Hub : Traits :

Mean Putamen Volume

5 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 82285156 86036955 3 1 3.6e-08 2.9e-08 1 100 AP003026.1
2 20 29833609 30922399 1 1 8.1e-08 2.4e-09 1 100 COX4I2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.75 1 0 0 0 1 AP003026.1
Reaction Time 2.51 1 0 0 0 1 AP003026.1
Bipolar Disorder 4.08 1 0 0 0 1 AP003026.1
Schizophrenia 1.95 1 0 0 0 1 AP003026.1
Type 2 Diabetes (T2D) 3.49 1 0 0 0 1 AP003026.1
Blood Eosinophil Count 1.30 1 0 0 0 1 COX4I2
Blood Platelet Count 9.22 2 1 3 0 1 AP003026.1 COX4I2
Blood Red Count 4.05 1 1 3 0 1 COX4I2
Blood White Count 0.68 1 0 0 0 1 AP003026.1
Heel T-Score 2.08 2 0 0 0 1 AP003026.1 COX4I2
Height 1.19 1 1 3 0 1 COX4I2
Systolic Blood Pressure 1.51 1 0 0 0 1 COX4I2
Smoking Status 2.04 1 0 0 0 1 COX4I2
Cardiovascular Disease 3.09 1 0 0 0 1 COX4I2
Respiratory disease 3.23 2 0 0 0 1 AP003026.1 COX4I2
Lung FVC 5.15 1 1 3 0 1 COX4I2
Neuroticism 3.23 1 0 0 0 1 AP003026.1
Hair Pigment 0.59 1 1 3 0 1 COX4I2
Frequency of depressed mood in last 2 weeks 3.23 1 0 0 0 1 AP003026.1
Hearing difficulty/problems: Yes 2.64 1 0 0 0 1 COX4I2
Ever used hormone-replacement therapy (HRT) 3.44 1 0 0 0 1 COX4I2
Fed-up feelings 4.73 1 0 0 0 1 AP003026.1
Taking other prescription medications 3.81 1 0 0 0 1 AP003026.1
High blood pressure 3.22 2 0 0 0 1 AP003026.1 COX4I2
Sitting height 6.19 1 1 3 0 1 COX4I2
Number of incorrect matches in round 3.09 1 0 0 0 1 AP003026.1
Frequency of tenseness / restlessness in last 2 weeks 2.76 1 0 0 0 1 AP003026.1
Mouth/teeth dental problems 3.07 1 0 0 0 1 AP003026.1
Illnesses of siblings 2.83 1 0 0 0 1 AP003026.1
Neuroticism score 3.08 1 0 0 0 1 AP003026.1
Worrier / anxious feelings 2.44 1 0 0 0 1 AP003026.1
Mouth/teeth dental problems: Dentures 2.80 1 0 0 0 1 COX4I2
Asthma 3.36 1 0 0 0 1 COX4I2
Standing height 1.51 1 1 3 0 1 COX4I2
Birth weight of first child 2.68 1 0 0 0 1 AP003026.1
Medication: Paracetamol 2.17 1 0 0 0 1 COX4I2
Gout (self-reported) 4.24 1 0 0 0 1 COX4I2
Medication: Ventolin 100micrograms inhaler 3.78 1 0 0 0 1 COX4I2
Wheeze or whistling in the chest in last year 4.93 2 0 0 0 1 AP003026.1 COX4I2
Health satisfaction 5.30 1 0 0 0 1 AP003026.1
Shortness of breath walking on level ground 4.11 1 0 0 0 1 AP003026.1
Medication for pain relief, constipation, heartburn 2.85 1 0 0 0 1 COX4I2
Medication: Blood pressure 2.75 1 0 0 0 1 COX4I2
Medication: Omeprazole 3.53 1 0 0 0 1 AP003026.1
Overall health rating 4.51 1 0 0 0 1 AP003026.1
Commuting to job workplace: Car/motor vehicle 4.99 1 0 0 0 1 COX4I2
Hypertension (Self-reported) 3.27 2 0 0 0 1 AP003026.1 COX4I2
Mood swings 3.30 1 0 0 0 1 AP003026.1
Loneliness, isolation 6.43 2 0 0 0 1 AP003026.1 COX4I2
Long-standing illness, disability or infirmity 9.88 1 1 3 0 1 AP003026.1
Back pain experienced in last month 5.08 1 0 0 0 1 COX4I2
Asthma (self-reported) 3.06 1 0 0 0 1 COX4I2
