TWAS hub - GAS7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.6057	0.0982	0.00002	0.372	NA	0.349	NA	0.393	2.6e-14	NA	2.6e-13	NA	3.3e-15
2	GTEx	Cells Transformed fibroblasts	0.2580	0.0670	0.00056	0.089	NA	0.139	NA	0.115	3.3e-07	NA	1.3e-10	NA	6.0e-09
3	GTEx	Heart Left Ventricle	0.2780	0.0915	0.00820	0.029	NA	0.105	NA	0.095	1.1e-02	NA	3.2e-06	NA	9.2e-06
4	GTEx	Whole Blood	0.1480	0.0470	0.00200	0.008	NA	0.013	NA	0.006	5.7e-02	NA	2.0e-02	NA	8.2e-02
5	NTR	Blood	0.0391	0.0136	0.00290	0.013	0.002	0.029	0.018	0.030	2.6e-05	0.061	8.9e-10	1.3e-06	3.7e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Glaucoma (self-reported)	8.6	10.1	36.9	-0.1	6.1	1.9	0.8	-3.0
Eye problems/disorders: Glaucoma	8.0	9.5	32.4	-0.6	5.7	1.5	0.1	-3.5
Other serious medical condition/disability diagnosed by doctor	3.9	5.1	10.6	1.8	1.1	2.8	3.3	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	13.6	3.7	-0.2	3.4	0.9	1.2
Neck or shoulder pain in last month	3.6	5.2	9.2	2.7	0.3	2.7	1.4	3.0
Irritability	3.1	5.3	9.7	3.1	-1.3	2.5	-0.6	2.9
Unable to work because of sickness or disability	3.1	4.0	11.7	0.5	-2.3	-0.6	3.4	1.6
Osteoarthritis (self-reported)	2.9	3.8	10.2	1.9	-3.2	0.3	1.6	1.6
Number of self-reported non-cancer illnesses	2.9	5.1	8.5	2.9	-0.0	2.4	2.9	1.7
Alcohol usually taken with meals	2.8	4.6	12.6	-3.5	0.9	-2.5	0.4	-1.7
Age at first live birth	2.8	4.9	10.5	-1.8	-3.2	-3.2	0.3	0.3
Pain experienced in last month	2.8	4.6	9.5	-3.1	0.2	-1.7	-2.3	-2.3
Father’s age at death	2.6	3.5	7.4	-1.4	-2.7	-2.2	-0.9	1.7
Number of live births	2.6	3.7	6.9	1.9	2.5	2.6	-1.4	-0.2
Miserableness	2.5	4.3	7.2	1.9	0.0	2.5	2.7	2.0
Medication: Allopurinol	2.4	3.2	6.9	2.6	-0.3	2.0	1.7	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.3	13.1	-1.6	-3.6	-3.0	-0.6	-1.4
Qualifications: None of the above	2.3	4.9	9.0	3.0	2.2	2.5	0.7	1.9
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	8.0	1.4	-0.4	1.2	2.8	1.4
Supplements: Calcium	2.3	2.6	4.7	1.2	2.2	1.2	-1.1	2.0
Financial difficulties in last 2 years	2.1	2.9	5.2	2.1	1.5	1.6	0.5	-2.3
Commuting to job workplace: Walk	2.1	2.2	6.5	0.3	2.5	1.1	1.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	7.8	-2.1	-2.7	-2.8	-0.4	-1.3
High blood pressure (siblings)	1.9	2.8	4.8	0.5	2.0	1.7	2.2	-1.4
Migraine (self-reported)	1.9	2.4	7.4	1.7	-2.7	-0.3	0.2	1.2
Bipolar Disorder (2018)	1.8	2.8	5.9	-2.1	0.1	-2.4	0.7	-1.7
Past tobacco smoking	1.8	3.2	8.0	-1.3	-2.4	-2.8	-0.7	0.4
Smoking status: Current	1.8	2.8	6.4	0.9	2.5	1.4	2.2	-0.3
Pulse rate	1.7	2.8	7.5	1.6	2.7	2.0	0.2	0.1
Loud music exposure frequency	1.7	1.8	4.0	-1.0	-2.0	-1.8	-0.9	0.2
Gout (self-reported)	1.7	2.4	5.6	2.4	-0.4	1.4	0.7	-2.0
Shortness of breath walking on level ground	1.7	2.0	5.1	2.3	0.2	1.4	0.3	1.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.9	-0.1	-2.2	1.3	-1.7	-0.5
