Hub : Traits :

Vitamin and mineral supplements

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 56838745 58303535 1 1 7.7e-08 2.1e-08 0.059 89 LRP1
2 15 63687200 65137171 1 1 6.2e-08 2.0e-07 1.000 100 SNX1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 2.19 1 0 0 0 1 SNX1
Breast Cancer 4.28 1 0 0 0 1 SNX1
Primary Biliary Cirrhosis 5.89 1 0 0 0 1 LRP1
Schizophrenia 2.36 1 0 0 0 1 LRP1
Blood Eosinophil Count 2.13 1 1 3 0 1 LRP1
Blood Platelet Count 0.42 1 0 0 0 1 LRP1
Blood White Count 2.44 1 1 3 0 1 SNX1
Heel T-Score 0.42 1 0 0 0 1 LRP1
BMI 1.86 1 0 0 0 1 LRP1
Height 1.31 2 1 3 0 1 LRP1 SNX1
Allergy or Eczema 3.68 1 0 0 0 1 LRP1
Hypothyroidism (self reported) 1.62 1 0 0 0 1 SNX1
Respiratory disease 7.96 1 1 3 0 1 LRP1
Lung FEV1/FVC ratio 12.87 1 1 3 0 1 LRP1
Neuroticism 2.09 1 0 0 0 1 LRP1
Chronotype (morning person) 1.34 1 0 0 0 1 SNX1
Hair Pigment 0.52 2 0 0 0 1 LRP1 SNX1
Number of treatments/medications taken 5.82 1 0 0 0 1 LRP1
Sensitivity / hurt feelings 3.89 1 0 0 0 1 LRP1
Systolic blood pressure, automated reading 1.35 1 0 0 0 1 LRP1
Supplements: Zinc 4.39 1 0 0 0 1 LRP1
Pack years adult smoking proportion 2.24 1 0 0 0 1 LRP1
Trunk fat percentage 3.20 2 0 0 0 1 LRP1 SNX1
Hand grip strength (right) 2.78 1 0 0 0 1 LRP1
Hayfever, allergic rhinitis or eczema 3.76 1 0 0 0 1 LRP1
Multivitamins +/- minerals 14.45 2 0 0 0 1 LRP1 SNX1
Supplements: Glucosamine 3.31 1 0 0 0 1 LRP1
Medication: Atenolol 2.18 1 0 0 0 1 SNX1
Sitting height 3.24 1 1 3 0 1 LRP1
Body mass index (BMI) 1.66 1 0 0 0 1 LRP1
Trunk fat mass 1.61 2 0 0 0 1 LRP1 SNX1
Waist circumference 1.25 1 0 0 0 1 SNX1
Number of incorrect matches in round 2.03 1 0 0 0 1 SNX1
Alcohol usually taken with meals 2.13 1 0 0 0 1 LRP1
Nervous feelings 1.36 1 0 0 0 1 SNX1
Hair/balding pattern: Pattern 2 2.87 1 0 0 0 1 LRP1
Forced vital capacity (FVC) 0.93 1 0 0 0 1 LRP1
Ever unenthusiastic/disinterested for a whole week 2.29 1 0 0 0 1 LRP1
Qualifications: None of the above 2.52 1 0 0 0 1 LRP1
Financial difficulties in last 2 years 2.57 1 0 0 0 1 SNX1
Allergy 4.85 1 0 0 0 1 LRP1
Hayfever/allergic rhinitis (self-reported) 7.01 1 0 0 0 1 LRP1
Fluid intelligence score 1.92 1 0 0 0 1 LRP1
Arm fat percentage (right) 2.60 2 0 0 0 1 LRP1 SNX1
Trunk fat-free mass 1.51 1 0 0 0 1 LRP1
Worrier / anxious feelings 3.25 2 0 0 0 1 LRP1 SNX1
Asthma 6.44 1 0 0 0 1 LRP1
Medication: Ibuprofen (e.g. Nurofen) 23.53 1 1 3 0 1 LRP1
Depression (self-reported) 2.56 1 0 0 0 1 LRP1
Prospective memory result 4.06 1 0 0 0 1 LRP1
Lung cancer (father) 4.51 1 0 0 0 1 SNX1
