Hub : Genes

TMCO1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.152	0.051	0.0023	0.024	NA	0.002	NA	0.011	5.0e-03	NA	2.0e-01	NA	4.5e-02
2	GTEx	Testis	0.255	0.074	0.0010	0.186	NA	0.088	NA	0.164	1.1e-08	NA	9.9e-05	NA	9.6e-08
3	TCGA	Rectum Adenocarcinoma	0.505	0.142	0.0065	0.046	-0.001	-0.010	NA	0.025	3.1e-02	0.34	6.4e-01	NA	8.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.2	1.8	4.1	0.9	-0.8	-2.0
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	0.6	1.3	-0.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	-0.4	-0.0	-1.2
Depression (Nagel 2018)	0.7	1.0	2.7	0.5	0.1	-1.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.4	-0.5	2.1	-1.0
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.4	0.0	-1.1
Schizophrenia (2018)	1.2	2.4	5.6	0.1	2.4	1.3
Schizophrenia vs Biploar Disorder	3.7	4.9	5.7	-2.0	2.2	2.4
Worry (Nagel 2018)	0.5	1.0	1.4	1.2	-0.7	-1.0
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.3	-1.3	0.1
Alzheimer’s Disease (in father)	0.4	0.5	1.1	-0.2	0.5	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.8	-0.6	0.4
Crohns Disease (2017)	0.6	1.3	2.2	1.5	1.3	0.4
Irritable Bowel Disease (IBD)	0.5	1.3	2.2	1.0	1.5	0.8
Ulcerative Colitis (UC)	0.7	1.3	2.3	-0.3	1.5	1.2
Major Depression (MDD)	0.6	0.7	1.6	0.3	0.5	-1.3
Reaction Time	0.6	1.2	2.9	1.7	0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.7	0.3	0.3	-1.6
Breast Cancer	0.3	0.7	1.5	-0.8	1.2	-0.0
Ovarian Cancer	2.3	3.0	7.2	-1.2	2.7	-0.7
Prostate Cancer	0.9	1.3	2.4	1.1	-1.5	-0.5
Age at First Birth	1.0	1.5	2.6	-0.8	1.6	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.1	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.6	0.0	-1.3	0.5
Coronary Artery Disease (CAD)	0.6	0.7	0.9	0.7	-0.8	1.0
Crohns Disease (2012)	0.7	1.1	2.4	1.0	1.6	-0.1
Mean Putamen Volume	1.8	2.1	4.4	-2.1	-1.3	-0.1
Fasting Glucose	0.1	0.2	0.4	0.0	0.6	-0.3
HbA1C	0.2	0.2	0.6	0.2	0.1	0.8
HDL Cholesterol	0.4	0.6	1.6	-0.2	0.6	1.3
LDL Cholesterol	0.5	0.7	1.2	0.7	-1.1	0.8
Lupus	0.3	0.5	1.2	-0.5	1.1	-0.1
Neuroticism (2016)	1.9	2.7	3.1	-1.8	1.6	-1.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.4	-0.2	0.1
Rheumatoid Arthritis	0.3	0.4	1.1	0.4	-1.1	0.0
Schizophrenia (2014)	0.9	2.1	5.2	0.3	2.3	0.9
Triglycerides	0.7	1.1	1.8	-0.6	1.1	1.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.2	0.2	0.5
Ulcerative Colitis	0.1	0.2	0.4	0.0	0.5	0.6
Blood Eosinophil Count	0.3	2.1	6.1	0.3	2.5	-0.5
Blood Platelet Count	0.0	0.3	0.3	0.5	0.5	-0.4
Blood Red Count	0.0	0.1	0.3	-0.5	-0.0	-0.0
Blood White Count	0.2	1.3	1.8	1.3	1.2	-0.8
Heel T-Score	0.1	1.1	2.7	-0.4	-0.6	1.6
BMI	0.3	1.9	2.7	1.6	-1.1	-1.3
Height	0.2	3.4	5.6	-2.4	1.3	1.7
Waist Hip Ratio (WHR)	0.9	4.1	11.6	3.4	-0.8	-0.0
Systolic Blood Pressure	0.2	0.8	1.9	1.4	-0.6	-0.2
