Hub : Traits :

Seen a psychiatrist for nerves, anxiety, tension or depression

9 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 52986978 54492569 2 1 2.3e-08 3.7e-08 0.4100 98 LRP8
2 1 66304567 67908644 1 1 3.9e-07 5.9e-07 0.0211 79 SGIP1
3 5 77597974 79229646 1 1 2.6e-07 1.6e-07 0.0627 87 DMGDH
4 6 25296606 26689223 1 1 3.3e-07 1.6e-08 0.0002 57 U91328.19
5 14 103455349 104859419 2 2 1.2e-07 4.8e-07 0.2330 94 RP11-73M18.6 RP11-73M18.8

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 8.20 2 0 0.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8
Verbal and Numeric Reasoning (VNR) 4.19 4 0 0.0 0.28 0.7201 RP11-73M18.6 RP11-73M18.8 SGIP1 U91328.19
Prostate Cancer 2.17 1 0 0.0 0.00 1.0000 RP11-73M18.6
Bipolar Disorder 3.30 1 0 0.0 0.00 1.0000 RP11-73M18.8
Neuroticism 4.09 2 0 0.0 0.00 1.0000 RP11-73M18.6 SGIP1
Schizophrenia 4.60 3 0 0.0 0.00 1.0000 LRP8 RP11-73M18.6 RP11-73M18.8
Blood Platelet Count 0.80 2 1 3.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8
Blood Red Count 0.64 1 0 0.0 0.00 1.0000 RP11-73M18.8
Blood White Count 3.58 4 2 6.1 -0.95 0.0502 DMGDH RP11-73M18.6 RP11-73M18.8 SGIP1
Heel T-Score 1.18 2 0 0.0 0.00 1.0000 DMGDH RP11-73M18.8
BMI 0.75 1 0 0.0 0.00 1.0000 DMGDH
Height 1.00 2 1 3.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8
Waist Hip Ratio (WHR) 0.64 1 0 0.0 0.00 1.0000 LRP8
Systolic Blood Pressure 2.53 3 1 3.0 0.00 1.0000 LRP8 RP11-73M18.6 SGIP1
Cardiovascular Disease 1.66 1 0 0.0 0.00 1.0000 SGIP1
Hypothyroidism (self reported) 1.53 1 0 0.0 0.00 1.0000 LRP8
Respiratory disease 2.57 1 0 0.0 0.00 1.0000 DMGDH
Type 2 Diabetes (T2D) 1.29 1 0 0.0 0.00 1.0000 DMGDH
Lung FVC 0.63 1 0 0.0 0.00 1.0000 DMGDH
Neuroticism 1.66 1 0 0.0 0.00 1.0000 LRP8
Hair Pigment 0.23 2 0 0.0 0.00 1.0000 RP11-73M18.6 SGIP1
Sensitivity / hurt feelings 3.49 1 1 3.0 0.00 1.0000 LRP8
Frequency of depressed mood in last 2 weeks 4.27 3 0 0.0 0.00 1.0000 LRP8 SGIP1 U91328.19
Other serious medical condition/disability diagnosed by doctor 4.20 2 0 0.0 0.00 1.0000 LRP8 SGIP1
Ever used hormone-replacement therapy (HRT) 1.91 1 0 0.0 0.00 1.0000 RP11-73M18.8
Systolic blood pressure, automated reading 2.95 3 0 0.0 0.00 1.0000 LRP8 SGIP1 U91328.19
Vitamin and mineral supplements 3.62 1 0 0.0 0.00 1.0000 U91328.19
Severe depression (siblings) 5.54 3 0 0.0 0.00 1.0000 DMGDH RP11-73M18.6 SGIP1
Pack years adult smoking proportion 2.55 1 0 0.0 0.00 1.0000 U91328.19
Leg fat-free mass (left) 2.97 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Trunk fat percentage 3.72 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Townsend deprivation index at recruitment 3.66 2 0 0.0 0.00 1.0000 DMGDH RP11-73M18.8
Maternal smoking around birth 3.70 2 0 0.0 0.00 1.0000 RP11-73M18.6 U91328.19
Fed-up feelings 2.41 1 0 0.0 0.00 1.0000 RP11-73M18.8
Frequency of unenthusiasm / disinterest in last 2 weeks 4.39 2 0 0.0 0.00 1.0000 DMGDH U91328.19
Taking other prescription medications 2.57 1 0 0.0 0.00 1.0000 LRP8
Age when periods started (menarche) 1.17 1 0 0.0 0.00 1.0000 DMGDH
Heel bone mineral density (BMD) T-score, automated (left) 2.02 1 0 0.0 0.00 1.0000 U91328.19
Qualifications: CSEs or equivalent 2.00 1 0 0.0 0.00 1.0000 SGIP1
High blood pressure 1.63 2 0 0.0 0.00 1.0000 RP11-73M18.6 SGIP1
Hayfever, allergic rhinitis or eczema 3.59 1 1 3.0 0.00 1.0000 U91328.19
