Hub : Traits :

Alzheimer’s Disease (in father)

4 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 19 44190626 46680895 4 4 1.3e-21 8.3e-193 1.7e-153 21 CEACAM19 ERCC1 ZNF229 ZNF285

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 90.94 3 3 9.1 0.00 1.0000 CEACAM19 ZNF229 ZNF285
Alzheimer’s Disease (including proxy) 193.21 3 3 9.1 0.00 1.0000 CEACAM19 ZNF229 ZNF285
Coronary Artery Disease (CAD) 4.55 2 0 0.0 0.00 1.0000 CEACAM19 ZNF229
HbA1C 2.23 1 0 0.0 0.00 1.0000 ERCC1
HDL Cholesterol 3.14 1 0 0.0 0.00 1.0000 ZNF229
LDL Cholesterol 28.26 4 3 9.1 0.99 0.0083 CEACAM19 ERCC1 ZNF229 ZNF285
Triglycerides 3.65 2 0 0.0 0.00 1.0000 ERCC1 ZNF285
Type 2 Diabetes (T2D) 2.24 1 0 0.0 0.00 1.0000 CEACAM19
Blood Platelet Count 3.66 3 1 3.0 0.00 1.0000 ERCC1 ZNF229 ZNF285
Blood White Count 0.51 1 0 0.0 0.00 1.0000 ERCC1
Heel T-Score 0.62 1 0 0.0 0.00 1.0000 ZNF285
BMI 1.57 3 0 0.0 0.00 1.0000 CEACAM19 ZNF229 ZNF285
Height 0.42 2 0 0.0 0.00 1.0000 CEACAM19 ZNF229
Waist Hip Ratio (WHR) 0.63 1 0 0.0 0.00 1.0000 ZNF285
Cardiovascular Disease 3.48 3 0 0.0 0.00 1.0000 ERCC1 ZNF229 ZNF285
Chronotype (morning person) 2.21 1 0 0.0 0.00 1.0000 ZNF285
Hand grip strength (left) 0.87 1 0 0.0 0.00 1.0000 ZNF229
Number of treatments/medications taken 1.40 1 0 0.0 0.00 1.0000 ZNF229
Hearing difficulty/problems: Yes 2.02 1 0 0.0 0.00 1.0000 CEACAM19
Relative age of first facial hair 0.92 1 0 0.0 0.00 1.0000 ERCC1
Leg fat-free mass (left) 0.58 1 0 0.0 0.00 1.0000 ZNF285
Trunk fat percentage 0.70 1 0 0.0 0.00 1.0000 ZNF229
Current tobacco smoking 1.20 1 0 0.0 0.00 1.0000 ZNF285
Relative age voice broke 1.28 1 0 0.0 0.00 1.0000 ERCC1
High blood pressure (mother) 1.72 1 0 0.0 0.00 1.0000 ZNF229
Body mass index (BMI) 0.87 1 0 0.0 0.00 1.0000 CEACAM19
Leg predicted mass (left) 0.60 1 0 0.0 0.00 1.0000 ZNF285
Trunk fat mass 0.95 2 0 0.0 0.00 1.0000 ZNF229 ZNF285
Nervous feelings 1.43 1 0 0.0 0.00 1.0000 ZNF229
Medication: Simvastatin 8.78 4 0 0.0 -0.99 0.0106 CEACAM19 ERCC1 ZNF229 ZNF285
Weight 1.02 2 0 0.0 0.00 1.0000 ZNF229 ZNF285
Trunk fat-free mass 0.52 1 0 0.0 0.00 1.0000 ZNF285
Time employed in main current job 2.88 1 0 0.0 0.00 1.0000 ZNF229
Alcohol intake versus 10 years previously 2.05 1 0 0.0 0.00 1.0000 ERCC1
Father's age at death 3.93 2 0 0.0 0.00 1.0000 ERCC1 ZNF229
Hair/balding pattern: Pattern 3 1.11 1 0 0.0 0.00 1.0000 CEACAM19
Medication: Cholesterol lowering 8.87 3 1 3.0 0.00 1.0000 CEACAM19 ZNF229 ZNF285
Illnesses of mother 6.55 3 0 0.0 0.00 1.0000 CEACAM19 ZNF229 ZNF285
Arm fat mass (right) 0.98 2 0 0.0 0.00 1.0000 ZNF229 ZNF285
Standing height 0.67 3 0 0.0 0.00 1.0000 CEACAM19 ZNF229 ZNF285
Breastfed as a baby 2.39 1 0 0.0 0.00 1.0000 ERCC1
Medication for cholesterol, blood pressure or diabetes 2.77 1 0 0.0 0.00 1.0000 ZNF229
Chronic bronchitis/emphysema (mother) 2.26 1 0 0.0 0.00 1.0000 CEACAM19
Shortness of breath walking on level ground 2.76 1 0 0.0 0.00 1.0000 ZNF285
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.88 1 0 0.0 0.00 1.0000 CEACAM19
Whole body fat mass 0.88 1 0 0.0 0.00 1.0000 ZNF229
Leg fat mass (right) 1.11 1 0 0.0 0.00 1.0000 ZNF285
Comparative height size at age 10 0.81 1 0 0.0 0.00 1.0000 ZNF229
Suffer from 'nerves' 1.29 1 0 0.0 0.00 1.0000 ZNF229
Overall health rating 0.92 1 0 0.0 0.00 1.0000 ZNF229
Medication: Aspirin 1.86 1 0 0.0 0.00 1.0000 ERCC1
Forced expiratory volume in 1-second (FEV1), predicted 1.37 1 0 0.0 0.00 1.0000 CEACAM19
Whole body fat-free mass 0.53 1 0 0.0 0.00 1.0000 ZNF285
Leg fat-free mass (right) 0.55 1 0 0.0 0.00 1.0000 ZNF285
Ever had bowel cancer screening 2.52 1 0 0.0 0.00 1.0000 CEACAM19
Diabetes diagnosed by doctor 2.35 1 0 0.0 0.00 1.0000 CEACAM19
Medication for cholesterol 2.99 1 0 0.0 0.00 1.0000 ZNF285
Breast cancer (self-reported) 1.71 1 0 0.0 0.00 1.0000 ERCC1
Medication: Aspirin 1.91 1 0 0.0 0.00 1.0000 ERCC1
Illnesses of father: None of the above (group 1) 2.21 1 0 0.0 0.00 1.0000 ZNF285
Whole body water mass 0.51 1 0 0.0 0.00 1.0000 ZNF285
Leg predicted mass (right) 0.54 1 0 0.0 0.00 1.0000 ZNF285
High cholesterol (Self-reported) 21.20 4 2 6.1 -0.99 0.0092 CEACAM19 ERCC1 ZNF229 ZNF285
Medication: Atorvastatin 10.11 2 0 0.0 0.00 1.0000 ZNF229 ZNF285
Basal metabolic rate 0.64 1 0 0.0 0.00 1.0000 ZNF285
Risk taking 1.36 1 0 0.0 0.00 1.0000 CEACAM19
Cholesterol lowering medication 12.57 4 0 0.0 -0.98 0.0247 CEACAM19 ERCC1 ZNF229 ZNF285
Leg fat mass (left) 1.23 2 0 0.0 0.00 1.0000 ZNF229 ZNF285

