Hub : Traits :

Ever had bowel cancer screening

2 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 41058968 42450682 1 1 2.9e-07 5.7e-06 0.0085 66 PRICKLE4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Blood Red Count 177.9 1 1 3 0 1 PRICKLE4
Height 1.5 1 1 3 0 1 PRICKLE4
Waist Hip Ratio (WHR) 3.2 1 0 0 0 1 PRICKLE4
Smoking Status 6.2 1 0 0 0 1 PRICKLE4
Allergy or Eczema 2.9 1 0 0 0 1 PRICKLE4
Lung FVC 2.9 1 0 0 0 1 PRICKLE4
Chronotype (morning person) 14.3 1 1 3 0 1 PRICKLE4
Frequency of depressed mood in last 2 weeks 4.2 1 0 0 0 1 PRICKLE4
Relative age of first facial hair 16.8 1 1 3 0 1 PRICKLE4
Other serious medical condition/disability diagnosed by doctor 13.2 1 0 0 0 1 PRICKLE4
Vitamin and mineral supplements 9.2 1 0 0 0 1 PRICKLE4
Supplements: Zinc 7.7 1 0 0 0 1 PRICKLE4
Pack years adult smoking proportion 6.8 1 0 0 0 1 PRICKLE4
Trunk fat percentage 1.7 1 0 0 0 1 PRICKLE4
Current tobacco smoking 4.6 1 0 0 0 1 PRICKLE4
Relative age voice broke 7.3 1 0 0 0 1 PRICKLE4
Age when periods started (menarche) 15.3 1 1 3 0 1 PRICKLE4
Hayfever, allergic rhinitis or eczema 2.4 1 0 0 0 1 PRICKLE4
Multivitamins +/- minerals 4.2 1 0 0 0 1 PRICKLE4
Stomach or abdominal pain in last month 10.2 1 0 0 0 1 PRICKLE4
Supplements: Glucosamine 7.8 1 0 0 0 1 PRICKLE4
Sitting height 1.4 1 0 0 0 1 PRICKLE4
Trunk fat mass 1.2 1 0 0 0 1 PRICKLE4
Past tobacco smoking 3.8 1 0 0 0 1 PRICKLE4
Alcohol usually taken with meals 10.0 1 0 0 0 1 PRICKLE4
Had menopause 7.3 1 0 0 0 1 PRICKLE4
Ever unenthusiastic/disinterested for a whole week 4.6 1 0 0 0 1 PRICKLE4
Qualifications: None of the above 4.6 1 0 0 0 1 PRICKLE4
Diabetes (self-reported) 3.7 1 0 0 0 1 PRICKLE4
Illnesses of siblings 8.4 1 0 0 0 1 PRICKLE4
Impedance of arm (right) 1.9 1 0 0 0 1 PRICKLE4
Number of live births 8.5 1 0 0 0 1 PRICKLE4
Pulse rate 4.5 1 0 0 0 1 PRICKLE4
Qualifications: A levels/AS levels or equivalent 4.1 1 0 0 0 1 PRICKLE4
Mouth/teeth dental problems: Dentures 8.3 1 0 0 0 1 PRICKLE4
Impedance of arm (left) 2.6 1 0 0 0 1 PRICKLE4
Standing height 1.3 1 0 0 0 1 PRICKLE4
Pulse wave reflection index 4.4 1 0 0 0 1 PRICKLE4
Loud music exposure frequency 7.3 1 0 0 0 1 PRICKLE4
Qualifications: O levels/GCSEs or equivalent 9.4 1 0 0 0 1 PRICKLE4
High blood pressure (siblings) 4.0 1 0 0 0 1 PRICKLE4
Exposure to tobacco smoke outside home 8.8 1 0 0 0 1 PRICKLE4
Neck or shoulder pain in last month 3.7 1 0 0 0 1 PRICKLE4
Migraine (self-reported) 4.9 1 0 0 0 1 PRICKLE4
Medication: Omeprazole 8.0 1 0 0 0 1 PRICKLE4
Mean time to correctly identify matches 3.9 1 0 0 0 1 PRICKLE4
Pulse rate, automated reading 6.6 1 0 0 0 1 PRICKLE4
Comparative height size at age 10 1.1 1 0 0 0 1 PRICKLE4
Chest pain or discomfort 3.6 1 0 0 0 1 PRICKLE4
Supplements: Vitamin C 17.4 1 0 0 0 1 PRICKLE4
Illnesses of father: Heart disease 9.7 1 0 0 0 1 PRICKLE4
Smoking status: Previous 3.6 1 0 0 0 1 PRICKLE4
Forced expiratory volume in 1-second (FEV1), predicted 2.7 1 0 0 0 1 PRICKLE4
Average weekly red wine intake 8.9 1 0 0 0 1 PRICKLE4
Long-standing illness, disability or infirmity 8.5 1 0 0 0 1 PRICKLE4
Diabetes diagnosed by doctor 3.4 1 0 0 0 1 PRICKLE4