Medication: Gliclazide 3.26 1 0 0 0 1 COX4I2
Illnesses of father: None of the above (group 1) 7.91 2 0 0 0 1 AP003026.1 COX4I2
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.75 1 0 0 0 1 COX4I2
Number of self-reported non-cancer illnesses 2.17 1 0 0 0 1 AP003026.1
Mother's age at death 4.06 1 0 0 0 1 AP003026.1
Commuting to job workplace: Public transport 9.71 1 0 0 0 1 COX4I2
Pain type(s) experienced in last month: Hip pain 3.73 1 0 0 0 1 AP003026.1
High cholesterol (Self-reported) 2.45 1 0 0 0 1 COX4I2
Diastolic blood pressure, automated reading 3.33 2 0 0 0 1 AP003026.1 COX4I2
Unable to work because of sickness or disability 5.60 1 0 0 0 1 AP003026.1
Vascular/heart problems diagnosed by doctor 3.49 2 0 0 0 1 AP003026.1 COX4I2
Medication: Omeprazole (e.g. Zanprol) 3.33 1 0 0 0 1 AP003026.1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.15
GTEx Adipose Visceral Omentum 0 0.0000 1.16
GTEx Adrenal Gland 0 0.0000 1.17
GTEx Artery Aorta 0 0.0000 1.13
GTEx Artery Coronary 0 0.0000 1.14
GTEx Artery Tibial 0 0.0000 1.13
GTEx Brain Caudate basal ganglia 0 0.0000 1.12
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.26
GTEx Brain Cerebellum 0 0.0000 1.17
GTEx Brain Cortex 0 0.0000 1.13
GTEx Brain Frontal Cortex BA9 0 0.0000 1.11
GTEx Brain Hippocampus 0 0.0000 1.21
GTEx Brain Hypothalamus 0 0.0000 1.24
GTEx Brain Nucleus accumbens basal ganglia 1 0.1160 1.36
GTEx Brain Putamen basal ganglia 0 0.0000 1.12
GTEx Breast Mammary Tissue 0 0.0000 1.26
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.19
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.22
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.16
GTEx Cells Transformed fibroblasts 0 0.0000 1.18
GTEx Colon Sigmoid 0 0.0000 1.18
GTEx Colon Transverse 0 0.0000 1.20
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.24
GTEx Esophagus Mucosa 0 0.0000 1.20
GTEx Esophagus Muscularis 0 0.0000 1.16
GTEx Heart Atrial Appendage 0 0.0000 1.16
GTEx Heart Left Ventricle 1 0.0659 1.18
GTEx Liver 0 0.0000 1.20
GTEx Lung 0 0.0000 1.18
GTEx Muscle Skeletal 0 0.0000 1.17
GTEx Nerve Tibial 0 0.0000 1.14
GTEx Ovary 0 0.0000 1.19
GTEx Pancreas 0 0.0000 1.21
GTEx Pituitary 0 0.0000 1.16
GTEx Prostate 0 0.0000 1.22
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.24
GTEx Skin Sun Exposed Lower leg 2 0.0555 1.19
GTEx Small Intestine Terminal Ileum 0 0.0000 1.24
GTEx Spleen 0 0.0000 1.20
GTEx Stomach 0 0.0000 1.27
GTEx Testis 0 0.0000 1.13
GTEx Thyroid 0 0.0000 1.17
GTEx Uterus 0 0.0000 1.31
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.20
METSIM Adipose 0 0.0000 1.11
NTR Blood 0 0.0000 1.14
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.12
YFS Blood 0 0.0000 1.12
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.10
TCGA Breast Tumor 0 0.0000 1.18
TCGA Breast Normal 0 0.0000 1.12
TCGA Ovarian Tumor 1 0.0344 1.12
TCGA Prostate Tumor 0 0.0000 1.13