Pulse wave Arterial Stiffness index 3.51 1 0 0 0 1 LRP1
Arm fat mass (right) 1.30 1 0 0 0 1 SNX1
Trunk predicted mass 1.52 1 0 0 0 1 LRP1
Standing height 1.74 1 1 3 0 1 LRP1
Birth weight of first child 1.62 1 0 0 0 1 LRP1
Peak expiratory flow (PEF) 1.16 1 0 0 0 1 LRP1
Pulse wave reflection index 3.28 1 0 0 0 1 LRP1
Blood clot in the leg (DVT) 5.29 1 0 0 0 1 SNX1
Medication: Paracetamol 24.21 1 1 3 0 1 LRP1
Headache pain in last month 50.63 1 1 3 0 1 LRP1
Gout (self-reported) 3.27 1 0 0 0 1 LRP1
Medication: Ventolin 100micrograms inhaler 2.72 1 0 0 0 1 LRP1
Birth weight 3.53 1 0 0 0 1 LRP1
High blood pressure (siblings) 3.46 1 0 0 0 1 LRP1
Body fat percentage 3.33 2 0 0 0 1 LRP1 SNX1
Leg fat percentage (right) 3.93 2 0 0 0 1 LRP1 SNX1
Arm fat-free mass (right) 0.67 1 0 0 0 1 LRP1
Comparative body size at age 10 1.27 1 0 0 0 1 SNX1
Reason for reducing amount of alcohol drunk: Health precaution 4.02 1 0 0 0 1 SNX1
Qualifications: College or University degree 1.40 1 0 0 0 1 SNX1
Medication for pain relief, constipation, heartburn 22.17 1 1 3 0 1 LRP1
Neck or shoulder pain in last month 2.39 1 0 0 0 1 LRP1
Migraine (self-reported) 39.64 1 1 3 0 1 LRP1
Medication: Ibuprofen 19.26 1 1 3 0 1 LRP1
Medication: Seretide 50 evohaler 3.86 1 0 0 0 1 LRP1
Whole body fat mass 1.41 2 0 0 0 1 LRP1 SNX1
Leg fat mass (right) 1.76 1 0 0 0 1 LRP1
Arm predicted mass (right) 0.63 1 0 0 0 1 LRP1
Alcohol intake frequency. 4.29 1 0 0 0 1 LRP1
Whole body fat-free mass 0.90 1 0 0 0 1 LRP1
Leg fat-free mass (right) 0.51 1 0 0 0 1 LRP1
Arm fat percentage (left) 2.87 2 0 0 0 1 LRP1 SNX1
Average weekly red wine intake 2.05 1 0 0 0 1 SNX1
Mood swings 3.32 1 0 0 0 1 LRP1
Commuting to job workplace: Walk 2.50 1 0 0 0 1 SNX1
Eye problems/disorders: Cataract 2.29 1 0 0 0 1 LRP1
Back pain experienced in last month 2.91 1 0 0 0 1 LRP1
Mineral and other dietary supplements 9.72 2 0 0 0 1 LRP1 SNX1
Asthma (self-reported) 6.28 1 0 0 0 1 LRP1
Illnesses of father: None of the above (group 1) 3.80 1 0 0 0 1 SNX1
Whole body water mass 0.91 1 0 0 0 1 LRP1
Leg predicted mass (right) 0.52 1 0 0 0 1 LRP1
Arm fat mass (left) 1.12 1 0 0 0 1 SNX1
Miserableness 3.00 1 0 0 0 1 LRP1
Pain type(s) experienced in last month: Hip pain 2.24 1 0 0 0 1 SNX1
Supplements: Fish oil (including cod liver oil) 7.75 2 0 0 0 1 LRP1 SNX1
Medication: Paracetamol 20.07 1 1 3 0 1 LRP1
Medication: Atorvastatin 2.31 1 0 0 0 1 SNX1
Illnesses of father: High blood pressure 3.53 1 0 0 0 1 SNX1
Leg fat percentage (left) 3.79 2 0 0 0 1 LRP1 SNX1
Arm fat-free mass (left) 0.58 1 0 0 0 1 LRP1