Back pain experienced in last month	1.7	2.4	4.0	1.4	1.5	2.0	2.0	0.1
Age at First Birth	1.6	2.3	4.5	-1.5	-2.1	-1.9	0.2	-1.2
Angina	1.6	2.2	4.2	1.4	0.8	1.8	0.8	2.0
Diabetes (mother)	1.6	2.1	6.2	1.2	-2.5	0.3	0.3	1.6
Serious illness, injury or assault to yourself	1.6	2.0	6.2	-1.3	-0.9	-0.8	2.5	0.7
Heart attack	1.6	2.0	5.2	-0.4	2.3	-0.0	2.2	-0.0
Falls in the last year	1.6	2.2	6.6	1.2	1.2	0.2	2.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.7	2.2	-1.7	1.4	0.2	0.5
Depression (self-reported)	1.6	1.9	5.3	1.8	0.8	2.3	0.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	9.7	-2.7	-2.5	-3.1	-1.4	0.4
Qualifications: College or University degree	1.6	5.1	12.0	-3.3	-1.5	-3.5	0.5	-0.5
Angina (self-reported)	1.6	2.1	3.5	1.4	1.0	1.8	0.8	1.9
Medication: Ibuprofen	1.6	1.9	5.4	2.3	-0.7	1.8	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	6.5	-2.5	-0.1	-2.1	-2.0	-1.5
Hearing aid user	1.6	1.8	6.3	-0.3	-0.8	-0.9	2.5	-1.0
Smoking Status	1.5	3.6	7.4	0.9	2.7	2.4	2.0	-0.3
Diabetes (father)	1.5	1.9	5.9	1.5	-0.9	0.5	-2.4	0.0
Forced vital capacity (FVC)	1.5	5.8	15.8	-2.1	-4.0	-2.8	-0.6	0.5
Alcohol intake versus 10 years previously	1.5	2.2	7.1	1.7	0.3	0.5	-0.9	-2.7
Forced vital capacity (FVC), Best measure	1.5	5.5	9.4	-2.5	-3.0	-3.1	-1.7	0.0
Age at last live birth	1.5	2.2	5.0	-0.6	-2.2	-2.2	0.2	-0.8
Knee pain experienced in last month	1.5	2.3	4.6	2.1	-0.8	0.9	1.6	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	13.5	-1.0	-3.7	-1.1	0.4	-0.0
Wears glasses or contact lenses	1.5	1.7	2.7	-1.6	1.6	-1.3	1.3	-0.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	5.5	-0.4	2.4	0.2	2.0	0.1
Irritable Bowel Disease (IBD)	1.4	3.3	6.7	-2.6	1.9	0.0	-2.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.5	1.4	-2.1	0.8	1.9	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	6.3	2.5	-1.6	1.1	0.6	1.1
Osteoporosis (self-reported)	1.4	1.7	5.8	0.0	2.4	0.3	-1.2	1.1
Illnesses of father: None of the above (group 1)	1.4	1.7	4.5	-1.8	0.0	-2.1	0.8	-0.6
Average weekly champagne plus white wine intake	1.4	1.9	5.4	-1.3	-2.3	-1.4	-0.6	-0.0
Heel T-Score	1.3	10.7	43.0	-1.1	-6.6	-3.0	-0.6	-0.5
Ever had hysterectomy (womb removed)	1.3	1.5	2.8	0.8	0.4	1.2	-1.7	1.6
Current tobacco smoking	1.3	2.1	4.5	1.0	2.1	1.3	1.7	-0.4
Medication: Atenolol	1.3	1.7	3.5	1.0	1.8	1.9	0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	9.0	-2.3	-3.0	-2.7	-0.3	0.8
Birth weight of first child	1.3	2.3	5.2	1.4	0.1	2.0	-0.8	2.3
Emphysema/chronic bronchitis	1.3	1.5	2.9	0.3	-0.8	-1.3	-1.5	-1.7
Handedness (chirality/laterality): Left-handed	1.3	1.6	6.9	0.3	-0.0	0.1	-2.6	-0.9
Crohns Disease (2017)	1.2	2.7	7.6	-1.2	2.8	1.2	-1.8	0.2
Breast Cancer	1.2	2.8	9.1	-3.0	1.3	-1.1	1.5	-0.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.1	-0.1	-1.3	-0.9	-1.8	1.1
