Hub : Genes

GAS7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.6057	0.0982	0.00002	0.372	NA	0.349	NA	0.393	2.6e-14	NA	2.6e-13	NA	3.3e-15
2	GTEx	Cells Transformed fibroblasts	0.2580	0.0670	0.00056	0.089	NA	0.139	NA	0.115	3.3e-07	NA	1.3e-10	NA	6.0e-09
3	GTEx	Heart Left Ventricle	0.2780	0.0915	0.00820	0.029	NA	0.105	NA	0.095	1.1e-02	NA	3.2e-06	NA	9.2e-06
4	GTEx	Whole Blood	0.1480	0.0470	0.00200	0.008	NA	0.013	NA	0.006	5.7e-02	NA	2.0e-02	NA	8.2e-02
5	NTR	Blood	0.0391	0.0136	0.00290	0.013	0.002	0.029	0.018	0.030	2.6e-05	0.061	8.9e-10	1.3e-06	3.7e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.8	2.8	5.9	-2.1	0.1	-2.4	0.7	-1.7
Bipolar Disorder or Schizophrenia	1.0	2.5	5.4	-2.3	0.9	-1.6	1.9	-0.3
Depressed Affect (Nagel 2018)	0.6	1.3	3.4	1.8	-1.6	0.4	0.3	0.4
Depression (Nagel 2018)	0.7	1.1	2.1	1.0	-1.5	0.9	1.3	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	-1.1	0.3	-0.4	0.2	0.8
Neuroticism (Nagel 2018)	0.4	0.9	2.2	1.5	-1.2	0.6	-0.3	-0.4
Schizophrenia (2018)	0.7	1.5	3.4	-1.3	0.7	-0.1	1.8	1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	0.7	-0.4	1.0	0.9	1.2
Worry (Nagel 2018)	0.6	1.2	2.1	1.5	-1.4	0.3	-1.1	-0.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	0.3	-1.2	-0.4	0.8	-0.5
Alzheimer’s Disease (in father)	0.8	0.9	3.6	-0.8	1.9	0.3	0.3	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-0.0	-0.4	-0.9	1.3	-0.3
Crohns Disease (2017)	1.2	2.7	7.6	-1.2	2.8	1.2	-1.8	0.2
Irritable Bowel Disease (IBD)	1.4	3.3	6.7	-2.6	1.9	0.0	-2.5	-0.2
Ulcerative Colitis (UC)	1.1	2.0	5.4	-2.3	0.8	-0.5	-1.9	-0.2
Major Depression (MDD)	0.9	1.1	1.8	1.3	1.3	0.8	0.4	1.1
Reaction Time	0.5	0.9	2.1	0.2	-1.0	-1.4	0.8	0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	-1.6	-1.4	-0.8	0.7	0.7
Breast Cancer	1.2	2.8	9.1	-3.0	1.3	-1.1	1.5	-0.3
Ovarian Cancer	0.7	0.9	2.4	-1.6	-0.2	-1.2	-0.6	0.0
Prostate Cancer	0.3	0.4	1.4	0.3	-0.4	1.2	0.8	0.2
Age at First Birth	1.6	2.3	4.5	-1.5	-2.1	-1.9	0.2	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	-0.4	-0.2	0.0	-0.5	-0.7
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.6	0.5	0.2	0.7	0.5
Crohns Disease (2012)	0.8	1.2	3.8	-1.1	1.0	0.2	-1.9	0.4
Mean Putamen Volume	0.6	0.6	2.0	0.3	1.4	0.9	-0.2	0.5
Fasting Glucose	0.3	0.4	1.1	0.7	-1.0	0.1	-0.5	0.3
HbA1C	0.2	0.3	0.6	0.3	-0.6	0.8	-0.3	-0.3
HDL Cholesterol	0.2	0.4	1.1	-0.2	0.5	0.2	0.8	1.1
LDL Cholesterol	0.7	1.1	3.1	1.4	-1.8	0.2	0.3	0.3
Lupus	0.6	0.9	2.0	0.1	-1.1	0.5	-1.1	1.4
Neuroticism (2016)	0.3	0.4	0.7	-0.8	0.8	-0.8	-0.2	-0.4
Primary Biliary Cirrhosis	1.0	1.4	3.8	0.5	-1.4	-0.6	-2.0	-0.7
Rheumatoid Arthritis	0.7	1.0	2.1	-0.4	1.3	1.5	0.1	1.0
Schizophrenia (2014)	0.8	1.7	4.9	-1.8	0.2	-0.3	2.2	0.6
Triglycerides	0.6	1.0	2.3	-0.7	-1.1	-0.9	-0.4	-1.5
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.1	-0.1	-1.3	-0.9	-1.8	1.1
