Hub : Genes

SLC19A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2650	0.0920	0.0021	0.026	NA	0.038	NA	0.041	0.071	NA	0.037	NA	0.032
2	NTR	Blood	0.0144	0.0074	0.0094	-0.001	0.003	0.000	0.002	0.000	0.860	0.041	0.320	0.062	0.460
3	TCGA	Lung Squamous Cell Carcinoma	0.0557	0.0284	0.0031	-0.002	-0.002	0.003	NA	0.001	0.750	0.850	0.150	NA	0.250
4	TCGA	Prostate Adenocarcinoma	0.0431	0.0248	0.0097	0.004	0.010	0.002	NA	0.003	0.120	0.026	0.170	NA	0.130

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.1	0.7	0.1	-0.8
Bipolar Disorder or Schizophrenia	0.4	1.1	2.8	-1.7	-0.6	-0.4	-0.9
Depressed Affect (Nagel 2018)	0.5	1.1	2.8	0.0	0.5	-1.7	-1.2
Depression (Nagel 2018)	1.6	2.3	5.8	0.5	1.6	-2.4	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.3	0.5	-1.3	0.2	1.8
Neuroticism (Nagel 2018)	1.1	2.6	5.3	0.2	1.7	-2.3	-1.4
Schizophrenia (2018)	0.8	1.7	4.4	-2.1	-1.4	-0.2	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	1.6	-1.3	-0.7	0.4	0.1
Worry (Nagel 2018)	0.7	1.4	2.2	0.3	1.5	-1.1	-1.5
Alzheimer’s Disease (in mother)	1.4	1.7	3.6	0.2	-1.7	-0.1	1.9
Alzheimer’s Disease (in father)	0.6	0.7	2.4	0.2	-1.6	-0.0	-0.5
Alzheimer’s Disease (including proxy)	1.3	1.9	4.2	0.9	-2.0	-0.3	1.6
Crohns Disease (2017)	1.2	2.5	8.0	-2.8	0.7	1.2	-0.5
Irritable Bowel Disease (IBD)	0.6	1.4	3.1	-1.8	1.1	0.2	-1.2
Ulcerative Colitis (UC)	0.4	0.8	1.5	-0.6	1.0	-0.6	-1.2
Major Depression (MDD)	1.0	1.2	3.3	-0.8	-1.8	-0.8	-0.2
Reaction Time	1.2	2.3	6.0	0.6	-2.4	1.0	1.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-0.0	-0.2	1.2	1.5
Breast Cancer	2.5	6.0	18.0	-2.0	-1.0	1.0	4.2
Ovarian Cancer	0.6	0.8	2.8	0.6	0.2	1.7	-0.1
Prostate Cancer	0.8	1.1	2.4	0.6	-1.5	-0.3	1.3
Age at First Birth	1.1	1.6	3.1	0.3	0.8	1.5	1.8
Bipolar Disorder (2011)	1.0	1.0	3.8	0.2	-2.0	-0.2	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	0.4	-0.3	-0.6	-0.7
Coronary Artery Disease (CAD)	0.7	0.8	2.9	-0.5	1.7	0.2	0.1
Crohns Disease (2012)	1.0	1.7	4.1	-2.0	1.1	1.0	-0.5
Mean Putamen Volume	0.6	0.6	1.7	-0.5	0.6	-1.3	0.4
Fasting Glucose	1.3	1.6	3.3	-1.4	-1.8	-0.2	1.0
HbA1C	1.1	1.2	3.1	-0.0	1.8	-0.2	-1.3
HDL Cholesterol	0.1	0.1	0.2	0.5	-0.2	0.5	0.2
LDL Cholesterol	1.0	1.5	3.0	-0.3	-1.7	1.1	1.4
Lupus	0.5	0.8	1.6	0.2	1.2	-0.3	-1.2
Neuroticism (2016)	1.2	1.8	5.9	0.7	0.3	-2.4	-0.8
Primary Biliary Cirrhosis	0.3	0.5	1.3	-0.2	-1.1	0.8	0.1
Rheumatoid Arthritis	0.9	1.2	2.5	1.4	-0.0	-1.6	-0.7
Schizophrenia (2014)	0.7	1.6	3.7	-1.6	-1.9	0.3	0.2
Triglycerides	0.7	1.1	3.5	-0.2	-0.8	1.9	0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.9	-0.4	-0.2	-1.3	-1.4
Ulcerative Colitis	0.6	0.9	2.8	-0.6	1.7	0.5	-0.5
