TWAS hub - GREM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.146	0.041	7.4e-06	0.071	0.057	0.082	0.103	0.091	5.3e-09	1.6e-07	3.0e-10	1.5e-12	3.7e-11
2	GTEx	Cells Transformed fibroblasts	0.295	0.063	3.8e-05	0.129	NA	0.126	NA	0.122	6.6e-10	NA	1.1e-09	NA	2.0e-09
3	GTEx	Colon Sigmoid	0.338	0.107	5.3e-03	-0.003	NA	-0.005	NA	-0.007	4.1e-01	NA	5.5e-01	NA	7.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Heel T-Score	39.7	315.5	918.1	5.3	30.3
Heel bone mineral density (BMD) T-score, automated (right)	27.3	62.5	179.6	2.8	13.4
Heel bone mineral density (BMD) T-score, automated (left)	25.0	56.7	161.3	3.0	12.7
Osteoporosis (self-reported)	8.3	10.2	28.9	-1.3	-5.4
Alcohol drinker status: Previous	3.9	4.4	7.6	2.4	2.8
Fasting Glucose	3.3	3.9	11.7	-0.3	-3.4
Fractured/broken bones in last 5 years	3.3	4.2	12.7	-0.3	-3.6
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	6.5	1.5	2.5
Average weekly fortified wine intake	2.6	3.0	8.2	2.9	0.9
Serious illness, injury or assault to yourself	2.5	3.0	8.7	-3.0	-0.6
Shortness of breath walking on level ground	2.4	2.8	7.3	1.1	-2.7
Mother’s age at death	2.4	3.0	5.9	1.8	2.4
Mouth/teeth dental problems: Dentures	2.3	3.9	10.8	3.3	1.0
Basal cell carcinoma (self-reported)	2.3	2.7	5.3	1.7	-2.3
Bipolar Disorder (2018)	2.2	3.4	6.1	2.0	2.5
Ulcerative Colitis	2.1	3.1	8.0	-1.1	2.8
Eye problems/disorders: Cataract	2.0	2.4	6.5	0.8	-2.5
Alzheimer’s Disease (in mother)	1.9	2.2	3.6	1.9	-1.7
Prostate Cancer	1.9	2.7	8.0	2.8	-0.3
Medication: Levothyroxine sodium	1.8	3.0	8.9	-3.0	-0.2
Happiness	1.8	2.2	6.5	-2.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	10.2	3.2	0.3
Irritable Bowel Disease (IBD)	1.6	3.9	11.8	-3.4	-0.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	5.4	-0.9	-2.3
Asthma	1.5	2.9	7.7	2.8	-1.0
Asthma (self-reported)	1.5	3.1	8.0	2.8	-1.1
Crohns Disease (2017)	1.4	3.1	7.1	-2.7	-1.5
Pain all over the body in last month	1.4	1.5	2.4	1.4	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	2.9	1.5	1.7
Chronic bronchitis/emphysema (mother)	1.4	1.7	3.1	1.4	-1.8
Medication: Aspirin	1.4	1.9	3.4	1.8	-1.5
Age started oral contraceptive pill	1.4	1.8	4.7	0.8	-2.2
Ulcerative Colitis (UC)	1.3	2.4	4.9	-2.2	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	1.2	1.7
Medication: Ibuprofen	1.3	1.6	2.9	1.4	1.7
Loneliness, isolation	1.3	1.9	3.1	-1.8	1.6
Crohns Disease (2012)	1.2	2.0	3.1	-1.8	-1.7
Multivitamins +/- minerals	1.2	1.6	2.9	1.4	1.7
Stomach or abdominal pain in last month	1.2	1.5	4.1	-2.0	-0.7
Had other major operations	1.2	1.4	3.9	2.0	0.5
Medication: Lansoprazole	1.2	1.4	2.3	1.4	-1.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.4	-2.5	-0.8
Health satisfaction	1.2	1.6	2.5	1.6	1.5
Severe depression (siblings)	1.1	1.3	3.2	-1.8	0.8
Illnesses of siblings	1.1	1.5	4.5	0.3	-2.1
Breastfed as a baby	1.1	1.4	4.2	0.1	-2.1
Wheeze or whistling in the chest in last year	1.1	1.9	5.8	2.4	0.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.6	1.1	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.9	0.1	2.0
Supplements: Calcium	1.1	1.3	2.7	-1.1	-1.6
Supplements: Zinc	1.0	1.1	3.2	-1.8	0.1
Townsend deprivation index at recruitment	1.0	1.4	4.0	-2.0	-0.3
Supplements: Glucosamine	1.0	1.3	2.3	1.3	1.5
Time employed in main current job	1.0	1.1	3.1	-1.8	-0.4
High blood pressure (siblings)	1.0	1.4	4.1	-0.0	2.0
Medication: Omeprazole	1.0	1.2	3.7	-0.0	-1.9
Number of full sisters	1.0	1.2	2.2	1.2	1.5
Leg pain on walking	1.0	1.3	3.7	1.9	0.4
