Hub : Traits :

Migraine (self-reported)

21 significantly associated models · 12 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 155739430 157168420 1 1 3.7e-07 1.9e-08 0.0032 72 MEF2D
2 6 12020241 13990267 2 1 1.5e-14 3.8e-14 1.0000 100 RP1-257A7.5
3 6 96275538 97756290 3 1 1.8e-14 5.1e-16 0.0050 88 KIAA0776
4 6 121106523 122500480 1 1 6.5e-08 5.9e-09 1.0000 100 RP1-172I22.1
5 10 29001607 30472392 1 1 8.2e-08 8.6e-06 0.0054 61 PTCHD3P1
6 12 56805309 58303535 3 1 7.3e-23 7.9e-23 1.0000 100 LRP1
7 14 55273730 56741515 1 1 4.8e-08 3.8e-05 0.0474 77 KTN1-AS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Coronary Artery Disease (CAD) 6.58 1 1 3.0 0.00 1.000 RP1-257A7.5
Primary Biliary Cirrhosis 3.32 2 0 0.0 0.00 1.000 LRP1 RP1-172I22.1
Blood Eosinophil Count 0.95 2 1 3.0 0.00 1.000 KTN1-AS1 LRP1
Blood Platelet Count 2.22 4 2 6.1 -0.09 0.914 KIAA0776 KTN1-AS1 MEF2D PTCHD3P1
Blood Red Count 1.13 2 1 3.0 0.00 1.000 RP1-172I22.1 RP1-257A7.5
Blood White Count 1.43 3 0 0.0 0.00 1.000 MEF2D PTCHD3P1 RP1-172I22.1
Heel T-Score 0.94 3 0 0.0 0.00 1.000 MEF2D PTCHD3P1 RP1-172I22.1
BMI 1.33 2 0 0.0 0.00 1.000 LRP1 MEF2D
Height 0.72 3 2 6.1 0.00 1.000 LRP1 MEF2D PTCHD3P1
Waist Hip Ratio (WHR) 1.60 1 1 3.0 0.00 1.000 MEF2D
Systolic Blood Pressure 2.67 3 2 6.1 0.00 1.000 KIAA0776 MEF2D RP1-257A7.5
Allergy or Eczema 1.31 1 0 0.0 0.00 1.000 LRP1
Respiratory disease 3.74 2 1 3.0 0.00 1.000 LRP1 RP1-172I22.1
Lung FEV1/FVC ratio 4.92 2 1 3.0 0.00 1.000 LRP1 MEF2D
Lung FVC 1.02 2 0 0.0 0.00 1.000 MEF2D PTCHD3P1
Neuroticism 1.41 1 0 0.0 0.00 1.000 LRP1
Hair Pigment 0.14 2 0 0.0 0.00 1.000 LRP1 MEF2D
Hand grip strength (left) 1.86 1 1 3.0 0.00 1.000 RP1-257A7.5
Number of treatments/medications taken 4.94 3 0 0.0 0.00 1.000 KIAA0776 LRP1 MEF2D
Sensitivity / hurt feelings 1.49 1 0 0.0 0.00 1.000 LRP1
Systolic blood pressure, automated reading 2.71 2 0 0.0 0.00 1.000 KIAA0776 RP1-257A7.5
Angina 5.67 2 1 3.0 0.00 1.000 MEF2D RP1-257A7.5
Vitamin and mineral supplements 4.02 1 1 3.0 0.00 1.000 LRP1
Trunk fat percentage 0.95 1 0 0.0 0.00 1.000 LRP1
Hand grip strength (right) 2.12 2 0 0.0 0.00 1.000 LRP1 RP1-257A7.5
High blood pressure 2.01 2 0 0.0 0.00 1.000 MEF2D RP1-172I22.1
Hayfever, allergic rhinitis or eczema 1.28 1 0 0.0 0.00 1.000 LRP1
Multivitamins +/- minerals 2.69 1 0 0.0 0.00 1.000 LRP1
Sitting height 1.24 1 1 3.0 0.00 1.000 LRP1
High blood pressure (mother) 2.90 1 0 0.0 0.00 1.000 RP1-257A7.5
Body mass index (BMI) 0.88 1 0 0.0 0.00 1.000 LRP1
Heel bone mineral density (BMD) T-score, automated (right) 1.35 1 0 0.0 0.00 1.000 PTCHD3P1
Heart attack 7.60 1 1 3.0 0.00 1.000 RP1-257A7.5
Allergy 1.87 1 0 0.0 0.00 1.000 LRP1
Hayfever/allergic rhinitis (self-reported) 2.67 1 0 0.0 0.00 1.000 LRP1
Medication: Simvastatin 2.30 1 0 0.0 0.00 1.000 RP1-172I22.1
Impedance of arm (right) 0.76 1 0 0.0 0.00 1.000 MEF2D
