Hub : Traits :

Glaucoma (self-reported)

24 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 164933115 166462417 3 1 2.1e-27 2.2e-29 1.0e+00 100 TMCO1
2 4 7060959 8640389 2 1 2.0e-09 4.1e-13 5.7e-07 52 AFAP1
3 9 21303958 22705094 1 1 5.7e-12 1.3e-14 4.2e-04 79 CDKN2B
4 14 60168943 61664530 1 1 4.2e-08 1.0e-10 3.1e-04 69 C14orf39
5 17 9114358 10799013 1 1 1.3e-09 1.2e-12 1.5e-04 71 GAS7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Breast Cancer 2.19 1 0 0.0 0 1.00000 CDKN2B
Coronary Artery Disease (CAD) 15.48 1 1 3.0 0 1.00000 CDKN2B
Type 2 Diabetes (T2D) 2.75 1 0 0.0 0 1.00000 CDKN2B
Blood Platelet Count 0.42 1 0 0.0 0 1.00000 CDKN2B
Blood Red Count 0.44 1 0 0.0 0 1.00000 CDKN2B
Blood White Count 0.50 1 0 0.0 0 1.00000 CDKN2B
Heel T-Score 3.27 2 2 6.1 0 1.00000 C14orf39 GAS7
BMI 0.79 1 0 0.0 0 1.00000 C14orf39
Height 5.79 3 3 9.1 0 1.00000 AFAP1 C14orf39 GAS7
Waist Hip Ratio (WHR) 2.10 2 1 3.0 0 1.00000 C14orf39 TMCO1
Systolic Blood Pressure 1.55 1 1 3.0 0 1.00000 AFAP1
Cardiovascular Disease 1.35 1 0 0.0 0 1.00000 TMCO1
Lung FEV1/FVC ratio 2.25 1 1 3.0 0 1.00000 AFAP1
Neuroticism 1.59 1 0 0.0 0 1.00000 AFAP1
Chronotype (morning person) 1.98 1 0 0.0 0 1.00000 C14orf39
Hair Pigment 0.55 1 1 3.0 0 1.00000 CDKN2B
Tanning 0.17 1 0 0.0 0 1.00000 GAS7
Hand grip strength (left) 2.82 2 0 0.0 0 1.00000 AFAP1 C14orf39
Average weekly spirits intake 2.33 1 0 0.0 0 1.00000 AFAP1
Hearing difficulty/problems: Yes 2.37 1 0 0.0 0 1.00000 AFAP1
Angina 15.39 1 1 3.0 0 1.00000 CDKN2B
Medication: Metformin 2.78 1 0 0.0 0 1.00000 CDKN2B
Impedance of leg (right) 1.28 1 0 0.0 0 1.00000 C14orf39
Leg fat-free mass (left) 3.57 1 1 3.0 0 1.00000 C14orf39
Trunk fat percentage 1.14 1 0 0.0 0 1.00000 AFAP1
Hand grip strength (right) 3.10 2 0 0.0 0 1.00000 AFAP1 C14orf39
Fed-up feelings 1.96 1 0 0.0 0 1.00000 AFAP1
Age when periods started (menarche) 3.67 1 1 3.0 0 1.00000 C14orf39
Heel bone mineral density (BMD) T-score, automated (left) 4.09 2 1 3.0 0 1.00000 C14orf39 GAS7
Medication: Atenolol 2.82 1 0 0.0 0 1.00000 CDKN2B
Sitting height 4.89 3 3 9.1 0 1.00000 AFAP1 C14orf39 GAS7
Body mass index (BMI) 1.01 1 0 0.0 0 1.00000 AFAP1
Impedance of leg (left) 1.06 1 0 0.0 0 1.00000 C14orf39
Leg predicted mass (left) 3.51 1 1 3.0 0 1.00000 C14orf39
Trunk fat mass 1.50 1 0 0.0 0 1.00000 C14orf39
Nervous feelings 1.68 1 0 0.0 0 1.00000 C14orf39
Forced vital capacity (FVC) 2.56 3 0 0.0 0 1.00000 AFAP1 C14orf39 GAS7
Heel bone mineral density (BMD) T-score, automated (right) 3.63 1 1 3.0 0 1.00000 C14orf39
Mouth/teeth dental problems 2.56 1 0 0.0 0 1.00000 CDKN2B
