Hub : Traits :

Financial difficulties in last 2 years

2 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	14	103398706	105007585	2	1	1e-07	7.4e-07	0.98	100	PPP1R13B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Bipolar Disorder or Schizophrenia	21.7	1	1	2.2	1	PPP1R13B
Schizophrenia (2018)	20.9	1	1	2.2	1	PPP1R13B
Schizophrenia (2014)	19.1	1	1	2.2	1	PPP1R13B
Risk taking	16.1	1	0	0.0	1	PPP1R13B
Alcohol drinker status: Previous	15.6	1	0	0.0	1	PPP1R13B
Current tobacco smoking	14.9	1	0	0.0	1	PPP1R13B
Smoking Status	13.6	1	1	2.2	1	PPP1R13B
Illness, injury, bereavement, stress in last 2 years	13.2	1	0	0.0	1	PPP1R13B
Smoking status: Current	12.9	1	0	0.0	1	PPP1R13B
Mouth/teeth dental problems	12.6	1	0	0.0	1	PPP1R13B
Maternal smoking around birth	12.1	1	0	0.0	1	PPP1R13B
Pack years adult smoking proportion	11.6	1	0	0.0	1	PPP1R13B
Frequency of tiredness / lethargy in last 2 weeks	10.7	1	0	0.0	1	PPP1R13B
Pain type(s) experienced in last month: Hip pain	10.6	1	0	0.0	1	PPP1R13B
Pack years of smoking	10.5	1	0	0.0	1	PPP1R13B
Long-standing illness, disability or infirmity	10.0	1	0	0.0	1	PPP1R13B
Hearing difficulty/problems: Yes	9.5	1	0	0.0	1	PPP1R13B
Hearing difficulty/problems with background noise	9.4	1	0	0.0	1	PPP1R13B
Mouth/teeth dental problems: Loose teeth	9.0	1	0	0.0	1	PPP1R13B
Seen a psychiatrist for nerves, anxiety, tension or depression	8.4	1	0	0.0	1	PPP1R13B
Prostate Cancer	7.8	1	0	0.0	1	PPP1R13B
Past tobacco smoking	7.5	1	0	0.0	1	PPP1R13B
Emphysema/chronic bronchitis	7.5	1	0	0.0	1	PPP1R13B
Mother's age at death	7.4	1	0	0.0	1	PPP1R13B
Bipolar Disorder (2018)	7.3	1	0	0.0	1	PPP1R13B
Cardiovascular Disease	7.2	1	0	0.0	1	PPP1R13B
Other serious medical condition/disability diagnosed by doctor	7.2	1	0	0.0	1	PPP1R13B
Age at First Birth	6.9	1	0	0.0	1	PPP1R13B
Exposure to tobacco smoke at home	6.9	1	0	0.0	1	PPP1R13B
Overall health rating	6.8	1	0	0.0	1	PPP1R13B
Ever depressed for a whole week	6.8	1	0	0.0	1	PPP1R13B
BMI	6.5	1	1	2.2	1	PPP1R13B
Seen doctor (GP) for nerves, anxiety, tension or depression	6.5	1	0	0.0	1	PPP1R13B
Health satisfaction	6.3	1	0	0.0	1	PPP1R13B
Body mass index (BMI)	6.2	1	1	2.2	1	PPP1R13B
Stomach or abdominal pain in last month	6.1	1	0	0.0	1	PPP1R13B
Financial situation satisfaction	6.1	1	0	0.0	1	PPP1R13B
Arm fat percentage (right)	5.9	1	0	0.0	1	PPP1R13B
Vascular/heart problems diagnosed by doctor	5.9	1	0	0.0	1	PPP1R13B
Number of self-reported non-cancer illnesses	5.8	1	0	0.0	1	PPP1R13B
Bipolar Disorder (2011)	5.6	1	0	0.0	1	PPP1R13B
Medication: Paracetamol	5.6	1	0	0.0	1	PPP1R13B
Townsend deprivation index at recruitment	5.5	1	0	0.0	1	PPP1R13B
Frequency of depressed mood in last 2 weeks	5.4	1	0	0.0	1	PPP1R13B
Impedance of leg (right)	5.3	1	0	0.0	1	PPP1R13B
Waist circumference	5.3	1	0	0.0	1	PPP1R13B
Diastolic blood pressure, automated reading	5.1	1	0	0.0	1	PPP1R13B
Heel T-Score	5.0	1	1	2.2	1	PPP1R13B
Arm fat mass (right)	5.0	1	0	0.0	1	PPP1R13B
Depression (Nagel 2018)	4.9	1	0	0.0	1	PPP1R13B
Supplements: Vitamin C	4.9	1	0	0.0	1	PPP1R13B
Impedance of leg (left)	4.8	1	0	0.0	1	PPP1R13B
