Hub : Genes

SLC19A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.2650 0.0920 0.0021 0.026 NA 0.038 NA 0.041 0.071 NA 0.037 NA 0.032
2 NTR Blood 0.0144 0.0074 0.0094 -0.001 0.003 0.000 0.002 0.000 0.860 0.041 0.320 0.062 0.460
3 TCGA Lung Squamous Cell Carcinoma 0.0557 0.0284 0.0031 -0.002 -0.002 0.003 NA 0.001 0.750 0.850 0.150 NA 0.250
4 TCGA Prostate Adenocarcinoma 0.0431 0.0248 0.0097 0.004 0.010 0.002 NA 0.003 0.120 0.026 0.170 NA 0.130

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.6 -0.1 0.7 0.1 -0.8
Bipolar Disorder or Schizophrenia 0.4 1.1 2.8 -1.7 -0.6 -0.4 -0.9
Depressed Affect (Nagel 2018) 0.5 1.1 2.8 0.0 0.5 -1.7 -1.2
Depression (Nagel 2018) 1.6 2.3 5.8 0.5 1.6 -2.4 -0.8
Intelligence (Savage-Jansen 2018) 0.4 1.3 3.3 0.5 -1.3 0.2 1.8
Neuroticism (Nagel 2018) 1.1 2.6 5.3 0.2 1.7 -2.3 -1.4
Schizophrenia (2018) 0.8 1.7 4.4 -2.1 -1.4 -0.2 -0.6
Schizophrenia vs Biploar Disorder 0.4 0.6 1.6 -1.3 -0.7 0.4 0.1
Worry (Nagel 2018) 0.7 1.4 2.2 0.3 1.5 -1.1 -1.5
Alzheimer’s Disease (in mother) 1.4 1.7 3.6 0.2 -1.7 -0.1 1.9
Alzheimer’s Disease (in father) 0.6 0.7 2.4 0.2 -1.6 -0.0 -0.5
Alzheimer’s Disease (including proxy) 1.3 1.9 4.2 0.9 -2.0 -0.3 1.6
Crohns Disease (2017) 1.2 2.5 8.0 -2.8 0.7 1.2 -0.5
Irritable Bowel Disease (IBD) 0.6 1.4 3.1 -1.8 1.1 0.2 -1.2
Ulcerative Colitis (UC) 0.4 0.8 1.5 -0.6 1.0 -0.6 -1.2
Major Depression (MDD) 1.0 1.2 3.3 -0.8 -1.8 -0.8 -0.2
Reaction Time 1.2 2.3 6.0 0.6 -2.4 1.0 1.4
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.3 -0.0 -0.2 1.2 1.5
Breast Cancer 2.5 6.0 18.0 -2.0 -1.0 1.0 4.2
Ovarian Cancer 0.6 0.8 2.8 0.6 0.2 1.7 -0.1
Prostate Cancer 0.8 1.1 2.4 0.6 -1.5 -0.3 1.3
Age at First Birth 1.1 1.6 3.1 0.3 0.8 1.5 1.8
Bipolar Disorder (2011) 1.0 1.0 3.8 0.2 -2.0 -0.2 0.3
Body Mass Index (BMI) (2010) 0.2 0.3 0.4 0.4 -0.3 -0.6 -0.7
Coronary Artery Disease (CAD) 0.7 0.8 2.9 -0.5 1.7 0.2 0.1
Crohns Disease (2012) 1.0 1.7 4.1 -2.0 1.1 1.0 -0.5
Mean Putamen Volume 0.6 0.6 1.7 -0.5 0.6 -1.3 0.4
Fasting Glucose 1.3 1.6 3.3 -1.4 -1.8 -0.2 1.0
HbA1C 1.1 1.2 3.1 -0.0 1.8 -0.2 -1.3
HDL Cholesterol 0.1 0.1 0.2 0.5 -0.2 0.5 0.2
LDL Cholesterol 1.0 1.5 3.0 -0.3 -1.7 1.1 1.4
Lupus 0.5 0.8 1.6 0.2 1.2 -0.3 -1.2
Neuroticism (2016) 1.2 1.8 5.9 0.7 0.3 -2.4 -0.8
Primary Biliary Cirrhosis 0.3 0.5 1.3 -0.2 -1.1 0.8 0.1
Rheumatoid Arthritis 0.9 1.2 2.5 1.4 -0.0 -1.6 -0.7
Schizophrenia (2014) 0.7 1.6 3.7 -1.6 -1.9 0.3 0.2
Triglycerides 0.7 1.1 3.5 -0.2 -0.8 1.9 0.5
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.9 -0.4 -0.2 -1.3 -1.4
Ulcerative Colitis 0.6 0.9 2.8 -0.6 1.7 0.5 -0.5