Smoking Status	0.8	1.8	3.3	1.8	-1.3	-0.8
Allergy or Eczema	0.0	0.1	0.2	-0.2	-0.1	-0.5
Cardiovascular Disease	1.6	5.4	11.6	3.4	-2.2	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	-0.5	-0.0
Respiratory disease	0.1	0.2	0.3	-0.6	0.5	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.3	-1.1	1.1	-0.5
Lung FEV1/FVC ratio	0.1	0.6	1.9	1.4	-0.0	0.1
Lung FVC	0.8	4.2	9.8	0.2	-1.7	3.1
Neuroticism	0.6	1.5	4.2	0.1	-0.6	-2.0
Chronotype (morning person)	0.9	2.1	5.7	0.5	0.7	2.4
Hair Pigment	0.1	3.7	4.8	-1.8	2.2	1.7
Tanning	0.0	0.4	0.8	0.9	-0.2	-0.5
Hand grip strength (left)	0.0	0.1	0.1	0.1	-0.3	0.3
Number of treatments/medications taken	2.1	3.8	11.1	0.5	-0.2	-3.3
Average weekly spirits intake	0.6	0.7	1.6	-1.3	0.6	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	0.2	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-0.1	0.3	-1.4
Hearing difficulty/problems: Yes	2.7	4.1	6.3	1.3	-2.5	-2.1
Relative age of first facial hair	0.4	0.8	2.2	0.3	-0.0	1.5
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.4	0.5	-1.8	-2.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	0.4	-0.7	-1.3
Ever had hysterectomy (womb removed)	1.2	1.4	2.4	1.2	-1.6	-0.3
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	-0.3	-0.3
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	2.0	-1.4	-0.3	-1.4
Angina	0.3	0.4	0.8	-0.4	-0.6	0.9
Medication for hormone replacement therapy	0.2	0.3	0.4	-0.6	0.7	-0.2
Vitamin and mineral supplements	0.8	1.1	1.5	-1.2	0.5	1.2
Supplements: Zinc	0.6	0.7	1.5	-0.5	0.4	-1.2
Medication: Co-codamol	0.6	0.7	2.0	-0.5	-0.1	-1.4
Medication: Metformin	0.5	0.7	2.0	0.3	0.1	-1.4
Diabetes (father)	1.3	1.6	3.5	-1.9	0.6	-0.9
Diabetes (mother)	0.3	0.4	0.8	-0.1	0.9	-0.5
Severe depression (siblings)	0.3	0.3	0.6	0.8	-0.6	-0.2
Pack years adult smoking proportion	0.4	0.6	1.3	-0.5	0.6	1.1
Impedance of leg (right)	0.5	2.4	3.0	-1.3	1.6	1.7
Leg fat-free mass (left)	0.2	1.1	1.5	0.8	-1.1	-1.2
Trunk fat percentage	0.2	0.9	2.3	0.2	-0.7	-1.5
Hand grip strength (right)	0.5	1.4	4.0	0.0	0.2	2.0
Townsend deprivation index at recruitment	1.5	2.1	3.3	1.7	-0.0	-1.8
Current tobacco smoking	1.5	2.5	3.0	1.7	-1.6	-1.4
Average weekly fortified wine intake	0.7	0.8	1.9	0.4	-1.4	-0.5
Maternal smoking around birth	1.1	1.6	2.9	1.4	-0.1	-1.7
Fed-up feelings	0.5	0.9	1.1	-1.1	-0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	5.6	0.5	0.2	-2.4
Relative age voice broke	0.8	1.2	2.6	1.0	0.2	1.6
Taking other prescription medications	0.5	0.7	1.8	0.3	-0.6	-1.4
Age when periods started (menarche)	0.4	1.0	2.4	1.6	0.3	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.3	0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.8	0.6	-1.3	0.5