Frequency of depressed mood in last 2 weeks	1.2	1.6	5.6	0.1	-1.4	-0.5	2.4	0.5
Pulse wave reflection index	1.2	1.5	3.9	-1.1	-2.0	-1.5	-0.1	0.1
Leg fat percentage (right)	1.2	4.3	10.8	3.3	1.6	2.3	-1.1	1.4
Ever had bowel cancer screening	1.2	1.4	3.3	0.7	0.3	1.6	-1.8	0.9
Cholesterol lowering medication	1.2	1.7	5.2	1.7	0.6	2.3	0.3	0.3
Ulcerative Colitis (UC)	1.1	2.0	5.4	-2.3	0.8	-0.5	-1.9	-0.2
Lung FVC	1.1	5.5	13.4	-3.7	-1.8	-3.0	-1.1	-0.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	1.9	0.4	1.6	0.5	0.6
Townsend deprivation index at recruitment	1.1	1.5	3.5	1.9	0.6	1.2	0.8	1.3
Sitting height	1.1	8.1	34.6	0.7	-5.9	-1.5	1.8	0.0
Arm fat percentage (right)	1.1	4.4	10.8	3.3	1.9	2.4	-1.1	0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	7.5	-0.9	-0.5	-0.5	-2.7	0.0
Overall health rating	1.1	2.5	7.4	2.7	-0.9	1.2	1.5	0.6
Mood swings	1.1	1.9	4.5	2.1	-0.5	1.7	0.9	1.1
Ever smoked	1.1	2.0	4.4	1.2	1.8	2.1	0.6	-0.6
Bipolar Disorder or Schizophrenia	1.0	2.5	5.4	-2.3	0.9	-1.6	1.9	-0.3
Primary Biliary Cirrhosis	1.0	1.4	3.8	0.5	-1.4	-0.6	-2.0	-0.7
Severe depression (siblings)	1.0	1.1	3.1	-0.9	-0.7	-1.0	1.8	0.2
Waist circumference	1.0	3.7	6.8	2.6	0.5	2.4	-1.5	1.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	5.9	-0.1	-0.6	0.5	0.0	2.4
Noisy workplace	1.0	1.2	3.1	1.0	-1.4	0.3	-1.8	-0.0
Asthma	1.0	1.9	4.4	1.2	-2.1	-0.9	1.7	-0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.7	1.6	0.2	1.7	-0.6	-0.7
Wheeze or whistling in the chest in last year	1.0	1.7	4.8	2.2	-0.6	1.3	1.2	-0.5
Family relationship satisfaction	1.0	1.2	3.0	-0.9	-1.7	-1.3	0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	-1.4	0.6	-0.6	-1.8	-0.4
Asthma (self-reported)	1.0	2.0	5.6	1.3	-2.4	-0.8	1.4	-0.2
High cholesterol (Self-reported)	1.0	1.8	4.1	1.9	0.4	2.0	-0.8	-0.7
Risk taking	1.0	1.4	3.1	0.9	0.1	1.8	1.2	1.3
Major Depression (MDD)	0.9	1.1	1.8	1.3	1.3	0.8	0.4	1.1
Ulcerative Colitis	0.9	1.3	3.8	-2.0	-0.4	-0.6	-1.4	-0.4
Chronotype (morning person)	0.9	2.1	6.3	1.0	1.0	0.9	2.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.1	0.6	-1.4	0.8	1.2	1.2
Chronic bronchitis/emphysema (father)	0.9	1.1	3.6	1.9	0.1	1.3	-0.0	0.2
Number of incorrect matches in round	0.9	1.6	3.5	-1.9	1.3	0.4	1.1	-1.2
Illnesses of siblings	0.9	1.2	2.8	-1.1	-1.1	-0.8	-1.7	0.0
Hair/balding pattern: Pattern 3	0.9	1.3	3.4	-0.3	0.5	-1.6	-1.9	-0.4
Medication: Lansoprazole	0.9	1.1	3.1	-0.1	1.7	-0.3	-0.1	1.5
Standing height	0.9	9.4	42.6	0.5	-6.5	-1.5	1.4	0.0
Exposure to tobacco smoke at home	0.9	1.0	3.5	0.6	0.7	0.6	1.9	-0.6
Body fat percentage	0.9	3.4	9.0	3.0	1.3	2.2	-1.1	0.9
Number of full brothers	0.9	1.2	2.2	1.0	1.5	0.9	1.3	-0.2
Eye problems/disorders: None of the above	0.9	1.0	3.7	0.2	-1.9	-1.1	0.1	0.5
Chest pain or discomfort	0.9	1.3	4.9	0.6	-0.7	0.6	2.2	0.5
Illnesses of siblings: Diabetes	0.9	1.1	2.8	1.7	0.1	0.9	-0.5	1.3