Blood Eosinophil Count 0.2 1.7 4.3 1.3 -0.6 -0.6 2.1
Blood Platelet Count 0.5 5.3 10.8 1.5 2.8 0.6 -3.3
Blood Red Count 0.2 1.6 3.1 -1.0 -1.5 -0.4 1.8
Blood White Count 0.4 3.3 6.2 -2.5 2.1 -1.5 -0.4
Heel T-Score 0.2 1.4 2.5 -1.0 -1.6 1.1 -1.0
BMI 0.1 0.5 0.9 0.9 -0.3 -1.0 -0.3
Height 0.1 2.1 6.2 -0.6 0.6 1.2 2.5
Waist Hip Ratio (WHR) 0.4 1.9 6.7 2.6 -0.7 0.6 0.2
Systolic Blood Pressure 1.1 5.8 15.0 1.9 3.9 1.6 -1.4
Smoking Status 0.7 1.7 2.8 1.2 0.6 -1.4 -1.7
Allergy or Eczema 1.4 3.8 7.7 2.1 -1.2 2.8 1.3
Cardiovascular Disease 0.7 2.3 4.5 1.8 2.1 -0.1 -1.1
Hypothyroidism (self reported) 0.1 0.2 0.6 0.3 -0.8 0.0 -0.3
Respiratory disease 0.3 0.7 1.6 0.4 0.9 1.3 0.1
Type 2 Diabetes (T2D) (2018) 1.4 2.7 6.5 2.5 -0.1 0.9 -1.9
Lung FEV1/FVC ratio 1.0 5.2 10.1 0.3 3.2 -2.6 -2.0
Lung FVC 0.2 0.8 2.9 1.7 0.4 -0.2 -0.1
Neuroticism 0.6 1.4 3.2 -0.1 1.8 -1.4 -0.7
Chronotype (morning person) 0.4 1.0 2.2 -0.9 -0.6 1.5 -0.7
Hair Pigment 0.0 0.7 1.8 0.2 1.4 0.8 0.5
Tanning 0.0 0.5 1.9 -0.2 0.4 -1.4 -0.0
Hand grip strength (left) 0.3 0.8 3.1 -0.1 -1.8 0.0 0.5
Number of treatments/medications taken 1.4 2.6 7.1 2.7 1.3 0.1 -1.2
Average weekly spirits intake 3.8 4.7 15.8 4.0 1.4 -0.0 -1.1
Sensitivity / hurt feelings 0.1 0.2 0.3 -0.6 0.6 -0.1 -0.3
Frequency of depressed mood in last 2 weeks 3.7 5.2 10.8 1.0 2.3 -3.3 -1.9
Hearing difficulty/problems: Yes 1.3 1.9 4.3 -0.1 -1.8 2.1 0.5
Relative age of first facial hair 0.5 1.1 3.9 -2.0 0.5 -0.5 -0.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.3 0.9 1.5 0.7 0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.8 0.2 -0.1 0.4 -0.9
Ever had hysterectomy (womb removed) 0.5 0.6 1.0 0.8 0.3 0.9 -1.0
Systolic blood pressure, automated reading 0.8 2.3 7.8 1.1 2.8 0.2 -0.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.3 0.2 0.3 0.7 -1.1
Angina 4.2 5.5 11.5 0.5 3.4 -1.4 -2.9
Medication for hormone replacement therapy 1.3 1.4 4.6 2.1 0.1 -0.9 -0.6
Vitamin and mineral supplements 0.5 0.7 1.1 1.1 -0.2 -1.0 0.7
Supplements: Zinc 1.2 1.3 2.6 -1.6 1.3 1.0 -0.2
Medication: Co-codamol 1.6 1.8 5.9 1.0 -0.0 -0.7 -2.4
Medication: Metformin 0.8 1.1 2.4 1.3 -1.6 0.6 0.1
Diabetes (father) 0.2 0.3 0.7 0.9 -0.5 -0.3 -0.1
Diabetes (mother) 1.1 1.4 3.4 0.5 -0.4 1.8 1.3
Severe depression (siblings) 0.5 0.5 1.4 0.8 -0.0 -1.2 -0.3
Pack years adult smoking proportion 1.1 1.6 3.8 -0.1 2.0 -0.8 -1.4
Impedance of leg (right) 0.0 0.2 0.3 0.6 0.2 0.5 0.5
Leg fat-free mass (left) 0.1 0.5 1.3 -0.5 0.2 -1.1 0.5
Trunk fat percentage 0.1 0.3 0.8 0.2 0.3 -0.9 -0.4
Hand grip strength (right) 0.1 0.4 0.6 0.7 -0.8 0.5 0.3
Townsend deprivation index at recruitment 1.4 2.0 4.3 0.4 2.1 -1.4 -1.3