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	5.8	0.9	-0.9	2.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.2	0.5	-0.2
Serious illness, injury or assault to yourself	1.9	2.3	4.2	1.2	-1.2	-2.1
High blood pressure	0.6	1.8	3.2	1.8	-0.4	-1.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.1	0.6	-0.3
Multivitamins +/- minerals	0.8	1.0	1.6	1.1	-0.5	-1.3
Stomach or abdominal pain in last month	1.0	1.3	3.2	-0.1	-0.7	-1.8
Supplements: Glucosamine	0.6	0.8	1.9	0.5	-1.4	0.5
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.7	1.2	-1.9	0.8
Medication: Atenolol	1.3	1.6	2.4	1.6	-1.5	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.1	-0.3	-0.7
Sitting height	0.3	2.1	3.6	-1.9	0.5	1.5
Chronic bronchitis/emphysema (father)	0.3	0.3	0.8	-0.4	-0.0	-0.9
High blood pressure (mother)	1.2	1.7	2.4	-1.0	1.3	-1.6
Body mass index (BMI)	0.6	2.6	5.7	1.1	-1.0	-2.4
Impedance of leg (left)	0.7	3.4	3.9	-1.8	2.0	1.8
Leg predicted mass (left)	0.2	1.3	1.8	0.9	-1.2	-1.3
Trunk fat mass	0.2	0.8	1.9	0.3	-0.7	-1.4
Waist circumference	0.9	3.4	4.7	1.9	-1.4	-2.2
Number of incorrect matches in round	0.1	0.2	0.3	0.5	0.2	-0.4
Past tobacco smoking	0.4	0.8	1.3	-1.0	1.1	0.3
Alcohol usually taken with meals	0.9	1.5	2.6	-1.6	1.2	0.6
Nervous feelings	0.2	0.4	1.1	0.2	1.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.4	-0.2	-1.1	-2.1
Hearing difficulty/problems with background noise	1.8	2.8	3.9	1.9	-2.0	-1.0
Hair/balding pattern: Pattern 2	0.9	1.2	3.6	0.0	1.9	-0.0
Had menopause	0.8	1.0	2.3	-0.7	-0.4	-1.5
Had other major operations	0.3	0.3	0.4	0.6	-0.7	-0.4
Forced vital capacity (FVC)	0.9	3.5	10.0	-0.6	-0.1	3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.3	0.3	-1.0	1.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.7	-0.2	-0.8
Qualifications: None of the above	1.0	2.0	4.3	2.1	-1.2	-0.6
Financial difficulties in last 2 years	2.3	3.2	5.6	1.2	-2.4	-1.6
Mouth/teeth dental problems	0.1	0.2	0.4	-0.1	-0.5	0.6
Heart attack	0.8	1.0	2.0	0.9	-1.4	0.3
Allergy	0.1	0.1	0.3	0.1	-0.2	0.6
Pain all over the body in last month	2.3	2.4	4.2	-1.7	0.4	-2.0
Diabetes (self-reported)	0.6	1.0	2.7	-0.3	0.4	-1.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.8	-0.3	0.7	0.9
Medication: Ramipril	0.1	0.1	0.1	0.4	-0.1	0.3
Medication: Simvastatin	0.0	0.1	0.1	-0.3	0.1	-0.4
Fluid intelligence score	0.9	1.9	4.9	0.7	-0.4	-2.2
Illnesses of siblings	0.6	0.8	2.1	-0.5	0.3	1.5
Neuroticism score	0.3	0.5	1.3	-0.5	0.3	-1.1
Weight	0.2	1.0	2.4	0.5	-0.6	-1.6
Impedance of arm (right)	0.3	1.3	2.3	-1.1	1.5	0.6
Arm fat percentage (right)	0.3	1.1	3.0	0.4	-0.5	-1.7
Trunk fat-free mass	0.0	0.1	0.1	0.1	-0.2	-0.3
Hip circumference	0.5	2.2	5.0	0.4	-1.2	-2.2
Time employed in main current job	0.2	0.2	0.3	-0.6	-0.5	-0.2
Alcohol intake versus 10 years previously	0.8	1.2	2.7	0.5	-1.6	0.9