Smoking status: Previous	0.9	1.3	4.7	0.9	1.1	2.2	-0.1	-0.2
Arm fat percentage (left)	0.9	3.7	8.4	2.9	1.8	2.3	-1.2	0.7
Friendships satisfaction	0.9	1.1	2.0	-0.8	-0.7	-1.4	-0.3	-1.4
Medication: Gliclazide	0.9	1.0	2.3	1.3	0.0	1.0	-0.1	1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.2	1.9	0.9	0.9	1.2	0.9	1.4
Fractured/broken bones in last 5 years	0.9	1.1	1.7	1.0	1.3	1.1	0.4	-1.3
Basal cell carcinoma (self-reported)	0.9	1.1	5.0	0.1	0.7	-0.0	-0.4	-2.2
Alzheimer’s Disease (in father)	0.8	0.9	3.6	-0.8	1.9	0.3	0.3	-0.2
Crohns Disease (2012)	0.8	1.2	3.8	-1.1	1.0	0.2	-1.9	0.4
Schizophrenia (2014)	0.8	1.7	4.9	-1.8	0.2	-0.3	2.2	0.6
BMI	0.8	4.6	10.0	3.2	2.1	1.8	-2.4	-0.1
Waist Hip Ratio (WHR)	0.8	3.4	9.9	1.1	-0.8	1.7	-3.1	1.6
Allergy or Eczema	0.8	2.1	6.5	-1.4	1.3	-0.6	0.3	-2.5
Cardiovascular Disease	0.8	2.7	5.1	2.3	-1.8	1.6	-0.8	-1.4
Sensitivity / hurt feelings	0.8	1.4	5.3	-0.2	-0.4	-0.4	2.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	1.1	-0.2	1.3	1.3	0.3
Trunk fat percentage	0.8	3.3	9.1	3.0	1.2	2.1	-1.0	0.7
Supplements: Glucosamine	0.8	1.1	1.5	1.2	-0.9	-1.2	-1.2	0.3
High blood pressure (mother)	0.8	1.1	2.7	1.6	-0.9	0.3	0.5	1.4
Prospective memory result	0.8	1.0	2.3	-0.7	1.4	0.3	-1.5	-0.4
Arm fat mass (right)	0.8	3.4	10.8	3.3	0.5	2.2	-0.8	0.9
Breastfed as a baby	0.8	1.0	2.1	1.2	-0.4	0.1	-1.2	1.5
Peak expiratory flow (PEF)	0.8	1.9	4.8	-1.3	-2.2	-1.5	-0.0	0.9
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	0.8	-0.8	0.0	-1.5	1.2
Exposure to tobacco smoke outside home	0.8	1.0	2.5	1.2	-0.8	-0.8	1.6	0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	4.8	-2.2	1.1	-0.7	-0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	4.2	-0.5	0.5	-0.1	2.0	-0.4
Leg fat mass (right)	0.8	3.2	10.5	3.2	0.4	2.0	-0.5	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.0	-1.4	-0.4	-0.9	-1.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.2	0.2	0.4	-0.0	-1.8	-0.8
Guilty feelings	0.8	1.2	2.9	1.7	-0.2	1.0	0.4	1.4
Mother’s age at death	0.8	1.0	3.0	-0.4	-1.3	-1.7	0.4	0.5
Leg fat percentage (left)	0.8	3.0	5.7	2.4	1.4	1.9	-1.0	1.5
Depression (Nagel 2018)	0.7	1.1	2.1	1.0	-1.5	0.9	1.3	0.2
Schizophrenia (2018)	0.7	1.5	3.4	-1.3	0.7	-0.1	1.8	1.3
Ovarian Cancer	0.7	0.9	2.4	-1.6	-0.2	-1.2	-0.6	0.0
LDL Cholesterol	0.7	1.1	3.1	1.4	-1.8	0.2	0.3	0.3
Rheumatoid Arthritis	0.7	1.0	2.1	-0.4	1.3	1.5	0.1	1.0
Neuroticism	0.7	1.6	5.0	2.2	-0.9	0.7	1.3	-0.4
Average weekly spirits intake	0.7	0.9	2.0	0.9	-1.0	-0.7	-0.3	1.4
Systolic blood pressure, automated reading	0.7	1.9	5.5	0.6	-0.5	1.8	-2.3	0.6
Supplements: Zinc	0.7	0.8	2.2	-0.5	1.5	-0.2	-0.2	-1.2
Hand grip strength (right)	0.7	1.9	4.0	-2.0	-1.8	-1.2	0.5	-0.7
Maternal smoking around birth	0.7	1.0	2.5	0.7	1.6	0.6	0.2	1.2
Qualifications: CSEs or equivalent	0.7	0.9	3.5	-0.4	0.1	-0.6	1.9	-0.8