Stomach or abdominal pain in last month 4.85 1 0 0.0 0.00 1.0000 SGIP1
Medication: Atenolol 2.94 1 0 0.0 0.00 1.0000 U91328.19
Medication: Levothyroxine sodium 4.25 1 1 3.0 0.00 1.0000 U91328.19
Sitting height 2.18 3 1 3.0 0.00 1.0000 LRP8 RP11-73M18.8 U91328.19
Body mass index (BMI) 3.23 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Leg predicted mass (left) 2.94 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Trunk fat mass 4.37 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Waist circumference 2.48 2 1 3.0 0.00 1.0000 LRP8 U91328.19
Number of incorrect matches in round 1.96 1 0 0.0 0.00 1.0000 LRP8
Past tobacco smoking 2.01 1 0 0.0 0.00 1.0000 LRP8
Alcohol usually taken with meals 2.70 1 0 0.0 0.00 1.0000 LRP8
Nervous feelings 3.48 2 1 3.0 0.00 1.0000 SGIP1 U91328.19
Frequency of tenseness / restlessness in last 2 weeks 3.38 2 0 0.0 0.00 1.0000 LRP8 SGIP1
Hearing difficulty/problems with background noise 3.89 2 0 0.0 0.00 1.0000 RP11-73M18.8 U91328.19
Forced vital capacity (FVC) 1.13 2 0 0.0 0.00 1.0000 DMGDH U91328.19
Heel bone mineral density (BMD) T-score, automated (right) 2.29 1 0 0.0 0.00 1.0000 U91328.19
Ever unenthusiastic/disinterested for a whole week 3.24 1 0 0.0 0.00 1.0000 RP11-73M18.8
Financial difficulties in last 2 years 3.82 2 0 0.0 0.00 1.0000 LRP8 RP11-73M18.6
Allergy 2.92 1 1 3.0 0.00 1.0000 U91328.19
Hayfever/allergic rhinitis (self-reported) 3.67 1 0 0.0 0.00 1.0000 U91328.19
Fluid intelligence score 4.15 3 0 0.0 0.00 1.0000 LRP8 RP11-73M18.6 RP11-73M18.8
Neuroticism score 3.60 2 0 0.0 0.00 1.0000 LRP8 U91328.19
Weight 4.39 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Impedance of arm (right) 0.83 2 0 0.0 0.00 1.0000 RP11-73M18.8 U91328.19
Arm fat percentage (right) 3.55 4 1 3.0 -0.20 0.7951 DMGDH LRP8 RP11-73M18.6 U91328.19
Trunk fat-free mass 2.62 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Hip circumference 4.80 1 1 3.0 0.00 1.0000 U91328.19
Worrier / anxious feelings 1.85 1 0 0.0 0.00 1.0000 LRP8
Frequency of tiredness / lethargy in last 2 weeks 4.37 1 0 0.0 0.00 1.0000 RP11-73M18.6
Forced expiratory volume in 1-second (FEV1) 1.60 1 0 0.0 0.00 1.0000 U91328.19
Qualifications: A levels/AS levels or equivalent 3.17 2 0 0.0 0.00 1.0000 RP11-73M18.8 U91328.19
Mouth/teeth dental problems: Dentures 6.56 1 1 3.0 0.00 1.0000 U91328.19
Asthma 1.46 1 0 0.0 0.00 1.0000 DMGDH
Prospective memory result 1.97 1 0 0.0 0.00 1.0000 LRP8
Lung cancer (father) 3.08 1 0 0.0 0.00 1.0000 U91328.19
Forced expiratory volume in 1-second (FEV1), Best measure 1.13 1 0 0.0 0.00 1.0000 U91328.19
Impedance of arm (left) 0.76 1 0 0.0 0.00 1.0000 U91328.19
Arm fat mass (right) 3.94 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Trunk predicted mass 2.61 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Standing height 1.63 3 2 6.1 0.00 1.0000 RP11-73M18.6 RP11-73M18.8 U91328.19
Tense / 'highly strung' 4.47 3 0 0.0 0.00 1.0000 LRP8 SGIP1 U91328.19
Seen doctor (GP) for nerves, anxiety, tension or depression 11.90 4 1 3.0 0.95 0.0461 DMGDH RP11-73M18.6 RP11-73M18.8 SGIP1
Birth weight of first child 1.31 1 0 0.0 0.00 1.0000 DMGDH
Peak expiratory flow (PEF) 1.68 2 0 0.0 0.00 1.0000 DMGDH U91328.19
Ever highly irritable/argumentative for 2 days 2.86 1 0 0.0 0.00 1.0000 RP11-73M18.6
