Hub : Traits :

Illnesses of father: None of the above (group 1)

10 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 21303958 22705094 1 1 7.7e-08 2.0e-13 2.2e-07 50 CDKN2B
2 15 90730363 92135418 1 1 5.7e-11 3.9e-10 3.8e-01 98 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.85 1 0 0.0 0 1 FES
Irritable Bowel Disease (IBD) 2.68 1 0 0.0 0 1 FES
Major Depression (MDD) 8.39 1 0 0.0 0 1 FES
Reaction Time 2.63 1 0 0.0 0 1 FES
Breast Cancer 9.16 2 0 0.0 0 1 CDKN2B FES
Ovarian Cancer 3.27 1 0 0.0 0 1 FES
Coronary Artery Disease (CAD) 40.78 2 1 3.0 0 1 CDKN2B FES
Primary Biliary Cirrhosis 3.71 1 0 0.0 0 1 CDKN2B
Schizophrenia 9.68 1 1 3.0 0 1 FES
Type 2 Diabetes (T2D) 7.40 1 0 0.0 0 1 CDKN2B
Ulcerative Colitis 2.84 1 0 0.0 0 1 FES
Blood Eosinophil Count 0.61 1 0 0.0 0 1 CDKN2B
Blood Platelet Count 1.05 1 0 0.0 0 1 CDKN2B
Blood Red Count 1.12 2 0 0.0 0 1 CDKN2B FES
Blood White Count 4.72 2 1 3.0 0 1 CDKN2B FES
Height 0.74 1 1 3.0 0 1 FES
Systolic Blood Pressure 30.98 1 1 3.0 0 1 FES
Smoking Status 4.55 1 0 0.0 0 1 FES
Allergy or Eczema 3.60 1 0 0.0 0 1 FES
Cardiovascular Disease 22.34 1 1 3.0 0 1 FES
Respiratory disease 4.82 1 0 0.0 0 1 FES
Type 2 Diabetes (T2D) 2.86 1 0 0.0 0 1 CDKN2B
Neuroticism 2.22 1 0 0.0 0 1 FES
Hair Pigment 1.89 2 2 6.1 0 1 CDKN2B FES
Hand grip strength (left) 3.56 1 0 0.0 0 1 FES
Number of treatments/medications taken 4.06 1 0 0.0 0 1 FES
Sensitivity / hurt feelings 5.60 1 0 0.0 0 1 FES
Systolic blood pressure, automated reading 22.76 1 1 3.0 0 1 FES
Angina 51.55 2 2 6.1 0 1 CDKN2B FES
Medication: Metformin 4.85 1 0 0.0 0 1 CDKN2B
Severe depression (siblings) 4.52 1 0 0.0 0 1 FES
Impedance of leg (right) 3.69 1 1 3.0 0 1 FES
Leg fat-free mass (left) 1.67 1 0 0.0 0 1 FES
High blood pressure 25.15 1 1 3.0 0 1 FES
Hayfever, allergic rhinitis or eczema 3.33 1 0 0.0 0 1 FES
Medication: Atenolol 21.11 2 1 3.0 0 1 CDKN2B FES
Sitting height 0.59 1 0 0.0 0 1 FES
High blood pressure (mother) 26.71 1 1 3.0 0 1 FES
Impedance of leg (left) 3.49 1 1 3.0 0 1 FES
Leg predicted mass (left) 1.60 1 0 0.0 0 1 FES
Number of incorrect matches in round 4.56 1 0 0.0 0 1 FES
Past tobacco smoking 4.06 1 0 0.0 0 1 FES
Alcohol usually taken with meals 4.65 1 0 0.0 0 1 FES
Mouth/teeth dental problems 3.50 1 0 0.0 0 1 CDKN2B
Heart attack 35.38 2 2 6.1 0 1 CDKN2B FES
Allergy 4.73 1 0 0.0 0 1 FES
Medication: Ramipril 9.36 1 0 0.0 0 1 FES
Medication: Simvastatin 14.37 2 1 3.0 0 1 CDKN2B FES
Illnesses of siblings 8.03 1 0 0.0 0 1 FES
Impedance of arm (right) 1.19 1 0 0.0 0 1 CDKN2B
Trunk fat-free mass 0.96 1 0 0.0 0 1 FES
Father's age at death 16.91 2 1 3.0 0 1 CDKN2B FES
Number of live births 3.76 1 0 0.0 0 1 FES
Mouth/teeth dental problems: Dentures 3.29 1 0 0.0 0 1 CDKN2B
Asthma 3.38 1 0 0.0 0 1 FES
Medication: Cholesterol lowering 18.67 2 1 3.0 0 1 CDKN2B FES
Lung cancer (father) 5.12 1 0 0.0 0 1 FES
Illnesses of mother 20.02 2 1 3.0 0 1 CDKN2B FES
Pulse wave Arterial Stiffness index 8.82 2 0 0.0 0 1 CDKN2B FES
Trunk predicted mass 0.94 1 0 0.0 0 1 FES
Breastfed as a baby 5.02 1 0 0.0 0 1 FES
Hair/balding pattern: Pattern 4 3.82 1 0 0.0 0 1 FES
Birth weight of first child 14.62 1 1 3.0 0 1 FES
Headache pain in last month 3.78 1 0 0.0 0 1 FES
Medication for cholesterol, blood pressure or diabetes 22.75 1 1 3.0 0 1 FES
Glaucoma (self-reported) 20.18 1 1 3.0 0 1 CDKN2B
Medication: Amlodipine 11.15 1 1 3.0 0 1 FES
Birth weight 8.82 1 1 3.0 0 1 FES
High blood pressure (siblings) 11.64 1 1 3.0 0 1 FES
Pulse wave peak to peak time 9.23 2 0 0.0 0 1 CDKN2B FES
Medication: Blood pressure 22.32 1 1 3.0 0 1 FES
Angina (self-reported) 51.34 2 2 6.1 0 1 CDKN2B FES
Mean time to correctly identify matches 3.83 1 0 0.0 0 1 FES
Heart disease (mother) 20.36 2 1 3.0 0 1 CDKN2B FES
Comparative height size at age 10 1.34 1 0 0.0 0 1 FES
Chest pain or discomfort 5.04 1 0 0.0 0 1 CDKN2B
Medication: Aspirin 26.68 2 2 6.1 0 1 CDKN2B FES
Hypertension (Self-reported) 25.36 1 1 3.0 0 1 FES
Illnesses of father: Heart disease 49.33 2 2 6.1 0 1 CDKN2B FES
Whole body fat-free mass 1.17 1 0 0.0 0 1 FES
Leg fat-free mass (right) 1.88 1 0 0.0 0 1 FES
Handedness (chirality/laterality): Left-handed 5.23 1 0 0.0 0 1 FES
Long-standing illness, disability or infirmity 4.85 1 0 0.0 0 1 CDKN2B
Medication for cholesterol 8.74 2 0 0.0 0 1 CDKN2B FES
Breast cancer (self-reported) 5.53 1 0 0.0 0 1 CDKN2B
Asthma (self-reported) 3.48 1 0 0.0 0 1 FES
Medication: Aspirin 27.08 2 2 6.1 0 1 CDKN2B FES
Medication: Gliclazide 5.12 1 0 0.0 0 1 CDKN2B
Whole body water mass 1.18 1 0 0.0 0 1 FES
Leg predicted mass (right) 1.94 1 0 0.0 0 1 FES
Eye problems/disorders: Glaucoma 27.71 1 1 3.0 0 1 CDKN2B
Medication: Blood pressure 18.95 1 1 3.0 0 1 FES
High cholesterol (Self-reported) 6.00 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 8.71 1 1 3.0 0 1 FES
Medication: Lisinopril 5.18 1 0 0.0 0 1 FES
Medication: Atorvastatin 13.93 2 1 3.0 0 1 CDKN2B FES
Illnesses of father: High blood pressure 20.07 1 1 3.0 0 1 FES
Ever smoked 3.55 1 0 0.0 0 1 FES
Basal metabolic rate 1.03 1 0 0.0 0 1 FES
Number of operations (self-reported) 4.15 1 0 0.0 0 1 CDKN2B
Risk taking 4.24 1 0 0.0 0 1 FES
Age started oral contraceptive pill 4.21 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 18.72 2 1 3.0 0 1 CDKN2B FES
Vascular/heart problems diagnosed by doctor 30.68 2 1 3.0 0 1 CDKN2B FES
Cholesterol lowering medication 4.95 1 0 0.0 0 1 CDKN2B
Basal cell carcinoma (self-reported) 9.93 1 0 0.0 0 1 CDKN2B
Heart attack/myocardial infarction (self-reported) 36.01 2 2 6.1 0 1 CDKN2B FES
Heart disease (siblings) 12.87 2 0 0.0 0 1 CDKN2B FES
Impedance of whole body 1.58 1 0 0.0 0 1 FES