Ulcerative Colitis	0.9	1.3	3.8	-2.0	-0.4	-0.6	-1.4	-0.4
Blood Eosinophil Count	0.2	1.7	3.6	0.4	1.9	1.3	1.0	-1.4
Blood Platelet Count	0.1	1.3	3.4	-1.2	0.1	-1.2	-1.8	-0.0
Blood Red Count	0.2	1.5	2.8	-1.1	1.7	-1.0	-1.2	-1.1
Blood White Count	0.1	0.9	1.5	1.2	0.9	0.9	-1.1	-0.1
Heel T-Score	1.3	10.7	43.0	-1.1	-6.6	-3.0	-0.6	-0.5
BMI	0.8	4.6	10.0	3.2	2.1	1.8	-2.4	-0.1
Height	0.5	10.3	46.4	-0.5	-6.8	-2.2	0.2	-0.3
Waist Hip Ratio (WHR)	0.8	3.4	9.9	1.1	-0.8	1.7	-3.1	1.6
Systolic Blood Pressure	0.3	1.3	4.0	-0.3	-1.0	1.0	-2.0	0.7
Smoking Status	1.5	3.6	7.4	0.9	2.7	2.4	2.0	-0.3
Allergy or Eczema	0.8	2.1	6.5	-1.4	1.3	-0.6	0.3	-2.5
Cardiovascular Disease	0.8	2.7	5.1	2.3	-1.8	1.6	-0.8	-1.4
Hypothyroidism (self reported)	0.5	1.1	2.7	1.6	-0.4	0.9	0.8	1.2
Respiratory disease	0.4	0.9	1.3	0.7	-1.2	-1.1	0.4	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.5	1.2	-0.3	1.2	1.0	-0.0
Lung FEV1/FVC ratio	0.2	0.9	1.6	1.3	1.1	0.4	0.3	1.1
Lung FVC	1.1	5.5	13.4	-3.7	-1.8	-3.0	-1.1	-0.6
Neuroticism	0.7	1.6	5.0	2.2	-0.9	0.7	1.3	-0.4
Chronotype (morning person)	0.9	2.1	6.3	1.0	1.0	0.9	2.5	1.2
Hair Pigment	0.0	0.3	1.0	-0.3	0.4	-1.0	-0.4	-0.5
Tanning	0.3	3.2	9.7	-0.4	3.1	1.5	1.9	0.3
Hand grip strength (left)	0.2	0.4	2.0	-0.1	-1.4	0.3	-0.3	-0.1
Number of treatments/medications taken	0.3	0.6	1.1	1.1	0.8	0.7	0.7	0.3
Average weekly spirits intake	0.7	0.9	2.0	0.9	-1.0	-0.7	-0.3	1.4
Sensitivity / hurt feelings	0.8	1.4	5.3	-0.2	-0.4	-0.4	2.3	-1.1
Frequency of depressed mood in last 2 weeks	1.2	1.6	5.6	0.1	-1.4	-0.5	2.4	0.5
Hearing difficulty/problems: Yes	0.5	0.7	2.3	0.5	-1.5	-0.7	-0.7	0.1
Relative age of first facial hair	0.2	0.4	1.1	-0.2	0.2	-0.8	-1.1	-0.5
Other serious medical condition/disability diagnosed by doctor	3.9	5.1	10.6	1.8	1.1	2.8	3.3	1.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	1.9	0.4	1.6	0.5	0.6
Ever had hysterectomy (womb removed)	1.3	1.5	2.8	0.8	0.4	1.2	-1.7	1.6
Systolic blood pressure, automated reading	0.7	1.9	5.5	0.6	-0.5	1.8	-2.3	0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	1.1	-0.2	1.3	1.3	0.3
Angina	1.6	2.2	4.2	1.4	0.8	1.8	0.8	2.0
Medication for hormone replacement therapy	0.6	0.7	1.4	0.4	0.7	0.9	-0.7	1.2
Vitamin and mineral supplements	0.6	0.8	1.9	-0.3	1.4	0.3	1.4	0.2
Supplements: Zinc	0.7	0.8	2.2	-0.5	1.5	-0.2	-0.2	-1.2
Medication: Co-codamol	0.3	0.3	1.0	0.8	1.0	0.3	0.1	0.3
Medication: Metformin	0.1	0.1	0.3	0.2	-0.3	-0.1	0.2	-0.5
Diabetes (father)	1.5	1.9	5.9	1.5	-0.9	0.5	-2.4	0.0
Diabetes (mother)	1.6	2.1	6.2	1.2	-2.5	0.3	0.3	1.6
Severe depression (siblings)	1.0	1.1	3.1	-0.9	-0.7	-1.0	1.8	0.2
Pack years adult smoking proportion	0.6	1.0	3.3	1.0	0.2	1.8	0.6	-0.4
Impedance of leg (right)	0.0	0.2	0.5	-0.3	-0.6	-0.7	-0.1	0.2
Leg fat-free mass (left)	0.3	1.8	4.1	2.0	-1.8	1.2	0.4	-0.3