Headache pain in last month 4.15 2 0 0.0 0.00 1.0000 LRP8 U91328.19
Hypothyroidism/myxoedema (self-reported) 4.46 2 1 3.0 0.00 1.0000 LRP8 U91328.19
Forced vital capacity (FVC), Best measure 0.79 1 0 0.0 0.00 1.0000 U91328.19
Body fat percentage 3.90 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Leg fat percentage (right) 4.00 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Arm fat-free mass (right) 3.49 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Comparative body size at age 10 1.50 1 0 0.0 0.00 1.0000 U91328.19
Worry too long after embarrassment 2.23 1 0 0.0 0.00 1.0000 LRP8
Wheeze or whistling in the chest in last year 1.85 1 0 0.0 0.00 1.0000 DMGDH
Age at first live birth 3.12 2 0 0.0 0.00 1.0000 LRP8 U91328.19
Shortness of breath walking on level ground 3.63 2 0 0.0 0.00 1.0000 DMGDH SGIP1
Qualifications: College or University degree 4.31 4 1 3.0 0.95 0.0460 LRP8 RP11-73M18.6 RP11-73M18.8 U91328.19
Mouth/teeth dental problems: Loose teeth 1.78 1 0 0.0 0.00 1.0000 SGIP1
Whole body fat mass 4.35 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Leg fat mass (right) 4.86 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Arm predicted mass (right) 3.51 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Pulse rate, automated reading 1.07 1 0 0.0 0.00 1.0000 SGIP1
Alcohol intake frequency. 1.84 1 0 0.0 0.00 1.0000 SGIP1
Comparative height size at age 10 1.49 3 1 3.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8 U91328.19
Suffer from 'nerves' 1.72 1 0 0.0 0.00 1.0000 LRP8
Overall health rating 1.71 1 0 0.0 0.00 1.0000 SGIP1
Had major operations 2.21 1 0 0.0 0.00 1.0000 SGIP1
Age at last live birth 3.45 2 0 0.0 0.00 1.0000 LRP8 U91328.19
Supplements: Vitamin C 2.77 1 0 0.0 0.00 1.0000 U91328.19
Hypertension (Self-reported) 1.42 1 0 0.0 0.00 1.0000 RP11-73M18.6
Smoking status: Previous 1.95 1 0 0.0 0.00 1.0000 LRP8
Forced expiratory volume in 1-second (FEV1), predicted 1.27 1 0 0.0 0.00 1.0000 U91328.19
Whole body fat-free mass 2.86 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Leg fat-free mass (right) 2.65 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Arm fat percentage (left) 3.31 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Mood swings 2.41 2 0 0.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8
Loneliness, isolation 2.61 1 0 0.0 0.00 1.0000 U91328.19
Long-standing illness, disability or infirmity 5.75 4 0 0.0 1.00 0.0023 DMGDH RP11-73M18.6 RP11-73M18.8 SGIP1
Back pain experienced in last month 3.17 1 0 0.0 0.00 1.0000 DMGDH
Mineral and other dietary supplements 1.73 1 0 0.0 0.00 1.0000 U91328.19
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.32 1 1 3.0 0.00 1.0000 U91328.19
Whole body water mass 2.81 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Leg predicted mass (right) 2.63 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Arm fat mass (left) 3.74 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Average weekly champagne plus white wine intake 3.14 1 0 0.0 0.00 1.0000 LRP8
Guilty feelings 3.19 2 0 0.0 0.00 1.0000 SGIP1 U91328.19
Mother's age at death 2.25 1 0 0.0 0.00 1.0000 LRP8
Tinnitus: Yes, now most or all of the time 2.11 1 0 0.0 0.00 1.0000 DMGDH
Supplements: Fish oil (including cod liver oil) 1.94 1 0 0.0 0.00 1.0000 U91328.19
