Hub : Genes

ATP1B1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1180 0.0510 3.5e-03 0.031 NA 0.043 NA 0.040 7.9e-03 NA 2.0e-03 NA 2.9e-03
2 GTEx Breast Mammary Tissue 0.1490 0.0590 7.9e-03 -0.006 NA 0.002 NA -0.003 9.8e-01 NA 2.3e-01 NA 5.3e-01
3 GTEx Esophagus Mucosa 0.1050 0.0400 4.0e-03 0.054 NA 0.063 NA 0.041 1.7e-04 NA 5.2e-05 NA 1.0e-03
4 GTEx Esophagus Muscularis 0.2320 0.0620 5.5e-05 0.022 NA 0.039 NA 0.024 1.7e-02 NA 2.1e-03 NA 1.2e-02
5 GTEx Stomach 0.1330 0.0550 7.3e-03 0.012 NA 0.008 NA 0.042 8.7e-02 NA 1.3e-01 NA 4.3e-03
6 YFS Blood 0.2702 0.0416 0.0e+00 0.163 0.143 0.173 0.182 0.178 5.4e-51 1.5e-44 2.5e-54 2.9e-57 4.8e-56
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0457 0.0194 3.9e-05 0.006 0.010 0.000 NA 0.002 6.4e-02 2.3e-02 3.6e-01 NA 1.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.9 2.9 6.1 1.5 0.0 1.8 2.5 2.2 1.3 -1.6
Bipolar Disorder or Schizophrenia 1.8 4.5 11.0 0.8 0.0 3.1 3.0 3.3 1.1 -0.5
Depressed Affect (Nagel 2018) 0.7 1.5 4.3 0.5 0.0 1.4 1.5 2.1 0.8 -1.1
Depression (Nagel 2018) 0.5 0.8 2.9 0.6 0.0 0.9 -0.8 -0.6 -0.6 -1.7
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.5 -0.8 0.0 1.9 1.1 -0.5 -1.9 1.5
Neuroticism (Nagel 2018) 1.4 3.2 7.0 2.5 0.0 1.8 1.3 1.9 0.9 -2.7
Schizophrenia (2018) 1.2 2.4 6.3 -0.2 0.0 2.5 1.8 2.5 0.7 0.7
Schizophrenia vs Biploar Disorder 0.4 0.6 1.7 0.6 0.0 1.0 -0.6 -0.5 -1.3 0.5
Worry (Nagel 2018) 0.6 1.3 4.1 1.8 0.0 0.9 0.3 0.9 -0.1 -2.0
Alzheimer’s Disease (in mother) 2.9 3.3 9.1 -2.4 0.0 -3.0 -1.9 -1.5 -0.2 1.6
Alzheimer’s Disease (in father) 1.1 1.2 3.3 -1.3 0.0 0.7 -0.1 -0.0 -1.7 1.8
Alzheimer’s Disease (including proxy) 2.2 3.2 7.6 -2.8 0.0 -1.7 -1.4 -1.3 -1.5 2.4
Crohns Disease (2017) 0.3 0.7 1.6 1.2 0.0 0.8 0.6 1.2 -0.2 -1.0
Irritable Bowel Disease (IBD) 0.7 1.7 4.4 1.2 0.0 1.5 1.3 2.1 -0.1 -1.4
Ulcerative Colitis (UC) 0.6 1.1 3.8 0.0 0.0 1.0 1.0 2.0 0.4 -1.2
Major Depression (MDD) 0.8 0.9 2.8 -1.1 0.0 -0.8 -1.7 -0.8 1.0 0.5
Reaction Time 0.7 1.4 4.4 -1.8 0.0 0.6 0.2 0.5 1.2 2.1
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.2 -0.2 0.0 1.8 0.9 0.7 -1.0 0.8
Breast Cancer 1.1 2.6 7.3 -0.9 0.0 -2.3 -2.7 -1.8 -0.2 1.2
Ovarian Cancer 0.6 0.8 3.6 0.1 0.0 -0.7 -0.8 -1.9 1.0 0.3
Prostate Cancer 1.0 1.4 3.2 0.1 0.0 1.3 1.8 1.7 1.2 -0.5
Age at First Birth 0.5 0.8 2.7 0.9 0.0 -0.1 -1.3 -1.6 0.2 0.1
Bipolar Disorder (2011) 0.3 0.3 1.4 -0.3 0.0 -0.2 -0.5 1.2 0.5 0.1
Body Mass Index (BMI) (2010) 0.4 0.5 1.6 -0.6 0.0 -0.8 -1.2 -0.6 0.2 0.8
Coronary Artery Disease (CAD) 2.4 2.9 12.2 2.3 0.0 0.2 0.2 0.5 1.5 -3.5
Crohns Disease (2012) 0.7 1.2 2.3 1.4 0.0 1.5 1.3 0.6 -1.0 -0.9
Mean Putamen Volume 0.1 0.1 0.6 -0.1 0.0 0.0 0.6 0.8 -0.2 0.2
Fasting Glucose 1.5 1.8 7.8 -1.2 0.0 -1.3 -0.2 2.8 1.2 0.7
HbA1C 1.2 1.3 4.8 2.0 0.0 0.3 0.5 0.0 0.3 -2.2
HDL Cholesterol 0.2 0.4 0.9 -0.7 0.0 -1.0 -0.7 -0.8 0.2 0.4
LDL Cholesterol 0.3 0.4 1.3 -0.6 0.0 -0.7 -1.1 -0.2 -0.7 0.5
Lupus 0.3 0.5 1.7 -0.7 0.0 0.6 0.6 0.6 -1.3 -0.5
Neuroticism (2016) 0.2 0.3 1.5 -0.3 0.0 -0.1 0.3 0.6 0.5 -1.2
Primary Biliary Cirrhosis 4.6 6.6 16.5 2.3 0.0 3.4 2.7 4.1 2.4 -0.5
Rheumatoid Arthritis 0.2 0.3 1.7 -0.2 0.0 0.5 0.2 -1.3 -0.5 -0.1
Schizophrenia (2014) 1.2 2.6 8.0 -0.5 0.0 2.8 1.7 2.4 0.6 1.0