Trunk fat percentage	0.8	3.3	9.1	3.0	1.2	2.1	-1.0	0.7
Hand grip strength (right)	0.7	1.9	4.0	-2.0	-1.8	-1.2	0.5	-0.7
Townsend deprivation index at recruitment	1.1	1.5	3.5	1.9	0.6	1.2	0.8	1.3
Current tobacco smoking	1.3	2.1	4.5	1.0	2.1	1.3	1.7	-0.4
Average weekly fortified wine intake	0.3	0.3	0.7	-0.5	0.7	-0.8	-0.4	-0.2
Maternal smoking around birth	0.7	1.0	2.5	0.7	1.6	0.6	0.2	1.2
Fed-up feelings	0.5	1.0	1.9	1.3	-1.4	-0.2	-0.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.1	0.6	-1.4	0.8	1.2	1.2
Relative age voice broke	0.2	0.3	1.0	0.1	-0.1	-0.7	1.0	-0.1
Taking other prescription medications	0.4	0.6	1.4	0.8	1.2	0.8	0.6	0.4
Age when periods started (menarche)	0.6	1.5	2.7	1.7	-1.2	1.3	-0.1	1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	0.2	0.5	0.9	0.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.3	13.1	-1.6	-3.6	-3.0	-0.6	-1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.8	0.4	-0.4	0.2	-0.6
Qualifications: CSEs or equivalent	0.7	0.9	3.5	-0.4	0.1	-0.6	1.9	-0.8
Serious illness, injury or assault to yourself	1.6	2.0	6.2	-1.3	-0.9	-0.8	2.5	0.7
High blood pressure	0.6	1.6	4.4	2.1	-0.9	1.2	0.7	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-1.0	-0.3	-0.4	-0.1	-0.9
Multivitamins +/- minerals	0.7	0.9	2.9	0.8	-1.7	0.2	-0.8	0.3
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.2	0.2	0.5	-1.2	0.8
Supplements: Glucosamine	0.8	1.1	1.5	1.2	-0.9	-1.2	-1.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	0.4	-0.2	0.9	-0.5	0.2
Medication: Atenolol	1.3	1.7	3.5	1.0	1.8	1.9	0.4	-0.5
Medication: Levothyroxine sodium	0.4	0.7	1.1	0.5	-0.6	1.0	-0.8	1.0
Sitting height	1.1	8.1	34.6	0.7	-5.9	-1.5	1.8	0.0
Chronic bronchitis/emphysema (father)	0.9	1.1	3.6	1.9	0.1	1.3	-0.0	0.2
High blood pressure (mother)	0.8	1.1	2.7	1.6	-0.9	0.3	0.5	1.4
Body mass index (BMI)	0.7	3.0	6.7	2.6	1.6	2.0	-0.8	1.1
Impedance of leg (left)	0.1	0.7	1.7	-1.3	-0.7	-1.1	-0.2	0.2
Leg predicted mass (left)	0.4	1.9	4.4	2.1	-1.8	1.2	0.3	-0.2
Trunk fat mass	0.7	3.0	10.0	3.2	-0.0	1.9	-0.6	0.8
Waist circumference	1.0	3.7	6.8	2.6	0.5	2.4	-1.5	1.9
Number of incorrect matches in round	0.9	1.6	3.5	-1.9	1.3	0.4	1.1	-1.2
Past tobacco smoking	1.8	3.2	8.0	-1.3	-2.4	-2.8	-0.7	0.4
Alcohol usually taken with meals	2.8	4.6	12.6	-3.5	0.9	-2.5	0.4	-1.7
Nervous feelings	0.2	0.4	1.0	-0.9	-0.2	-1.0	-0.1	0.0
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.5	1.4	-2.1	0.8	1.9	0.0
Hearing difficulty/problems with background noise	0.5	0.9	3.3	1.8	-0.8	0.1	-0.6	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	0.2	-1.2	-0.1	-0.6	0.7
Had menopause	0.2	0.3	0.5	0.7	0.3	-0.5	-0.3	0.6
Had other major operations	0.2	0.3	0.5	-0.7	0.4	0.5	0.2	0.5
Forced vital capacity (FVC)	1.5	5.8	15.8	-2.1	-4.0	-2.8	-0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	7.8	-2.1	-2.7	-2.8	-0.4	-1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	-0.3	0.0	0.2	0.6	1.1