Multivitamins +/- minerals	0.7	0.9	2.9	0.8	-1.7	0.2	-0.8	0.3
Body mass index (BMI)	0.7	3.0	6.7	2.6	1.6	2.0	-0.8	1.1
Trunk fat mass	0.7	3.0	10.0	3.2	-0.0	1.9	-0.6	0.8
Mouth/teeth dental problems	0.7	1.0	3.4	-0.4	-1.2	-0.6	1.8	-0.0
Neuroticism score	0.7	1.5	3.9	1.1	-2.0	-0.2	1.2	0.8
Hair/balding pattern: Pattern 4	0.7	1.7	4.2	0.0	0.0	2.0	2.0	0.5
Headache pain in last month	0.7	1.2	2.4	1.6	-0.6	1.0	1.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.5	-0.8	1.5	1.6	-0.4	-0.5
Birth weight	0.7	1.6	6.3	2.5	-0.6	0.8	0.1	-0.9
Heart disease (mother)	0.7	0.8	2.4	-0.5	0.0	-1.2	0.2	-1.5
Whole body fat mass	0.7	2.9	9.5	3.1	0.1	2.1	-0.7	0.7
Comparative height size at age 10	0.7	3.9	15.4	1.7	-3.9	0.5	0.8	-0.4
Suffer from ‘nerves’	0.7	1.1	2.6	0.8	-0.6	-0.5	-1.6	1.3
Medication: Aspirin	0.7	0.9	1.8	1.2	0.7	0.9	1.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	-0.2	1.5	0.4	-0.2	1.2
Loneliness, isolation	0.7	1.0	3.9	0.3	-0.8	-0.5	2.0	0.2
Long-standing illness, disability or infirmity	0.7	1.1	3.5	1.3	0.3	0.0	1.9	0.3
Mineral and other dietary supplements	0.7	0.9	2.5	-1.0	0.2	0.6	1.6	-0.7
Breast cancer (self-reported)	0.7	0.8	2.8	0.9	0.6	0.3	-0.3	1.7
Arm fat mass (left)	0.7	3.0	8.5	2.9	0.8	2.1	-0.7	0.9
Ever taken oral contraceptive pill	0.7	0.8	1.6	-1.2	-0.8	-1.2	-0.4	0.3
Commuting to job workplace: Public transport	0.7	0.9	1.7	1.1	1.2	-1.3	-0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.5	-2.1	0.5	-1.2	-1.4	0.9
Heart disease (siblings)	0.7	0.9	3.2	0.6	0.0	-0.6	0.8	-1.8
Alcohol drinker status: Previous	0.7	0.8	2.2	0.4	1.5	0.5	-0.1	1.3
Depressed Affect (Nagel 2018)	0.6	1.3	3.4	1.8	-1.6	0.4	0.3	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	0.7	-0.4	1.0	0.9	1.2
Worry (Nagel 2018)	0.6	1.2	2.1	1.5	-1.4	0.3	-1.1	-0.8
Mean Putamen Volume	0.6	0.6	2.0	0.3	1.4	0.9	-0.2	0.5
Lupus	0.6	0.9	2.0	0.1	-1.1	0.5	-1.1	1.4
Triglycerides	0.6	1.0	2.3	-0.7	-1.1	-0.9	-0.4	-1.5
Medication for hormone replacement therapy	0.6	0.7	1.4	0.4	0.7	0.9	-0.7	1.2
Vitamin and mineral supplements	0.6	0.8	1.9	-0.3	1.4	0.3	1.4	0.2
Pack years adult smoking proportion	0.6	1.0	3.3	1.0	0.2	1.8	0.6	-0.4
Age when periods started (menarche)	0.6	1.5	2.7	1.7	-1.2	1.3	-0.1	1.2
High blood pressure	0.6	1.6	4.4	2.1	-0.9	1.2	0.7	-0.9
Pain all over the body in last month	0.6	0.6	1.5	0.1	-0.5	-0.2	-1.1	1.2
Medication: Simvastatin	0.6	0.8	2.4	0.9	1.6	0.6	0.2	-0.7
Blood clot in the leg (DVT)	0.6	0.7	1.4	1.2	0.8	0.3	-0.6	1.2
Medication: Paracetamol	0.6	0.9	2.1	1.5	-1.3	-0.5	-0.7	0.1
Number of children fathered	0.6	0.7	1.5	0.5	1.2	0.6	-0.3	1.1
Medication: Seretide 50 evohaler	0.6	0.7	1.7	1.1	-0.0	0.3	0.8	-1.3
Had major operations	0.6	0.7	1.5	0.7	1.1	1.2	0.4	-0.5
Leg pain on walking	0.6	0.8	1.8	1.4	-0.9	0.6	-0.0	0.9