Triglycerides 0.3 0.5 1.7 0.6 0.0 0.3 -0.9 -0.8 -1.3 -0.4
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.4 0.4 0.0 -1.2 -0.2 -0.1 0.2 -0.8
Ulcerative Colitis 1.9 2.7 5.6 1.6 0.0 2.2 2.4 1.4 -0.6 -1.9
Blood Eosinophil Count 0.3 2.4 6.7 -0.3 0.0 2.6 1.2 1.9 2.3 0.4
Blood Platelet Count 0.5 5.8 14.3 3.8 0.0 2.6 2.7 2.1 0.4 -2.8
Blood Red Count 0.6 6.2 13.0 -2.2 0.0 -3.0 -3.2 -3.6 -1.6 1.8
Blood White Count 0.1 0.5 1.3 -0.0 0.0 0.7 -0.4 -1.1 -0.8 -0.8
Heel T-Score 0.1 0.8 4.4 -0.2 0.0 0.7 -0.6 0.1 -2.1 0.0
BMI 0.2 0.9 2.8 -0.2 0.0 -1.7 -0.7 0.5 1.3 -0.9
Height 0.1 1.9 7.0 -0.8 0.0 -1.9 -1.0 -2.6 -0.0 1.1
Waist Hip Ratio (WHR) 0.0 0.2 0.6 0.2 0.0 0.6 -0.7 -0.1 -0.1 0.4
Systolic Blood Pressure 4.1 20.4 41.3 6.3 0.0 6.4 5.8 2.7 -1.9 -4.2
Smoking Status 0.7 1.7 4.7 1.0 0.0 1.1 1.2 2.2 1.5 -0.9
Allergy or Eczema 0.2 0.5 1.1 0.6 0.0 0.8 0.7 1.0 -1.1 0.3
Cardiovascular Disease 0.5 1.7 7.3 1.8 0.0 0.8 0.6 -0.1 -0.4 -2.7
Hypothyroidism (self reported) 0.4 0.9 4.2 -0.7 0.0 -1.2 -2.0 -0.1 0.3 0.0
Respiratory disease 0.4 0.9 3.1 0.9 0.0 1.8 0.8 0.6 -1.1 -0.7
Type 2 Diabetes (T2D) (2018) 0.9 1.6 4.3 -0.1 0.0 -2.1 -1.1 -0.0 1.7 -1.8
Lung FEV1/FVC ratio 0.7 3.4 8.9 0.8 0.0 -2.1 -1.3 -3.0 -0.5 -2.8
Lung FVC 0.1 0.7 1.8 0.6 0.0 1.3 1.3 0.6 0.8 0.0
Neuroticism 1.0 2.5 6.0 2.3 0.0 1.7 1.3 1.1 0.1 -2.5
Chronotype (morning person) 0.9 2.0 8.3 0.2 0.0 1.8 1.0 1.0 2.9 0.5
Hair Pigment 0.0 0.9 2.0 1.4 0.0 -0.2 -1.4 -1.3 0.3 -0.8
Tanning 0.1 1.7 4.9 -1.0 0.0 1.2 1.8 2.2 1.2 0.3
Hand grip strength (left) 0.2 0.6 2.1 -0.0 0.0 0.7 1.4 0.3 -1.1 0.5
Number of treatments/medications taken 0.3 0.6 2.0 1.2 0.0 0.2 -0.6 -0.5 -0.3 -1.4
Average weekly spirits intake 0.3 0.4 0.8 0.1 0.0 -0.9 -0.9 -0.3 -0.0 -0.9
Sensitivity / hurt feelings 0.6 1.1 3.2 1.8 0.0 0.3 0.1 0.1 1.7 -1.2
Frequency of depressed mood in last 2 weeks 1.3 1.9 8.9 1.8 0.0 0.6 0.1 -0.6 0.1 -3.0
Hearing difficulty/problems: Yes 1.8 2.7 8.7 -1.1 0.0 -1.5 -3.0 -1.5 -0.1 2.0
Relative age of first facial hair 0.2 0.5 0.9 -0.8 0.0 0.8 1.0 -0.8 0.7 0.4
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.6 1.0 0.0 -0.9 -1.5 -1.9 0.3 -0.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.7 1.6 0.0 0.2 -0.5 -0.5 -0.4 -1.0
Ever had hysterectomy (womb removed) 1.8 2.0 7.2 2.7 0.0 1.2 0.8 0.5 -0.6 -2.0
Systolic blood pressure, automated reading 2.1 6.2 15.2 3.9 0.0 3.1 2.6 -0.0 -2.0 -2.7
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 5.8 -0.9 0.0 1.0 1.1 2.4 2.1 -0.2
Angina 3.3 4.3 15.9 3.3 0.0 1.2 1.3 0.3 -0.7 -4.0
Medication for hormone replacement therapy 0.2 0.3 0.6 0.5 0.0 -0.3 -0.7 -0.8 0.4 -0.5
Vitamin and mineral supplements 0.5 0.6 1.3 -1.2 0.0 -0.4 -1.1 -0.5 -0.6 1.0
Supplements: Zinc 0.5 0.6 2.5 0.4 0.0 0.1 0.1 -1.6 -1.2 -0.0
Medication: Co-codamol 0.3 0.4 1.2 -0.3 0.0 -0.6 -0.8 -0.2 0.5 -1.1
Medication: Metformin 0.6 0.8 2.9 -1.7 0.0 -1.4 -0.8 0.1 0.7 -0.2
Diabetes (father) 0.3 0.4 0.9 0.5 0.0 1.0 0.5 0.8 0.7 -0.1
Diabetes (mother) 1.1 1.4 2.9 -0.8 0.0 -1.3 -1.3 -1.7 -1.7 0.1
Severe depression (siblings) 0.9 1.0 3.6 0.1 0.0 1.5 -0.1 -0.9 -1.9 0.5
Pack years adult smoking proportion 1.7 2.6 9.0 1.4 0.0 -2.5 -0.7 -0.1 0.8 -3.0
