Hub : Traits :

Deep venous thrombosis (DVT) (self-reported)

38 significantly associated models · 22 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 167970917 170514229 6 6 1.9e-15 7.3e-166 1.4e-117 30 AL021068.1 ATP1B1 C1orf112 DPT NME7
2 4 154758667 156166231 1 1 6.7e-17 2.4e-18 5.6e-04 84 PLRG1
3 4 186328499 187829016 2 2 1.8e-13 1.9e-23 1.2e-11 54 CYP4V2 FAM149A
4 9 135336094 137552398 8 6 4.1e-39 8.4e-64 9.7e-07 92 ABO AL590710.1 C9orf96 SARDH SURF1 VAV2
5 10 70516744 71966819 1 1 5.5e-10 5.6e-10 1.0e+00 100 TSPAN15
6 17 6652789 8057572 1 1 3.3e-07 1.8e-05 4.9e-03 57 CHRNB1
7 20 32898339 34562581 3 1 2.7e-09 3.9e-09 2.3e-02 85 EIF6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 0.88 1 0 0.0 0.00 1.0e+00 ABO
Irritable Bowel Disease (IBD) 1.17 2 0 0.0 0.00 1.0e+00 ABO EIF6
Ulcerative Colitis (UC) 1.57 1 0 0.0 0.00 1.0e+00 EIF6
Major Depression (MDD) 1.79 1 0 0.0 0.00 1.0e+00 CHRNB1
Reaction Time 1.10 1 0 0.0 0.00 1.0e+00 EIF6
Ovarian Cancer 1.85 1 0 0.0 0.00 1.0e+00 SURF1
LDL Cholesterol 1.70 1 0 0.0 0.00 1.0e+00 SURF1
Primary Biliary Cirrhosis 1.93 1 0 0.0 0.00 1.0e+00 ATP1B1
Ulcerative Colitis 1.50 1 0 0.0 0.00 1.0e+00 EIF6
Blood Eosinophil Count 0.62 3 1 3.0 0.00 1.0e+00 ABO SARDH VAV2
Blood Platelet Count 1.01 8 3 9.1 0.12 7.8e-01 ABO AL590710.1 ATP1B1 CHRNB1 CYP4V2 EIF6 SURF1 TSPAN15
Blood Red Count 2.48 7 4 12.1 0.29 5.4e-01 ABO AL590710.1 ATP1B1 C9orf96 CHRNB1 SARDH SURF1
Blood White Count 1.54 5 4 12.1 0.94 1.9e-02 ABO AL590710.1 C9orf96 SARDH SURF1
Heel T-Score 0.88 3 2 6.1 0.00 1.0e+00 C9orf96 CYP4V2 SURF1
BMI 0.38 1 0 0.0 0.00 1.0e+00 CHRNB1
Height 2.50 5 4 12.1 -0.08 9.0e-01 AL590710.1 CHRNB1 EIF6 PLRG1 SURF1
Waist Hip Ratio (WHR) 0.63 1 0 0.0 0.00 1.0e+00 CHRNB1
Systolic Blood Pressure 1.23 3 1 3.0 0.00 1.0e+00 ATP1B1 C9orf96 CHRNB1
Allergy or Eczema 1.40 1 0 0.0 0.00 1.0e+00 AL590710.1
Respiratory disease 1.20 1 0 0.0 0.00 1.0e+00 CHRNB1
Lung FEV1/FVC ratio 1.19 2 2 6.1 0.00 1.0e+00 EIF6 NME7
Lung FVC 0.85 3 1 3.0 0.00 1.0e+00 AL590710.1 CHRNB1 EIF6
Hair Pigment 0.35 1 1 3.0 0.00 1.0e+00 EIF6
Tanning 0.99 1 1 3.0 0.00 1.0e+00 EIF6
Hand grip strength (left) 1.85 4 1 3.0 -0.40 6.0e-01 AL590710.1 CHRNB1 EIF6 SARDH
Number of treatments/medications taken 0.89 1 0 0.0 0.00 1.0e+00 DPT
Frequency of depressed mood in last 2 weeks 0.97 1 0 0.0 0.00 1.0e+00 NME7
Ever used hormone-replacement therapy (HRT) 1.21 1 0 0.0 0.00 1.0e+00 C1orf112
Systolic blood pressure, automated reading 1.04 1 0 0.0 0.00 1.0e+00 ATP1B1
Angina 1.49 1 0 0.0 0.00 1.0e+00 ATP1B1
Impedance of leg (right) 0.71 1 0 0.0 0.00 1.0e+00 EIF6
Leg fat-free mass (left) 1.34 1 1 3.0 0.00 1.0e+00 EIF6
Trunk fat percentage 0.72 2 0 0.0 0.00 1.0e+00 ABO CHRNB1
Hand grip strength (right) 2.48 3 1 3.0 0.00 1.0e+00 AL590710.1 CHRNB1 EIF6
Age when periods started (menarche) 0.91 1 0 0.0 0.00 1.0e+00 EIF6
High blood pressure 1.44 2 0 0.0 0.00 1.0e+00 ABO C9orf96
Hayfever, allergic rhinitis or eczema 1.16 1 0 0.0 0.00 1.0e+00 AL590710.1
Sitting height 2.75 3 1 3.0 0.00 1.0e+00 CHRNB1 EIF6 SURF1
Body mass index (BMI) 0.53 1 0 0.0 0.00 1.0e+00 CHRNB1
Impedance of leg (left) 0.73 3 0 0.0 0.00 1.0e+00 EIF6 SARDH SURF1