Medication: Aspirin	1.0	1.3	2.3	1.5	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.4	-0.5	-1.8
Alzheimer’s Disease (including proxy)	0.9	1.3	2.1	1.5	-1.3
Ovarian Cancer	0.9	1.2	2.1	-1.2	1.5
Primary Biliary Cirrhosis	0.9	1.3	3.8	-0.3	-1.9
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.6	-1.6	0.7
Respiratory disease	0.9	1.9	5.7	2.4	0.0
Relative age of first facial hair	0.9	1.9	5.6	0.4	-2.4
Back pain experienced in last month	0.9	1.3	3.5	-1.9	-0.6
Medication: Gliclazide	0.9	1.1	2.6	1.6	0.7
Cholesterol lowering medication	0.9	1.3	3.1	1.8	0.9
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.1	-0.5	1.8
Fed-up feelings	0.8	1.5	4.5	-0.1	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.1	-0.0	1.8
Allergy	0.8	1.8	4.5	-2.1	1.0
Impedance of arm (right)	0.8	3.9	11.6	3.4	0.3
Medication: Cholesterol lowering	0.8	1.3	3.7	-1.9	0.4
Impedance of arm (left)	0.8	3.6	10.6	3.3	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	-1.4	0.9
Number of full brothers	0.8	1.0	2.3	-1.5	-0.8
Eye problems/disorders: None of the above	0.8	0.9	1.6	-1.3	1.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.9	-1.1	1.4
Average weekly champagne plus white wine intake	0.8	1.1	2.9	1.7	0.7
Illnesses of father: High blood pressure	0.8	1.0	2.7	0.6	1.6
Depression (Nagel 2018)	0.7	1.1	3.2	-0.1	1.8
Schizophrenia vs Biploar Disorder	0.7	1.0	2.1	-1.5	-0.9
Body Mass Index (BMI) (2010)	0.7	1.0	1.7	-1.3	-1.1
HbA1C	0.7	0.8	2.1	-0.5	-1.5
Medication for hormone replacement therapy	0.7	0.8	1.9	-0.6	-1.4
Heart attack	0.7	0.9	1.7	-1.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.4	1.8	0.0
Knee pain experienced in last month	0.7	1.1	3.2	-0.0	1.8
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	-1.2	-1.1
Eye problems/disorders: Glaucoma	0.7	0.9	1.8	-1.3	-0.9
Medication: Lisinopril	0.7	0.9	2.1	-0.8	-1.4
Lung FEV1/FVC ratio	0.6	3.3	5.2	-2.1	-2.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.5	-0.6	1.2
Vitamin and mineral supplements	0.6	0.8	2.0	-0.6	-1.4
Leg fat-free mass (left)	0.6	3.0	7.0	1.5	2.6
Leg predicted mass (left)	0.6	3.1	6.9	1.6	2.6
Standing height	0.6	6.2	11.8	2.6	3.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	1.3	-0.6
Worry too long after embarrassment	0.6	1.0	3.1	0.2	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	1.3	-0.7
Comparative height size at age 10	0.6	3.5	7.9	2.8	1.6
Family relationship satisfaction	0.6	0.8	2.4	-1.5	0.0
Average weekly red wine intake	0.6	0.9	2.5	-0.3	1.6
Commuting to job workplace: Walk	0.6	0.7	2.0	-0.3	-1.4
Leg predicted mass (right)	0.6	2.9	7.1	1.3	2.7
Wears glasses or contact lenses	0.6	0.7	1.6	0.6	1.3
Hearing aid user	0.6	0.7	1.5	-0.8	-1.2
Number of operations (self-reported)	0.6	1.0	2.9	1.7	-0.1
Average weekly beer plus cider intake	0.6	0.9	2.7	-1.6	0.1
Risk taking	0.6	0.9	2.6	0.2	1.6
Diastolic blood pressure, automated reading	0.6	1.9	5.6	2.4	0.0
Unable to work because of sickness or disability	0.6	0.7	2.2	-1.5	0.2
Bipolar Disorder or Schizophrenia	0.5	1.3	2.6	1.6	1.1
Height	0.5	9.6	15.5	3.9	3.6
Chronotype (morning person)	0.5	1.2	3.5	1.9	-0.3
Current tobacco smoking	0.5	0.8	1.3	-1.1	1.0
Taking other prescription medications	0.5	0.8	1.7	0.8	-1.3
Qualifications: CSEs or equivalent	0.5	0.7	2.0	-0.4	-1.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.7	1.6	-0.8
Impedance of leg (left)	0.5	2.6	7.7	0.1	-2.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.2	0.4	1.5