Impedance of leg (right) 0.1 0.6 2.5 1.6 0.0 0.3 -0.8 -0.4 -0.0 -0.8
Leg fat-free mass (left) 0.1 0.3 0.8 -0.8 0.0 -0.5 0.9 0.4 0.6 -0.1
Trunk fat percentage 0.3 1.2 2.8 0.6 0.0 -1.0 -0.5 1.4 1.7 -1.5
Hand grip strength (right) 0.5 1.3 3.9 1.4 0.0 1.4 2.0 0.6 -0.2 -1.0
Townsend deprivation index at recruitment 1.0 1.4 4.2 2.0 0.0 -0.2 0.1 -1.2 0.7 -1.9
Current tobacco smoking 1.4 2.2 7.6 1.7 0.0 0.4 0.7 0.5 2.0 -2.8
Average weekly fortified wine intake 3.2 3.8 9.7 1.8 0.0 2.0 3.1 2.4 1.0 -1.6
Maternal smoking around birth 0.8 1.1 3.3 1.8 0.0 1.4 0.5 0.3 0.2 -1.4
Fed-up feelings 0.8 1.4 4.2 1.1 0.0 0.4 1.1 1.1 1.4 -2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 4.4 1.3 0.0 0.7 -0.3 -0.8 -0.9 -2.1
Relative age voice broke 0.8 1.3 5.2 -0.1 0.0 -1.4 -0.9 -2.3 1.0 -0.0
Taking other prescription medications 0.8 1.2 4.2 -0.5 0.0 -0.6 -2.0 -0.9 1.6 0.4
Age when periods started (menarche) 0.5 1.3 3.3 -1.4 0.0 0.4 0.6 -1.4 -1.2 1.8
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 7.2 2.7 0.0 1.3 0.7 1.2 0.3 -2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.4 -0.6 0.0 0.4 -0.9 -1.2 -0.7 -0.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 1.2 0.0 0.0 -0.5 -1.1 0.2 0.0 0.1
Qualifications: CSEs or equivalent 1.1 1.5 7.0 0.8 0.0 -0.2 -0.5 0.0 2.7 -1.5
Serious illness, injury or assault to yourself 1.0 1.2 2.5 -1.3 0.0 -1.6 -1.4 -0.4 0.8 1.2
High blood pressure 0.8 2.3 6.9 2.5 0.0 1.4 1.0 0.2 -0.2 -2.6
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.4 0.9 0.0 1.9 1.3 1.2 -0.5 -0.4
Multivitamins +/- minerals 0.7 0.9 2.3 1.1 0.0 1.1 1.5 0.5 0.9 -0.7
Stomach or abdominal pain in last month 1.6 2.0 4.9 -0.3 0.0 -2.1 -2.2 -2.0 -0.6 -0.0
Supplements: Glucosamine 0.3 0.4 1.4 -0.8 0.0 0.1 -0.6 -0.1 0.7 1.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.4 0.6 0.0 -1.4 -0.5 -0.4 1.9 -1.7
Medication: Atenolol 1.0 1.2 3.5 1.9 0.0 1.3 0.9 1.4 -0.5 -0.5
Medication: Levothyroxine sodium 0.3 0.6 3.7 0.3 0.0 0.0 -1.9 -0.4 -0.3 0.1
Sitting height 0.1 0.7 2.2 -0.6 0.0 -1.5 -0.7 -0.9 0.0 0.8
Chronic bronchitis/emphysema (father) 0.4 0.5 2.1 0.1 0.0 1.5 -0.5 -0.5 -0.4 0.8
High blood pressure (mother) 0.5 0.6 1.5 0.6 0.0 0.5 1.2 -0.4 -1.2 -0.9
Body mass index (BMI) 0.2 0.9 3.3 -0.3 0.0 -1.1 -0.5 1.0 1.8 -0.8
Impedance of leg (left) 0.1 0.7 2.6 1.6 0.0 -0.1 -0.9 0.1 0.3 -1.1
Leg predicted mass (left) 0.1 0.3 0.8 -0.8 0.0 -0.4 0.9 0.4 0.6 -0.0
Trunk fat mass 0.2 1.0 2.8 0.1 0.0 -1.2 -0.5 1.3 1.7 -1.0
Waist circumference 0.1 0.4 1.4 0.6 0.0 -0.6 -0.6 0.3 0.7 -1.2
Number of incorrect matches in round 0.7 1.1 3.6 0.1 0.0 0.9 1.2 1.3 -1.9 -0.6
Past tobacco smoking 0.2 0.4 1.6 -0.2 0.0 0.2 -0.6 -1.3 0.1 -0.7
Alcohol usually taken with meals 2.3 3.7 9.1 -2.1 0.0 -2.2 -2.1 -0.7 -1.7 3.0
Nervous feelings 0.4 0.8 2.3 1.5 0.0 -0.3 -0.6 -1.1 -0.4 -1.1
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 6.0 0.5 0.0 -2.0 -2.5 -1.6 0.0 -1.1
Hearing difficulty/problems with background noise 0.5 0.8 3.9 0.6 0.0 -0.7 -2.0 -0.8 0.6 -0.2
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 0.6 0.0 0.4 0.5 -0.6 -0.1 0.3
Had menopause 0.4 0.4 1.5 0.9 0.0 0.2 -0.1 -1.2 0.1 -0.9
Had other major operations 1.3 1.6 3.2 1.8 0.0 1.5 1.4 0.7 0.0 -1.8