Current tobacco smoking 2.5 4.0 10.5 0.1 1.8 -3.2 -1.5
Average weekly fortified wine intake 2.0 2.3 4.4 0.7 1.2 -1.7 -2.1
Maternal smoking around birth 0.8 1.2 2.2 1.5 0.9 1.4 0.4
Fed-up feelings 0.8 1.4 2.4 0.1 1.6 -1.5 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.6 4.8 10.8 1.2 2.3 -3.3 -1.3
Relative age voice broke 0.6 0.9 3.4 -1.8 -0.0 -0.1 0.1
Taking other prescription medications 1.5 2.3 7.1 2.7 -0.1 -0.5 -1.4
Age when periods started (menarche) 0.3 0.6 1.3 0.5 0.2 1.0 1.1
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 4.3 -0.4 0.6 -0.1 -2.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 2.4 -1.3 -1.5 -0.1 -1.5
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.8 0.1 -1.2 1.7 0.2
Qualifications: CSEs or equivalent 0.2 0.3 0.9 -1.0 0.1 -0.1 0.4
Serious illness, injury or assault to yourself 0.8 1.0 1.8 0.8 -0.1 1.3 1.4
High blood pressure 1.0 2.8 7.0 1.7 2.6 -0.3 -1.2
Hayfever, allergic rhinitis or eczema 1.0 2.1 3.7 1.8 -0.5 1.9 1.1
Multivitamins +/- minerals 0.5 0.6 2.0 -0.5 0.1 1.4 0.5
Stomach or abdominal pain in last month 0.6 0.8 2.4 0.5 1.6 0.2 -0.7
Supplements: Glucosamine 0.9 1.1 2.0 -0.1 -1.4 1.0 1.2
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 5.8 -0.9 0.5 -0.4 -2.4
Medication: Atenolol 0.9 1.1 4.1 2.0 0.3 0.2 -0.4
Medication: Levothyroxine sodium 0.4 0.8 2.0 1.4 0.3 0.0 -1.0
Sitting height 0.3 2.5 4.5 -0.9 -2.0 -0.8 2.1
Chronic bronchitis/emphysema (father) 0.0 0.1 0.1 -0.4 -0.3 -0.0 0.0
High blood pressure (mother) 0.6 0.8 2.2 0.3 1.5 0.1 1.0
Body mass index (BMI) 0.2 0.8 1.3 1.0 0.1 -1.1 -1.1
Impedance of leg (left) 0.0 0.2 0.6 -0.5 -0.0 0.8 0.2
Leg predicted mass (left) 0.1 0.5 1.2 -0.6 0.1 -1.1 0.6
Trunk fat mass 0.1 0.3 1.0 0.4 -0.1 -1.0 -0.3
Waist circumference 0.2 0.6 1.1 1.1 0.6 -0.8 -0.4
Number of incorrect matches in round 0.9 1.6 3.8 1.9 1.2 -0.8 -0.5
Past tobacco smoking 1.1 1.9 4.8 -2.2 0.6 -1.6 0.3
Alcohol usually taken with meals 1.5 2.5 6.1 0.5 -2.5 0.5 1.8
Nervous feelings 0.3 0.6 1.7 -0.5 1.3 -0.3 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 3.2 -0.5 1.4 -1.5 -1.8
Hearing difficulty/problems with background noise 0.8 1.2 2.2 0.0 1.2 1.5 -1.2
Hair/balding pattern: Pattern 2 0.5 0.7 1.6 -0.6 0.6 1.3 0.6
Had menopause 0.4 0.4 0.9 -0.2 0.0 -0.9 -1.0
Had other major operations 0.9 1.1 3.3 0.1 1.8 -0.5 -0.8
Forced vital capacity (FVC) 0.1 0.3 0.7 -0.8 0.3 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 3.3 -1.8 -1.8 0.1 -1.1
Ever unenthusiastic/disinterested for a whole week 2.7 3.3 7.6 -1.1 0.5 -2.0 -2.8