Blood Eosinophil Count	0.2	1.7	4.3	1.3	-0.6	-0.6	2.1
Blood Platelet Count	0.5	5.3	10.8	1.5	2.8	0.6	-3.3
Blood Red Count	0.2	1.6	3.1	-1.0	-1.5	-0.4	1.8
Blood White Count	0.4	3.3	6.2	-2.5	2.1	-1.5	-0.4
Heel T-Score	0.2	1.4	2.5	-1.0	-1.6	1.1	-1.0
BMI	0.1	0.5	0.9	0.9	-0.3	-1.0	-0.3
Height	0.1	2.1	6.2	-0.6	0.6	1.2	2.5
Waist Hip Ratio (WHR)	0.4	1.9	6.7	2.6	-0.7	0.6	0.2
Systolic Blood Pressure	1.1	5.8	15.0	1.9	3.9	1.6	-1.4
Smoking Status	0.7	1.7	2.8	1.2	0.6	-1.4	-1.7
Allergy or Eczema	1.4	3.8	7.7	2.1	-1.2	2.8	1.3
Cardiovascular Disease	0.7	2.3	4.5	1.8	2.1	-0.1	-1.1
Hypothyroidism (self reported)	0.1	0.2	0.6	0.3	-0.8	0.0	-0.3
Respiratory disease	0.3	0.7	1.6	0.4	0.9	1.3	0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.7	6.5	2.5	-0.1	0.9	-1.9
Lung FEV1/FVC ratio	1.0	5.2	10.1	0.3	3.2	-2.6	-2.0
Lung FVC	0.2	0.8	2.9	1.7	0.4	-0.2	-0.1
Neuroticism	0.6	1.4	3.2	-0.1	1.8	-1.4	-0.7
Chronotype (morning person)	0.4	1.0	2.2	-0.9	-0.6	1.5	-0.7
Hair Pigment	0.0	0.7	1.8	0.2	1.4	0.8	0.5
Tanning	0.0	0.5	1.9	-0.2	0.4	-1.4	-0.0
Hand grip strength (left)	0.3	0.8	3.1	-0.1	-1.8	0.0	0.5
Number of treatments/medications taken	1.4	2.6	7.1	2.7	1.3	0.1	-1.2
Average weekly spirits intake	3.8	4.7	15.8	4.0	1.4	-0.0	-1.1
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.6	0.6	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	3.7	5.2	10.8	1.0	2.3	-3.3	-1.9
Hearing difficulty/problems: Yes	1.3	1.9	4.3	-0.1	-1.8	2.1	0.5
Relative age of first facial hair	0.5	1.1	3.9	-2.0	0.5	-0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	0.9	1.5	0.7	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	0.2	-0.1	0.4	-0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.0	0.8	0.3	0.9	-1.0
Systolic blood pressure, automated reading	0.8	2.3	7.8	1.1	2.8	0.2	-0.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	0.2	0.3	0.7	-1.1
Angina	4.2	5.5	11.5	0.5	3.4	-1.4	-2.9
Medication for hormone replacement therapy	1.3	1.4	4.6	2.1	0.1	-0.9	-0.6
Vitamin and mineral supplements	0.5	0.7	1.1	1.1	-0.2	-1.0	0.7
Supplements: Zinc	1.2	1.3	2.6	-1.6	1.3	1.0	-0.2
Medication: Co-codamol	1.6	1.8	5.9	1.0	-0.0	-0.7	-2.4
Medication: Metformin	0.8	1.1	2.4	1.3	-1.6	0.6	0.1
Diabetes (father)	0.2	0.3	0.7	0.9	-0.5	-0.3	-0.1
Diabetes (mother)	1.1	1.4	3.4	0.5	-0.4	1.8	1.3
Severe depression (siblings)	0.5	0.5	1.4	0.8	-0.0	-1.2	-0.3
Pack years adult smoking proportion	1.1	1.6	3.8	-0.1	2.0	-0.8	-1.4
Impedance of leg (right)	0.0	0.2	0.3	0.6	0.2	0.5	0.5
Leg fat-free mass (left)	0.1	0.5	1.3	-0.5	0.2	-1.1	0.5
Trunk fat percentage	0.1	0.3	0.8	0.2	0.3	-0.9	-0.4
Hand grip strength (right)	0.1	0.4	0.6	0.7	-0.8	0.5	0.3