Arm fat percentage (right) 1.03 1 0 0.0 0.00 1.000 LRP1
Trunk fat-free mass 0.59 1 0 0.0 0.00 1.000 LRP1
Pulse rate 2.12 1 0 0.0 0.00 1.000 PTCHD3P1
Asthma 2.74 1 0 0.0 0.00 1.000 LRP1
Medication: Ibuprofen (e.g. Nurofen) 14.97 4 2 6.1 0.86 0.145 KIAA0776 LRP1 MEF2D RP1-257A7.5
Medication: Cholesterol lowering 1.91 1 0 0.0 0.00 1.000 MEF2D
Pulse wave Arterial Stiffness index 4.07 1 0 0.0 0.00 1.000 RP1-257A7.5
Impedance of arm (left) 0.81 1 0 0.0 0.00 1.000 MEF2D
Trunk predicted mass 0.61 1 0 0.0 0.00 1.000 LRP1
Standing height 0.65 1 1 3.0 0.00 1.000 LRP1
Birth weight of first child 2.95 1 0 0.0 0.00 1.000 PTCHD3P1
Pulse wave reflection index 3.40 1 0 0.0 0.00 1.000 PTCHD3P1
Medication: Paracetamol 15.34 5 3 9.1 0.94 0.020 KIAA0776 LRP1 MEF2D RP1-172I22.1 RP1-257A7.5
Headache pain in last month 35.43 6 5 15.2 0.91 0.013 KIAA0776 KTN1-AS1 LRP1 MEF2D RP1-172I22.1 RP1-257A7.5
Birth weight 2.77 2 0 0.0 0.00 1.000 LRP1 PTCHD3P1
High blood pressure (siblings) 2.09 1 0 0.0 0.00 1.000 LRP1
Body fat percentage 1.22 1 0 0.0 0.00 1.000 LRP1
Leg fat percentage (right) 1.74 1 0 0.0 0.00 1.000 LRP1
Pulse wave peak to peak time 3.80 1 0 0.0 0.00 1.000 RP1-257A7.5
Mouth/teeth dental problems: Loose teeth 1.69 1 0 0.0 0.00 1.000 PTCHD3P1
Medication for pain relief, constipation, heartburn 14.13 4 3 9.1 -0.49 0.514 KIAA0776 LRP1 MEF2D RP1-257A7.5
Medication: Blood pressure 1.99 1 0 0.0 0.00 1.000 RP1-172I22.1
Angina (self-reported) 5.40 2 1 3.0 0.00 1.000 MEF2D RP1-257A7.5
Medication: Ibuprofen 12.22 3 2 6.1 0.00 1.000 LRP1 MEF2D RP1-257A7.5
Heart disease (mother) 2.81 1 0 0.0 0.00 1.000 RP1-257A7.5
Leg fat mass (right) 0.86 1 0 0.0 0.00 1.000 LRP1
Pulse rate, automated reading 3.99 3 2 6.1 0.00 1.000 MEF2D PTCHD3P1 RP1-257A7.5
Alcohol intake frequency. 4.17 2 0 0.0 0.00 1.000 LRP1 RP1-257A7.5
Comparative height size at age 10 0.44 1 0 0.0 0.00 1.000 MEF2D
Suffer from 'nerves' 1.07 1 0 0.0 0.00 1.000 RP1-172I22.1
Had major operations 2.47 1 0 0.0 0.00 1.000 RP1-257A7.5
Medication: Aspirin 3.82 1 0 0.0 0.00 1.000 MEF2D
Hypertension (Self-reported) 2.18 3 0 0.0 0.00 1.000 MEF2D RP1-172I22.1 RP1-257A7.5
Illnesses of father: Heart disease 4.92 1 1 3.0 0.00 1.000 RP1-257A7.5
Whole body fat-free mass 0.48 1 0 0.0 0.00 1.000 LRP1
Arm fat percentage (left) 1.09 1 0 0.0 0.00 1.000 LRP1
Mood swings 1.36 1 0 0.0 0.00 1.000 LRP1
Mineral and other dietary supplements 3.14 1 0 0.0 0.00 1.000 LRP1
Asthma (self-reported) 2.83 1 0 0.0 0.00 1.000 LRP1
Medication: Aspirin 3.93 1 0 0.0 0.00 1.000 MEF2D
Whole body water mass 0.48 1 0 0.0 0.00 1.000 LRP1
Number of self-reported non-cancer illnesses 1.63 1 0 0.0 0.00 1.000 MEF2D
Miserableness 1.30 1 0 0.0 0.00 1.000 LRP1
Supplements: Fish oil (including cod liver oil) 2.55 1 0 0.0 0.00 1.000 LRP1
High cholesterol (Self-reported) 1.58 1 0 0.0 0.00 1.000 MEF2D
Medication: Bendroflumethiazide 1.80 1 0 0.0 0.00 1.000 RP1-257A7.5