Mouth/teeth dental problems: Bleeding gums	4.8	1	0	0.0	1	PPP1R13B
Pulse wave peak to peak time	4.8	1	0	0.0	1	PPP1R13B
Arm fat percentage (left)	4.7	1	0	0.0	1	PPP1R13B
Arm fat mass (left)	4.7	1	0	0.0	1	PPP1R13B
Neck or shoulder pain in last month	4.6	1	0	0.0	1	PPP1R13B
Back pain experienced in last month	4.6	1	0	0.0	1	PPP1R13B
Unable to work because of sickness or disability	4.5	1	0	0.0	1	PPP1R13B
Intelligence (Savage-Jansen 2018)	4.4	1	0	0.0	1	PPP1R13B
Relative age of first facial hair	4.4	1	0	0.0	1	PPP1R13B
Hypertension (Self-reported)	4.4	1	0	0.0	1	PPP1R13B
Ever smoked	4.4	1	0	0.0	1	PPP1R13B
Major Depression (MDD)	4.3	1	0	0.0	1	PPP1R13B
Medication for pain relief, constipation, heartburn	4.3	1	0	0.0	1	PPP1R13B
Schizophrenia vs Biploar Disorder	4.2	1	0	0.0	1	PPP1R13B
Heel bone mineral density (BMD) T-score, automated (left)	4.2	1	0	0.0	1	PPP1R13B
Supplements: Glucosamine	4.2	1	0	0.0	1	PPP1R13B
High blood pressure	4.1	1	0	0.0	1	PPP1R13B
Qualifications: College or University degree	4.1	1	0	0.0	1	PPP1R13B
Blood White Count	4.0	1	1	2.2	1	PPP1R13B
Loneliness, isolation	4.0	1	0	0.0	1	PPP1R13B
Fluid intelligence score	3.9	1	0	0.0	1	PPP1R13B
Pulse rate, automated reading	3.9	1	0	0.0	1	PPP1R13B
Medication for cholesterol	3.6	1	0	0.0	1	PPP1R13B
Taking other prescription medications	3.5	1	0	0.0	1	PPP1R13B
Frequency of tenseness / restlessness in last 2 weeks	3.4	1	0	0.0	1	PPP1R13B
Hip circumference	3.4	1	0	0.0	1	PPP1R13B
Impedance of whole body	3.3	1	0	0.0	1	PPP1R13B
Depressed Affect (Nagel 2018)	3.2	1	0	0.0	1	PPP1R13B
Pain experienced in last month	3.2	1	0	0.0	1	PPP1R13B
Qualifications: A levels/AS levels or equivalent	3.1	1	0	0.0	1	PPP1R13B
Medication: Blood pressure	3.1	1	0	0.0	1	PPP1R13B
Leg fat mass (left)	2.9	1	0	0.0	1	PPP1R13B
Impedance of arm (left)	2.5	1	0	0.0	1	PPP1R13B
Whole body fat mass	2.5	1	0	0.0	1	PPP1R13B
Verbal and Numeric Reasoning (VNR)	2.4	1	0	0.0	1	PPP1R13B
Leg fat mass (right)	2.4	1	0	0.0	1	PPP1R13B
Height	2.3	1	1	2.2	1	PPP1R13B
Body fat percentage	2.2	1	0	0.0	1	PPP1R13B
Comparative height size at age 10	2.2	1	0	0.0	1	PPP1R13B
Blood Eosinophil Count	2.1	1	0	0.0	1	PPP1R13B
Weight	2.1	1	0	0.0	1	PPP1R13B
Leg fat percentage (left)	2.0	1	0	0.0	1	PPP1R13B
Hair Pigment	1.9	1	1	2.2	1	PPP1R13B
Trunk fat percentage	1.9	1	0	0.0	1	PPP1R13B
Leg fat-free mass (left)	1.8	1	0	0.0	1	PPP1R13B
Trunk fat mass	1.8	1	0	0.0	1	PPP1R13B
Impedance of arm (right)	1.8	1	0	0.0	1	PPP1R13B
Leg fat-free mass (right)	1.8	1	0	0.0	1	PPP1R13B
Leg predicted mass (left)	1.7	1	0	0.0	1	PPP1R13B
Leg predicted mass (right)	1.7	1	0	0.0	1	PPP1R13B
Leg fat percentage (right)	1.6	1	0	0.0	1	PPP1R13B
Blood Red Count	1.4	1	0	0.0	1	PPP1R13B
Lung FEV1/FVC ratio	1.4	1	0	0.0	1	PPP1R13B
Standing height	1.1	1	0	0.0	1	PPP1R13B
Basal metabolic rate	1.1	1	0	0.0	1	PPP1R13B
Arm fat-free mass (left)	1.1	1	0	0.0	1	PPP1R13B
Arm predicted mass (left)	1.1	1	0	0.0	1	PPP1R13B

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue	1	0.051	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
NTR	Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3