Glaucoma (self-reported)	0.5	0.6	1.6	-1.3	-0.6
Gout (self-reported)	0.5	0.7	1.9	1.4	0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.7	1.3	0.5
Pulse rate, automated reading	0.5	1.5	4.5	0.1	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	-1.0	-1.0
Leg fat-free mass (right)	0.5	2.8	6.8	1.3	2.6
Smoking status: Current	0.5	0.8	1.7	-0.9	1.3
Medication: Bendroflumethiazide	0.5	0.8	1.7	-1.3	0.7
Leg fat percentage (left)	0.5	1.9	5.5	-0.2	-2.4
Ever depressed for a whole week	0.5	0.6	1.7	-0.1	1.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.2	-1.1	-0.8
Depressed Affect (Nagel 2018)	0.4	0.9	2.7	0.2	1.6
HDL Cholesterol	0.4	0.6	1.7	1.3	0.4
Lupus	0.4	0.7	1.0	-1.0	1.0
Neuroticism (2016)	0.4	0.6	1.5	0.4	1.2
Smoking Status	0.4	1.0	2.6	-1.6	0.5
Hypothyroidism (self reported)	0.4	1.0	2.7	-1.6	-0.4
Sensitivity / hurt feelings	0.4	0.7	1.8	0.6	1.3
Medication: Co-codamol	0.4	0.5	1.0	-0.8	-1.0
Pack years adult smoking proportion	0.4	0.6	1.6	0.3	-1.3
Impedance of leg (right)	0.4	1.8	5.1	0.6	-2.2
Sitting height	0.4	2.9	8.7	0.2	3.0
Financial difficulties in last 2 years	0.4	0.5	1.4	-0.1	-1.2
Mouth/teeth dental problems	0.4	0.6	1.7	-1.3	0.2
Fluid intelligence score	0.4	0.8	1.6	1.3	-0.9
Trunk fat-free mass	0.4	2.1	6.4	0.3	2.5
Number of live births	0.4	0.6	1.9	0.1	1.4
Noisy workplace	0.4	0.4	0.8	-0.7	-0.9
Trunk predicted mass	0.4	2.0	5.9	0.3	2.4
Loud music exposure frequency	0.4	0.4	0.9	0.9	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.6	4.6	-0.3	2.1
Leg fat percentage (right)	0.4	1.5	4.6	0.2	-2.1
Neck or shoulder pain in last month	0.4	0.5	1.4	-0.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.8	0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.2	1.2
Whole body fat-free mass	0.4	2.1	6.1	0.6	2.5
Mood swings	0.4	0.8	1.5	0.9	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.6	0.9
Whole body water mass	0.4	2.3	6.4	0.8	2.5
Guilty feelings	0.4	0.6	1.5	0.5	-1.2
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.6	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.3	-0.6	1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.6	0.8	-0.8
Worry (Nagel 2018)	0.3	0.7	1.2	1.0	-1.1
Reaction Time	0.3	0.6	1.3	-1.1	0.8
Breast Cancer	0.3	0.7	1.2	1.1	1.0
Coronary Artery Disease (CAD)	0.3	0.4	1.2	0.1	-1.1
Rheumatoid Arthritis	0.3	0.4	1.2	1.1	-0.2
Blood Red Count	0.3	2.6	7.7	0.3	-2.8
Allergy or Eczema	0.3	0.7	2.0	1.4	-0.2
Average weekly spirits intake	0.3	0.4	0.6	-0.7	-0.8
Systolic blood pressure, automated reading	0.3	0.8	2.2	1.5	-0.2
Diabetes (father)	0.3	0.3	0.9	0.2	0.9
Trunk fat percentage	0.3	1.4	3.6	1.9	-0.7
Age when periods started (menarche)	0.3	0.7	1.9	0.5	1.4
Medication: Atenolol	0.3	0.3	0.6	-0.8	0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.9	0.1
Had menopause	0.3	0.4	0.9	-0.6	-1.0
Forced vital capacity (FVC)	0.3	1.0	3.1	-0.1	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	0.1	-0.9
Prospective memory result	0.3	0.4	1.1	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.6	-0.5	1.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	0.7	0.9
Medication: Amlodipine	0.3	0.4	0.9	-0.6	0.9
Body fat percentage	0.3	1.0	1.7	1.2	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.2	1.1
Pulse wave peak to peak time	0.3	0.3	0.9	0.3	0.9
Qualifications: College or University degree	0.3	1.0	2.9	1.7	0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	-1.2	-0.3
Medication: Blood pressure	0.3	0.5	1.4	-1.2	-0.4
Suffer from ‘nerves’	0.3	0.4	0.9	0.5	-1.0
