Hub : Traits :

Osteoporosis (self-reported)

7 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 239954252 241470634 1 1 7.5e-08 5.3e-07 0.1070 90 GREM2
2 4 88199484 89590831 1 1 8.0e-09 1.2e-10 0.0029 79 SPP1
3 7 119935156 121634913 1 1 1.2e-10 1.1e-13 0.0002 75 CPED1
4 11 26818083 28220506 1 1 3.9e-07 2.4e-07 0.0405 84 LIN7C
5 11 67533195 69154873 2 2 6.5e-09 9.6e-12 0.0008 76 GAL PPP6R3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Fasting Glucose 2.74 1 0 0.0 0.00 1.0000 GREM2
Ulcerative Colitis 1.77 1 0 0.0 0.00 1.0000 GREM2
Blood Eosinophil Count 0.78 2 0 0.0 0.00 1.0000 GAL PPP6R3
Blood Platelet Count 0.29 1 0 0.0 0.00 1.0000 CPED1
Blood Red Count 0.60 2 0 0.0 0.00 1.0000 GREM2 PPP6R3
Heel T-Score 151.56 6 6 18.2 0.68 0.1358 CPED1 GAL GREM2 LIN7C PPP6R3 SPP1
BMI 1.30 4 0 0.0 0.58 0.4217 CPED1 GAL PPP6R3 SPP1
Height 2.69 5 3 9.1 0.96 0.0092 GAL GREM2 LIN7C PPP6R3 SPP1
Waist Hip Ratio (WHR) 2.25 2 2 6.1 0.00 1.0000 CPED1 PPP6R3
Cardiovascular Disease 0.90 1 0 0.0 0.00 1.0000 CPED1
Lung FEV1/FVC ratio 0.69 1 0 0.0 0.00 1.0000 CPED1
Lung FVC 0.80 1 0 0.0 0.00 1.0000 PPP6R3
Hair Pigment 0.47 3 1 3.0 0.00 1.0000 GAL PPP6R3 SPP1
Hand grip strength (left) 1.55 1 0 0.0 0.00 1.0000 PPP6R3
Number of treatments/medications taken 1.36 1 0 0.0 0.00 1.0000 CPED1
Impedance of leg (right) 4.00 4 1 3.0 0.63 0.3681 CPED1 GAL PPP6R3 SPP1
Leg fat-free mass (left) 5.25 4 2 6.1 -0.92 0.0837 CPED1 GAL LIN7C PPP6R3
Hand grip strength (right) 1.60 1 0 0.0 0.00 1.0000 LIN7C
Fed-up feelings 1.45 1 0 0.0 0.00 1.0000 LIN7C
Frequency of unenthusiasm / disinterest in last 2 weeks 1.66 1 0 0.0 0.00 1.0000 LIN7C
Taking other prescription medications 1.81 1 0 0.0 0.00 1.0000 CPED1
Age when periods started (menarche) 1.07 1 0 0.0 0.00 1.0000 SPP1
Heel bone mineral density (BMD) T-score, automated (left) 105.91 6 6 18.2 -0.69 0.1317 CPED1 GAL GREM2 LIN7C PPP6R3 SPP1
Hayfever, allergic rhinitis or eczema 1.44 1 0 0.0 0.00 1.0000 PPP6R3
Medication: Levothyroxine sodium 1.60 1 0 0.0 0.00 1.0000 PPP6R3
Sitting height 2.86 5 2 6.1 -0.92 0.0274 CPED1 GAL GREM2 LIN7C PPP6R3
Body mass index (BMI) 1.17 2 0 0.0 0.00 1.0000 PPP6R3 SPP1
Impedance of leg (left) 4.59 5 1 3.0 0.61 0.2775 CPED1 GAL GREM2 PPP6R3 SPP1
Leg predicted mass (left) 5.25 4 2 6.1 -0.92 0.0849 CPED1 GAL LIN7C PPP6R3
Trunk fat mass 0.97 1 0 0.0 0.00 1.0000 LIN7C
Waist circumference 0.67 1 0 0.0 0.00 1.0000 LIN7C
Nervous feelings 1.59 1 0 0.0 0.00 1.0000 LIN7C
Forced vital capacity (FVC) 2.92 3 2 6.1 0.00 1.0000 GAL PPP6R3 SPP1
Heel bone mineral density (BMD) T-score, automated (right) 104.23 6 6 18.2 -0.69 0.1254 CPED1 GAL GREM2 LIN7C PPP6R3 SPP1
Allergy 1.37 1 0 0.0 0.00 1.0000 PPP6R3
Medication: Simvastatin 2.16 1 0 0.0 0.00 1.0000 CPED1
Weight 3.07 4 1 3.0 -0.94 0.0639 CPED1 GAL LIN7C PPP6R3