Forced vital capacity (FVC) 0.2 0.9 3.0 0.7 0.0 1.0 1.7 0.8 1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.0 -0.5 0.0 0.4 -0.6 -1.0 -0.8 -0.2
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.4 0.0 0.0 -1.6 -1.4 0.1 1.1 -0.8
Qualifications: None of the above 0.2 0.5 2.2 0.8 0.0 0.5 -0.2 -0.8 0.1 -1.5
Financial difficulties in last 2 years 4.2 5.6 11.4 3.0 0.0 1.9 1.9 1.9 2.8 -3.4
Mouth/teeth dental problems 0.3 0.5 1.5 -0.6 0.0 -0.1 0.9 1.2 0.8 0.0
Heart attack 1.2 1.6 6.5 2.0 0.0 0.4 0.3 0.1 0.6 -2.5
Allergy 0.3 0.7 1.9 -0.3 0.0 -1.4 -0.8 0.5 1.1 0.7
Pain all over the body in last month 2.5 2.7 7.7 2.0 0.0 1.6 1.4 1.7 -0.2 -2.8
Diabetes (self-reported) 0.8 1.2 2.4 0.1 0.0 -1.5 -1.2 -0.2 1.6 -1.4
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 2.6 1.6 0.0 1.3 1.5 1.4 1.2 -1.2
Medication: Ramipril 0.9 1.2 4.0 1.5 0.0 0.8 1.1 0.0 0.5 -2.0
Medication: Simvastatin 0.1 0.1 0.3 -0.5 0.0 -0.2 -0.5 0.5 -0.1 -0.5
Fluid intelligence score 0.4 0.8 3.8 0.2 0.0 2.0 1.2 0.5 -0.1 -0.2
Illnesses of siblings 0.9 1.2 5.6 -0.3 0.0 0.6 2.4 1.6 -0.2 -0.1
Neuroticism score 2.1 4.3 11.4 3.2 0.0 1.7 1.6 1.6 0.5 -3.4
Weight 0.2 0.8 2.2 -0.2 0.0 -1.5 -0.2 0.4 1.4 -0.9
Impedance of arm (right) 0.1 0.4 1.0 1.0 0.0 0.4 0.6 0.8 -0.6 -0.2
Arm fat percentage (right) 0.3 1.2 3.2 0.3 0.0 -1.0 -0.3 1.8 1.6 -1.0
Trunk fat-free mass 0.1 0.5 1.7 -1.3 0.0 -1.0 -0.0 -0.4 0.0 0.9
Hip circumference 0.1 0.6 2.4 -0.1 0.0 -1.5 -0.3 0.2 0.7 -1.0
Time employed in main current job 1.0 1.2 3.1 -1.5 0.0 -0.7 0.2 0.0 -1.8 1.6
Alcohol intake versus 10 years previously 0.9 1.3 7.0 0.8 0.0 0.3 0.1 -0.0 2.6 -1.3
Father’s age at death 2.0 2.7 9.7 -2.7 0.0 0.4 0.6 1.2 -0.2 3.1
Worrier / anxious feelings 0.3 0.5 1.2 0.9 0.0 0.5 0.1 1.0 0.5 -1.1
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 6.1 1.8 0.0 -0.6 -1.1 -1.5 -0.8 -2.5
Falls in the last year 0.6 0.9 3.8 0.4 0.0 0.2 -0.7 -1.0 0.7 -2.0
Hair/balding pattern: Pattern 3 0.5 0.7 1.5 -1.0 0.0 -1.2 -0.7 1.2 0.4 0.7
Number of live births 1.7 2.4 5.8 -0.2 0.0 -1.4 -2.1 -2.4 -1.4 1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.3 0.8 0.0 0.1 1.1 -0.1 0.7 -0.5
Pulse rate 0.2 0.3 1.6 -0.2 0.0 -0.7 -0.2 -0.1 1.3 -0.5
Happiness 1.9 2.3 5.6 0.0 0.0 1.2 2.3 2.4 1.8 -0.7
Noisy workplace 0.4 0.5 2.2 1.5 0.0 0.6 0.3 0.1 0.6 -0.7
Qualifications: A levels/AS levels or equivalent 0.2 0.3 1.3 -0.4 0.0 -0.2 0.4 -0.8 0.3 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.4 1.2 0.0 0.4 0.1 -0.7 0.3 -1.9
Mouth/teeth dental problems: Dentures 0.9 1.6 3.4 -0.9 0.0 -1.9 -1.7 -1.3 -0.8 1.3
Asthma 1.2 2.3 4.0 1.9 0.0 2.0 1.7 0.9 -1.0 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.1 -0.3 0.0 -1.1 -1.3 -2.0 -0.1 -0.1
Medication: Cholesterol lowering 0.2 0.3 1.0 -1.0 0.0 -0.4 -0.3 -0.8 -0.1 -0.3
Depression (self-reported) 0.3 0.4 1.4 1.2 0.0 0.0 -0.0 0.7 0.1 -1.0
Medication: Lansoprazole 2.0 2.2 5.5 0.0 0.0 -2.1 -2.2 -2.4 0.6 0.4
Prospective memory result 0.7 0.9 2.9 -1.7 0.0 -1.0 -0.9 -1.0 -0.1 0.8
Lung cancer (father) 0.3 0.4 1.4 -0.4 0.0 0.6 0.2 -0.3 -1.2 0.7
Illnesses of mother 0.3 0.4 1.4 -0.9 0.0 0.3 0.1 0.5 1.2 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.8 0.6 0.0 -0.0 1.3 0.4 1.1 -0.6