Qualifications: None of the above 1.1 2.5 4.7 2.2 1.3 0.4 -1.8
Financial difficulties in last 2 years 3.4 4.6 8.4 -1.1 2.3 -1.9 -2.9
Mouth/teeth dental problems 1.1 1.7 4.7 2.2 -0.2 -1.4 0.3
Heart attack 3.3 4.3 8.5 2.9 2.6 -0.3 -1.2
Allergy 0.8 1.8 2.6 -1.5 -1.2 1.0 -1.6
Pain all over the body in last month 1.9 2.0 3.6 1.0 1.9 -0.3 -1.8
Diabetes (self-reported) 1.1 1.6 3.1 1.5 -0.4 1.1 -1.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 3.5 0.2 0.3 1.9 -0.3
Medication: Ramipril 2.0 2.6 6.2 1.7 2.5 0.6 -0.9
Medication: Simvastatin 1.1 1.7 3.6 1.6 0.7 -0.1 -1.9
Fluid intelligence score 0.2 0.3 0.7 -0.5 -0.9 0.3 0.5
Illnesses of siblings 0.9 1.3 4.7 -2.2 -0.3 -0.5 -0.1
Neuroticism score 1.1 2.4 4.8 -1.0 2.2 -1.1 -1.6
Weight 0.1 0.4 1.4 0.1 0.2 -1.2 -0.3
Impedance of arm (right) 0.2 1.1 2.2 -1.0 0.9 0.8 1.5
Arm fat percentage (right) 0.1 0.4 0.8 0.9 0.3 -0.7 -0.3
Trunk fat-free mass 0.1 0.4 0.7 -0.3 -0.8 -0.6 0.8
Hip circumference 0.2 0.7 2.1 -0.8 0.4 -1.4 0.3
Time employed in main current job 1.6 1.9 4.3 2.1 -1.1 -0.3 1.4
Alcohol intake versus 10 years previously 1.9 2.8 7.9 -0.5 1.2 -1.3 -2.8
Father’s age at death 1.4 1.9 4.3 1.3 -2.1 0.3 1.2
Worrier / anxious feelings 0.3 0.6 2.4 -1.6 -0.3 -0.1 0.1
Frequency of tiredness / lethargy in last 2 weeks 3.9 6.3 14.3 -1.1 3.8 -2.8 -1.3
Falls in the last year 2.3 3.2 4.5 1.3 1.6 -2.0 -2.1
Hair/balding pattern: Pattern 3 0.2 0.2 0.9 -0.1 -0.9 -0.0 0.2
Number of live births 1.0 1.4 5.4 -0.5 -0.1 0.1 -2.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.9 -1.4 0.7 0.5 0.2
Pulse rate 0.2 0.3 0.6 0.8 -0.3 -0.6 -0.5
Happiness 0.8 0.9 1.8 -1.3 0.5 0.2 -1.3
Noisy workplace 3.1 3.9 13.3 -0.3 3.6 0.4 -1.4
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.8 -0.5 -1.7 1.3 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.5 0.9 1.0 -1.2 -0.3
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 -0.8 -0.4 0.7 0.2
Asthma 0.5 1.0 2.3 -0.5 1.5 -0.4 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.7 -1.6 0.7 -1.0 -0.6
Medication: Cholesterol lowering 1.1 1.7 3.5 1.9 0.9 -1.0 -1.2
Depression (self-reported) 0.8 1.0 1.4 -0.7 1.0 -1.2 -1.1
Medication: Lansoprazole 1.7 1.9 3.4 1.8 -0.3 1.7 1.1
Prospective memory result 0.3 0.4 1.1 1.1 0.7 -0.3 0.1
Lung cancer (father) 0.1 0.2 0.3 -0.1 -0.5 0.5 -0.3
Illnesses of mother 0.9 1.1 3.4 -0.5 0.1 -0.8 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.6 -1.9 0.8 0.8 0.4
Pulse wave Arterial Stiffness index 3.2 3.7 6.3 1.8 2.5 -1.1 -2.0
Impedance of arm (left) 0.3 1.5 2.6 -1.2 1.3 0.6 1.6
Arm fat mass (right) 0.1 0.2 0.8 0.4 0.1 -0.9 0.0
Trunk predicted mass 0.1 0.6 0.8 -0.4 -0.9 -0.6 0.9