Qualifications: None of the above	2.3	4.9	9.0	3.0	2.2	2.5	0.7	1.9
Financial difficulties in last 2 years	2.1	2.9	5.2	2.1	1.5	1.6	0.5	-2.3
Mouth/teeth dental problems	0.7	1.0	3.4	-0.4	-1.2	-0.6	1.8	-0.0
Heart attack	1.6	2.0	5.2	-0.4	2.3	-0.0	2.2	-0.0
Allergy	0.2	0.4	1.1	-0.4	0.9	0.2	0.3	1.0
Pain all over the body in last month	0.6	0.6	1.5	0.1	-0.5	-0.2	-1.1	1.2
Diabetes (self-reported)	0.4	0.6	1.0	0.6	1.0	0.8	0.8	-0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	5.9	-0.1	-0.6	0.5	0.0	2.4
Medication: Ramipril	0.2	0.3	0.6	0.4	0.8	-0.2	-0.1	-0.7
Medication: Simvastatin	0.6	0.8	2.4	0.9	1.6	0.6	0.2	-0.7
Fluid intelligence score	0.1	0.3	0.5	-0.6	-0.1	0.4	0.5	-0.7
Illnesses of siblings	0.9	1.2	2.8	-1.1	-1.1	-0.8	-1.7	0.0
Neuroticism score	0.7	1.5	3.9	1.1	-2.0	-0.2	1.2	0.8
Weight	0.5	2.4	7.5	2.7	-1.3	1.4	-0.1	0.9
Impedance of arm (right)	0.0	0.1	0.3	0.1	-0.6	-0.4	-0.3	-0.2
Arm fat percentage (right)	1.1	4.4	10.8	3.3	1.9	2.4	-1.1	0.8
Trunk fat-free mass	0.5	2.8	10.7	1.7	-3.3	0.1	0.7	-0.0
Hip circumference	0.3	1.2	3.2	1.8	-0.3	1.2	-0.2	1.0
Time employed in main current job	0.2	0.2	0.7	0.3	0.3	0.8	-0.1	-0.5
Alcohol intake versus 10 years previously	1.5	2.2	7.1	1.7	0.3	0.5	-0.9	-2.7
Father’s age at death	2.6	3.5	7.4	-1.4	-2.7	-2.2	-0.9	1.7
Worrier / anxious feelings	0.2	0.4	1.3	0.1	-1.1	-0.2	-0.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	6.3	2.5	-1.6	1.1	0.6	1.1
Falls in the last year	1.6	2.2	6.6	1.2	1.2	0.2	2.6	1.1
Hair/balding pattern: Pattern 3	0.9	1.3	3.4	-0.3	0.5	-1.6	-1.9	-0.4
Number of live births	2.6	3.7	6.9	1.9	2.5	2.6	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	9.0	-2.3	-3.0	-2.7	-0.3	0.8
Pulse rate	1.7	2.8	7.5	1.6	2.7	2.0	0.2	0.1
Happiness	0.2	0.2	0.9	-0.4	-0.9	-0.1	-0.2	0.1
Noisy workplace	1.0	1.2	3.1	1.0	-1.4	0.3	-1.8	-0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.5	-0.7	-0.9	-0.6	-0.2
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	8.0	1.4	-0.4	1.2	2.8	1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-0.7	1.4	-1.0	-0.3	-0.7
Asthma	1.0	1.9	4.4	1.2	-2.1	-0.9	1.7	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.7	2.2	-1.7	1.4	0.2	0.5
Medication: Cholesterol lowering	0.1	0.2	0.5	0.6	-0.1	-0.7	0.5	-0.3
Depression (self-reported)	1.6	1.9	5.3	1.8	0.8	2.3	0.4	0.3
Medication: Lansoprazole	0.9	1.1	3.1	-0.1	1.7	-0.3	-0.1	1.5
Prospective memory result	0.8	1.0	2.3	-0.7	1.4	0.3	-1.5	-0.4
Lung cancer (father)	0.3	0.4	0.7	0.7	0.8	0.3	-0.5	-0.6
Illnesses of mother	0.4	0.5	1.7	0.8	0.3	1.3	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	9.7	-2.7	-2.5	-3.1	-1.4	0.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.4	0.7	0.5	1.2	0.1	0.4