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.23
GTEx Adipose Visceral Omentum 1 0.0491 1.27
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 0 0.0000 1.22
GTEx Artery Coronary 0 0.0000 1.24
GTEx Artery Tibial 1 0.0266 1.27
GTEx Brain Caudate basal ganglia 0 0.0000 1.26
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.29
GTEx Brain Cerebellum 0 0.0000 1.22
GTEx Brain Cortex 0 0.0000 1.25
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.38
GTEx Brain Hypothalamus 0 0.0000 1.19
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.25
GTEx Brain Putamen basal ganglia 0 0.0000 1.39
GTEx Breast Mammary Tissue 0 0.0000 1.19
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.25
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.23
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.36
GTEx Cells Transformed fibroblasts 1 0.0238 1.25
GTEx Colon Sigmoid 0 0.0000 1.27
GTEx Colon Transverse 0 0.0000 1.27
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 0 0.0000 1.23
GTEx Esophagus Muscularis 0 0.0000 1.22
GTEx Heart Atrial Appendage 0 0.0000 1.24
GTEx Heart Left Ventricle 0 0.0000 1.25
GTEx Liver 0 0.0000 1.21
GTEx Lung 1 0.0348 1.23
GTEx Muscle Skeletal 0 0.0000 1.28
GTEx Nerve Tibial 0 0.0000 1.20
GTEx Ovary 0 0.0000 1.26
GTEx Pancreas 0 0.0000 1.25
GTEx Pituitary 0 0.0000 1.25
GTEx Prostate 0 0.0000 1.37
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.22
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.24
GTEx Small Intestine Terminal Ileum 0 0.0000 1.26
GTEx Spleen 0 0.0000 1.21
GTEx Stomach 0 0.0000 1.27
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 1 0.0250 1.28
GTEx Uterus 0 0.0000 1.33
GTEx Vagina 0 0.0000 1.18
GTEx Whole Blood 0 0.0000 1.24
METSIM Adipose 1 0.0217 1.19
NTR Blood 0 0.0000 1.21
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.22
YFS Blood 0 0.0000 1.23
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.19
TCGA Breast Tumor 0 0.0000 1.26
TCGA Breast Normal 1 0.0238 1.20
TCGA Ovarian Tumor 1 0.0342 1.24
TCGA Prostate Tumor 1 0.0289 1.21