Medication: Paracetamol 11.79 4 2 6.1 0.95 0.047 KIAA0776 LRP1 MEF2D RP1-257A7.5
Leg fat percentage (left) 1.66 1 0 0.0 0.00 1.000 LRP1
Number of operations (self-reported) 2.07 1 0 0.0 0.00 1.000 LRP1
Diastolic blood pressure, automated reading 1.94 2 0 0.0 0.00 1.000 PTCHD3P1 RP1-172I22.1
Myopia 2.31 1 0 0.0 0.00 1.000 LRP1
Vascular/heart problems diagnosed by doctor 1.62 2 0 0.0 0.00 1.000 MEF2D RP1-172I22.1
Pain experienced in last month 7.11 3 1 3.0 0.00 1.000 KIAA0776 LRP1 RP1-257A7.5
Heart attack/myocardial infarction (self-reported) 7.79 1 1 3.0 0.00 1.000 RP1-257A7.5
Heart disease (siblings) 3.42 1 1 3.0 0.00 1.000 RP1-257A7.5
Impedance of whole body 0.52 1 0 0.0 0.00 1.000 MEF2D
Leg fat mass (left) 0.82 1 0 0.0 0.00 1.000 LRP1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.22
GTEx Adipose Visceral Omentum 0 0.0000 1.32
GTEx Adrenal Gland 0 0.0000 1.19
GTEx Artery Aorta 4 0.1344 1.35
GTEx Artery Coronary 1 0.0845 1.39
GTEx Artery Tibial 6 0.1595 1.38
GTEx Brain Caudate basal ganglia 0 0.0000 1.37
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.34
GTEx Brain Cerebellum 0 0.0000 1.21
GTEx Brain Cortex 0 0.0000 1.24
GTEx Brain Frontal Cortex BA9 0 0.0000 1.30
GTEx Brain Hippocampus 0 0.0000 1.28
GTEx Brain Hypothalamus 0 0.0000 1.22
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.23
GTEx Brain Putamen basal ganglia 0 0.0000 1.27
GTEx Breast Mammary Tissue 0 0.0000 1.21
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.25
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.15
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.32
GTEx Cells Transformed fibroblasts 0 0.0000 1.32
GTEx Colon Sigmoid 0 0.0000 1.28
GTEx Colon Transverse 0 0.0000 1.23
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.24
GTEx Esophagus Mucosa 0 0.0000 1.30
GTEx Esophagus Muscularis 0 0.0000 1.26
GTEx Heart Atrial Appendage 0 0.0000 1.20
GTEx Heart Left Ventricle 0 0.0000 1.26
GTEx Liver 0 0.0000 1.28
GTEx Lung 0 0.0000 1.28
GTEx Muscle Skeletal 0 0.0000 1.25
GTEx Nerve Tibial 0 0.0000 1.25
GTEx Ovary 0 0.0000 1.17
GTEx Pancreas 1 0.0613 1.27
GTEx Pituitary 0 0.0000 1.20
GTEx Prostate 0 0.0000 1.25
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.34
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.22
GTEx Small Intestine Terminal Ileum 0 0.0000 1.19
GTEx Spleen 0 0.0000 1.33
GTEx Stomach 0 0.0000 1.30
GTEx Testis 1 0.0317 1.26
GTEx Thyroid 1 0.0250 1.28
GTEx Uterus 0 0.0000 1.23
GTEx Vagina 0 0.0000 1.23
GTEx Whole Blood 0 0.0000 1.28
METSIM Adipose 2 0.0434 1.21
NTR Blood 1 0.0416 1.23
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.26
YFS Blood 0 0.0000 1.18
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.27
TCGA Breast Tumor 0 0.0000 1.27
TCGA Breast Normal 0 0.0000 1.20
TCGA Ovarian Tumor 2 0.0684 1.19
TCGA Prostate Tumor 0 0.0000 1.22