Townsend deprivation index at recruitment	1.4	2.0	4.3	0.4	2.1	-1.4	-1.3
Current tobacco smoking	2.5	4.0	10.5	0.1	1.8	-3.2	-1.5
Average weekly fortified wine intake	2.0	2.3	4.4	0.7	1.2	-1.7	-2.1
Maternal smoking around birth	0.8	1.2	2.2	1.5	0.9	1.4	0.4
Fed-up feelings	0.8	1.4	2.4	0.1	1.6	-1.5	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.8	10.8	1.2	2.3	-3.3	-1.3
Relative age voice broke	0.6	0.9	3.4	-1.8	-0.0	-0.1	0.1
Taking other prescription medications	1.5	2.3	7.1	2.7	-0.1	-0.5	-1.4
Age when periods started (menarche)	0.3	0.6	1.3	0.5	0.2	1.0	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.3	-0.4	0.6	-0.1	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.4	-1.3	-1.5	-0.1	-1.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.8	0.1	-1.2	1.7	0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-1.0	0.1	-0.1	0.4
Serious illness, injury or assault to yourself	0.8	1.0	1.8	0.8	-0.1	1.3	1.4
High blood pressure	1.0	2.8	7.0	1.7	2.6	-0.3	-1.2
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.7	1.8	-0.5	1.9	1.1
Multivitamins +/- minerals	0.5	0.6	2.0	-0.5	0.1	1.4	0.5
Stomach or abdominal pain in last month	0.6	0.8	2.4	0.5	1.6	0.2	-0.7
Supplements: Glucosamine	0.9	1.1	2.0	-0.1	-1.4	1.0	1.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.8	-0.9	0.5	-0.4	-2.4
Medication: Atenolol	0.9	1.1	4.1	2.0	0.3	0.2	-0.4
Medication: Levothyroxine sodium	0.4	0.8	2.0	1.4	0.3	0.0	-1.0
Sitting height	0.3	2.5	4.5	-0.9	-2.0	-0.8	2.1
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	-0.4	-0.3	-0.0	0.0
High blood pressure (mother)	0.6	0.8	2.2	0.3	1.5	0.1	1.0
Body mass index (BMI)	0.2	0.8	1.3	1.0	0.1	-1.1	-1.1
Impedance of leg (left)	0.0	0.2	0.6	-0.5	-0.0	0.8	0.2
Leg predicted mass (left)	0.1	0.5	1.2	-0.6	0.1	-1.1	0.6
Trunk fat mass	0.1	0.3	1.0	0.4	-0.1	-1.0	-0.3
Waist circumference	0.2	0.6	1.1	1.1	0.6	-0.8	-0.4
Number of incorrect matches in round	0.9	1.6	3.8	1.9	1.2	-0.8	-0.5
Past tobacco smoking	1.1	1.9	4.8	-2.2	0.6	-1.6	0.3
Alcohol usually taken with meals	1.5	2.5	6.1	0.5	-2.5	0.5	1.8
Nervous feelings	0.3	0.6	1.7	-0.5	1.3	-0.3	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.2	-0.5	1.4	-1.5	-1.8
Hearing difficulty/problems with background noise	0.8	1.2	2.2	0.0	1.2	1.5	-1.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.6	-0.6	0.6	1.3	0.6
Had menopause	0.4	0.4	0.9	-0.2	0.0	-0.9	-1.0
Had other major operations	0.9	1.1	3.3	0.1	1.8	-0.5	-0.8
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.8	0.3	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.3	-1.8	-1.8	0.1	-1.1
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	7.6	-1.1	0.5	-2.0	-2.8