Impedance of arm (left)	0.0	0.1	0.2	-0.4	-0.2	-0.3	-0.2	-0.4
Arm fat mass (right)	0.8	3.4	10.8	3.3	0.5	2.2	-0.8	0.9
Trunk predicted mass	0.5	2.9	11.2	1.7	-3.3	0.1	0.7	0.0
Standing height	0.9	9.4	42.6	0.5	-6.5	-1.5	1.4	0.0
Length of working week for main job	0.3	0.3	1.1	0.0	0.5	1.1	-0.3	-0.3
Exposure to tobacco smoke at home	0.9	1.0	3.5	0.6	0.7	0.6	1.9	-0.6
Breastfed as a baby	0.8	1.0	2.1	1.2	-0.4	0.1	-1.2	1.5
Tense / ‘highly strung’	0.4	0.7	1.6	1.3	-1.3	0.3	0.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	13.6	3.7	-0.2	3.4	0.9	1.2
Hair/balding pattern: Pattern 4	0.7	1.7	4.2	0.0	0.0	2.0	2.0	0.5
Birth weight of first child	1.3	2.3	5.2	1.4	0.1	2.0	-0.8	2.3
Peak expiratory flow (PEF)	0.8	1.9	4.8	-1.3	-2.2	-1.5	-0.0	0.9
Pulse wave reflection index	1.2	1.5	3.9	-1.1	-2.0	-1.5	-0.1	0.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	0.8	-0.8	0.0	-1.5	1.2
Loud music exposure frequency	1.7	1.8	4.0	-1.0	-2.0	-1.8	-0.9	0.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	7.5	-0.9	-0.5	-0.5	-2.7	0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.7	1.6	0.2	1.7	-0.6	-0.7
Blood clot in the leg (DVT)	0.6	0.7	1.4	1.2	0.8	0.3	-0.6	1.2
Medication: Paracetamol	0.6	0.9	2.1	1.5	-1.3	-0.5	-0.7	0.1
Headache pain in last month	0.7	1.2	2.4	1.6	-0.6	1.0	1.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.5	-0.8	1.5	1.6	-0.4	-0.5
Glaucoma (self-reported)	8.6	10.1	36.9	-0.1	6.1	1.9	0.8	-3.0
Gout (self-reported)	1.7	2.4	5.6	2.4	-0.4	1.4	0.7	-2.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.7	1.2	0.4	1.3	-0.4	0.2
Medication: Amlodipine	0.2	0.3	0.5	-0.6	-0.6	-0.7	-0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.2	1.5	-0.9	-0.5	0.3	0.2
Birth weight	0.7	1.6	6.3	2.5	-0.6	0.8	0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	-0.6	-0.2	0.6	-0.3	-0.1
High blood pressure (siblings)	1.9	2.8	4.8	0.5	2.0	1.7	2.2	-1.4
Forced vital capacity (FVC), Best measure	1.5	5.5	9.4	-2.5	-3.0	-3.1	-1.7	0.0
Body fat percentage	0.9	3.4	9.0	3.0	1.3	2.2	-1.1	0.9
Leg fat percentage (right)	1.2	4.3	10.8	3.3	1.6	2.3	-1.1	1.4
Arm fat-free mass (right)	0.4	2.0	5.1	1.8	-2.2	0.8	1.0	0.0
Exposure to tobacco smoke outside home	0.8	1.0	2.5	1.2	-0.8	-0.8	1.6	0.4
Comparative body size at age 10	0.2	0.4	1.4	-0.2	0.2	-0.4	1.2	-0.8
Number of full brothers	0.9	1.2	2.2	1.0	1.5	0.9	1.3	-0.2
Worry too long after embarrassment	0.3	0.5	0.9	0.6	-1.0	-0.2	0.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.5	0.7	1.0	1.0	0.7
Wheeze or whistling in the chest in last year	1.0	1.7	4.8	2.2	-0.6	1.3	1.2	-0.5
Number of children fathered	0.6	0.7	1.5	0.5	1.2	0.6	-0.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	0.6	-0.7	0.0	-0.5	0.9
Age at first live birth	2.8	4.9	10.5	-1.8	-3.2	-3.2	0.3	0.3
Pulse wave peak to peak time	0.5	0.6	1.4	-0.4	-0.9	-1.2	0.0	-0.5