Standing height 0.2 2.1 5.0 -1.8 0.0 -0.2 2.2
Length of working week for main job 0.3 0.3 0.5 -0.6 0.3 -0.4 -0.7
Exposure to tobacco smoke at home 0.7 0.8 2.0 0.8 -0.1 -1.4 0.7
Breastfed as a baby 0.2 0.3 0.4 0.5 0.3 -0.6 -0.7
Tense / ‘highly strung’ 0.7 1.1 1.8 -1.0 0.5 -1.2 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 3.3 5.1 12.2 -1.0 1.7 -2.0 -3.5
Hair/balding pattern: Pattern 4 1.8 4.4 9.8 3.1 -2.6 0.9 0.1
Birth weight of first child 0.8 1.4 2.3 -0.8 -1.3 1.5 -1.1
Peak expiratory flow (PEF) 0.4 0.9 2.9 -1.7 0.6 0.3 -0.5
Pulse wave reflection index 0.9 1.1 2.8 0.7 0.8 -0.7 -1.7
Ever highly irritable/argumentative for 2 days 1.6 1.9 6.7 -0.1 2.6 -0.3 -1.0
Loud music exposure frequency 0.2 0.3 0.8 -0.9 0.2 0.3 -0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 -0.7 0.3 -0.1 0.5
Mouth/teeth dental problems: Bleeding gums 1.3 1.6 6.1 -2.5 -0.4 0.0 -0.5
Blood clot in the leg (DVT) 21.2 27.3 69.9 -1.6 3.8 -8.4 4.8
Medication: Paracetamol 1.4 2.3 4.5 0.2 1.7 -2.1 -1.4
Headache pain in last month 0.1 0.3 0.4 0.0 -0.6 -0.6 0.6
Medication for cholesterol, blood pressure or diabetes 2.4 3.9 10.2 -3.2 -1.5 1.0 1.5
Glaucoma (self-reported) 0.1 0.1 0.4 -0.1 -0.2 -0.6 -0.4
Gout (self-reported) 0.3 0.4 1.1 1.1 -0.6 -0.3 0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.9 0.6 -0.2 -0.0 -0.9
Medication: Amlodipine 1.3 1.9 3.0 1.3 1.7 0.1 -1.7
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.2 -0.3 0.7 -0.3 -1.5
Birth weight 0.6 1.3 2.6 1.5 -0.5 1.6 -0.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 -0.5 -1.3 0.9 0.3
High blood pressure (siblings) 1.0 1.4 3.0 1.7 1.2 1.1 0.1
Forced vital capacity (FVC), Best measure 0.4 1.3 2.9 -1.7 0.1 1.0 1.2
Body fat percentage 0.2 0.6 1.3 0.7 0.4 -1.1 -0.7
Leg fat percentage (right) 0.4 1.5 3.6 1.9 0.2 -1.1 -1.1
Arm fat-free mass (right) 0.1 0.6 1.5 -0.5 -0.3 -1.2 -0.6
Exposure to tobacco smoke outside home 0.8 1.1 2.0 1.1 1.4 -0.2 -1.1
Comparative body size at age 10 0.1 0.3 0.7 -0.5 0.3 -0.1 -0.8
Number of full brothers 0.3 0.4 1.3 0.1 1.1 0.3 -0.1
Worry too long after embarrassment 0.3 0.5 1.3 -1.2 0.7 -0.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 5.6 -0.8 1.4 -2.4 -2.2
Wheeze or whistling in the chest in last year 0.5 0.9 2.0 1.4 0.6 -0.3 -1.0
Number of children fathered 1.7 1.9 3.4 1.7 -1.0 1.8 0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 3.0 1.2 0.1 0.2 1.7
Age at first live birth 1.7 3.0 5.8 -1.8 -2.4 0.6 1.7
Pulse wave peak to peak time 3.6 4.3 6.2 -1.8 -2.5 1.3 2.4
Health satisfaction 1.3 1.7 3.2 0.3 1.8 -1.6 -1.1
Shortness of breath walking on level ground 5.4 6.4 10.5 2.8 3.2 -1.6 -2.2
