Hub : Traits :

Illnesses of mother

12 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 90730363 92135418 1 1 3.0e-12 4.5e-12 1.000 100 FES
2 17 37483599 38916313 1 1 1.7e-07 4.4e-03 0.035 45 MED24
3 17 46303558 47688526 1 1 3.9e-07 2.9e-08 0.014 80 UBE2Z

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.04 1 0 0.0 0 1 FES
Irritable Bowel Disease (IBD) 1.80 1 0 0.0 0 1 FES
Major Depression (MDD) 4.76 1 0 0.0 0 1 FES
Breast Cancer 2.43 1 0 0.0 0 1 FES
Prostate Cancer 4.58 1 0 0.0 0 1 MED24
Coronary Artery Disease (CAD) 7.42 2 0 0.0 0 1 FES UBE2Z
Crohns Disease (2012) 2.48 1 0 0.0 0 1 FES
Schizophrenia 7.05 1 1 3.0 0 1 FES
Type 2 Diabetes (T2D) 3.64 1 0 0.0 0 1 UBE2Z
Blood Eosinophil Count 4.98 2 2 6.1 0 1 MED24 UBE2Z
Blood Platelet Count 1.24 2 1 3.0 0 1 MED24 UBE2Z
Blood Red Count 0.88 1 0 0.0 0 1 FES
Blood White Count 16.04 2 2 6.1 0 1 FES MED24
BMI 3.78 1 1 3.0 0 1 UBE2Z
Height 4.52 3 1 3.0 0 1 FES MED24 UBE2Z
Systolic Blood Pressure 18.40 2 1 3.0 0 1 FES UBE2Z
Smoking Status 3.37 1 0 0.0 0 1 FES
Allergy or Eczema 2.94 2 0 0.0 0 1 FES MED24
Cardiovascular Disease 16.99 2 2 6.1 0 1 FES UBE2Z
Hypothyroidism (self reported) 1.59 1 0 0.0 0 1 UBE2Z
Respiratory disease 2.88 1 0 0.0 0 1 FES
Type 2 Diabetes (T2D) 4.69 1 0 0.0 0 1 UBE2Z
Neuroticism 2.65 1 0 0.0 0 1 UBE2Z
Hair Pigment 0.50 1 1 3.0 0 1 FES
Tanning 0.29 1 0 0.0 0 1 UBE2Z
Hand grip strength (left) 1.68 1 0 0.0 0 1 FES
Number of treatments/medications taken 3.95 1 0 0.0 0 1 FES
Sensitivity / hurt feelings 7.15 2 0 0.0 0 1 FES UBE2Z
Other serious medical condition/disability diagnosed by doctor 3.05 1 0 0.0 0 1 MED24
Systolic blood pressure, automated reading 13.66 2 1 3.0 0 1 FES UBE2Z
Angina 8.91 1 1 3.0 0 1 FES
Medication: Metformin 2.66 1 0 0.0 0 1 UBE2Z
Diabetes (father) 5.33 1 0 0.0 0 1 UBE2Z
Pack years adult smoking proportion 3.98 1 0 0.0 0 1 UBE2Z
Impedance of leg (right) 3.38 2 1 3.0 0 1 FES UBE2Z
Leg fat-free mass (left) 0.76 1 0 0.0 0 1 FES
Trunk fat percentage 1.16 1 0 0.0 0 1 UBE2Z
Current tobacco smoking 3.17 1 0 0.0 0 1 FES
Fed-up feelings 4.17 1 0 0.0 0 1 UBE2Z
High blood pressure 17.92 2 2 6.1 0 1 FES UBE2Z
Medication: Atenolol 9.47 1 1 3.0 0 1 FES
Sitting height 3.64 2 1 3.0 0 1 FES UBE2Z
High blood pressure (mother) 28.28 2 2 6.1 0 1 FES UBE2Z
Body mass index (BMI) 3.08 1 1 3.0 0 1 UBE2Z
Impedance of leg (left) 3.18 2 0 0.0 0 1 FES UBE2Z
Leg predicted mass (left) 0.76 1 0 0.0 0 1 FES
Number of incorrect matches in round 2.78 1 0 0.0 0 1 FES
Alcohol usually taken with meals 3.07 1 0 0.0 0 1 FES
Hearing difficulty/problems with background noise 2.38 1 0 0.0 0 1 UBE2Z
Forced vital capacity (FVC) 1.60 1 0 0.0 0 1 UBE2Z
Qualifications: None of the above 1.87 1 0 0.0 0 1 UBE2Z
Heart attack 6.31 1 0 0.0 0 1 FES
Allergy 3.28 2 0 0.0 0 1 FES MED24
Diabetes (self-reported) 2.84 1 0 0.0 0 1 UBE2Z
Medication: Ramipril 4.42 1 0 0.0 0 1 FES
Medication: Simvastatin 9.04 2 0 0.0 0 1 FES UBE2Z
Illnesses of siblings 8.16 2 0 0.0 0 1 FES UBE2Z
Neuroticism score 2.69 1 0 0.0 0 1 UBE2Z
Impedance of arm (right) 1.15 1 0 0.0 0 1 MED24