Number of operations (self-reported) 4.38 1 0 0 0 1 LRP1
Average weekly beer plus cider intake 3.42 1 0 0 0 1 LRP1
Myopia 7.35 1 0 0 0 1 LRP1
Pain experienced in last month 11.84 1 1 3 0 1 LRP1
Supplements: Calcium 9.96 2 0 0 0 1 LRP1 SNX1
Deep venous thrombosis (DVT) (self-reported) 5.56 1 0 0 0 1 SNX1
Alcohol drinker status: Previous 2.87 1 0 0 0 1 LRP1
Leg fat mass (left) 1.70 1 0 0 0 1 LRP1
Arm predicted mass (left) 0.56 1 0 0 0 1 LRP1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.36
GTEx Adipose Visceral Omentum 0 0.0000 1.39
GTEx Adrenal Gland 0 0.0000 1.36
GTEx Artery Aorta 0 0.0000 1.36
GTEx Artery Coronary 0 0.0000 1.40
GTEx Artery Tibial 1 0.0266 1.40
GTEx Brain Caudate basal ganglia 0 0.0000 1.41
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.42
GTEx Brain Cerebellum 0 0.0000 1.42
GTEx Brain Cortex 0 0.0000 1.44
GTEx Brain Frontal Cortex BA9 0 0.0000 1.41
GTEx Brain Hippocampus 0 0.0000 1.34
GTEx Brain Hypothalamus 0 0.0000 1.41
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.36
GTEx Brain Putamen basal ganglia 0 0.0000 1.40
GTEx Breast Mammary Tissue 0 0.0000 1.48
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.46
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.45
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.50
GTEx Cells Transformed fibroblasts 0 0.0000 1.36
GTEx Colon Sigmoid 0 0.0000 1.43
GTEx Colon Transverse 0 0.0000 1.42
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.38
GTEx Esophagus Mucosa 0 0.0000 1.40
GTEx Esophagus Muscularis 0 0.0000 1.42
GTEx Heart Atrial Appendage 0 0.0000 1.35
GTEx Heart Left Ventricle 0 0.0000 1.39
GTEx Liver 0 0.0000 1.49
GTEx Lung 0 0.0000 1.39
GTEx Muscle Skeletal 0 0.0000 1.42
GTEx Nerve Tibial 0 0.0000 1.38
GTEx Ovary 0 0.0000 1.46
GTEx Pancreas 0 0.0000 1.43
GTEx Pituitary 0 0.0000 1.44
GTEx Prostate 0 0.0000 1.56
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.44
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.37
GTEx Small Intestine Terminal Ileum 0 0.0000 1.46
GTEx Spleen 0 0.0000 1.42
GTEx Stomach 0 0.0000 1.50
GTEx Testis 0 0.0000 1.42
GTEx Thyroid 0 0.0000 1.36
GTEx Uterus 0 0.0000 1.53
GTEx Vagina 0 0.0000 1.46
GTEx Whole Blood 1 0.0502 1.37
METSIM Adipose 0 0.0000 1.29
NTR Blood 0 0.0000 1.31
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.34
YFS Blood 0 0.0000 1.28
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.30
TCGA Breast Tumor 0 0.0000 1.39
TCGA Breast Normal 0 0.0000 1.23
TCGA Ovarian Tumor 0 0.0000 1.31
TCGA Prostate Tumor 0 0.0000 1.33