Illnesses of father: Heart disease	0.6	0.9	1.8	0.6	1.4	1.3	0.3	-0.4
Average weekly red wine intake	0.6	0.8	1.5	-1.1	0.5	-1.2	-1.0	0.4
Qualifications: nursing, teaching	0.6	0.9	1.5	-0.9	0.5	-1.2	1.2	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	0.8	-1.3	0.4	1.1	-0.2
Illnesses of father: High blood pressure	0.6	0.7	1.8	0.8	-1.0	1.4	-0.1	0.4
Average weekly beer plus cider intake	0.6	0.9	2.3	1.5	0.7	1.0	-0.6	0.7
Ever depressed for a whole week	0.6	0.8	2.2	0.5	1.5	1.2	-0.4	-0.1
Myopia	0.6	0.9	2.3	-0.6	1.2	0.3	1.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.9	0.5	0.0	-1.0	1.3
Pack years of smoking	0.6	0.8	2.9	1.1	0.2	1.7	-0.1	-0.3
Leg fat mass (left)	0.6	2.5	7.6	2.8	0.4	1.9	-0.5	1.0
Reaction Time	0.5	0.9	2.1	0.2	-1.0	-1.4	0.8	0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	-1.6	-1.4	-0.8	0.7	0.7
Height	0.5	10.3	46.4	-0.5	-6.8	-2.2	0.2	-0.3
Hypothyroidism (self reported)	0.5	1.1	2.7	1.6	-0.4	0.9	0.8	1.2
Hearing difficulty/problems: Yes	0.5	0.7	2.3	0.5	-1.5	-0.7	-0.7	0.1
Fed-up feelings	0.5	1.0	1.9	1.3	-1.4	-0.2	-0.2	1.1
Hearing difficulty/problems with background noise	0.5	0.9	3.3	1.8	-0.8	0.1	-0.6	-0.2
Weight	0.5	2.4	7.5	2.7	-1.3	1.4	-0.1	0.9
Trunk fat-free mass	0.5	2.8	10.7	1.7	-3.3	0.1	0.7	-0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-0.7	1.4	-1.0	-0.3	-0.7
Trunk predicted mass	0.5	2.9	11.2	1.7	-3.3	0.1	0.7	0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.2	1.5	-0.9	-0.5	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.5	0.7	1.0	1.0	0.7
Pulse wave peak to peak time	0.5	0.6	1.4	-0.4	-0.9	-1.2	0.0	-0.5
Health satisfaction	0.5	0.6	1.1	1.0	-0.3	0.9	-0.1	1.0
Medication: Omeprazole	0.5	0.6	2.9	0.4	0.2	-0.2	-1.7	0.3
Mean time to correctly identify matches	0.5	1.0	3.1	0.5	-0.8	-1.8	-0.8	0.5
Supplements: Vitamin C	0.5	0.6	1.3	-0.6	1.1	0.4	-1.1	0.0
Hypertension (Self-reported)	0.5	1.4	4.2	2.0	-0.8	1.1	0.3	-1.1
Eye problems/disorders: Cataract	0.5	0.5	1.6	-0.4	-0.7	0.4	-0.4	1.3
Medication: Aspirin	0.5	0.7	2.0	1.4	0.4	0.9	0.7	0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	0.6	-0.7	-0.4	-0.8	1.2
Medication: Atorvastatin	0.5	0.7	1.7	0.8	-1.3	0.7	0.6	-0.4
Number of operations (self-reported)	0.5	0.8	2.2	0.3	0.5	0.7	-1.0	1.5
Arm predicted mass (left)	0.5	2.4	5.8	2.2	-2.4	1.0	0.5	0.4
Neuroticism (Nagel 2018)	0.4	0.9	2.2	1.5	-1.2	0.6	-0.3	-0.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	0.3	-1.2	-0.4	0.8	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-0.0	-0.4	-0.9	1.3	-0.3
Respiratory disease	0.4	0.9	1.3	0.7	-1.2	-1.1	0.4	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.5	1.2	-0.3	1.2	1.0	-0.0
Taking other prescription medications	0.4	0.6	1.4	0.8	1.2	0.8	0.6	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	0.2	0.5	0.9	0.1	1.0