Friendships satisfaction 6.2 1 0 0 0 1 PRICKLE4
Qualifications: nursing, teaching 5.4 1 0 0 0 1 PRICKLE4
Mineral and other dietary supplements 15.9 1 0 0 0 1 PRICKLE4
Osteoporosis (self-reported) 8.1 1 0 0 0 1 PRICKLE4
Illnesses of father: None of the above (group 1) 9.3 1 0 0 0 1 PRICKLE4
Smoking status: Current 3.9 1 0 0 0 1 PRICKLE4
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.6 1 0 0 0 1 PRICKLE4
Wears glasses or contact lenses 5.5 1 0 0 0 1 PRICKLE4
Ever taken oral contraceptive pill 9.7 1 0 0 0 1 PRICKLE4
Pain type(s) experienced in last month: Hip pain 5.0 1 0 0 0 1 PRICKLE4
Supplements: Fish oil (including cod liver oil) 5.4 1 0 0 0 1 PRICKLE4
Illnesses of father: High blood pressure 7.4 1 0 0 0 1 PRICKLE4
Alcohol drinker status: Never 7.6 1 0 0 0 1 PRICKLE4
Ever smoked 4.6 1 0 0 0 1 PRICKLE4
Average weekly beer plus cider intake 13.3 1 0 0 0 1 PRICKLE4
Medication: Omeprazole (e.g. Zanprol) 12.8 1 0 0 0 1 PRICKLE4
Supplements: Calcium 7.2 1 0 0 0 1 PRICKLE4
Pack years of smoking 3.9 1 0 0 0 1 PRICKLE4
Impedance of whole body 1.1 1 0 0 0 1 PRICKLE4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.18
GTEx Adipose Visceral Omentum 0 0.0000 1.23
GTEx Adrenal Gland 0 0.0000 1.19
GTEx Artery Aorta 0 0.0000 1.17
GTEx Artery Coronary 0 0.0000 1.24
GTEx Artery Tibial 0 0.0000 1.16
GTEx Brain Caudate basal ganglia 0 0.0000 1.13
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.14
GTEx Brain Cerebellum 0 0.0000 1.18
GTEx Brain Cortex 0 0.0000 1.14
GTEx Brain Frontal Cortex BA9 0 0.0000 1.21
GTEx Brain Hippocampus 0 0.0000 1.00
GTEx Brain Hypothalamus 0 0.0000 1.03
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.17
GTEx Brain Putamen basal ganglia 0 0.0000 1.28
GTEx Breast Mammary Tissue 0 0.0000 1.17
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.18
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.19
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.21
GTEx Cells Transformed fibroblasts 0 0.0000 1.17
GTEx Colon Sigmoid 0 0.0000 1.15
GTEx Colon Transverse 0 0.0000 1.22
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.19
GTEx Esophagus Mucosa 0 0.0000 1.19
GTEx Esophagus Muscularis 0 0.0000 1.21
GTEx Heart Atrial Appendage 0 0.0000 1.20
GTEx Heart Left Ventricle 0 0.0000 1.16
GTEx Liver 0 0.0000 1.22
GTEx Lung 0 0.0000 1.23
GTEx Muscle Skeletal 0 0.0000 1.17
GTEx Nerve Tibial 0 0.0000 1.18
GTEx Ovary 0 0.0000 1.18
GTEx Pancreas 0 0.0000 1.19
GTEx Pituitary 0 0.0000 1.25
GTEx Prostate 0 0.0000 1.18
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.18
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.19
GTEx Small Intestine Terminal Ileum 0 0.0000 1.28
GTEx Spleen 0 0.0000 1.29
GTEx Stomach 0 0.0000 1.18
GTEx Testis 0 0.0000 1.19
GTEx Thyroid 0 0.0000 1.17
GTEx Uterus 0 0.0000 1.35
GTEx Vagina 0 0.0000 1.22
GTEx Whole Blood 0 0.0000 1.18
METSIM Adipose 0 0.0000 1.14
NTR Blood 0 0.0000 1.10
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.18
YFS Blood 0 0.0000 1.20
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.13
TCGA Breast Tumor 0 0.0000 1.13
TCGA Breast Normal 0 0.0000 1.12
TCGA Ovarian Tumor 0 0.0000 1.14
TCGA Prostate Tumor 0 0.0000 1.22