Pulse wave Arterial Stiffness index 1.1 1.3 3.5 1.2 0.0 -0.8 -0.4 -1.2 1.3 -1.9
Impedance of arm (left) 0.1 0.3 1.3 1.2 0.0 -0.0 -0.2 -0.4 -0.4 -0.6
Arm fat mass (right) 0.3 1.1 3.6 -0.1 0.0 -1.2 -0.5 1.1 1.9 -0.9
Trunk predicted mass 0.1 0.6 1.8 -1.3 0.0 -1.0 -0.0 -0.4 0.0 0.9
Standing height 0.1 0.5 1.8 -0.0 0.0 -1.3 0.2 -1.2 -0.5 0.2
Length of working week for main job 0.3 0.3 1.1 -0.8 0.0 0.2 1.1 0.3 0.4 -0.2
Exposure to tobacco smoke at home 0.5 0.6 2.3 0.1 0.0 -1.0 -0.2 0.0 1.5 -0.8
Breastfed as a baby 0.2 0.2 0.5 0.4 0.0 0.3 0.5 -0.5 0.3 -0.7
Tense / ‘highly strung’ 0.9 1.6 6.2 2.0 0.0 0.7 0.4 0.5 -0.2 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 11.8 2.4 0.0 -0.8 -0.2 0.7 -1.2 -3.4
Hair/balding pattern: Pattern 4 0.1 0.3 0.9 0.5 0.0 -0.2 -0.6 0.5 -0.9 -0.2
Birth weight of first child 2.0 3.7 11.4 0.3 0.0 2.1 3.1 3.4 -0.2 0.6
Peak expiratory flow (PEF) 0.2 0.4 1.2 0.9 0.0 -1.1 0.2 0.1 0.2 -0.9
Pulse wave reflection index 0.1 0.1 0.2 0.1 0.0 -0.3 -0.2 -0.2 0.5 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.9 1.2 0.0 0.9 0.4 0.4 0.5 -1.7
Loud music exposure frequency 1.8 1.9 3.5 1.4 0.0 1.2 1.8 1.9 0.6 -1.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.6 1.2 0.0 1.3 1.6 1.5 0.9 -0.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.3 0.6 0.0 1.5 1.0 0.6 1.0 -0.5
Blood clot in the leg (DVT) 13.1 16.9 49.0 -6.0 0.0 -2.9 -2.6 -7.0 -3.5 2.4
Medication: Paracetamol 0.2 0.3 1.0 -0.5 0.0 0.3 0.2 -1.0 -0.4 -0.5
Headache pain in last month 0.9 1.5 3.5 -1.6 0.0 -0.6 -1.7 -0.7 0.6 1.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 1.1 0.0 0.2 0.2 0.5 1.0 0.4
Glaucoma (self-reported) 0.6 0.7 2.6 0.8 0.0 0.9 0.4 1.6 -0.3 -0.6
Gout (self-reported) 0.4 0.5 1.2 -0.4 0.0 -1.1 -0.9 -0.9 0.6 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 3.0 -0.3 0.0 -0.2 -1.7 -0.0 0.3 0.1
Medication: Amlodipine 0.8 1.1 4.3 1.0 0.0 0.8 0.7 -0.8 -2.1 -0.7
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.5 1.2 0.0 0.3 -0.3 -0.9 0.5 -0.9
Birth weight 0.4 0.8 3.3 -0.5 0.0 -1.0 -1.0 0.2 1.8 0.6
Chronic bronchitis/emphysema (mother) 0.9 1.1 6.6 -0.3 0.0 0.3 -0.5 -0.7 -0.1 2.6
High blood pressure (siblings) 1.0 1.4 4.1 1.0 0.0 -1.0 -1.7 -2.0 -0.4 -0.7
Forced vital capacity (FVC), Best measure 0.2 0.7 2.3 0.4 0.0 0.3 1.3 0.8 1.5 -0.1
Body fat percentage 0.3 1.3 2.6 0.6 0.0 -1.1 -0.8 1.2 1.6 -1.6
Leg fat percentage (right) 0.3 1.1 2.1 0.3 0.0 -1.4 -1.5 0.5 1.3 -1.2
Arm fat-free mass (right) 0.1 0.3 0.6 -0.3 0.0 -0.8 0.0 -0.5 0.7 -0.7
Exposure to tobacco smoke outside home 0.7 1.0 3.0 1.7 0.0 -0.9 -1.1 -0.5 0.7 -1.1
Comparative body size at age 10 0.3 0.8 3.0 0.1 0.0 0.2 0.9 1.7 1.4 -0.2
Number of full brothers 0.5 0.7 2.0 1.4 0.0 -1.3 -0.9 -0.3 -0.2 -0.3
Worry too long after embarrassment 1.4 2.3 4.0 2.0 0.0 1.9 1.4 1.7 1.0 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 6.4 1.8 0.0 -0.9 -0.3 -0.5 -0.3 -2.5
Wheeze or whistling in the chest in last year 0.3 0.6 1.8 0.3 0.0 0.3 -0.6 -0.8 1.3 -1.1
Number of children fathered 0.9 1.0 2.9 0.3 0.0 -1.7 -1.6 0.5 -0.8 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.6 -0.7 0.0 0.9 -0.3 -1.5 -1.6 0.9
Age at first live birth 1.6 2.9 11.1 -2.5 0.0 -0.2 -1.1 0.2 -1.2 3.3