Heart attack 11.73 1 1 3.0 0 1.00000 CDKN2B
Medication: Simvastatin 2.61 1 0 0.0 0 1.00000 CDKN2B
Neuroticism score 1.81 1 0 0.0 0 1.00000 AFAP1
Weight 2.78 1 1 3.0 0 1.00000 C14orf39
Impedance of arm (right) 0.86 1 0 0.0 0 1.00000 CDKN2B
Arm fat percentage (right) 1.40 1 0 0.0 0 1.00000 AFAP1
Trunk fat-free mass 5.75 3 1 3.0 0 1.00000 AFAP1 C14orf39 GAS7
Hip circumference 1.92 1 1 3.0 0 1.00000 C14orf39
Father's age at death 4.28 1 0 0.0 0 1.00000 CDKN2B
Forced expiratory volume in 1-second (FEV1) 2.54 1 0 0.0 0 1.00000 AFAP1
Medication: Cholesterol lowering 3.22 1 0 0.0 0 1.00000 CDKN2B
Illnesses of mother 2.46 1 0 0.0 0 1.00000 CDKN2B
Forced expiratory volume in 1-second (FEV1), Best measure 2.41 1 0 0.0 0 1.00000 AFAP1
Impedance of arm (left) 0.85 1 0 0.0 0 1.00000 C14orf39
Arm fat mass (right) 1.41 1 0 0.0 0 1.00000 C14orf39
Trunk predicted mass 5.84 3 1 3.0 0 1.00000 AFAP1 C14orf39 GAS7
Standing height 5.87 3 3 9.1 0 1.00000 AFAP1 C14orf39 GAS7
Forced vital capacity (FVC), Best measure 2.17 2 0 0.0 0 1.00000 AFAP1 C14orf39
Body fat percentage 1.08 1 0 0.0 0 1.00000 AFAP1
Leg fat percentage (right) 0.97 1 0 0.0 0 1.00000 AFAP1
Arm fat-free mass (right) 4.52 1 1 3.0 0 1.00000 C14orf39
Age at first live birth 2.82 1 0 0.0 0 1.00000 GAS7
Shortness of breath walking on level ground 2.64 1 0 0.0 0 1.00000 AFAP1
Qualifications: College or University degree 1.25 1 0 0.0 0 1.00000 C14orf39
Eye problems/disorders: None of the above 7.52 2 0 0.0 0 1.00000 AFAP1 TMCO1
Angina (self-reported) 15.21 1 1 3.0 0 1.00000 CDKN2B
Heart disease (mother) 7.18 1 1 3.0 0 1.00000 CDKN2B
Whole body fat mass 1.22 1 0 0.0 0 1.00000 C14orf39
Leg fat mass (right) 0.89 1 0 0.0 0 1.00000 C14orf39
Arm predicted mass (right) 4.64 1 1 3.0 0 1.00000 C14orf39
Comparative height size at age 10 3.01 2 1 3.0 0 1.00000 C14orf39 GAS7
Chest pain or discomfort 1.71 1 0 0.0 0 1.00000 CDKN2B
Had major operations 4.31 1 0 0.0 0 1.00000 C14orf39
Age at last live birth 2.62 1 0 0.0 0 1.00000 AFAP1
Medication: Aspirin 6.59 1 1 3.0 0 1.00000 CDKN2B
Illnesses of father: Heart disease 14.14 1 1 3.0 0 1.00000 CDKN2B
Forced expiratory volume in 1-second (FEV1), predicted 4.95 3 0 0.0 0 1.00000 AFAP1 C14orf39 GAS7
Whole body fat-free mass 5.04 1 1 3.0 0 1.00000 C14orf39
Leg fat-free mass (right) 3.78 1 1 3.0 0 1.00000 C14orf39
Arm fat percentage (left) 1.33 1 0 0.0 0 1.00000 AFAP1
Long-standing illness, disability or infirmity 2.91 1 0 0.0 0 1.00000 CDKN2B
Breast cancer (self-reported) 3.01 1 0 0.0 0 1.00000 CDKN2B
Osteoarthritis (self-reported) 1.83 1 0 0.0 0 1.00000 GAS7