Qualifications: College or University degree 1.7 5.5 15.0 -1.8 -3.9 0.7 1.9
Eye problems/disorders: None of the above 0.3 0.4 1.2 -1.1 -0.2 0.3 0.3
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.6 -0.6 0.9 -1.6 -0.9
Emphysema/chronic bronchitis 0.8 0.9 1.7 1.2 0.2 -0.5 -1.3
Medication for pain relief, constipation, heartburn 2.0 3.4 8.5 -0.2 -2.9 1.5 1.6
Neck or shoulder pain in last month 1.3 1.9 3.8 -1.0 1.0 -1.3 -1.9
Medication: Blood pressure 3.0 5.3 11.6 3.4 2.7 -0.2 -1.4
Angina (self-reported) 3.7 4.9 10.6 0.6 3.3 -1.2 -2.7
Migraine (self-reported) 0.4 0.5 1.0 0.9 -0.2 -1.0 -0.5
Medication: Ibuprofen 0.8 1.0 1.7 -1.3 0.8 -1.0 -0.8
Medication: Allopurinol 0.9 1.2 4.0 2.0 -0.6 0.1 0.7
Medication: Omeprazole 0.8 1.0 1.7 1.2 1.3 -0.5 -0.8
Medication: Seretide 50 evohaler 1.2 1.4 3.1 1.8 0.5 -0.8 -1.3
Mean time to correctly identify matches 1.1 2.1 4.5 1.3 -2.1 1.3 0.8
Heart disease (mother) 1.1 1.3 3.7 0.2 1.9 0.6 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.7 -1.7 1.9 0.5 -0.0
Whole body fat mass 0.1 0.5 1.6 0.4 0.3 -1.2 -0.5
Leg fat mass (right) 0.2 0.6 1.1 1.0 0.2 -1.1 -0.6
Arm predicted mass (right) 0.1 0.6 1.8 -0.8 -0.1 -1.3 -0.3
Pulse rate, automated reading 0.4 1.2 2.4 1.5 0.4 -1.5 0.5
Alcohol intake frequency. 1.5 3.5 6.9 -0.2 2.4 -1.1 -2.6
Comparative height size at age 10 0.1 0.7 1.4 -1.0 0.3 -0.4 1.2
Number of full sisters 0.8 1.0 2.6 0.1 1.6 -1.0 -0.7
Suffer from ‘nerves’ 1.5 2.4 3.9 2.0 1.9 -1.2 -0.8
Overall health rating 1.9 4.1 5.9 1.9 1.7 -2.1 -2.4
Chest pain or discomfort 2.0 2.9 5.7 0.9 2.4 -1.8 -1.4
Had major operations 0.5 0.6 1.7 1.3 0.4 -0.1 -0.6
Age at last live birth 0.9 1.3 2.2 -1.5 -1.3 0.7 0.9
Family relationship satisfaction 2.3 2.8 5.6 -2.4 1.1 -0.3 -2.1
Leg pain on walking 4.8 6.0 11.1 2.0 2.6 -1.5 -3.3
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 4.0 -0.2 1.7 2.0 0.7
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.6 1.6 -0.0 1.6 0.1
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 3.7 -1.9 -1.2 -0.5 -0.9
Medication: Aspirin 3.3 4.3 14.2 0.3 3.8 -1.2 -1.2
Supplements: Vitamin C 1.1 1.4 2.5 -1.2 -0.4 1.2 -1.6
Knee pain experienced in last month 0.6 0.9 1.4 1.0 1.1 -0.5 -1.2
Hypertension (Self-reported) 1.3 3.7 8.0 2.2 2.8 -0.3 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.5 -0.7 -1.6 -0.8 0.3
Illnesses of father: Heart disease 0.3 0.4 0.9 1.0 -0.0 0.2 -0.7
Illnesses of siblings: Diabetes 1.2 1.5 3.2 1.3 -1.0 0.1 1.8
Smoking status: Previous 1.6 2.4 6.2 1.5 -1.2 2.5 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 5.2 -2.3 0.0 1.3 0.5
