0.4	-0.8	0.1	-0.7	-0.7
Eye problems/disorders: Glaucoma	0.5	0.5	1.4	1.2	0.9	-0.6	1.0	-0.2	-0.6	0.8	0.5	0.7	0.4
Medication: Blood pressure	0.5	1.0	2.3	-0.7	1.4	-0.8	0.3	-1.2	0.3	0.7	0.4	1.4	1.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.9	-0.8	0.3	-0.3	-1.7	-0.4	0.8	-0.7	-1.6	0.4	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	-0.7	-0.2	-1.2	-0.3	0.7	-0.9	-0.8	0.1	-0.3	1.1
High cholesterol (Self-reported)	2.0	3.5	8.9	-2.3	1.4	-2.8	-3.0	-1.3	1.4	-0.9	-0.4	1.6	2.0
Medication: Bendroflumethiazide	1.3	2.0	6.5	-0.6	1.1	-2.5	-0.1	-1.7	0.5	1.0	-0.8	1.1	2.6
Medication: Paracetamol	1.3	2.0	4.1	-0.7	1.8	-1.0	-1.3	-1.6	1.7	0.3	-0.6	1.8	2.0
Medication: Lisinopril	2.1	2.7	8.5	-1.4	1.3	-1.8	-2.9	-1.2	1.1	-1.3	-1.0	1.3	2.0
Medication: Atorvastatin	0.3	0.4	1.0	-1.0	-0.7	0.1	-0.9	0.4	-0.2	-0.7	-0.6	-0.7	-0.7
Illnesses of father: High blood pressure	0.7	0.8	1.7	0.9	0.8	0.4	1.3	-1.3	0.2	0.9	-0.6	0.6	1.2
Alcohol drinker status: Never	1.1	1.3	3.0	1.1	1.2	-0.5	1.7	-0.0	0.3	1.4	-0.9	1.1	1.7
Ever smoked	0.1	0.2	0.8	-0.6	-0.5	-0.4	-0.2	0.1	-0.6	-0.9	0.2	-0.7	0.2
Basal metabolic rate	0.5	2.7	10.2	-0.7	0.8	3.2	-1.7	-2.7	1.3	-0.0	-1.3	1.0	-0.9
Leg fat percentage (left)	0.6	2.3	9.0	-0.8	1.0	0.3	-2.8	-1.3	-0.1	-1.1	-3.0	1.1	0.7
Arm fat-free mass (left)	0.3	1.7	6.2	-0.8	0.3	2.2	-1.7	-2.5	1.0	-0.3	-0.6	0.5	-1.0
Number of operations (self-reported)	0.5	0.8	1.6	0.1	-1.2	-0.7	-1.3	-1.2	-0.1	-0.5	-1.2	-0.9	0.4
Average weekly beer plus cider intake	0.6	0.9	2.4	-0.6	-0.4	1.0	0.3	1.3	-1.1	-1.2	0.6	-0.6	-1.5
Irritability	1.4	2.4	7.1	-2.0	-1.5	-0.1	-2.1	1.4	-1.4	-2.7	0.1	-1.4	-0.3
Risk taking	0.3	0.4	2.2	-0.6	-0.3	0.2	0.4	0.2	-1.5	-0.9	0.1	-0.5	-0.4
Ever had prostate specific antigen (PSA) test	3.4	4.0	9.6	-3.0	0.9	-1.4	-2.5	-3.1	2.8	0.6	-1.0	1.3	1.1
Fractured/broken bones in last 5 years	22.6	29.1	144.0	-7.3	-0.7	-12.0	-6.0	-0.3	-1.3	-5.0	-0.1	-0.5	5.5
Age started oral contraceptive pill	0.6	0.7	2.9	-1.2	-0.5	0.6	-1.7	0.5	0.2	-0.6	-0.9	-0.2	-0.6
Diastolic blood pressure, automated reading	1.3	3.9	9.6	-3.1	1.9	-0.5	-2.3	-1.2	-0.0	-0.8	-2.9	2.0	2.4
Ever depressed for a whole week	0.7	0.8	3.1	0.2	-1.8	-0.9	-0.2	-0.3	0.1	-0.2	0.5	-1.7	-0.8
Unable to work because of sickness or disability	0.6	0.7	2.0	0.5	1.4	-0.4	-0.1	-0.6	0.4	0.6	-0.5	1.3	1.4
Commuting to job workplace: Cycle	1.2	1.5	6.1	1.2	1.3	0.5	0.7	-0.4	0.7	0.9	-1.3	1.3	2.5
Myopia	1.9	2.7	6.3	-0.2	-2.5	-0.5	-0.2	2.3	-2.2	-1.7	0.7	-2.4	-1.2
Vascular/heart problems diagnosed by doctor	1.7	4.5	9.4	0.6	-2.8	2.0	0.6	2.5	-1.7	-1.6	1.9	-2.9	-3.1
Cholesterol lowering medication	2.2	3.3	6.5	-1.2	2.4	-2.5	-0.7	-2.0	1.5	0.8	-0.7	2.5	2.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	7.9	-0.4	-0.7	-2.8	-0.7	1.4	-0.6	-1.6	0.8	-0.8	0.8
Pain experienced in last month	0.6	0.9	3.4	1.0	-0.4	-0.4	1.9	0.3	-1.3	0.6	1.4	-0.6	0.5
Supplements: Calcium	1.4	1.6	7.8	-2.4	-0.6	-2.8	0.4	-0.1	-0.4	0.3	-0.2	-0.6	1.1
Basal cell carcinoma (self-reported)	3.4	4.0	9.2	2.1	2.1	0.2	1.2	-1.8	1.9	3.0	-2.6	2.1	1.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	3.6	0.6	-0.5	0.3	-0.7	0.9	-0.8	-0.5	-1.9	-0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	2.2	-0.5	-1.5	0.6	-1.0	-0.4	0.7	-0.8	-0.5	-1.3	-1.2
Heart disease (siblings)	0.5	0.7	2.4	1.6	0.5	0.6	0.8	-0.5	0.8	1.4	0.2	0.5	0.1
Alcohol drinker status: Previous	0.4	0.4	1.3	-0.8	0.1	0.5	-0.8	-1.1	1.1	-0.3	0.0	0.2	-0.4
Pack years of smoking	0.6	0.8	2.6	-1.1	0.0	1.6	-0.2	0.2	-0.2	-0.5	-1.5	0.1	-1.4
Impedance of whole body	0.8	3.8	8.5	-2.2	-1.4	-2.9	-2.4	1.8	-1.2	-2.5	-1.3	-1.4	1.9
Leg fat mass (left)	0.6	2.4	7.2	-0.8	0.9	1.9	-2.6	-1.8	0.2	-0.7	-2.7	1.0	-0.0
Arm predicted mass (left)	0.4	2.1	7.7	-0.7	0.8	2.2	-1.8	-2.8	1.3	-0.1	-1.0	1.0	-0.8