Pulse wave peak to peak time 1.0 1.2 2.9 -0.9 0.0 0.9 0.6 1.3 -1.3 1.7
Health satisfaction 0.4 0.5 1.3 0.7 0.0 0.1 0.6 0.0 1.0 -1.1
Shortness of breath walking on level ground 1.2 1.4 4.7 1.7 0.0 0.8 -0.6 -0.9 -0.7 -2.2
Qualifications: College or University degree 0.5 1.6 6.9 -1.7 0.0 -1.2 -0.3 0.3 0.1 2.6
Eye problems/disorders: None of the above 0.3 0.4 1.1 0.9 0.0 0.2 -0.4 -1.0 -0.6 0.0
Mouth/teeth dental problems: Loose teeth 1.1 1.3 5.3 1.1 0.0 -0.1 -0.2 -0.4 1.5 -2.3
Emphysema/chronic bronchitis 0.6 0.7 2.0 0.5 0.0 -0.8 -1.2 -1.4 0.6 -0.2
Medication for pain relief, constipation, heartburn 0.6 1.0 2.9 -0.4 0.0 0.4 0.6 1.7 1.1 1.4
Neck or shoulder pain in last month 0.4 0.5 1.3 1.1 0.0 0.5 0.7 0.1 -0.8 -1.0
Medication: Blood pressure 0.4 0.7 2.9 -0.0 0.0 0.7 0.7 0.2 -1.7 -0.8
Angina (self-reported) 2.8 3.7 13.3 3.1 0.0 1.1 1.1 0.1 -0.5 -3.7
Migraine (self-reported) 2.1 2.5 7.8 1.1 0.0 2.8 1.1 2.7 0.6 -0.1
Medication: Ibuprofen 0.3 0.4 1.8 0.0 0.0 -0.5 -0.5 -1.3 -0.3 -0.4
Medication: Allopurinol 0.2 0.3 0.8 -0.4 0.0 -0.5 -0.7 -0.4 0.9 0.1
Medication: Omeprazole 0.6 0.8 3.8 1.9 0.0 0.7 -0.7 0.2 -0.3 -0.7
Medication: Seretide 50 evohaler 0.4 0.4 2.5 0.3 0.0 0.2 0.4 -0.4 1.6 -0.4
Mean time to correctly identify matches 0.7 1.4 5.7 -2.0 0.0 -0.3 -0.5 0.1 0.0 2.4
Heart disease (mother) 1.6 2.0 7.0 2.5 0.0 0.6 0.2 0.3 -0.5 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 4.9 2.2 0.0 0.5 1.2 -0.2 -0.5 -2.1
Whole body fat mass 0.3 1.1 2.9 0.1 0.0 -1.3 -0.5 1.1 1.7 -1.1
Leg fat mass (right) 0.2 0.9 2.2 -0.2 0.0 -1.5 -1.1 0.5 1.4 -0.9
Arm predicted mass (right) 0.1 0.3 0.8 -0.7 0.0 -0.9 -0.1 -0.2 0.6 -0.5
Pulse rate, automated reading 0.2 0.6 2.0 0.0 0.0 -1.3 -0.6 0.2 0.5 -1.4
Alcohol intake frequency. 0.9 2.1 6.2 2.1 0.0 1.2 0.7 -0.8 -1.0 -2.5
Comparative height size at age 10 0.1 0.8 2.0 0.8 0.0 -0.4 0.8 1.0 1.4 -1.0
Number of full sisters 0.8 1.0 2.9 1.5 0.0 -0.1 0.3 -0.8 1.0 -1.7
Suffer from ‘nerves’ 0.4 0.6 1.6 0.6 0.0 -1.1 -0.7 -0.6 0.2 -1.3
Overall health rating 0.5 1.0 4.7 1.1 0.0 -0.5 -0.1 -0.8 0.2 -2.2
Chest pain or discomfort 0.8 1.2 5.7 1.1 0.0 -0.4 -0.8 -0.0 0.8 -2.4
Had major operations 0.9 1.1 2.1 -0.4 0.0 -1.4 -1.2 -1.4 -1.4 -0.1
Age at last live birth 0.7 1.0 4.5 -0.9 0.0 0.2 -1.0 0.5 -0.4 2.1
Family relationship satisfaction 0.5 0.6 3.0 0.5 0.0 0.3 1.7 -0.2 0.2 -1.0
Leg pain on walking 1.7 2.1 5.8 1.6 0.0 1.8 1.6 0.7 0.6 -2.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 3.1 1.8 0.0 -0.1 -1.1 -0.2 0.4 -1.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 3.8 -0.2 0.0 -0.0 0.4 1.9 0.4 0.3
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 9.4 -0.9 0.0 0.2 0.2 -0.1 -3.1 1.7
Medication: Aspirin 2.0 2.6 9.9 1.4 0.0 0.6 0.7 -0.5 -2.4 -3.1
Supplements: Vitamin C 0.5 0.6 3.3 0.1 0.0 0.1 0.8 1.8 -0.2 -0.6
Knee pain experienced in last month 0.1 0.2 0.5 -0.4 0.0 -0.7 -0.7 -0.5 -0.1 0.2
Hypertension (Self-reported) 0.8 2.1 6.6 2.3 0.0 1.3 0.9 0.1 -0.5 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 3.0 -0.2 0.0 0.2 -1.2 -0.6 1.7 0.4
Illnesses of father: Heart disease 0.4 0.6 1.4 1.2 0.0 1.0 0.4 0.6 -0.5 -1.0
Illnesses of siblings: Diabetes 1.4 1.7 5.6 -0.9 0.0 -1.6 -2.4 -1.1 1.2 0.5