Whole body fat-free mass 0.1 0.5 0.9 -0.7 -0.5 -0.9 0.6
Leg fat-free mass (right) 0.1 0.8 1.9 -1.4 -0.1 -0.8 0.7
Arm fat percentage (left) 0.1 0.4 0.9 0.7 0.4 -0.9 -0.3
Average weekly red wine intake 1.0 1.5 2.5 -0.8 -1.2 -1.3 1.6
Handedness (chirality/laterality): Left-handed 2.0 2.4 4.4 -1.6 -1.1 1.2 2.1
Mood swings 1.4 2.5 4.3 -1.7 1.0 -1.4 -2.1
Loneliness, isolation 1.1 1.6 3.0 1.2 0.8 -1.7 -1.1
Long-standing illness, disability or infirmity 1.4 2.1 3.7 1.8 1.9 0.3 -1.3
Ever had bowel cancer screening 1.2 1.4 4.0 -0.9 -0.4 2.0 -0.9
Diabetes diagnosed by doctor 1.3 2.1 3.6 1.9 0.5 1.5 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 5.8 0.8 2.4 0.6 -0.2
Friendships satisfaction 1.2 1.5 2.7 -1.1 0.8 -1.6 -1.3
Qualifications: nursing, teaching 1.4 2.2 6.3 0.7 -2.5 1.2 0.7
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.0 0.5 -0.2 -0.5
Eye problems/disorders: Cataract 0.4 0.4 0.8 0.2 0.4 -0.8 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.6 -1.9 0.8 1.1 -0.2
Medication for cholesterol 1.4 2.1 4.8 -1.4 -1.0 0.7 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.5 0.6 -1.0 1.0 1.6
Back pain experienced in last month 1.5 2.2 4.7 -1.8 2.2 0.1 -0.9
Mineral and other dietary supplements 1.8 2.5 4.8 -0.3 1.6 -2.2 -1.6
Breast cancer (self-reported) 0.8 0.9 2.2 0.4 1.1 -1.5 -0.3
Asthma (self-reported) 0.5 0.9 2.6 -0.5 1.6 -0.3 -0.8
Osteoporosis (self-reported) 0.8 1.0 3.5 -0.6 -0.1 -0.6 -1.9
Osteoarthritis (self-reported) 3.6 4.7 11.0 1.6 2.3 -0.5 -3.3
Medication: Aspirin 2.6 3.3 11.8 0.7 3.4 -0.7 -0.7
Medication: Gliclazide 0.7 0.7 1.3 1.1 0.8 0.4 -0.9
Illnesses of father: None of the above (group 1) 0.2 0.2 0.8 0.4 -0.9 -0.1 0.0
Smoking status: Current 2.9 4.7 11.6 0.4 1.8 -3.4 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.3 -0.9 1.0 -0.9 -1.1
Whole body water mass 0.1 0.5 1.1 -0.7 -0.4 -1.1 0.4
Leg predicted mass (right) 0.1 0.8 1.8 -1.3 -0.1 -0.9 0.7
Arm fat mass (left) 0.1 0.3 1.0 0.5 0.1 -1.0 0.1
Number of self-reported non-cancer illnesses 4.6 8.0 17.9 1.8 4.2 -0.9 -3.2
Average weekly champagne plus white wine intake 1.2 1.6 5.0 0.4 -1.1 2.2 0.3
Miserableness 0.7 1.1 2.2 -0.5 0.9 -1.5 -1.1
Guilty feelings 1.4 2.1 3.0 -1.6 1.7 -0.9 -1.4
Wears glasses or contact lenses 0.7 0.8 1.7 1.1 -1.3 -0.6 0.1
Ever taken oral contraceptive pill 1.0 1.1 3.0 -0.1 -0.4 1.1 1.7
Hearing aid user 2.6 3.0 7.1 2.7 1.7 0.7 -1.1
Mother’s age at death 2.9 3.6 7.3 0.3 -2.5 0.9 2.7
Financial situation satisfaction 0.7 0.8 1.9 -0.2 1.0 0.6 -1.4
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.3 0.6 0.6 -0.1 -0.1