Leg predicted mass (left) 1.34 1 1 3.0 0.00 1.0e+00 EIF6
Hearing difficulty/problems with background noise 0.96 1 0 0.0 0.00 1.0e+00 ABO
Forced vital capacity (FVC) 1.03 3 0 0.0 0.00 1.0e+00 AL590710.1 EIF6 SURF1
Allergy 3.22 4 1 3.0 -0.65 3.5e-01 ABO AL590710.1 EIF6 SARDH
Neuroticism score 0.78 1 0 0.0 0.00 1.0e+00 ATP1B1
Weight 0.68 1 1 3.0 0.00 1.0e+00 EIF6
Impedance of arm (right) 1.74 4 1 3.0 1.00 2.1e-04 ABO AL590710.1 C9orf96 VAV2
Arm fat percentage (right) 0.90 2 0 0.0 0.00 1.0e+00 ABO CHRNB1
Trunk fat-free mass 2.51 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Father's age at death 2.04 1 0 0.0 0.00 1.0e+00 NME7
Frequency of tiredness / lethargy in last 2 weeks 1.28 1 0 0.0 0.00 1.0e+00 NME7
Forced expiratory volume in 1-second (FEV1) 1.05 2 0 0.0 0.00 1.0e+00 AL590710.1 EIF6
Qualifications: A levels/AS levels or equivalent 0.93 1 0 0.0 0.00 1.0e+00 CHRNB1
Forced expiratory volume in 1-second (FEV1), Best measure 1.14 2 0 0.0 0.00 1.0e+00 AL590710.1 EIF6
Impedance of arm (left) 1.85 4 1 3.0 1.00 2.8e-04 ABO AL590710.1 C9orf96 VAV2
Trunk predicted mass 2.52 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Standing height 2.41 5 2 6.1 0.15 8.1e-01 AL590710.1 CHRNB1 EIF6 PLRG1 SURF1
Length of working week for main job 1.48 1 0 0.0 0.00 1.0e+00 SURF1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.05 1 0 0.0 0.00 1.0e+00 NME7
Birth weight of first child 0.81 1 0 0.0 0.00 1.0e+00 ATP1B1
Peak expiratory flow (PEF) 1.88 2 0 0.0 0.00 1.0e+00 ABO EIF6
Mouth/teeth dental problems: Bleeding gums 1.11 1 0 0.0 0.00 1.0e+00 EIF6
Blood clot in the leg (DVT) 39.20 17 17 51.5 1.00 1.0e-25 ABO AL021068.1 AL590710.1 ATP1B1 C1orf112 C9orf96 CHRNB1 CYP4V2 DPT EIF6 FAM149A NME7 PLRG1 SARDH SURF1 TSPAN15 VAV2
Chronic bronchitis/emphysema (mother) 1.22 1 0 0.0 0.00 1.0e+00 VAV2
Forced vital capacity (FVC), Best measure 1.01 2 0 0.0 0.00 1.0e+00 AL590710.1 EIF6
Body fat percentage 0.73 2 0 0.0 0.00 1.0e+00 ABO CHRNB1
Leg fat percentage (right) 0.81 2 0 0.0 0.00 1.0e+00 CHRNB1 EIF6
Arm fat-free mass (right) 2.21 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Qualifications: College or University degree 1.38 2 0 0.0 0.00 1.0e+00 CHRNB1 EIF6
Medication for pain relief, constipation, heartburn 1.41 1 0 0.0 0.00 1.0e+00 NME7
Arm predicted mass (right) 2.18 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Alcohol intake frequency. 1.18 1 0 0.0 0.00 1.0e+00 NME7
Comparative height size at age 10 1.34 1 1 3.0 0.00 1.0e+00 EIF6
Age at last live birth 1.73 1 0 0.0 0.00 1.0e+00 VAV2
Medication: Aspirin 2.37 1 0 0.0 0.00 1.0e+00 NME7
Hypertension (Self-reported) 1.42 2 0 0.0 0.00 1.0e+00 ABO C9orf96
Forced expiratory volume in 1-second (FEV1), predicted 1.30 1 1 3.0 0.00 1.0e+00 EIF6
Whole body fat-free mass 2.03 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Leg fat-free mass (right) 1.41 1 1 3.0 0.00 1.0e+00 EIF6
Arm fat percentage (left) 0.99 3 0 0.0 0.00 1.0e+00 ABO CHRNB1 EIF6
Ever had bowel cancer screening 1.67 1 0 0.0 0.00 1.0e+00 ABO
Medication: Aspirin 2.10 1 0 0.0 0.00 1.0e+00 NME7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.64 1 0 0.0 0.00 1.0e+00 CHRNB1