Smoking status: Previous 0.7 1.0 3.8 -1.1 0.0 -0.6 -0.1 1.0 -1.0 1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.3 0.6 0.0 0.3 0.9 -0.4 -1.1 -0.2
Whole body fat-free mass 0.1 0.3 1.2 -1.1 0.0 -0.8 0.4 -0.0 0.4 0.4
Leg fat-free mass (right) 0.1 0.4 1.0 -1.0 0.0 -0.6 0.8 0.4 0.5 0.1
Arm fat percentage (left) 0.3 1.3 3.5 0.1 0.0 -1.3 -0.8 1.2 1.9 -1.2
Average weekly red wine intake 0.9 1.3 4.1 -2.0 0.0 -0.7 -0.9 0.8 -0.1 1.8
Handedness (chirality/laterality): Left-handed 1.1 1.3 4.2 -0.3 0.0 0.2 -1.1 -0.8 -1.8 2.0
Mood swings 0.7 1.3 2.7 1.3 0.0 0.8 1.4 1.7 -0.0 -1.6
Loneliness, isolation 0.9 1.2 3.0 1.7 0.0 1.7 0.8 0.7 0.3 -1.2
Long-standing illness, disability or infirmity 1.1 1.7 3.7 1.8 0.0 -0.7 -1.6 -1.4 0.1 -1.9
Ever had bowel cancer screening 0.5 0.6 1.4 -0.1 0.0 -0.1 -1.1 -1.1 0.2 1.2
Diabetes diagnosed by doctor 0.9 1.5 4.1 0.0 0.0 -2.0 -1.0 -0.4 1.5 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 0.6 0.0 0.5 -0.1 -0.3 -0.3 -0.8
Friendships satisfaction 0.8 1.0 2.8 0.8 0.0 1.4 1.7 0.1 -0.8 -1.0
Qualifications: nursing, teaching 0.5 0.8 2.4 -0.9 0.0 0.0 0.5 0.5 -1.4 1.5
Commuting to job workplace: Walk 1.0 1.1 3.0 1.4 0.0 0.0 0.6 -0.9 1.7 -1.3
Eye problems/disorders: Cataract 0.2 0.2 1.1 -0.2 0.0 -1.1 -0.0 -0.5 0.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 0.4 0.0 0.3 -0.2 0.1 0.4 -0.5
Medication for cholesterol 0.9 1.4 5.2 -2.3 0.0 -0.5 0.5 0.2 -0.5 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 -0.9 0.0 -0.4 -0.4 0.3 0.8 1.0
Back pain experienced in last month 1.5 2.2 6.1 2.5 0.0 -0.2 -1.6 -1.3 -1.5 -1.7
Mineral and other dietary supplements 0.5 0.7 1.1 0.8 0.0 0.8 1.1 0.8 -0.8 -1.1
Breast cancer (self-reported) 0.9 1.1 2.9 0.7 0.0 1.0 1.0 1.7 0.4 -1.4
Asthma (self-reported) 1.4 2.7 4.5 2.0 0.0 2.1 1.9 1.1 -1.1 -2.1
Osteoporosis (self-reported) 0.6 0.8 2.8 -0.0 0.0 0.1 -1.7 -1.0 1.3 0.5
Osteoarthritis (self-reported) 0.4 0.5 1.8 0.9 0.0 0.1 -0.5 -0.5 0.3 -1.3
Medication: Aspirin 1.9 2.5 9.8 1.4 0.0 0.4 0.6 -0.8 -2.1 -3.1
Medication: Gliclazide 0.5 0.6 1.9 0.4 0.0 0.7 1.0 0.4 -0.6 -1.4
Illnesses of father: None of the above (group 1) 1.4 1.7 6.2 -1.3 0.0 -2.5 -1.7 -1.0 0.4 0.3
Smoking status: Current 1.7 2.7 8.4 2.0 0.0 0.4 0.9 0.7 2.3 -2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.5 -0.3 0.0 0.7 0.4 -0.2 0.0 -0.0
Whole body water mass 0.0 0.3 0.9 -0.9 0.0 -0.6 0.5 0.0 0.5 0.2
Leg predicted mass (right) 0.1 0.4 0.9 -0.9 0.0 -0.6 0.9 0.5 0.5 0.0
Arm fat mass (left) 0.2 0.9 2.4 -0.2 0.0 -1.3 -0.7 0.8 1.5 -0.9
Number of self-reported non-cancer illnesses 3.1 5.3 15.8 3.9 0.0 1.9 1.2 1.0 -0.1 -4.0
Average weekly champagne plus white wine intake 0.8 1.0 2.6 -1.4 0.0 -0.3 -0.6 1.6 0.8 1.3
Miserableness 0.2 0.4 1.3 0.4 0.0 0.4 0.4 1.1 0.2 -0.9
Guilty feelings 1.3 1.9 7.8 2.3 0.0 0.5 -0.2 0.1 -0.1 -2.8
Wears glasses or contact lenses 1.1 1.3 3.4 -1.9 0.0 -0.8 -1.3 0.5 0.9 1.4
Ever taken oral contraceptive pill 0.2 0.3 0.9 -0.4 0.0 0.9 0.4 0.7 0.1 0.2
Hearing aid user 0.9 1.0 3.4 1.1 0.0 -1.1 -0.5 -1.0 -0.2 -1.8
Mother’s age at death 2.0 2.5 8.8 -3.0 0.0 -1.6 -0.8 -1.0 -0.1 2.1
Financial situation satisfaction 0.9 1.1 3.3 0.9 0.0 0.7 1.8 0.8 0.9 -1.2
Tinnitus: Yes, now most or all of the time 1.3 1.6 4.2 1.1 0.0 1.5 2.0 1.5 -0.1 -0.9