Medication: Atorvastatin 1.84 1 0 0.0 0.00 1.0000 U91328.19
Ever smoked 2.47 1 0 0.0 0.00 1.0000 LRP8
Basal metabolic rate 3.17 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Leg fat percentage (left) 3.86 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Arm fat-free mass (left) 3.11 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19
Irritability 4.78 3 0 0.0 0.00 1.0000 LRP8 RP11-73M18.6 RP11-73M18.8
Risk taking 3.71 2 0 0.0 0.00 1.0000 RP11-73M18.6 U91328.19
Ever depressed for a whole week 5.41 3 0 0.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8 SGIP1
Unable to work because of sickness or disability 2.45 1 0 0.0 0.00 1.0000 SGIP1
Vascular/heart problems diagnosed by doctor 1.77 1 0 0.0 0.00 1.0000 RP11-73M18.6
Pain experienced in last month 2.79 1 0 0.0 0.00 1.0000 RP11-73M18.6
Heart disease (siblings) 2.13 1 0 0.0 0.00 1.0000 RP11-73M18.6
Alcohol drinker status: Previous 5.62 3 0 0.0 0.00 1.0000 RP11-73M18.6 RP11-73M18.8 SGIP1
Pack years of smoking 2.39 1 0 0.0 0.00 1.0000 U91328.19
Impedance of whole body 0.62 1 0 0.0 0.00 1.0000 U91328.19
Leg fat mass (left) 4.92 2 1 3.0 0.00 1.0000 DMGDH U91328.19
Arm predicted mass (left) 3.23 2 1 3.0 0.00 1.0000 RP11-73M18.8 U91328.19

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.30
GTEx Adipose Visceral Omentum 0 0.0000 1.30
GTEx Adrenal Gland 0 0.0000 1.30
GTEx Artery Aorta 0 0.0000 1.27
GTEx Artery Coronary 0 0.0000 1.27
GTEx Artery Tibial 0 0.0000 1.30
GTEx Brain Caudate basal ganglia 0 0.0000 1.35
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.30
GTEx Brain Cerebellum 0 0.0000 1.26
GTEx Brain Cortex 0 0.0000 1.44
GTEx Brain Frontal Cortex BA9 0 0.0000 1.32
GTEx Brain Hippocampus 0 0.0000 1.39
GTEx Brain Hypothalamus 0 0.0000 1.29
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.29
GTEx Brain Putamen basal ganglia 0 0.0000 1.35
GTEx Breast Mammary Tissue 0 0.0000 1.34
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.28
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.38
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.38
GTEx Cells Transformed fibroblasts 0 0.0000 1.32
GTEx Colon Sigmoid 0 0.0000 1.31
GTEx Colon Transverse 0 0.0000 1.34
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.32
GTEx Esophagus Mucosa 0 0.0000 1.34
GTEx Esophagus Muscularis 0 0.0000 1.31
GTEx Heart Atrial Appendage 1 0.0633 1.29
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 0 0.0000 1.15
GTEx Lung 0 0.0000 1.35
GTEx Muscle Skeletal 1 0.0346 1.28
GTEx Nerve Tibial 1 0.0231 1.29
GTEx Ovary 1 0.1101 1.44
GTEx Pancreas 0 0.0000 1.30
GTEx Pituitary 0 0.0000 1.30
GTEx Prostate 0 0.0000 1.27
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.36
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.36
GTEx Small Intestine Terminal Ileum 0 0.0000 1.41
GTEx Spleen 0 0.0000 1.33
GTEx Stomach 0 0.0000 1.30
GTEx Testis 0 0.0000 1.33
GTEx Thyroid 0 0.0000 1.32
GTEx Uterus 0 0.0000 1.38
GTEx Vagina 0 0.0000 1.33
GTEx Whole Blood 1 0.0502 1.29
METSIM Adipose 0 0.0000 1.28
NTR Blood 0 0.0000 1.37
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.33
YFS Blood 0 0.0000 1.31
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.32
TCGA Breast Tumor 0 0.0000 1.18
TCGA Breast Normal 0 0.0000 1.18
TCGA Ovarian Tumor 0 0.0000 1.22
TCGA Prostate Tumor 0 0.0000 1.30