Impedance of arm (right) 1.93 3 1 3.0 0.00 1.0000 GAL PPP6R3 SPP1
Arm fat percentage (right) 0.64 1 0 0.0 0.00 1.0000 LIN7C
Trunk fat-free mass 5.31 4 2 6.1 -0.89 0.1103 CPED1 GAL LIN7C PPP6R3
Hip circumference 1.28 2 0 0.0 0.00 1.0000 CPED1 PPP6R3
Alcohol intake versus 10 years previously 1.66 1 0 0.0 0.00 1.0000 PPP6R3
Frequency of tiredness / lethargy in last 2 weeks 1.51 1 0 0.0 0.00 1.0000 LIN7C
Falls in the last year 1.46 1 0 0.0 0.00 1.0000 CPED1
Forced expiratory volume in 1-second (FEV1) 3.07 3 1 3.0 0.00 1.0000 GAL PPP6R3 SPP1
Noisy workplace 2.70 1 0 0.0 0.00 1.0000 PPP6R3
Medication: Ibuprofen (e.g. Nurofen) 1.47 1 0 0.0 0.00 1.0000 PPP6R3
Forced expiratory volume in 1-second (FEV1), Best measure 2.45 2 0 0.0 0.00 1.0000 GAL PPP6R3
Impedance of arm (left) 1.72 1 1 3.0 0.00 1.0000 PPP6R3
Arm fat mass (right) 1.29 2 0 0.0 0.00 1.0000 LIN7C PPP6R3
Trunk predicted mass 5.34 4 2 6.1 -0.89 0.1122 CPED1 GAL LIN7C PPP6R3
Standing height 3.00 5 2 6.1 -0.96 0.0083 GAL GREM2 LIN7C PPP6R3 SPP1
Breastfed as a baby 2.26 1 0 0.0 0.00 1.0000 LIN7C
Birth weight of first child 1.49 1 0 0.0 0.00 1.0000 PPP6R3
Peak expiratory flow (PEF) 3.28 2 0 0.0 0.00 1.0000 GAL PPP6R3
Qualifications: O levels/GCSEs or equivalent 1.36 1 0 0.0 0.00 1.0000 CPED1
Hypothyroidism/myxoedema (self-reported) 1.97 1 0 0.0 0.00 1.0000 PPP6R3
Birth weight 1.68 1 0 0.0 0.00 1.0000 PPP6R3
Forced vital capacity (FVC), Best measure 2.49 3 0 0.0 0.00 1.0000 GAL PPP6R3 SPP1
Arm fat-free mass (right) 4.46 2 2 6.1 0.00 1.0000 GAL PPP6R3
Comparative body size at age 10 2.50 2 0 0.0 0.00 1.0000 LIN7C PPP6R3
Shortness of breath walking on level ground 1.79 1 0 0.0 0.00 1.0000 GREM2
Qualifications: College or University degree 0.56 1 0 0.0 0.00 1.0000 PPP6R3
Medication for pain relief, constipation, heartburn 1.20 1 0 0.0 0.00 1.0000 CPED1
Medication: Blood pressure 1.34 1 0 0.0 0.00 1.0000 CPED1
Whole body fat mass 0.89 1 0 0.0 0.00 1.0000 LIN7C
Leg fat mass (right) 1.03 1 0 0.0 0.00 1.0000 LIN7C
Arm predicted mass (right) 4.35 2 2 6.1 0.00 1.0000 GAL PPP6R3
Alcohol intake frequency. 1.66 1 0 0.0 0.00 1.0000 PPP6R3
Comparative height size at age 10 2.18 2 1 3.0 0.00 1.0000 GAL PPP6R3
Forced expiratory volume in 1-second (FEV1), predicted 1.78 1 0 0.0 0.00 1.0000 PPP6R3
Whole body fat-free mass 5.31 4 2 6.1 -0.90 0.1012 CPED1 GAL LIN7C PPP6R3
Leg fat-free mass (right) 5.28 4 2 6.1 -0.91 0.0871 CPED1 GAL LIN7C PPP6R3
Loneliness, isolation 1.54 1 0 0.0 0.00 1.0000 LIN7C
Ever had bowel cancer screening 1.72 1 0 0.0 0.00 1.0000 CPED1
Whole body water mass 5.40 4 2 6.1 -0.89 0.1050 CPED1 GAL LIN7C PPP6R3
Leg predicted mass (right) 5.41 4 2 6.1 -0.91 0.0864 CPED1 GAL LIN7C PPP6R3
Arm fat mass (left) 1.22 2 0 0.0 0.00 1.0000 LIN7C PPP6R3
Average weekly champagne plus white wine intake 2.22 2 0 0.0 0.00 1.0000 GAL PPP6R3
Miserableness 0.88 1 0 0.0 0.00 1.0000 LIN7C