Commuting to job workplace: Public transport 0.2 0.2 0.9 0.6 0.0 0.0 0.1 -0.0 0.3 -0.9
Eye problems/disorders: Glaucoma 0.5 0.6 2.4 0.3 0.0 1.1 0.7 1.6 0.0 -0.5
Medication: Blood pressure 1.8 3.4 11.8 3.4 0.0 1.5 1.1 0.8 0.2 -2.8
Pain type(s) experienced in last month: Hip pain 1.5 1.9 4.7 2.2 0.0 -0.7 -1.8 -2.0 -0.4 -0.7
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 -0.2 0.0 0.1 0.2 -0.3 0.2 0.1
High cholesterol (Self-reported) 0.1 0.2 0.8 -0.2 0.0 -0.9 -0.7 -0.4 0.2 -0.4
Medication: Bendroflumethiazide 0.8 1.2 2.9 0.6 0.0 0.8 1.7 1.7 -1.1 -0.6
Medication: Paracetamol 0.3 0.4 1.7 -0.7 0.0 -0.2 0.5 -1.3 -0.3 -0.6
Medication: Lisinopril 1.2 1.5 3.6 1.7 0.0 1.9 1.3 0.8 0.7 -1.2
Medication: Atorvastatin 1.6 2.0 7.3 1.0 0.0 -1.5 -1.5 -2.7 0.7 -0.8
Illnesses of father: High blood pressure 1.3 1.6 3.5 1.6 0.0 0.7 1.8 0.9 0.6 -1.9
Alcohol drinker status: Never 1.4 1.7 4.8 1.0 0.0 1.2 1.0 1.2 -2.2 -1.4
Ever smoked 0.3 0.6 1.1 -0.9 0.0 -0.8 0.1 1.0 0.7 0.9
Basal metabolic rate 0.1 0.3 0.8 -0.9 0.0 -0.9 0.3 0.2 0.7 0.0
Leg fat percentage (left) 0.4 1.4 2.6 0.3 0.0 -1.6 -1.5 0.9 1.6 -1.3
Arm fat-free mass (left) 0.0 0.2 0.4 -0.5 0.0 -0.4 0.4 0.3 0.6 -0.3
Number of operations (self-reported) 1.3 1.9 5.9 2.4 0.0 1.1 0.6 0.6 -0.7 -2.3
Average weekly beer plus cider intake 0.5 0.7 1.7 0.6 0.0 1.1 0.2 -1.1 0.4 -1.3
Irritability 1.5 2.5 4.5 2.0 0.0 2.1 2.1 1.1 -0.6 -1.7
Risk taking 0.6 0.9 2.1 -0.8 0.0 -1.5 -1.0 -1.2 -1.0 0.1
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.1 1.0 0.0 0.2 0.9 1.1 -0.7 -0.8
Fractured/broken bones in last 5 years 0.2 0.3 1.1 -1.1 0.0 -0.2 -0.6 0.5 -0.0 0.3
Age started oral contraceptive pill 0.1 0.2 0.6 0.4 0.0 0.3 -0.3 -0.8 -0.3 0.3
Diastolic blood pressure, automated reading 0.4 1.2 5.6 -0.8 0.0 1.2 0.1 0.7 0.1 2.4
Ever depressed for a whole week 0.5 0.6 3.7 -0.5 0.0 0.1 -0.6 1.9 -0.1 -0.0
Unable to work because of sickness or disability 0.4 0.5 2.8 0.3 0.0 -0.2 -0.2 -0.2 0.6 -1.7
Commuting to job workplace: Cycle 0.5 0.6 1.9 -0.8 0.0 -1.2 -0.0 -0.5 -1.4 -0.0
Myopia 3.3 4.8 11.2 2.6 0.0 3.0 2.6 3.3 -0.0 0.1
Vascular/heart problems diagnosed by doctor 1.0 2.6 9.5 -2.6 0.0 -1.2 -0.7 0.4 0.2 3.1
Cholesterol lowering medication 0.5 0.8 2.7 0.8 0.0 -0.9 -1.6 -0.7 0.6 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.8 2.0 0.0 0.9 -0.1 0.2 -0.8 -1.2
Pain experienced in last month 0.6 0.9 3.6 0.3 0.0 1.1 1.9 1.3 0.3 -0.0
Supplements: Calcium 0.4 0.4 1.4 1.2 0.0 0.3 -0.5 0.3 0.9 -0.1
Basal cell carcinoma (self-reported) 0.4 0.5 1.3 0.1 0.0 -1.0 -1.1 -0.1 -1.0 -0.3
Heart attack/myocardial infarction (self-reported) 1.2 1.5 5.9 2.0 0.0 0.6 0.5 0.1 0.5 -2.4
Deep venous thrombosis (DVT) (self-reported) 12.7 16.4 46.4 -6.0 0.0 -2.7 -2.6 -6.8 -3.5 2.4
Heart disease (siblings) 0.7 0.8 3.5 0.1 0.0 1.4 -0.7 -0.1 1.9 -0.2
Alcohol drinker status: Previous 1.9 2.2 6.5 2.3 0.0 1.7 0.3 -0.6 -0.4 -2.5
Pack years of smoking 1.5 2.2 7.7 0.7 0.0 -2.8 -1.3 -0.1 0.7 -2.2
Impedance of whole body 0.1 0.5 2.2 1.5 0.0 0.1 -0.3 -0.2 -0.0 -1.1
Leg fat mass (left) 0.3 1.2 3.0 -0.2 0.0 -1.7 -1.2 0.8 1.6 -1.0
Arm predicted mass (left) 0.1 0.3 0.7 -0.4 0.0 -0.9 0.1 0.0 0.7 -0.6