Qualifications: None of the above	1.1	2.5	4.7	2.2	1.3	0.4	-1.8
Financial difficulties in last 2 years	3.4	4.6	8.4	-1.1	2.3	-1.9	-2.9
Mouth/teeth dental problems	1.1	1.7	4.7	2.2	-0.2	-1.4	0.3
Heart attack	3.3	4.3	8.5	2.9	2.6	-0.3	-1.2
Allergy	0.8	1.8	2.6	-1.5	-1.2	1.0	-1.6
Pain all over the body in last month	1.9	2.0	3.6	1.0	1.9	-0.3	-1.8
Diabetes (self-reported)	1.1	1.6	3.1	1.5	-0.4	1.1	-1.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.5	0.2	0.3	1.9	-0.3
Medication: Ramipril	2.0	2.6	6.2	1.7	2.5	0.6	-0.9
Medication: Simvastatin	1.1	1.7	3.6	1.6	0.7	-0.1	-1.9
Fluid intelligence score	0.2	0.3	0.7	-0.5	-0.9	0.3	0.5
Illnesses of siblings	0.9	1.3	4.7	-2.2	-0.3	-0.5	-0.1
Neuroticism score	1.1	2.4	4.8	-1.0	2.2	-1.1	-1.6
Weight	0.1	0.4	1.4	0.1	0.2	-1.2	-0.3
Impedance of arm (right)	0.2	1.1	2.2	-1.0	0.9	0.8	1.5
Arm fat percentage (right)	0.1	0.4	0.8	0.9	0.3	-0.7	-0.3
Trunk fat-free mass	0.1	0.4	0.7	-0.3	-0.8	-0.6	0.8
Hip circumference	0.2	0.7	2.1	-0.8	0.4	-1.4	0.3
Time employed in main current job	1.6	1.9	4.3	2.1	-1.1	-0.3	1.4
Alcohol intake versus 10 years previously	1.9	2.8	7.9	-0.5	1.2	-1.3	-2.8
Father’s age at death	1.4	1.9	4.3	1.3	-2.1	0.3	1.2
Worrier / anxious feelings	0.3	0.6	2.4	-1.6	-0.3	-0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	14.3	-1.1	3.8	-2.8	-1.3
Falls in the last year	2.3	3.2	4.5	1.3	1.6	-2.0	-2.1
Hair/balding pattern: Pattern 3	0.2	0.2	0.9	-0.1	-0.9	-0.0	0.2
Number of live births	1.0	1.4	5.4	-0.5	-0.1	0.1	-2.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.9	-1.4	0.7	0.5	0.2
Pulse rate	0.2	0.3	0.6	0.8	-0.3	-0.6	-0.5
Happiness	0.8	0.9	1.8	-1.3	0.5	0.2	-1.3
Noisy workplace	3.1	3.9	13.3	-0.3	3.6	0.4	-1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.8	-0.5	-1.7	1.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.5	0.9	1.0	-1.2	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.8	-0.4	0.7	0.2
Asthma	0.5	1.0	2.3	-0.5	1.5	-0.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.7	-1.6	0.7	-1.0	-0.6
Medication: Cholesterol lowering	1.1	1.7	3.5	1.9	0.9	-1.0	-1.2
Depression (self-reported)	0.8	1.0	1.4	-0.7	1.0	-1.2	-1.1
Medication: Lansoprazole	1.7	1.9	3.4	1.8	-0.3	1.7	1.1
Prospective memory result	0.3	0.4	1.1	1.1	0.7	-0.3	0.1
Lung cancer (father)	0.1	0.2	0.3	-0.1	-0.5	0.5	-0.3
Illnesses of mother	0.9	1.1	3.4	-0.5	0.1	-0.8	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.6	-1.9	0.8	0.8	0.4
Pulse wave Arterial Stiffness index	3.2	3.7	6.3	1.8	2.5	-1.1	-2.0
Impedance of arm (left)	0.3	1.5	2.6	-1.2	1.3	0.6	1.6
Arm fat mass (right)	0.1	0.2	0.8	0.4	0.1	-0.9	0.0