Health satisfaction	0.5	0.6	1.1	1.0	-0.3	0.9	-0.1	1.0
Shortness of breath walking on level ground	1.7	2.0	5.1	2.3	0.2	1.4	0.3	1.6
Qualifications: College or University degree	1.6	5.1	12.0	-3.3	-1.5	-3.5	0.5	-0.5
Eye problems/disorders: None of the above	0.9	1.0	3.7	0.2	-1.9	-1.1	0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.1	-0.4	-1.1	-0.7	0.2	0.5
Emphysema/chronic bronchitis	1.3	1.5	2.9	0.3	-0.8	-1.3	-1.5	-1.7
Medication for pain relief, constipation, heartburn	0.8	1.4	4.8	-2.2	1.1	-0.7	-0.4	-0.2
Neck or shoulder pain in last month	3.6	5.2	9.2	2.7	0.3	2.7	1.4	3.0
Medication: Blood pressure	0.3	0.6	1.0	0.9	-1.0	-0.7	0.5	0.7
Angina (self-reported)	1.6	2.1	3.5	1.4	1.0	1.8	0.8	1.9
Migraine (self-reported)	1.9	2.4	7.4	1.7	-2.7	-0.3	0.2	1.2
Medication: Ibuprofen	1.6	1.9	5.4	2.3	-0.7	1.8	0.4	0.1
Medication: Allopurinol	2.4	3.2	6.9	2.6	-0.3	2.0	1.7	-1.5
Medication: Omeprazole	0.5	0.6	2.9	0.4	0.2	-0.2	-1.7	0.3
Medication: Seretide 50 evohaler	0.6	0.7	1.7	1.1	-0.0	0.3	0.8	-1.3
Mean time to correctly identify matches	0.5	1.0	3.1	0.5	-0.8	-1.8	-0.8	0.5
Heart disease (mother)	0.7	0.8	2.4	-0.5	0.0	-1.2	0.2	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	4.2	-0.5	0.5	-0.1	2.0	-0.4
Whole body fat mass	0.7	2.9	9.5	3.1	0.1	2.1	-0.7	0.7
Leg fat mass (right)	0.8	3.2	10.5	3.2	0.4	2.0	-0.5	0.9
Arm predicted mass (right)	0.3	1.6	4.3	1.7	-2.1	0.7	0.7	0.2
Pulse rate, automated reading	0.1	0.2	0.4	0.1	0.5	0.7	0.0	-0.5
Alcohol intake frequency.	0.2	0.4	0.7	0.7	0.8	-0.1	0.5	0.6
Comparative height size at age 10	0.7	3.9	15.4	1.7	-3.9	0.5	0.8	-0.4
Number of full sisters	0.3	0.4	1.2	1.1	0.6	0.3	0.3	0.0
Suffer from ‘nerves’	0.7	1.1	2.6	0.8	-0.6	-0.5	-1.6	1.3
Overall health rating	1.1	2.5	7.4	2.7	-0.9	1.2	1.5	0.6
Chest pain or discomfort	0.9	1.3	4.9	0.6	-0.7	0.6	2.2	0.5
Had major operations	0.6	0.7	1.5	0.7	1.1	1.2	0.4	-0.5
Age at last live birth	1.5	2.2	5.0	-0.6	-2.2	-2.2	0.2	-0.8
Family relationship satisfaction	1.0	1.2	3.0	-0.9	-1.7	-1.3	0.8	-0.2
Leg pain on walking	0.6	0.8	1.8	1.4	-0.9	0.6	-0.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.0	-1.4	-0.4	-0.9	-1.3	-0.0
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.9	-0.1	-2.2	1.3	-1.7	-0.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	-1.4	0.6	-0.6	-1.8	-0.4
Medication: Aspirin	0.7	0.9	1.8	1.2	0.7	0.9	1.4	0.2
Supplements: Vitamin C	0.5	0.6	1.3	-0.6	1.1	0.4	-1.1	0.0
Knee pain experienced in last month	1.5	2.3	4.6	2.1	-0.8	0.9	1.6	1.7
Hypertension (Self-reported)	0.5	1.4	4.2	2.0	-0.8	1.1	0.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	-0.2	1.5	0.4	-0.2	1.2
Illnesses of father: Heart disease	0.6	0.9	1.8	0.6	1.4	1.3	0.3	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.8	1.7	0.1	0.9	-0.5	1.3