Father’s age at death	1.0	1.3	2.6	-1.6	-0.2	1.1
Worrier / anxious feelings	0.3	0.5	1.3	-0.0	0.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.0	-0.4	-1.4	-1.0
Falls in the last year	0.2	0.3	0.7	0.2	-0.9	-0.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-0.9	-1.0	0.1
Number of live births	0.7	0.9	2.3	1.5	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	9.5	-0.5	0.5	3.1
Pulse rate	0.3	0.5	1.1	-0.1	-0.7	-1.0
Happiness	0.7	0.9	2.0	-1.4	0.1	-0.8
Noisy workplace	2.2	2.7	7.6	0.4	-0.6	-2.8
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.6	-1.3	-1.6	1.1
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	4.7	-1.8	1.4	2.2
Mouth/teeth dental problems: Dentures	1.8	3.1	6.1	2.5	-1.7	-0.4
Asthma	0.1	0.2	0.3	-0.5	0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	0.4	-0.9	-1.2
Medication: Cholesterol lowering	0.2	0.4	0.8	0.3	-0.9	-0.5
Depression (self-reported)	2.8	3.3	7.4	-1.5	0.5	-2.7
Medication: Lansoprazole	3.5	4.0	7.5	0.7	-2.7	-2.0
Prospective memory result	0.3	0.3	0.4	-0.6	0.6	-0.3
Lung cancer (father)	0.2	0.2	0.7	-0.0	0.2	-0.8
Illnesses of mother	2.1	2.5	6.6	-1.0	0.1	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.9	-1.3	0.3	2.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	1.0	-0.6	0.3
Impedance of arm (left)	0.1	0.5	0.8	-0.9	0.5	0.8
Arm fat mass (right)	0.3	1.4	3.0	0.7	-0.9	-1.7
Trunk predicted mass	0.0	0.1	0.1	0.1	-0.2	-0.3
Standing height	0.2	1.9	3.8	-1.2	0.7	1.9
Length of working week for main job	1.3	1.4	1.6	1.2	-1.2	1.2
Exposure to tobacco smoke at home	1.3	1.5	2.7	1.6	-1.3	0.2
Breastfed as a baby	1.4	1.8	2.1	-1.4	1.4	1.1
Tense / ‘highly strung’	0.5	0.8	2.1	0.4	-1.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.4	1.2	-0.8	-0.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	1.4	-0.4	0.0
Birth weight of first child	0.1	0.1	0.2	0.3	0.3	-0.5
Peak expiratory flow (PEF)	0.4	1.0	1.3	-1.1	0.9	0.9
Pulse wave reflection index	1.6	2.0	5.2	2.3	0.8	-0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.6	0.5	-0.8
Loud music exposure frequency	2.5	2.8	8.1	0.4	-2.8	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.1	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.9	-0.9	2.0	-0.5
Blood clot in the leg (DVT)	0.4	0.6	1.0	0.7	-0.4	1.0
Medication: Paracetamol	0.2	0.3	0.4	0.7	0.6	0.1
Headache pain in last month	0.2	0.3	0.8	0.1	-0.9	0.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.1	3.2	-1.1	1.4	1.8
Glaucoma (self-reported)	40.8	48.0	116.6	-10.8	5.0	-1.7
Gout (self-reported)	0.1	0.1	0.3	-0.3	-0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	0.8	-1.0	-0.3
Medication: Amlodipine	0.8	1.1	1.9	1.1	0.2	-1.4
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.4	1.6	1.3	-0.3
Birth weight	0.6	1.2	2.5	-0.8	0.7	-1.6