Long-standing illness, disability or infirmity	0.3	0.4	0.6	0.8	-0.8
Friendships satisfaction	0.3	0.3	0.6	-0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.6	-1.0
Financial situation satisfaction	0.3	0.4	1.2	-0.3	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.5	-0.9
Commuting to job workplace: Public transport	0.3	0.4	1.1	-1.0	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	-1.0	-0.4
Medication: Paracetamol	0.3	0.4	1.2	1.1	-0.2
Medication: Atorvastatin	0.3	0.3	0.9	-0.2	1.0
Basal metabolic rate	0.3	1.8	4.5	1.0	2.1
Irritability	0.3	0.4	0.9	1.0	0.6
Impedance of whole body	0.3	1.5	3.2	1.8	-1.1
Neuroticism (Nagel 2018)	0.2	0.4	0.6	0.7	0.8
Schizophrenia (2014)	0.2	0.4	1.3	0.2	-1.1
Blood Platelet Count	0.2	2.7	6.2	1.4	2.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-0.9	-0.5
Lung FVC	0.2	1.3	3.3	-1.8	0.7
Angina	0.2	0.2	0.6	0.2	-0.8
Relative age voice broke	0.2	0.3	0.7	0.4	-0.9
High blood pressure (mother)	0.2	0.2	0.7	-0.8	0.1
Trunk fat mass	0.2	0.8	2.3	1.5	-0.2
Past tobacco smoking	0.2	0.3	0.9	0.3	-0.9
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.2	0.9
Medication: Ramipril	0.2	0.3	0.8	-0.4	-0.9
Medication: Simvastatin	0.2	0.3	0.9	-0.4	-0.9
Weight	0.2	1.0	2.3	1.5	0.8
Hip circumference	0.2	0.9	2.6	1.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	-0.8	1.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	1.2	0.3
Depression (self-reported)	0.2	0.2	0.7	-0.8	-0.1
Illnesses of mother	0.2	0.3	0.8	-0.9	0.1
Arm fat mass (right)	0.2	0.6	1.9	1.4	0.2
Tense / ‘highly strung’	0.2	0.4	0.6	0.6	0.8
Medication: Paracetamol	0.2	0.3	0.5	0.6	-0.7
Angina (self-reported)	0.2	0.3	0.8	-0.1	-0.9
Medication: Allopurinol	0.2	0.3	0.5	-0.7	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.8	0.1
Smoking status: Previous	0.2	0.2	0.7	-0.8	-0.3
Arm fat percentage (left)	0.2	0.6	1.4	1.2	-0.7
Qualifications: nursing, teaching	0.2	0.3	0.7	0.2	-0.9
Breast cancer (self-reported)	0.2	0.2	0.4	-0.6	-0.6
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.3	-0.9
Miserableness	0.2	0.3	1.0	-1.0	0.2
Ever smoked	0.2	0.4	1.1	-0.2	1.0
Heart disease (siblings)	0.2	0.3	0.6	-0.8	0.4
Pack years of smoking	0.2	0.3	1.0	0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.6	-0.7
Schizophrenia (2018)	0.1	0.2	0.4	0.4	-0.6
Mean Putamen Volume	0.1	0.1	0.2	-0.2	0.4
LDL Cholesterol	0.1	0.1	0.2	0.5	0.5
Blood White Count	0.1	0.9	2.2	0.8	1.5
Neuroticism	0.1	0.2	0.4	0.7	0.5
Hair Pigment	0.1	3.0	8.8	3.0	-0.4
Tanning	0.1	1.1	2.9	0.6	1.7
Number of treatments/medications taken	0.1	0.1	0.3	0.5	0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.4	0.3
Medication: Metformin	0.1	0.1	0.2	-0.2	0.4
Diabetes (mother)	0.1	0.1	0.1	-0.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.1	0.6
Waist circumference	0.1	0.4	1.1	1.1	0.1
Number of incorrect matches in round	0.1	0.1	0.3	-0.3	-0.5
Nervous feelings	0.1	0.2	0.6	0.3	-0.8
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	0.7	0.2
Qualifications: None of the above	0.1	0.1	0.3	-0.6	0.2
Neuroticism score	0.1	0.2	0.4	0.3	0.6
Arm fat percentage (right)	0.1	0.5	1.5	1.2	-0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.5	0.6
Worrier / anxious feelings	0.1	0.3	0.8	0.9	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.8	0.1
Pulse rate	0.1	0.2	0.4	-0.7	-0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.1	-0.4
Length of working week for main job	0.1	0.1	0.1	-0.2	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.5	-0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.2	0.8