Smoking status: Previous	0.9	1.3	4.7	0.9	1.1	2.2	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	13.5	-1.0	-3.7	-1.1	0.4	-0.0
Whole body fat-free mass	0.4	2.2	7.5	1.8	-2.7	0.5	0.5	-0.1
Leg fat-free mass (right)	0.3	1.4	3.8	1.4	-1.9	0.9	0.2	-0.4
Arm fat percentage (left)	0.9	3.7	8.4	2.9	1.8	2.3	-1.2	0.7
Average weekly red wine intake	0.6	0.8	1.5	-1.1	0.5	-1.2	-1.0	0.4
Handedness (chirality/laterality): Left-handed	1.3	1.6	6.9	0.3	-0.0	0.1	-2.6	-0.9
Mood swings	1.1	1.9	4.5	2.1	-0.5	1.7	0.9	1.1
Loneliness, isolation	0.7	1.0	3.9	0.3	-0.8	-0.5	2.0	0.2
Long-standing illness, disability or infirmity	0.7	1.1	3.5	1.3	0.3	0.0	1.9	0.3
Ever had bowel cancer screening	1.2	1.4	3.3	0.7	0.3	1.6	-1.8	0.9
Diabetes diagnosed by doctor	0.3	0.5	1.6	0.3	0.5	0.8	1.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.2	0.2	0.4	-0.0	-1.8	-0.8
Friendships satisfaction	0.9	1.1	2.0	-0.8	-0.7	-1.4	-0.3	-1.4
Qualifications: nursing, teaching	0.6	0.9	1.5	-0.9	0.5	-1.2	1.2	0.7
Commuting to job workplace: Walk	2.1	2.2	6.5	0.3	2.5	1.1	1.8	-0.6
Eye problems/disorders: Cataract	0.5	0.5	1.6	-0.4	-0.7	0.4	-0.4	1.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.1	-0.3	-0.2	-1.0	0.4
Medication for cholesterol	0.3	0.4	1.1	-0.8	-0.3	-1.0	0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.4	1.2	-0.1	0.3	-0.8	-0.2
Back pain experienced in last month	1.7	2.4	4.0	1.4	1.5	2.0	2.0	0.1
Mineral and other dietary supplements	0.7	0.9	2.5	-1.0	0.2	0.6	1.6	-0.7
Breast cancer (self-reported)	0.7	0.8	2.8	0.9	0.6	0.3	-0.3	1.7
Asthma (self-reported)	1.0	2.0	5.6	1.3	-2.4	-0.8	1.4	-0.2
Osteoporosis (self-reported)	1.4	1.7	5.8	0.0	2.4	0.3	-1.2	1.1
Osteoarthritis (self-reported)	2.9	3.8	10.2	1.9	-3.2	0.3	1.6	1.6
Medication: Aspirin	0.5	0.7	2.0	1.4	0.4	0.9	0.7	0.2
Medication: Gliclazide	0.9	1.0	2.3	1.3	0.0	1.0	-0.1	1.5
Illnesses of father: None of the above (group 1)	1.4	1.7	4.5	-1.8	0.0	-2.1	0.8	-0.6
Smoking status: Current	1.8	2.8	6.4	0.9	2.5	1.4	2.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	6.5	-2.5	-0.1	-2.1	-2.0	-1.5
Whole body water mass	0.4	2.1	6.9	1.8	-2.6	0.5	0.5	-0.1
Leg predicted mass (right)	0.3	1.4	3.5	1.5	-1.9	1.0	0.1	-0.4
Arm fat mass (left)	0.7	3.0	8.5	2.9	0.8	2.1	-0.7	0.9
Number of self-reported non-cancer illnesses	2.9	5.1	8.5	2.9	-0.0	2.4	2.9	1.7
Average weekly champagne plus white wine intake	1.4	1.9	5.4	-1.3	-2.3	-1.4	-0.6	-0.0
Miserableness	2.5	4.3	7.2	1.9	0.0	2.5	2.7	2.0
Guilty feelings	0.8	1.2	2.9	1.7	-0.2	1.0	0.4	1.4
Wears glasses or contact lenses	1.5	1.7	2.7	-1.6	1.6	-1.3	1.3	-0.0
Ever taken oral contraceptive pill	0.7	0.8	1.6	-1.2	-0.8	-1.2	-0.4	0.3
Hearing aid user	1.6	1.8	6.3	-0.3	-0.8	-0.9	2.5	-1.0
Mother’s age at death	0.8	1.0	3.0	-0.4	-1.3	-1.7	0.4	0.5
Financial situation satisfaction	0.4	0.5	1.3	0.9	-1.2	-0.1	0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	0.8	-1.3	0.4	1.1	-0.2