Arm fat percentage (right) 3.58 1 1 3.0 0 1 UBE2Z
Trunk fat-free mass 1.04 1 0 0.0 0 1 UBE2Z
Father's age at death 6.49 1 0 0.0 0 1 FES
Frequency of tiredness / lethargy in last 2 weeks 4.02 1 0 0.0 0 1 UBE2Z
Number of live births 2.63 1 0 0.0 0 1 FES
Forced expiratory volume in 1-second (FEV1) 1.52 1 0 0.0 0 1 UBE2Z
Asthma 2.67 1 0 0.0 0 1 FES
Medication: Cholesterol lowering 9.13 2 1 3.0 0 1 FES UBE2Z
Lung cancer (father) 4.04 1 0 0.0 0 1 FES
Impedance of arm (left) 1.18 1 0 0.0 0 1 MED24
Arm fat mass (right) 1.93 1 0 0.0 0 1 UBE2Z
Trunk predicted mass 1.02 1 0 0.0 0 1 UBE2Z
Standing height 3.97 1 1 3.0 0 1 UBE2Z
Breastfed as a baby 6.26 2 0 0.0 0 1 FES UBE2Z
Hair/balding pattern: Pattern 4 1.69 1 0 0.0 0 1 FES
Birth weight of first child 7.53 1 1 3.0 0 1 FES
Peak expiratory flow (PEF) 1.75 1 0 0.0 0 1 UBE2Z
Headache pain in last month 2.14 1 0 0.0 0 1 FES
Medication for cholesterol, blood pressure or diabetes 15.20 2 1 3.0 0 1 FES UBE2Z
Hypothyroidism/myxoedema (self-reported) 1.73 1 0 0.0 0 1 UBE2Z
Medication: Amlodipine 8.30 2 0 0.0 0 1 FES UBE2Z
Birth weight 3.87 1 0 0.0 0 1 FES
High blood pressure (siblings) 10.69 2 1 3.0 0 1 FES UBE2Z
Forced vital capacity (FVC), Best measure 1.22 1 0 0.0 0 1 UBE2Z
Body fat percentage 1.57 1 0 0.0 0 1 UBE2Z
Leg fat percentage (right) 1.72 1 0 0.0 0 1 UBE2Z
Worry too long after embarrassment 3.06 1 0 0.0 0 1 UBE2Z
Wheeze or whistling in the chest in last year 3.89 1 0 0.0 0 1 MED24
Age at first live birth 1.77 1 0 0.0 0 1 UBE2Z
Shortness of breath walking on level ground 4.51 1 0 0.0 0 1 MED24
Qualifications: College or University degree 1.79 1 0 0.0 0 1 UBE2Z
Medication: Blood pressure 16.85 2 1 3.0 0 1 FES UBE2Z
Angina (self-reported) 9.65 1 1 3.0 0 1 FES
Medication: Omeprazole 3.60 1 0 0.0 0 1 MED24
Mean time to correctly identify matches 2.61 1 0 0.0 0 1 FES
Heart disease (mother) 7.22 2 0 0.0 0 1 FES UBE2Z
Whole body fat mass 1.02 1 0 0.0 0 1 UBE2Z
Leg fat mass (right) 1.08 1 0 0.0 0 1 UBE2Z
Alcohol intake frequency. 2.65 1 0 0.0 0 1 UBE2Z
Comparative height size at age 10 2.63 3 0 0.0 0 1 FES MED24 UBE2Z
Overall health rating 3.90 1 0 0.0 0 1 UBE2Z
Chest pain or discomfort 4.24 1 0 0.0 0 1 MED24
Medication: Aspirin 9.84 2 0 0.0 0 1 FES UBE2Z
Knee pain experienced in last month 4.50 1 0 0.0 0 1 MED24
Hypertension (Self-reported) 18.17 2 2 6.1 0 1 FES UBE2Z
Illnesses of father: Heart disease 13.35 2 1 3.0 0 1 FES UBE2Z
Whole body fat-free mass 0.74 1 0 0.0 0 1 FES
Leg fat-free mass (right) 0.86 1 0 0.0 0 1 FES
Arm fat percentage (left) 3.22 1 1 3.0 0 1 UBE2Z
Diabetes diagnosed by doctor 3.57 1 0 0.0 0 1 UBE2Z
Ever had stillbirth, spontaneous miscarriage or termination 3.94 1 0 0.0 0 1 FES
Medication for cholesterol 3.07 1 0 0.0 0 1 FES
Asthma (self-reported) 2.96 1 0 0.0 0 1 FES
Medication: Aspirin 10.53 2 1 3.0 0 1 FES UBE2Z
Illnesses of father: None of the above (group 1) 11.47 2 1 3.0 0 1 FES UBE2Z
Whole body water mass 0.77 1 0 0.0 0 1 FES
Leg predicted mass (right) 0.90 1 0 0.0 0 1 FES
Arm fat mass (left) 1.73 1 0 0.0 0 1 UBE2Z
Number of self-reported non-cancer illnesses 3.21 1 0 0.0 0 1 FES