High cholesterol (Self-reported) 1.16 1 0 0.0 0.00 1.0000 CPED1
Medication: Lisinopril 2.30 1 0 0.0 0.00 1.0000 LIN7C
Basal metabolic rate 4.87 4 2 6.1 -0.90 0.0966 CPED1 GAL LIN7C PPP6R3
Arm fat-free mass (left) 4.33 2 2 6.1 0.00 1.0000 GAL PPP6R3
Fractured/broken bones in last 5 years 22.35 2 1 3.0 0.00 1.0000 CPED1 GREM2
Medication: Omeprazole (e.g. Zanprol) 2.57 1 0 0.0 0.00 1.0000 CPED1
Supplements: Calcium 4.18 2 0 0.0 0.00 1.0000 CPED1 SPP1
Basal cell carcinoma (self-reported) 4.01 1 0 0.0 0.00 1.0000 PPP6R3
Alcohol drinker status: Previous 1.57 1 0 0.0 0.00 1.0000 GREM2
Impedance of whole body 3.07 4 1 3.0 0.58 0.4213 CPED1 GAL PPP6R3 SPP1
Leg fat mass (left) 0.98 1 0 0.0 0.00 1.0000 LIN7C
Arm predicted mass (left) 4.45 2 2 6.1 0.00 1.0000 GAL PPP6R3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.20
GTEx Adipose Visceral Omentum 0 0.0000 1.28
GTEx Adrenal Gland 0 0.0000 1.24
GTEx Artery Aorta 0 0.0000 1.29
GTEx Artery Coronary 0 0.0000 1.21
GTEx Artery Tibial 1 0.0266 1.26
GTEx Brain Caudate basal ganglia 0 0.0000 1.21
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.30
GTEx Brain Cerebellum 0 0.0000 1.29
GTEx Brain Cortex 0 0.0000 1.27
GTEx Brain Frontal Cortex BA9 0 0.0000 1.33
GTEx Brain Hippocampus 0 0.0000 1.42
GTEx Brain Hypothalamus 0 0.0000 1.24
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.40
GTEx Breast Mammary Tissue 0 0.0000 1.28
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.23
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.23
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.20
GTEx Cells Transformed fibroblasts 1 0.0238 1.25
GTEx Colon Sigmoid 0 0.0000 1.25
GTEx Colon Transverse 0 0.0000 1.27
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.26
GTEx Esophagus Mucosa 1 0.0301 1.25
GTEx Esophagus Muscularis 0 0.0000 1.29
GTEx Heart Atrial Appendage 0 0.0000 1.22
GTEx Heart Left Ventricle 0 0.0000 1.30
GTEx Liver 0 0.0000 1.31
GTEx Lung 0 0.0000 1.24
GTEx Muscle Skeletal 0 0.0000 1.23
GTEx Nerve Tibial 1 0.0231 1.26
GTEx Ovary 0 0.0000 1.32
GTEx Pancreas 0 0.0000 1.19
GTEx Pituitary 0 0.0000 1.33
GTEx Prostate 0 0.0000 1.21
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.23
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.26
GTEx Small Intestine Terminal Ileum 0 0.0000 1.19
GTEx Spleen 0 0.0000 1.29
GTEx Stomach 0 0.0000 1.24
GTEx Testis 0 0.0000 1.32
GTEx Thyroid 0 0.0000 1.22
GTEx Uterus 0 0.0000 1.28
GTEx Vagina 0 0.0000 1.24
GTEx Whole Blood 0 0.0000 1.21
METSIM Adipose 0 0.0000 1.22
NTR Blood 0 0.0000 1.29
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.26
YFS Blood 0 0.0000 1.19
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.21
TCGA Breast Tumor 0 0.0000 1.24
TCGA Breast Normal 1 0.0238 1.17
TCGA Ovarian Tumor 0 0.0000 1.19
TCGA Prostate Tumor 0 0.0000 1.23