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.2	0.2	0.5	-1.2	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.1	0.5	-0.6	1.0	-0.8	1.0
Leg predicted mass (left)	0.4	1.9	4.4	2.1	-1.8	1.2	0.3	-0.2
Diabetes (self-reported)	0.4	0.6	1.0	0.6	1.0	0.8	0.8	-0.5
Illnesses of mother	0.4	0.5	1.7	0.8	0.3	1.3	-0.0	-0.2
Pulse wave Arterial Stiffness index	0.4	0.4	1.4	0.7	0.5	1.2	0.1	0.4
Tense / ‘highly strung’	0.4	0.7	1.6	1.3	-1.3	0.3	0.3	-0.0
Arm fat-free mass (right)	0.4	2.0	5.1	1.8	-2.2	0.8	1.0	0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.1	-0.4	-1.1	-0.7	0.2	0.5
Whole body fat-free mass	0.4	2.2	7.5	1.8	-2.7	0.5	0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.4	1.2	-0.1	0.3	-0.8	-0.2
Whole body water mass	0.4	2.1	6.9	1.8	-2.6	0.5	0.5	-0.1
Financial situation satisfaction	0.4	0.5	1.3	0.9	-1.2	-0.1	0.3	-0.2
Medication: Paracetamol	0.4	0.6	1.2	0.6	-1.1	-0.5	-0.4	-0.8
Alcohol drinker status: Never	0.4	0.4	1.2	-0.7	0.5	-0.2	-0.5	1.1
Basal metabolic rate	0.4	2.3	5.7	2.2	-2.4	0.9	0.3	0.1
Arm fat-free mass (left)	0.4	2.2	6.1	2.1	-2.5	0.8	0.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	0.6	1.0	0.3	-0.6	0.7
Prostate Cancer	0.3	0.4	1.4	0.3	-0.4	1.2	0.8	0.2
Fasting Glucose	0.3	0.4	1.1	0.7	-1.0	0.1	-0.5	0.3
Neuroticism (2016)	0.3	0.4	0.7	-0.8	0.8	-0.8	-0.2	-0.4
Systolic Blood Pressure	0.3	1.3	4.0	-0.3	-1.0	1.0	-2.0	0.7
Tanning	0.3	3.2	9.7	-0.4	3.1	1.5	1.9	0.3
Number of treatments/medications taken	0.3	0.6	1.1	1.1	0.8	0.7	0.7	0.3
Medication: Co-codamol	0.3	0.3	1.0	0.8	1.0	0.3	0.1	0.3
Leg fat-free mass (left)	0.3	1.8	4.1	2.0	-1.8	1.2	0.4	-0.3
Average weekly fortified wine intake	0.3	0.3	0.7	-0.5	0.7	-0.8	-0.4	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	0.2	-1.2	-0.1	-0.6	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	-0.3	0.0	0.2	0.6	1.1
Hip circumference	0.3	1.2	3.2	1.8	-0.3	1.2	-0.2	1.0
Lung cancer (father)	0.3	0.4	0.7	0.7	0.8	0.3	-0.5	-0.6
Length of working week for main job	0.3	0.3	1.1	0.0	0.5	1.1	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.7	1.2	0.4	1.3	-0.4	0.2
Worry too long after embarrassment	0.3	0.5	0.9	0.6	-1.0	-0.2	0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	0.6	-0.7	0.0	-0.5	0.9
Medication: Blood pressure	0.3	0.6	1.0	0.9	-1.0	-0.7	0.5	0.7
Arm predicted mass (right)	0.3	1.6	4.3	1.7	-2.1	0.7	0.7	0.2
Number of full sisters	0.3	0.4	1.2	1.1	0.6	0.3	0.3	0.0
Leg fat-free mass (right)	0.3	1.4	3.8	1.4	-1.9	0.9	0.2	-0.4
Diabetes diagnosed by doctor	0.3	0.5	1.6	0.3	0.5	0.8	1.3	-0.0
Medication for cholesterol	0.3	0.4	1.1	-0.8	-0.3	-1.0	0.1	-0.5
Leg predicted mass (right)	0.3	1.4	3.5	1.5	-1.9	1.0	0.1	-0.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-1.1	0.2	-0.8	0.2	-0.1
Diastolic blood pressure, automated reading	0.3	0.9	2.6	0.1	-1.2	1.6	-0.5	0.3