Average weekly champagne plus white wine intake 4.35 1 0 0.0 0 1 UBE2Z
Medication: Blood pressure 10.20 1 1 3.0 0 1 FES
Supplements: Fish oil (including cod liver oil) 3.59 1 0 0.0 0 1 MED24
High cholesterol (Self-reported) 4.09 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 4.65 1 0 0.0 0 1 FES
Medication: Lisinopril 2.52 1 0 0.0 0 1 FES
Illnesses of father: High blood pressure 13.41 1 1 3.0 0 1 FES
Ever smoked 2.35 1 0 0.0 0 1 FES
Leg fat percentage (left) 1.82 1 0 0.0 0 1 UBE2Z
Irritability 3.00 1 0 0.0 0 1 UBE2Z
Age started oral contraceptive pill 3.39 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 12.11 2 1 3.0 0 1 FES UBE2Z
Vascular/heart problems diagnosed by doctor 19.36 2 2 6.1 0 1 FES UBE2Z
Pain experienced in last month 3.88 1 0 0.0 0 1 MED24
Heart attack/myocardial infarction (self-reported) 6.86 1 0 0.0 0 1 FES
Heart disease (siblings) 5.38 1 0 0.0 0 1 FES
Impedance of whole body 1.89 2 0 0.0 0 1 FES UBE2Z
Leg fat mass (left) 1.12 1 0 0.0 0 1 UBE2Z

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.25
GTEx Adipose Visceral Omentum 1 0.0491 1.31
GTEx Adrenal Gland 0 0.0000 1.21
GTEx Artery Aorta 0 0.0000 1.27
GTEx Artery Coronary 0 0.0000 1.27
GTEx Artery Tibial 1 0.0266 1.29
GTEx Brain Caudate basal ganglia 0 0.0000 1.24
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.24
GTEx Brain Cerebellum 0 0.0000 1.31
GTEx Brain Cortex 0 0.0000 1.23
GTEx Brain Frontal Cortex BA9 0 0.0000 1.36
GTEx Brain Hippocampus 0 0.0000 1.13
GTEx Brain Hypothalamus 0 0.0000 1.21
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.24
GTEx Brain Putamen basal ganglia 0 0.0000 1.12
GTEx Breast Mammary Tissue 0 0.0000 1.21
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.21
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.26
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.29
GTEx Cells Transformed fibroblasts 1 0.0238 1.26
GTEx Colon Sigmoid 0 0.0000 1.24
GTEx Colon Transverse 0 0.0000 1.23
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.30
GTEx Esophagus Mucosa 0 0.0000 1.27
GTEx Esophagus Muscularis 0 0.0000 1.28
GTEx Heart Atrial Appendage 0 0.0000 1.22
GTEx Heart Left Ventricle 0 0.0000 1.24
GTEx Liver 0 0.0000 1.11
GTEx Lung 1 0.0348 1.24
GTEx Muscle Skeletal 1 0.0346 1.28
GTEx Nerve Tibial 0 0.0000 1.24
GTEx Ovary 0 0.0000 1.28
GTEx Pancreas 0 0.0000 1.23
GTEx Pituitary 0 0.0000 1.23
GTEx Prostate 0 0.0000 1.21
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.25
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.27
GTEx Small Intestine Terminal Ileum 0 0.0000 1.34
GTEx Spleen 0 0.0000 1.24
GTEx Stomach 0 0.0000 1.24
GTEx Testis 0 0.0000 1.22
GTEx Thyroid 1 0.0250 1.32
GTEx Uterus 0 0.0000 1.30
GTEx Vagina 0 0.0000 1.22
GTEx Whole Blood 1 0.0502 1.27
METSIM Adipose 1 0.0217 1.22
NTR Blood 0 0.0000 1.21
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.21
YFS Blood 0 0.0000 1.20
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.23
TCGA Breast Tumor 0 0.0000 1.24
TCGA Breast Normal 1 0.0238 1.14
TCGA Ovarian Tumor 1 0.0342 1.20
TCGA Prostate Tumor 1 0.0289 1.24