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.091
GTEx Adipose Visceral Omentum 1 0.0490 1.117
GTEx Adrenal Gland 0 0.0000 1.131
GTEx Artery Aorta 0 0.0000 1.063
GTEx Artery Coronary 0 0.0000 1.086
GTEx Artery Tibial 0 0.0000 1.072
GTEx Brain Caudate basal ganglia 0 0.0000 0.983
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.121
GTEx Brain Cerebellum 0 0.0000 1.052
GTEx Brain Cortex 0 0.0000 1.037
GTEx Brain Frontal Cortex BA9 0 0.0000 1.101
GTEx Brain Hippocampus 0 0.0000 1.075
GTEx Brain Hypothalamus 0 0.0000 1.151
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.098
GTEx Brain Putamen basal ganglia 0 0.0000 1.151
GTEx Breast Mammary Tissue 0 0.0000 1.081
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.095
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.087
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.060
GTEx Cells Transformed fibroblasts 0 0.0000 1.063
GTEx Colon Sigmoid 0 0.0000 1.101
GTEx Colon Transverse 0 0.0000 1.126
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.103
GTEx Esophagus Mucosa 0 0.0000 1.115
GTEx Esophagus Muscularis 0 0.0000 1.114
GTEx Heart Atrial Appendage 0 0.0000 1.069
GTEx Heart Left Ventricle 0 0.0000 1.077
GTEx Liver 0 0.0000 1.146
GTEx Lung 0 0.0000 1.080
GTEx Muscle Skeletal 0 0.0000 1.089
GTEx Nerve Tibial 1 0.0231 1.088
GTEx Ovary 0 0.0000 0.987
GTEx Pancreas 0 0.0000 1.114
GTEx Pituitary 0 0.0000 1.110
GTEx Prostate 0 0.0000 1.050
GTEx Skin Not Sun Exposed Suprapubic 1 0.0406 1.144
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.080
GTEx Small Intestine Terminal Ileum 0 0.0000 1.062
GTEx Spleen 0 0.0000 1.098
GTEx Stomach 0 0.0000 1.068
GTEx Testis 0 0.0000 1.087
GTEx Thyroid 1 0.0250 1.124
GTEx Uterus 0 0.0000 1.045
GTEx Vagina 0 0.0000 1.166
GTEx Whole Blood 0 0.0000 1.092
METSIM Adipose 0 0.0000 1.060
NTR Blood 0 0.0000 1.091
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.094
YFS Blood 0 0.0000 1.081
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.075
TCGA Breast Tumor 0 0.0000 1.046
TCGA Breast Normal 0 0.0000 1.065
TCGA Ovarian Tumor 0 0.0000 1.038
TCGA Prostate Tumor 0 0.0000 1.062