Hub : Traits :

Ever depressed for a whole week

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 20 47031920 48503461 1 1 2.7e-07 5.6e-06 0.021 74 STAU1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 4.70 1 0 0 0 1 STAU1
Crohns Disease (2017) 4.54 1 0 0 0 1 STAU1
Major Depression (MDD) 6.28 1 0 0 0 1 STAU1
Reaction Time 8.67 1 0 0 0 1 STAU1
Verbal and Numeric Reasoning (VNR) 13.22 1 1 3 0 1 STAU1
Ovarian Cancer 4.84 1 0 0 0 1 STAU1
Bipolar Disorder 5.11 1 0 0 0 1 STAU1
Crohns Disease (2012) 2.75 1 0 0 0 1 STAU1
HDL Cholesterol 3.09 1 0 0 0 1 STAU1
Rheumatoid Arthritis 3.05 1 0 0 0 1 STAU1
Blood Platelet Count 0.40 1 0 0 0 1 STAU1
BMI 5.79 1 1 3 0 1 STAU1
Height 2.10 1 1 3 0 1 STAU1
Systolic Blood Pressure 1.07 1 0 0 0 1 STAU1
Allergy or Eczema 1.52 1 0 0 0 1 STAU1
Cardiovascular Disease 3.70 1 0 0 0 1 STAU1
Hypothyroidism (self reported) 2.76 1 0 0 0 1 STAU1
Lung FVC 2.52 1 0 0 0 1 STAU1
Hand grip strength (left) 2.16 1 0 0 0 1 STAU1
Frequency of depressed mood in last 2 weeks 4.72 1 0 0 0 1 STAU1
Diabetes (father) 3.69 1 0 0 0 1 STAU1
Pack years adult smoking proportion 3.04 1 0 0 0 1 STAU1
Trunk fat percentage 5.30 1 0 0 0 1 STAU1
Hand grip strength (right) 3.60 1 0 0 0 1 STAU1
Average weekly fortified wine intake 4.65 1 0 0 0 1 STAU1
Frequency of unenthusiasm / disinterest in last 2 weeks 5.22 1 0 0 0 1 STAU1
Serious illness, injury or assault to yourself 4.73 1 0 0 0 1 STAU1
Sitting height 2.42 1 0 0 0 1 STAU1
Body mass index (BMI) 5.06 1 0 0 0 1 STAU1
Trunk fat mass 3.63 1 0 0 0 1 STAU1
Waist circumference 1.45 1 0 0 0 1 STAU1
Forced vital capacity (FVC) 3.84 1 0 0 0 1 STAU1
Ever unenthusiastic/disinterested for a whole week 13.38 1 0 0 0 1 STAU1
Qualifications: None of the above 3.62 1 0 0 0 1 STAU1
Mouth/teeth dental problems 4.82 1 0 0 0 1 STAU1
Fluid intelligence score 5.79 1 0 0 0 1 STAU1
Weight 0.92 1 0 0 0 1 STAU1
Arm fat percentage (right) 6.35 1 1 3 0 1 STAU1
Time employed in main current job 5.19 1 0 0 0 1 STAU1
Father's age at death 3.62 1 0 0 0 1 STAU1
Frequency of tiredness / lethargy in last 2 weeks 5.18 1 0 0 0 1 STAU1
Hair/balding pattern: Pattern 3 3.21 1 0 0 0 1 STAU1
Forced expiratory volume in 1-second (FEV1) 3.46 1 0 0 0 1 STAU1
Qualifications: A levels/AS levels or equivalent 3.64 1 0 0 0 1 STAU1
Forced expiratory volume in 1-second (FEV1), Best measure 4.23 1 0 0 0 1 STAU1
Arm fat mass (right) 3.68 1 0 0 0 1 STAU1
Standing height 2.80 1 1 3 0 1 STAU1
Tense / 'highly strung' 3.65 1 0 0 0 1 STAU1
Pulse wave reflection index 3.34 1 0 0 0 1 STAU1
Mouth/teeth dental problems: Bleeding gums 7.18 1 0 0 0 1 STAU1
Medication: Paracetamol 2.72 1 0 0 0 1 STAU1
Medication: Ventolin 100micrograms inhaler 3.07 1 0 0 0 1 STAU1
Forced vital capacity (FVC), Best measure 5.88 1 0 0 0 1 STAU1
Body fat percentage 6.42 1 1 3 0 1 STAU1
Leg fat percentage (right) 8.44 1 1 3 0 1 STAU1
Comparative body size at age 10 1.73 1 0 0 0 1 STAU1
Wheeze or whistling in the chest in last year 3.96 1 0 0 0 1 STAU1
Number of children fathered 7.31 1 0 0 0 1 STAU1
Qualifications: College or University degree 7.38 1 0 0 0 1 STAU1