Trunk predicted mass	0.1	0.6	0.8	-0.4	-0.9	-0.6	0.9
Standing height	0.2	2.1	5.0	-1.8	0.0	-0.2	2.2
Length of working week for main job	0.3	0.3	0.5	-0.6	0.3	-0.4	-0.7
Exposure to tobacco smoke at home	0.7	0.8	2.0	0.8	-0.1	-1.4	0.7
Breastfed as a baby	0.2	0.3	0.4	0.5	0.3	-0.6	-0.7
Tense / ‘highly strung’	0.7	1.1	1.8	-1.0	0.5	-1.2	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	12.2	-1.0	1.7	-2.0	-3.5
Hair/balding pattern: Pattern 4	1.8	4.4	9.8	3.1	-2.6	0.9	0.1
Birth weight of first child	0.8	1.4	2.3	-0.8	-1.3	1.5	-1.1
Peak expiratory flow (PEF)	0.4	0.9	2.9	-1.7	0.6	0.3	-0.5
Pulse wave reflection index	0.9	1.1	2.8	0.7	0.8	-0.7	-1.7
Ever highly irritable/argumentative for 2 days	1.6	1.9	6.7	-0.1	2.6	-0.3	-1.0
Loud music exposure frequency	0.2	0.3	0.8	-0.9	0.2	0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.7	0.3	-0.1	0.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	6.1	-2.5	-0.4	0.0	-0.5
Blood clot in the leg (DVT)	21.2	27.3	69.9	-1.6	3.8	-8.4	4.8
Medication: Paracetamol	1.4	2.3	4.5	0.2	1.7	-2.1	-1.4
Headache pain in last month	0.1	0.3	0.4	0.0	-0.6	-0.6	0.6
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	10.2	-3.2	-1.5	1.0	1.5
Glaucoma (self-reported)	0.1	0.1	0.4	-0.1	-0.2	-0.6	-0.4
Gout (self-reported)	0.3	0.4	1.1	1.1	-0.6	-0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	0.6	-0.2	-0.0	-0.9
Medication: Amlodipine	1.3	1.9	3.0	1.3	1.7	0.1	-1.7
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.2	-0.3	0.7	-0.3	-1.5
Birth weight	0.6	1.3	2.6	1.5	-0.5	1.6	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	-0.5	-1.3	0.9	0.3
High blood pressure (siblings)	1.0	1.4	3.0	1.7	1.2	1.1	0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	2.9	-1.7	0.1	1.0	1.2
Body fat percentage	0.2	0.6	1.3	0.7	0.4	-1.1	-0.7
Leg fat percentage (right)	0.4	1.5	3.6	1.9	0.2	-1.1	-1.1
Arm fat-free mass (right)	0.1	0.6	1.5	-0.5	-0.3	-1.2	-0.6
Exposure to tobacco smoke outside home	0.8	1.1	2.0	1.1	1.4	-0.2	-1.1
Comparative body size at age 10	0.1	0.3	0.7	-0.5	0.3	-0.1	-0.8
Number of full brothers	0.3	0.4	1.3	0.1	1.1	0.3	-0.1
Worry too long after embarrassment	0.3	0.5	1.3	-1.2	0.7	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.6	-0.8	1.4	-2.4	-2.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	1.4	0.6	-0.3	-1.0
Number of children fathered	1.7	1.9	3.4	1.7	-1.0	1.8	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.0	1.2	0.1	0.2	1.7
Age at first live birth	1.7	3.0	5.8	-1.8	-2.4	0.6	1.7
Pulse wave peak to peak time	3.6	4.3	6.2	-1.8	-2.5	1.3	2.4
Health satisfaction	1.3	1.7	3.2	0.3	1.8	-1.6	-1.1