Commuting to job workplace: Public transport 1.0 1.2 2.5 -1.3 0.8 -1.6 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 1.3 -0.9 -0.3 -1.1 -0.4
Medication: Blood pressure 0.9 1.6 3.4 1.4 1.9 0.0 -1.1
Pain type(s) experienced in last month: Hip pain 2.1 2.6 7.3 -0.4 2.7 1.6 -0.5
Supplements: Fish oil (including cod liver oil) 1.4 1.8 2.9 0.6 -1.0 1.7 1.7
High cholesterol (Self-reported) 0.9 1.6 2.2 1.2 1.1 1.1 -1.5
Medication: Bendroflumethiazide 0.4 0.7 2.1 1.4 0.5 0.4 0.5
Medication: Paracetamol 1.4 2.1 3.9 0.9 1.6 -2.0 -1.0
Medication: Lisinopril 1.2 1.6 6.3 -0.2 0.0 -0.2 -2.5
Medication: Atorvastatin 0.3 0.4 0.9 0.2 0.8 0.9 0.0
Illnesses of father: High blood pressure 1.3 1.6 2.6 -0.6 1.6 -1.0 -1.6
Alcohol drinker status: Never 1.8 2.1 3.7 -1.9 1.1 -1.9 0.4
Ever smoked 0.9 1.7 4.9 2.2 -1.3 0.3 0.0
Basal metabolic rate 0.1 0.4 0.9 -0.6 -0.3 -1.0 0.5
Leg fat percentage (left) 0.3 1.0 1.8 1.2 -0.0 -0.9 -1.3
Arm fat-free mass (left) 0.1 0.5 1.5 -0.5 -0.4 -1.2 -0.1
Number of operations (self-reported) 1.6 2.4 3.6 1.5 1.8 -0.4 -1.9
Average weekly beer plus cider intake 0.4 0.6 1.6 0.0 0.7 -0.6 -1.2
Irritability 1.3 2.1 4.8 -0.3 1.8 -2.2 -0.6
Risk taking 0.7 1.0 2.5 0.2 1.6 -0.9 -0.7
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.9 0.3 -0.1 -0.6 -1.0
Fractured/broken bones in last 5 years 0.5 0.6 1.8 1.4 0.2 -0.8 0.3
Age started oral contraceptive pill 0.2 0.3 1.0 -0.2 -0.1 1.0 0.4
Diastolic blood pressure, automated reading 0.8 2.4 5.9 0.9 -2.4 -0.4 1.6
Ever depressed for a whole week 1.5 1.9 4.2 -1.3 -0.3 -1.3 -2.1
Unable to work because of sickness or disability 2.5 3.3 5.4 2.3 1.7 -1.5 -1.6
Commuting to job workplace: Cycle 0.4 0.5 1.4 -0.0 -0.2 -1.2 0.6
Myopia 1.2 1.7 3.8 0.2 -1.9 0.7 1.6
Vascular/heart problems diagnosed by doctor 1.7 4.7 10.7 -2.2 -3.3 0.7 1.6
Cholesterol lowering medication 0.5 0.8 2.4 0.4 0.4 0.6 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.4 1.6 3.4 1.6 1.8 -0.0 -0.8
Pain experienced in last month 1.3 2.2 4.9 1.1 -2.2 1.0 1.3
Supplements: Calcium 0.2 0.3 0.5 -0.7 0.1 0.6 0.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.3 0.7 -0.5 -0.7 1.1
Heart attack/myocardial infarction (self-reported) 3.0 3.9 8.0 2.8 2.5 -0.3 -1.2
Deep venous thrombosis (DVT) (self-reported) 21.4 27.5 71.8 -1.0 3.9 -8.5 4.7
Heart disease (siblings) 2.0 2.4 5.5 2.3 0.1 -1.6 -1.3
Alcohol drinker status: Previous 5.4 6.1 11.0 1.1 3.3 -1.6 -3.1
Pack years of smoking 0.7 1.1 2.0 0.0 1.4 -0.8 -1.3
Impedance of whole body 0.1 0.6 0.9 -0.9 0.7 0.6 0.9
Leg fat mass (left) 0.1 0.4 1.1 0.7 0.0 -1.1 -0.5
Arm predicted mass (left) 0.1 0.5 1.7 -0.5 -0.3 -1.3 -0.1