Medication: Ibuprofen 3.23 1 0 0 0 1 STAU1
Mean time to correctly identify matches 8.50 1 0 0 0 1 STAU1
Whole body fat mass 4.26 1 0 0 0 1 STAU1
Leg fat mass (right) 4.98 1 0 0 0 1 STAU1
Comparative height size at age 10 1.84 1 0 0 0 1 STAU1
Knee pain experienced in last month 5.53 1 0 0 0 1 STAU1
Hypertension (Self-reported) 1.62 1 0 0 0 1 STAU1
Arm fat percentage (left) 6.32 1 1 3 0 1 STAU1
Handedness (chirality/laterality): Left-handed 3.77 1 0 0 0 1 STAU1
Friendships satisfaction 5.25 1 0 0 0 1 STAU1
Qualifications: nursing, teaching 3.70 1 0 0 0 1 STAU1
Smoking status: Current 3.06 1 0 0 0 1 STAU1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.63 1 0 0 0 1 STAU1
Arm fat mass (left) 4.08 1 0 0 0 1 STAU1
Mother's age at death 3.20 1 0 0 0 1 STAU1
High cholesterol (Self-reported) 4.16 1 0 0 0 1 STAU1
Medication: Paracetamol 4.82 1 0 0 0 1 STAU1
Leg fat percentage (left) 8.69 1 1 3 0 1 STAU1
Commuting to job workplace: Cycle 3.22 1 0 0 0 1 STAU1
Pain experienced in last month 3.11 1 0 0 0 1 STAU1
Leg fat mass (left) 5.30 1 0 0 0 1 STAU1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.26
GTEx Adipose Visceral Omentum 0 0.0000 1.32
GTEx Adrenal Gland 0 0.0000 1.25
GTEx Artery Aorta 0 0.0000 1.26
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 0 0.0000 1.23
GTEx Brain Caudate basal ganglia 0 0.0000 1.24
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.29
GTEx Brain Cerebellum 0 0.0000 1.27
GTEx Brain Cortex 0 0.0000 1.34
GTEx Brain Frontal Cortex BA9 0 0.0000 1.36
GTEx Brain Hippocampus 0 0.0000 1.37
GTEx Brain Hypothalamus 0 0.0000 1.33
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.33
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 0 0.0000 1.29
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.24
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.28
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.32
GTEx Cells Transformed fibroblasts 0 0.0000 1.25
GTEx Colon Sigmoid 0 0.0000 1.32
GTEx Colon Transverse 0 0.0000 1.34
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 0 0.0000 1.26
GTEx Esophagus Muscularis 0 0.0000 1.30
GTEx Heart Atrial Appendage 0 0.0000 1.32
GTEx Heart Left Ventricle 0 0.0000 1.27
GTEx Liver 0 0.0000 1.30
GTEx Lung 0 0.0000 1.25
GTEx Muscle Skeletal 0 0.0000 1.26
GTEx Nerve Tibial 0 0.0000 1.21
GTEx Ovary 0 0.0000 1.43
GTEx Pancreas 0 0.0000 1.27
GTEx Pituitary 0 0.0000 1.32
GTEx Prostate 0 0.0000 1.37
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.27
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.25
GTEx Small Intestine Terminal Ileum 0 0.0000 1.32
GTEx Spleen 0 0.0000 1.39
GTEx Stomach 0 0.0000 1.23
GTEx Testis 0 0.0000 1.27
GTEx Thyroid 0 0.0000 1.27
GTEx Uterus 0 0.0000 1.42
GTEx Vagina 0 0.0000 1.41
GTEx Whole Blood 0 0.0000 1.20
METSIM Adipose 0 0.0000 1.18
NTR Blood 0 0.0000 1.16
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 0 0.0000 1.17
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.21
TCGA Breast Tumor 0 0.0000 1.30
TCGA Breast Normal 0 0.0000 1.16
TCGA Ovarian Tumor 0 0.0000 1.16
TCGA Prostate Tumor 0 0.0000 1.19