Whole body water mass 1.99 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Leg predicted mass (right) 1.40 1 1 3.0 0.00 1.0e+00 EIF6
Number of self-reported non-cancer illnesses 1.17 1 0 0.0 0.00 1.0e+00 ATP1B1
Medication: Blood pressure 1.61 2 0 0.0 0.00 1.0e+00 ATP1B1 CHRNB1
High cholesterol (Self-reported) 1.24 1 0 0.0 0.00 1.0e+00 SURF1
Medication: Bendroflumethiazide 1.62 1 0 0.0 0.00 1.0e+00 ABO
Medication: Atorvastatin 2.23 1 0 0.0 0.00 1.0e+00 C9orf96
Basal metabolic rate 1.66 2 1 3.0 0.00 1.0e+00 AL590710.1 EIF6
Leg fat percentage (left) 0.78 2 0 0.0 0.00 1.0e+00 CHRNB1 EIF6
Arm fat-free mass (left) 2.10 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Risk taking 1.13 1 0 0.0 0.00 1.0e+00 PLRG1
Diastolic blood pressure, automated reading 1.26 2 0 0.0 0.00 1.0e+00 ABO C9orf96
Myopia 2.04 2 0 0.0 0.00 1.0e+00 ATP1B1 VAV2
Vascular/heart problems diagnosed by doctor 1.17 1 0 0.0 0.00 1.0e+00 ABO
Alcohol drinker status: Previous 1.85 1 0 0.0 0.00 1.0e+00 NME7
Impedance of whole body 1.02 3 1 3.0 0.00 1.0e+00 ABO C9orf96 EIF6
Arm predicted mass (left) 2.17 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.29
GTEx Adipose Visceral Omentum 0 0.0000 1.29
GTEx Adrenal Gland 0 0.0000 1.35
GTEx Artery Aorta 1 0.0336 1.27
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 2 0.0532 1.31
GTEx Brain Caudate basal ganglia 1 0.1087 1.36
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.22
GTEx Brain Cerebellum 1 0.0505 1.30
GTEx Brain Cortex 0 0.0000 1.28
GTEx Brain Frontal Cortex BA9 0 0.0000 1.33
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.35
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.32
GTEx Brain Putamen basal ganglia 0 0.0000 1.29
GTEx Breast Mammary Tissue 2 0.1013 1.38
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.12
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.25
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.32
GTEx Cells Transformed fibroblasts 1 0.0238 1.29
GTEx Colon Sigmoid 0 0.0000 1.23
GTEx Colon Transverse 1 0.0484 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 2 0.0602 1.32
GTEx Esophagus Muscularis 0 0.0000 1.26
GTEx Heart Atrial Appendage 1 0.0633 1.27
GTEx Heart Left Ventricle 0 0.0000 1.24
GTEx Liver 0 0.0000 1.21
GTEx Lung 1 0.0348 1.27
GTEx Muscle Skeletal 0 0.0000 1.31
GTEx Nerve Tibial 1 0.0231 1.27
GTEx Ovary 0 0.0000 1.18
GTEx Pancreas 1 0.0613 1.35
GTEx Pituitary 1 0.0897 1.32
GTEx Prostate 0 0.0000 1.28
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.34
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.34
GTEx Small Intestine Terminal Ileum 0 0.0000 1.41
GTEx Spleen 2 0.1417 1.28
GTEx Stomach 1 0.0688 1.31
GTEx Testis 1 0.0317 1.30
GTEx Thyroid 1 0.0250 1.25
GTEx Uterus 1 0.1764 1.38
GTEx Vagina 1 0.1575 1.32
GTEx Whole Blood 1 0.0502 1.24
METSIM Adipose 4 0.0868 1.26
NTR Blood 0 0.0000 1.21
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.23
YFS Blood 0 0.0000 1.19
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.23
TCGA Breast Tumor 0 0.0000 1.32
TCGA Breast Normal 2 0.0475 1.20
TCGA Ovarian Tumor 1 0.0342 1.19
TCGA Prostate Tumor 1 0.0289 1.28