Shortness of breath walking on level ground	5.4	6.4	10.5	2.8	3.2	-1.6	-2.2
Qualifications: College or University degree	1.7	5.5	15.0	-1.8	-3.9	0.7	1.9
Eye problems/disorders: None of the above	0.3	0.4	1.2	-1.1	-0.2	0.3	0.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.6	-0.6	0.9	-1.6	-0.9
Emphysema/chronic bronchitis	0.8	0.9	1.7	1.2	0.2	-0.5	-1.3
Medication for pain relief, constipation, heartburn	2.0	3.4	8.5	-0.2	-2.9	1.5	1.6
Neck or shoulder pain in last month	1.3	1.9	3.8	-1.0	1.0	-1.3	-1.9
Medication: Blood pressure	3.0	5.3	11.6	3.4	2.7	-0.2	-1.4
Angina (self-reported)	3.7	4.9	10.6	0.6	3.3	-1.2	-2.7
Migraine (self-reported)	0.4	0.5	1.0	0.9	-0.2	-1.0	-0.5
Medication: Ibuprofen	0.8	1.0	1.7	-1.3	0.8	-1.0	-0.8
Medication: Allopurinol	0.9	1.2	4.0	2.0	-0.6	0.1	0.7
Medication: Omeprazole	0.8	1.0	1.7	1.2	1.3	-0.5	-0.8
Medication: Seretide 50 evohaler	1.2	1.4	3.1	1.8	0.5	-0.8	-1.3
Mean time to correctly identify matches	1.1	2.1	4.5	1.3	-2.1	1.3	0.8
Heart disease (mother)	1.1	1.3	3.7	0.2	1.9	0.6	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.7	-1.7	1.9	0.5	-0.0
Whole body fat mass	0.1	0.5	1.6	0.4	0.3	-1.2	-0.5
Leg fat mass (right)	0.2	0.6	1.1	1.0	0.2	-1.1	-0.6
Arm predicted mass (right)	0.1	0.6	1.8	-0.8	-0.1	-1.3	-0.3
Pulse rate, automated reading	0.4	1.2	2.4	1.5	0.4	-1.5	0.5
Alcohol intake frequency.	1.5	3.5	6.9	-0.2	2.4	-1.1	-2.6
Comparative height size at age 10	0.1	0.7	1.4	-1.0	0.3	-0.4	1.2
Number of full sisters	0.8	1.0	2.6	0.1	1.6	-1.0	-0.7
Suffer from ‘nerves’	1.5	2.4	3.9	2.0	1.9	-1.2	-0.8
Overall health rating	1.9	4.1	5.9	1.9	1.7	-2.1	-2.4
Chest pain or discomfort	2.0	2.9	5.7	0.9	2.4	-1.8	-1.4
Had major operations	0.5	0.6	1.7	1.3	0.4	-0.1	-0.6
Age at last live birth	0.9	1.3	2.2	-1.5	-1.3	0.7	0.9
Family relationship satisfaction	2.3	2.8	5.6	-2.4	1.1	-0.3	-2.1
Leg pain on walking	4.8	6.0	11.1	2.0	2.6	-1.5	-3.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.0	-0.2	1.7	2.0	0.7
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.6	1.6	-0.0	1.6	0.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	3.7	-1.9	-1.2	-0.5	-0.9
Medication: Aspirin	3.3	4.3	14.2	0.3	3.8	-1.2	-1.2
Supplements: Vitamin C	1.1	1.4	2.5	-1.2	-0.4	1.2	-1.6
Knee pain experienced in last month	0.6	0.9	1.4	1.0	1.1	-0.5	-1.2
Hypertension (Self-reported)	1.3	3.7	8.0	2.2	2.8	-0.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.5	-0.7	-1.6	-0.8	0.3
Illnesses of father: Heart disease	0.3	0.4	0.9	1.0	-0.0	0.2	-0.7
Illnesses of siblings: Diabetes	1.2	1.5	3.2	1.3	-1.0	0.1	1.8
Smoking status: Previous	1.6	2.4	6.2	1.5	-1.2	2.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.2	-2.3	0.0	1.3	0.5