Birth weight of first child	0.1	0.3	0.7	0.8	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.6	-0.3
Headache pain in last month	0.1	0.2	0.6	0.8	0.1
Birth weight	0.1	0.3	1.0	-0.0	-1.0
Arm fat-free mass (right)	0.1	0.6	1.7	-0.0	1.3
Comparative body size at age 10	0.1	0.2	0.3	-0.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	0.2
Number of children fathered	0.1	0.1	0.3	-0.3	-0.5
Age at first live birth	0.1	0.2	0.6	0.8	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.1	-0.4
Migraine (self-reported)	0.1	0.1	0.2	0.5	0.2
Heart disease (mother)	0.1	0.1	0.3	-0.5	0.2
Whole body fat mass	0.1	0.3	0.7	0.8	-0.4
Leg fat mass (right)	0.1	0.4	1.0	0.4	-1.0
Arm predicted mass (right)	0.1	0.6	1.6	0.5	1.3
Alcohol intake frequency.	0.1	0.3	1.0	1.0	-0.0
Chest pain or discomfort	0.1	0.1	0.4	0.1	-0.6
Had major operations	0.1	0.1	0.3	-0.5	0.1
Supplements: Vitamin C	0.1	0.2	0.5	-0.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.1	-0.5
Ever had bowel cancer screening	0.1	0.2	0.4	0.3	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.6	-0.4
Medication for cholesterol	0.1	0.2	0.6	-0.8	-0.3
Arm fat mass (left)	0.1	0.4	1.2	1.1	-0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.6	0.1
Medication: Blood pressure	0.1	0.2	0.5	0.7	0.4
Arm fat-free mass (left)	0.1	0.5	1.3	0.2	1.2
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.1	0.7
Myopia	0.1	0.1	0.2	0.0	0.5
Pain experienced in last month	0.1	0.2	0.6	0.0	-0.8
Leg fat mass (left)	0.1	0.4	1.0	0.3	-1.0
Arm predicted mass (left)	0.1	0.4	1.2	0.3	1.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.3	-0.0
Major Depression (MDD)	0.0	0.1	0.1	0.4	0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.2	-0.5
Age at First Birth	0.0	0.0	0.0	-0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	-0.1
Triglycerides	0.0	0.0	0.1	0.3	0.1
Blood Eosinophil Count	0.0	0.3	0.6	0.8	0.5
BMI	0.0	0.0	0.1	0.3	0.2
Waist Hip Ratio (WHR)	0.0	0.0	0.1	-0.3	-0.0
Systolic Blood Pressure	0.0	0.0	0.0	-0.1	-0.1
Cardiovascular Disease	0.0	0.0	0.0	0.0	0.2
Hand grip strength (left)	0.0	0.0	0.1	0.2	0.1
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.1	0.3
Hand grip strength (right)	0.0	0.1	0.2	-0.2	-0.4
Maternal smoking around birth	0.0	0.0	0.1	0.4	-0.0
High blood pressure	0.0	0.1	0.3	-0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.2	0.3
Body mass index (BMI)	0.0	0.1	0.3	0.2	-0.5
Alcohol usually taken with meals	0.0	0.1	0.1	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.0	0.3
Diabetes (self-reported)	0.0	0.0	0.1	0.0	-0.3
Father’s age at death	0.0	0.0	0.1	0.2	-0.3
Falls in the last year	0.0	0.1	0.1	-0.4	-0.2
Lung cancer (father)	0.0	0.0	0.1	-0.2	0.1
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.2	0.1
Pulse wave reflection index	0.0	0.0	0.0	0.2	0.1
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.0	-0.2
Mean time to correctly identify matches	0.0	0.0	0.1	-0.4	-0.0
Overall health rating	0.0	0.1	0.3	0.6	-0.1
Age at last live birth	0.0	0.0	0.0	0.2	0.0
Hypertension (Self-reported)	0.0	0.1	0.4	-0.1	-0.6
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.0	-0.2
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.2	0.4
High cholesterol (Self-reported)	0.0	0.0	0.0	0.0	-0.0
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	-0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	0.4	-0.2

Hub : Genes

GREM2

Models

Trait associations