Commuting to job workplace: Cycle	0.3	0.4	1.3	1.1	-0.5	0.2	0.3	-0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	-0.4	-0.2	0.0	-0.5	-0.7
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.6	0.5	0.2	0.7	0.5
HbA1C	0.2	0.3	0.6	0.3	-0.6	0.8	-0.3	-0.3
HDL Cholesterol	0.2	0.4	1.1	-0.2	0.5	0.2	0.8	1.1
Blood Eosinophil Count	0.2	1.7	3.6	0.4	1.9	1.3	1.0	-1.4
Blood Red Count	0.2	1.5	2.8	-1.1	1.7	-1.0	-1.2	-1.1
Lung FEV1/FVC ratio	0.2	0.9	1.6	1.3	1.1	0.4	0.3	1.1
Hand grip strength (left)	0.2	0.4	2.0	-0.1	-1.4	0.3	-0.3	-0.1
Relative age of first facial hair	0.2	0.4	1.1	-0.2	0.2	-0.8	-1.1	-0.5
Relative age voice broke	0.2	0.3	1.0	0.1	-0.1	-0.7	1.0	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.8	0.4	-0.4	0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-1.0	-0.3	-0.4	-0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	0.4	-0.2	0.9	-0.5	0.2
Nervous feelings	0.2	0.4	1.0	-0.9	-0.2	-1.0	-0.1	0.0
Had menopause	0.2	0.3	0.5	0.7	0.3	-0.5	-0.3	0.6
Had other major operations	0.2	0.3	0.5	-0.7	0.4	0.5	0.2	0.5
Allergy	0.2	0.4	1.1	-0.4	0.9	0.2	0.3	1.0
Medication: Ramipril	0.2	0.3	0.6	0.4	0.8	-0.2	-0.1	-0.7
Time employed in main current job	0.2	0.2	0.7	0.3	0.3	0.8	-0.1	-0.5
Worrier / anxious feelings	0.2	0.4	1.3	0.1	-1.1	-0.2	-0.4	-0.8
Happiness	0.2	0.2	0.9	-0.4	-0.9	-0.1	-0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.5	-0.7	-0.9	-0.6	-0.2
Medication: Amlodipine	0.2	0.3	0.5	-0.6	-0.6	-0.7	-0.3	0.2
Comparative body size at age 10	0.2	0.4	1.4	-0.2	0.2	-0.4	1.2	-0.8
Alcohol intake frequency.	0.2	0.4	0.7	0.7	0.8	-0.1	0.5	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.1	-0.3	-0.2	-1.0	0.4
Medication: Blood pressure	0.2	0.3	0.6	0.5	0.1	0.8	0.3	-0.8
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.4	-0.5	0.8	0.0	-0.9
Age started oral contraceptive pill	0.2	0.2	0.6	-0.0	0.3	-0.8	0.6	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	-1.1	0.3	-0.4	0.2	0.8
Blood Platelet Count	0.1	1.3	3.4	-1.2	0.1	-1.2	-1.8	-0.0
Blood White Count	0.1	0.9	1.5	1.2	0.9	0.9	-1.1	-0.1
Medication: Metformin	0.1	0.1	0.3	0.2	-0.3	-0.1	0.2	-0.5
Impedance of leg (left)	0.1	0.7	1.7	-1.3	-0.7	-1.1	-0.2	0.2
Fluid intelligence score	0.1	0.3	0.5	-0.6	-0.1	0.4	0.5	-0.7
Medication: Cholesterol lowering	0.1	0.2	0.5	0.6	-0.1	-0.7	0.5	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	-0.6	-0.2	0.6	-0.3	-0.1
Pulse rate, automated reading	0.1	0.2	0.4	0.1	0.5	0.7	0.0	-0.5
Medication: Lisinopril	0.1	0.1	0.2	-0.0	-0.4	0.2	-0.4	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.3	1.0	-0.3	0.4	-1.0	-0.4	-0.5
Impedance of leg (right)	0.0	0.2	0.5	-0.3	-0.6	-0.7	-0.1	0.2
Impedance of arm (right)	0.0	0.1	0.3	0.1	-0.6	-0.4	-0.3	-0.2
Impedance of arm (left)	0.0	0.1	0.2	-0.4	-0.2	-0.3	-0.2	-0.4
Impedance of whole body	0.0	0.2	0.6	-0.8	-0.4	-0.5	-0.0	-0.0

Hub : Genes

GAS7

Models

Trait associations