Whole body fat-free mass	0.1	0.5	0.9	-0.7	-0.5	-0.9	0.6
Leg fat-free mass (right)	0.1	0.8	1.9	-1.4	-0.1	-0.8	0.7
Arm fat percentage (left)	0.1	0.4	0.9	0.7	0.4	-0.9	-0.3
Average weekly red wine intake	1.0	1.5	2.5	-0.8	-1.2	-1.3	1.6
Handedness (chirality/laterality): Left-handed	2.0	2.4	4.4	-1.6	-1.1	1.2	2.1
Mood swings	1.4	2.5	4.3	-1.7	1.0	-1.4	-2.1
Loneliness, isolation	1.1	1.6	3.0	1.2	0.8	-1.7	-1.1
Long-standing illness, disability or infirmity	1.4	2.1	3.7	1.8	1.9	0.3	-1.3
Ever had bowel cancer screening	1.2	1.4	4.0	-0.9	-0.4	2.0	-0.9
Diabetes diagnosed by doctor	1.3	2.1	3.6	1.9	0.5	1.5	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	5.8	0.8	2.4	0.6	-0.2
Friendships satisfaction	1.2	1.5	2.7	-1.1	0.8	-1.6	-1.3
Qualifications: nursing, teaching	1.4	2.2	6.3	0.7	-2.5	1.2	0.7
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.0	0.5	-0.2	-0.5
Eye problems/disorders: Cataract	0.4	0.4	0.8	0.2	0.4	-0.8	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.6	-1.9	0.8	1.1	-0.2
Medication for cholesterol	1.4	2.1	4.8	-1.4	-1.0	0.7	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.5	0.6	-1.0	1.0	1.6
Back pain experienced in last month	1.5	2.2	4.7	-1.8	2.2	0.1	-0.9
Mineral and other dietary supplements	1.8	2.5	4.8	-0.3	1.6	-2.2	-1.6
Breast cancer (self-reported)	0.8	0.9	2.2	0.4	1.1	-1.5	-0.3
Asthma (self-reported)	0.5	0.9	2.6	-0.5	1.6	-0.3	-0.8
Osteoporosis (self-reported)	0.8	1.0	3.5	-0.6	-0.1	-0.6	-1.9
Osteoarthritis (self-reported)	3.6	4.7	11.0	1.6	2.3	-0.5	-3.3
Medication: Aspirin	2.6	3.3	11.8	0.7	3.4	-0.7	-0.7
Medication: Gliclazide	0.7	0.7	1.3	1.1	0.8	0.4	-0.9
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	0.4	-0.9	-0.1	0.0
Smoking status: Current	2.9	4.7	11.6	0.4	1.8	-3.4	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.3	-0.9	1.0	-0.9	-1.1
Whole body water mass	0.1	0.5	1.1	-0.7	-0.4	-1.1	0.4
Leg predicted mass (right)	0.1	0.8	1.8	-1.3	-0.1	-0.9	0.7
Arm fat mass (left)	0.1	0.3	1.0	0.5	0.1	-1.0	0.1
Number of self-reported non-cancer illnesses	4.6	8.0	17.9	1.8	4.2	-0.9	-3.2
Average weekly champagne plus white wine intake	1.2	1.6	5.0	0.4	-1.1	2.2	0.3
Miserableness	0.7	1.1	2.2	-0.5	0.9	-1.5	-1.1
Guilty feelings	1.4	2.1	3.0	-1.6	1.7	-0.9	-1.4
Wears glasses or contact lenses	0.7	0.8	1.7	1.1	-1.3	-0.6	0.1
Ever taken oral contraceptive pill	1.0	1.1	3.0	-0.1	-0.4	1.1	1.7
Hearing aid user	2.6	3.0	7.1	2.7	1.7	0.7	-1.1
Mother’s age at death	2.9	3.6	7.3	0.3	-2.5	0.9	2.7
Financial situation satisfaction	0.7	0.8	1.9	-0.2	1.0	0.6	-1.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.6	0.6	-0.1	-0.1