Commuting to job workplace: Public transport	0.7	0.9	1.7	1.1	1.2	-1.3	-0.2	-0.2
Eye problems/disorders: Glaucoma	8.0	9.5	32.4	-0.6	5.7	1.5	0.1	-3.5
Medication: Blood pressure	0.2	0.3	0.6	0.5	0.1	0.8	0.3	-0.8
Pain type(s) experienced in last month: Hip pain	0.9	1.2	1.9	0.9	0.9	1.2	0.9	1.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	0.6	-0.7	-0.4	-0.8	1.2
High cholesterol (Self-reported)	1.0	1.8	4.1	1.9	0.4	2.0	-0.8	-0.7
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.4	-0.5	0.8	0.0	-0.9
Medication: Paracetamol	0.4	0.6	1.2	0.6	-1.1	-0.5	-0.4	-0.8
Medication: Lisinopril	0.1	0.1	0.2	-0.0	-0.4	0.2	-0.4	-0.5
Medication: Atorvastatin	0.5	0.7	1.7	0.8	-1.3	0.7	0.6	-0.4
Illnesses of father: High blood pressure	0.6	0.7	1.8	0.8	-1.0	1.4	-0.1	0.4
Alcohol drinker status: Never	0.4	0.4	1.2	-0.7	0.5	-0.2	-0.5	1.1
Ever smoked	1.1	2.0	4.4	1.2	1.8	2.1	0.6	-0.6
Basal metabolic rate	0.4	2.3	5.7	2.2	-2.4	0.9	0.3	0.1
Leg fat percentage (left)	0.8	3.0	5.7	2.4	1.4	1.9	-1.0	1.5
Arm fat-free mass (left)	0.4	2.2	6.1	2.1	-2.5	0.8	0.3	0.4
Number of operations (self-reported)	0.5	0.8	2.2	0.3	0.5	0.7	-1.0	1.5
Average weekly beer plus cider intake	0.6	0.9	2.3	1.5	0.7	1.0	-0.6	0.7
Irritability	3.1	5.3	9.7	3.1	-1.3	2.5	-0.6	2.9
Risk taking	1.0	1.4	3.1	0.9	0.1	1.8	1.2	1.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-1.1	0.2	-0.8	0.2	-0.1
Fractured/broken bones in last 5 years	0.9	1.1	1.7	1.0	1.3	1.1	0.4	-1.3
Age started oral contraceptive pill	0.2	0.2	0.6	-0.0	0.3	-0.8	0.6	0.2
Diastolic blood pressure, automated reading	0.3	0.9	2.6	0.1	-1.2	1.6	-0.5	0.3
Ever depressed for a whole week	0.6	0.8	2.2	0.5	1.5	1.2	-0.4	-0.1
Unable to work because of sickness or disability	3.1	4.0	11.7	0.5	-2.3	-0.6	3.4	1.6
Commuting to job workplace: Cycle	0.3	0.4	1.3	1.1	-0.5	0.2	0.3	-0.6
Myopia	0.6	0.9	2.3	-0.6	1.2	0.3	1.5	0.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.5	-2.1	0.5	-1.2	-1.4	0.9
Cholesterol lowering medication	1.2	1.7	5.2	1.7	0.6	2.3	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	0.6	1.0	0.3	-0.6	0.7
Pain experienced in last month	2.8	4.6	9.5	-3.1	0.2	-1.7	-2.3	-2.3
Supplements: Calcium	2.3	2.6	4.7	1.2	2.2	1.2	-1.1	2.0
Basal cell carcinoma (self-reported)	0.9	1.1	5.0	0.1	0.7	-0.0	-0.4	-2.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	5.5	-0.4	2.4	0.2	2.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.9	0.5	0.0	-1.0	1.3
Heart disease (siblings)	0.7	0.9	3.2	0.6	0.0	-0.6	0.8	-1.8
Alcohol drinker status: Previous	0.7	0.8	2.2	0.4	1.5	0.5	-0.1	1.3
Pack years of smoking	0.6	0.8	2.9	1.1	0.2	1.7	-0.1	-0.3
Impedance of whole body	0.0	0.2	0.6	-0.8	-0.4	-0.5	-0.0	-0.0
Leg fat mass (left)	0.6	2.5	7.6	2.8	0.4	1.9	-0.5	1.0
Arm predicted mass (left)	0.5	2.4	5.8	2.2	-2.4	1.0	0.5	0.4