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.8	0.7	-1.3	-1.0
High blood pressure (siblings)	0.1	0.2	0.6	0.0	0.0	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.7	3.5	-1.3	0.2	1.9
Body fat percentage	0.3	1.0	2.5	0.2	-0.7	-1.6
Leg fat percentage (right)	0.5	1.7	4.0	0.7	-0.8	-2.0
Arm fat-free mass (right)	0.1	0.5	0.6	0.6	-0.7	-0.8
Exposure to tobacco smoke outside home	1.2	1.7	2.5	0.4	-1.6	-1.5
Comparative body size at age 10	0.3	0.7	1.8	-0.2	0.5	-1.4
Number of full brothers	1.1	1.4	3.9	-0.0	2.0	0.5
Worry too long after embarrassment	2.1	3.4	5.8	-2.1	2.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.5	-0.8	0.7	1.2
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	-0.4	0.1	0.1
Number of children fathered	1.8	2.1	3.3	0.9	-1.4	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.4	0.7	0.1
Age at first live birth	0.6	1.0	2.6	-1.6	0.6	0.0
Pulse wave peak to peak time	0.5	0.6	1.3	-1.1	0.7	-0.1
Health satisfaction	0.2	0.3	0.7	-0.2	-0.2	-0.8
Shortness of breath walking on level ground	1.2	1.5	2.2	1.1	-1.5	-1.0
Qualifications: College or University degree	0.2	0.6	1.0	-0.8	-0.5	1.0
Eye problems/disorders: None of the above	4.6	5.3	13.9	3.7	-0.5	1.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	-0.0	-0.0	-1.2
Emphysema/chronic bronchitis	3.0	3.3	5.1	1.9	-2.3	-1.1
Medication for pain relief, constipation, heartburn	2.5	4.3	4.6	-2.0	2.1	2.1
Neck or shoulder pain in last month	1.9	2.7	7.0	-0.5	-0.8	-2.7
Medication: Blood pressure	0.3	0.6	0.6	0.8	-0.8	-0.8
Angina (self-reported)	0.3	0.3	0.8	-0.5	-0.2	0.9
Migraine (self-reported)	0.2	0.3	0.6	0.6	0.0	-0.8
Medication: Ibuprofen	0.2	0.3	0.6	0.1	-0.3	-0.8
Medication: Allopurinol	0.1	0.2	0.5	-0.7	-0.1	0.3
Medication: Omeprazole	4.4	5.2	9.4	-0.2	-3.1	-2.5
Medication: Seretide 50 evohaler	1.4	1.6	2.4	-1.1	1.2	-1.6
Mean time to correctly identify matches	0.7	1.4	3.3	1.8	-0.7	0.7
Heart disease (mother)	0.1	0.1	0.4	-0.1	0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.6	1.1	-1.3	0.7
Whole body fat mass	0.2	0.9	1.8	0.4	-0.9	-1.3
Leg fat mass (right)	0.3	1.3	2.8	0.7	-0.8	-1.7
Arm predicted mass (right)	0.1	0.5	0.6	0.5	-0.7	-0.8
Pulse rate, automated reading	0.4	1.1	2.8	0.8	-0.0	-1.7
Alcohol intake frequency.	0.9	2.1	5.6	0.2	-2.4	-0.7
Comparative height size at age 10	0.5	2.6	3.0	-1.3	1.7	1.7
Number of full sisters	0.2	0.2	0.4	0.6	0.0	-0.5
Suffer from ‘nerves’	0.4	0.6	1.1	-0.0	0.8	1.1
Overall health rating	1.0	2.1	4.5	1.3	-0.6	-2.1
Chest pain or discomfort	0.1	0.1	0.2	-0.4	-0.3	0.2
Had major operations	3.8	4.5	7.2	2.7	-2.0	-1.5
Age at last live birth	0.2	0.3	0.8	-0.4	0.9	0.3
Family relationship satisfaction	0.0	0.1	0.1	-0.3	0.1	0.2
Leg pain on walking	1.5	1.9	5.4	0.4	-2.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	7.0	-2.6	0.2	0.2