Commuting to job workplace: Public transport	1.0	1.2	2.5	-1.3	0.8	-1.6	-0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.9	-0.3	-1.1	-0.4
Medication: Blood pressure	0.9	1.6	3.4	1.4	1.9	0.0	-1.1
Pain type(s) experienced in last month: Hip pain	2.1	2.6	7.3	-0.4	2.7	1.6	-0.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	2.9	0.6	-1.0	1.7	1.7
High cholesterol (Self-reported)	0.9	1.6	2.2	1.2	1.1	1.1	-1.5
Medication: Bendroflumethiazide	0.4	0.7	2.1	1.4	0.5	0.4	0.5
Medication: Paracetamol	1.4	2.1	3.9	0.9	1.6	-2.0	-1.0
Medication: Lisinopril	1.2	1.6	6.3	-0.2	0.0	-0.2	-2.5
Medication: Atorvastatin	0.3	0.4	0.9	0.2	0.8	0.9	0.0
Illnesses of father: High blood pressure	1.3	1.6	2.6	-0.6	1.6	-1.0	-1.6
Alcohol drinker status: Never	1.8	2.1	3.7	-1.9	1.1	-1.9	0.4
Ever smoked	0.9	1.7	4.9	2.2	-1.3	0.3	0.0
Basal metabolic rate	0.1	0.4	0.9	-0.6	-0.3	-1.0	0.5
Leg fat percentage (left)	0.3	1.0	1.8	1.2	-0.0	-0.9	-1.3
Arm fat-free mass (left)	0.1	0.5	1.5	-0.5	-0.4	-1.2	-0.1
Number of operations (self-reported)	1.6	2.4	3.6	1.5	1.8	-0.4	-1.9
Average weekly beer plus cider intake	0.4	0.6	1.6	0.0	0.7	-0.6	-1.2
Irritability	1.3	2.1	4.8	-0.3	1.8	-2.2	-0.6
Risk taking	0.7	1.0	2.5	0.2	1.6	-0.9	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.3	-0.1	-0.6	-1.0
Fractured/broken bones in last 5 years	0.5	0.6	1.8	1.4	0.2	-0.8	0.3
Age started oral contraceptive pill	0.2	0.3	1.0	-0.2	-0.1	1.0	0.4
Diastolic blood pressure, automated reading	0.8	2.4	5.9	0.9	-2.4	-0.4	1.6
Ever depressed for a whole week	1.5	1.9	4.2	-1.3	-0.3	-1.3	-2.1
Unable to work because of sickness or disability	2.5	3.3	5.4	2.3	1.7	-1.5	-1.6
Commuting to job workplace: Cycle	0.4	0.5	1.4	-0.0	-0.2	-1.2	0.6
Myopia	1.2	1.7	3.8	0.2	-1.9	0.7	1.6
Vascular/heart problems diagnosed by doctor	1.7	4.7	10.7	-2.2	-3.3	0.7	1.6
Cholesterol lowering medication	0.5	0.8	2.4	0.4	0.4	0.6	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.4	1.6	3.4	1.6	1.8	-0.0	-0.8
Pain experienced in last month	1.3	2.2	4.9	1.1	-2.2	1.0	1.3
Supplements: Calcium	0.2	0.3	0.5	-0.7	0.1	0.6	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	0.7	-0.5	-0.7	1.1
Heart attack/myocardial infarction (self-reported)	3.0	3.9	8.0	2.8	2.5	-0.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	21.4	27.5	71.8	-1.0	3.9	-8.5	4.7
Heart disease (siblings)	2.0	2.4	5.5	2.3	0.1	-1.6	-1.3
Alcohol drinker status: Previous	5.4	6.1	11.0	1.1	3.3	-1.6	-3.1
Pack years of smoking	0.7	1.1	2.0	0.0	1.4	-0.8	-1.3
Impedance of whole body	0.1	0.6	0.9	-0.9	0.7	0.6	0.9
Leg fat mass (left)	0.1	0.4	1.1	0.7	0.0	-1.1	-0.5
Arm predicted mass (left)	0.1	0.5	1.7	-0.5	-0.3	-1.3	-0.1