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.3	-0.3	-0.7	-1.5
Illness, injury, bereavement, stress in last 2 years	1.8	2.1	3.4	-0.1	1.8	1.8
Medication: Aspirin	0.3	0.3	0.6	0.4	-0.8	-0.4
Supplements: Vitamin C	0.3	0.3	0.7	0.6	0.1	0.8
Knee pain experienced in last month	1.7	2.7	6.1	2.5	-1.3	-0.4
Hypertension (Self-reported)	0.5	1.5	2.4	1.6	-0.5	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.9	6.8	1.3	-2.6	-1.8
Illnesses of father: Heart disease	1.4	2.0	4.1	2.0	-1.4	-0.1
Illnesses of siblings: Diabetes	0.5	0.7	2.0	1.4	0.2	0.1
Smoking status: Previous	0.2	0.4	1.1	-0.1	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.5	-1.9	0.3	-0.5
Whole body fat-free mass	0.1	0.4	0.7	0.3	-0.6	-0.8
Leg fat-free mass (right)	0.1	0.7	1.4	0.4	-0.8	-1.2
Arm fat percentage (left)	0.3	1.3	2.7	0.6	-0.9	-1.6
Average weekly red wine intake	0.1	0.1	0.2	0.1	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.3	-1.0	-0.6	1.1
Mood swings	0.0	0.1	0.1	0.1	-0.3	-0.2
Loneliness, isolation	1.4	2.0	4.8	-0.3	-1.1	-2.2
Long-standing illness, disability or infirmity	1.0	1.5	2.5	0.9	-1.1	-1.6
Ever had bowel cancer screening	0.4	0.5	1.3	1.1	0.4	-0.4
Diabetes diagnosed by doctor	0.7	1.2	2.2	-0.9	0.7	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.0	1.4	0.1	0.8
Friendships satisfaction	0.1	0.2	0.4	-0.6	0.2	0.3
Qualifications: nursing, teaching	1.1	1.7	3.3	-1.8	1.1	-0.7
Commuting to job workplace: Walk	0.6	0.6	1.7	-1.3	0.1	0.3
Eye problems/disorders: Cataract	2.1	2.5	4.6	1.6	-2.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.5	-1.2	0.1	-0.8
Medication for cholesterol	0.2	0.4	0.7	0.1	-0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.7	0.1	-0.9
Back pain experienced in last month	0.7	1.1	1.8	1.1	-1.3	-0.2
Mineral and other dietary supplements	0.2	0.3	0.3	-0.6	0.5	0.4
Breast cancer (self-reported)	1.7	2.0	3.9	2.0	-1.4	-0.4
Asthma (self-reported)	0.1	0.1	0.3	0.2	0.6	0.1
Osteoporosis (self-reported)	0.4	0.4	1.2	-0.3	1.1	-0.3
Osteoarthritis (self-reported)	0.8	1.0	1.7	0.9	-0.6	-1.3
Medication: Aspirin	0.0	0.0	0.1	0.1	-0.3	-0.2
Medication: Gliclazide	0.9	1.0	2.3	-0.5	-0.7	-1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-1.1	-0.1	0.4
Smoking status: Current	1.5	2.3	2.6	1.5	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.6	0.1	-0.1	1.3
Whole body water mass	0.1	0.5	0.8	0.5	-0.6	-0.9
Leg predicted mass (right)	0.1	0.8	1.4	0.4	-0.9	-1.2
Arm fat mass (left)	0.4	1.6	3.5	0.8	-0.9	-1.9
Number of self-reported non-cancer illnesses	2.4	4.2	10.1	0.7	-1.4	-3.2
Average weekly champagne plus white wine intake	0.9	1.2	3.1	-0.2	-1.8	0.7
Miserableness	1.9	3.3	6.9	-2.6	0.6	-1.6
Guilty feelings	1.5	2.2	3.0	-1.7	1.7	-0.9
Wears glasses or contact lenses	0.2	0.2	0.5	-0.7	-0.1	0.1
Ever taken oral contraceptive pill	1.1	1.3	2.1	-1.2	0.4	-1.5
Hearing aid user	0.3	0.4	0.6	0.8	0.5	0.5
Mother’s age at death	0.9	1.1	2.4	-1.6	0.3	-0.9
Financial situation satisfaction	0.2	0.3	0.8	0.4	0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-1.2	0.7	0.5
Commuting to job workplace: Public transport	0.3	0.3	0.4	0.4	-0.6	0.6
Eye problems/disorders: Glaucoma	43.5	51.6	130.0	-11.4	4.9	-1.0
Medication: Blood pressure	0.3	0.5	0.8	0.4	0.9	-0.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.2	0.6	-2.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.2	-0.3	0.0
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.0	-0.5	0.6
Medication: Bendroflumethiazide	1.0	1.4	2.6	-1.6	0.8	-1.0
Medication: Paracetamol	0.2	0.4	0.6	0.8	0.6	0.3
Medication: Lisinopril	0.1	0.1	0.3	-0.0	0.6	-0.1
Medication: Atorvastatin	0.3	0.4	0.8	-0.5	-0.9	0.4
Illnesses of father: High blood pressure	0.3	0.4	0.7	-0.5	0.5	0.8
Alcohol drinker status: Never	0.8	0.9	1.5	-1.2	-0.5	-1.0
Ever smoked	0.5	0.9	1.4	1.1	-1.2	0.0
Basal metabolic rate	0.1	0.5	0.9	0.4	-0.7	-1.0
Leg fat percentage (left)	0.4	1.3	3.4	0.4	-0.5	-1.9
Arm fat-free mass (left)	0.1	0.3	0.9	0.3	-0.0	-0.9
Number of operations (self-reported)	1.4	2.0	3.2	1.5	-0.8	-1.8
Average weekly beer plus cider intake	1.1	1.5	2.1	0.7	-1.4	-1.4
Irritability	1.3	2.2	3.6	1.9	-1.6	-0.6
Risk taking	1.4	2.0	4.9	-2.2	-0.3	-1.1
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.7	-0.8	-0.0	1.6
Fractured/broken bones in last 5 years	0.5	0.6	0.8	-0.5	0.9	-0.8
Age started oral contraceptive pill	0.2	0.3	0.6	-0.5	0.1	-0.7
Diastolic blood pressure, automated reading	0.3	0.9	2.7	0.1	0.2	-1.6
Ever depressed for a whole week	2.0	2.4	5.3	-1.0	-0.9	-2.3
Unable to work because of sickness or disability	0.4	0.5	0.9	0.4	-0.8	-0.9
Commuting to job workplace: Cycle	1.5	1.9	3.6	-0.9	1.0	1.9
Myopia	4.5	6.5	14.1	-3.8	2.2	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.6	-1.6	0.8	1.4
Cholesterol lowering medication	0.3	0.4	1.0	1.0	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	3.8	4.7	8.4	-0.2	-2.9	-2.4
Pain experienced in last month	1.6	2.7	5.3	-0.6	1.5	2.3
Supplements: Calcium	0.7	0.8	1.5	0.1	1.2	0.9
Basal cell carcinoma (self-reported)	0.7	0.8	1.5	-0.4	-1.2	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.8	0.7	-1.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.4	0.1	0.8
Heart disease (siblings)	2.3	2.9	7.1	-1.2	0.0	-2.7
Alcohol drinker status: Previous	1.8	2.1	4.2	1.3	-2.0	-0.6
Pack years of smoking	0.5	0.8	1.8	-0.4	0.6	1.3
Impedance of whole body	0.3	1.7	1.9	-1.3	1.4	1.2
Leg fat mass (left)	0.2	1.0	2.3	0.5	-0.6	-1.5
Arm predicted mass (left)	0.1	0.4	1.1	0.5	-0.2	-1.0