Medication: Aspirin 6.36 1 1 3.0 0 1.00000 CDKN2B
Medication: Gliclazide 1.95 1 0 0.0 0 1.00000 CDKN2B
Illnesses of father: None of the above (group 1) 5.27 1 1 3.0 0 1.00000 CDKN2B
Whole body water mass 4.94 1 1 3.0 0 1.00000 C14orf39
Leg predicted mass (right) 3.79 1 1 3.0 0 1.00000 C14orf39
Arm fat mass (left) 1.17 1 0 0.0 0 1.00000 C14orf39
Miserableness 2.41 1 0 0.0 0 1.00000 AFAP1
Eye problems/disorders: Glaucoma 52.20 5 5 15.2 1 0.00013 AFAP1 C14orf39 CDKN2B GAS7 TMCO1
Medication: Atorvastatin 4.66 1 1 3.0 0 1.00000 CDKN2B
Basal metabolic rate 4.51 1 1 3.0 0 1.00000 C14orf39
Leg fat percentage (left) 0.88 1 0 0.0 0 1.00000 AFAP1
Arm fat-free mass (left) 5.07 1 1 3.0 0 1.00000 C14orf39
Number of operations (self-reported) 2.79 1 0 0.0 0 1.00000 C14orf39
Diastolic blood pressure, automated reading 1.14 1 0 0.0 0 1.00000 CDKN2B
Myopia 4.69 2 0 0.0 0 1.00000 C14orf39 TMCO1
Vascular/heart problems diagnosed by doctor 1.27 1 0 0.0 0 1.00000 CDKN2B
Cholesterol lowering medication 1.81 1 0 0.0 0 1.00000 CDKN2B
Basal cell carcinoma (self-reported) 4.16 1 0 0.0 0 1.00000 CDKN2B
Heart attack/myocardial infarction (self-reported) 12.03 1 1 3.0 0 1.00000 CDKN2B
Heart disease (siblings) 2.00 1 0 0.0 0 1.00000 CDKN2B
Impedance of whole body 0.96 1 0 0.0 0 1.00000 C14orf39
Leg fat mass (left) 0.92 1 0 0.0 0 1.00000 C14orf39
Arm predicted mass (left) 5.00 1 1 3.0 0 1.00000 C14orf39

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.20
GTEx Adipose Visceral Omentum 0 0.0000 1.20
GTEx Adrenal Gland 0 0.0000 1.18
GTEx Artery Aorta 1 0.0336 1.25
GTEx Artery Coronary 0 0.0000 1.20
GTEx Artery Tibial 2 0.0532 1.23
GTEx Brain Caudate basal ganglia 0 0.0000 1.21
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.20
GTEx Brain Cerebellum 1 0.0505 1.19
GTEx Brain Cortex 0 0.0000 1.19
GTEx Brain Frontal Cortex BA9 0 0.0000 1.14
GTEx Brain Hippocampus 0 0.0000 1.25
GTEx Brain Hypothalamus 0 0.0000 1.22
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.10
GTEx Brain Putamen basal ganglia 0 0.0000 1.09
GTEx Breast Mammary Tissue 0 0.0000 1.22
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.24
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.23
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.15
GTEx Cells Transformed fibroblasts 2 0.0476 1.22
GTEx Colon Sigmoid 1 0.0684 1.23
GTEx Colon Transverse 0 0.0000 1.16
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.23
GTEx Esophagus Mucosa 0 0.0000 1.19
GTEx Esophagus Muscularis 0 0.0000 1.19
GTEx Heart Atrial Appendage 0 0.0000 1.16
GTEx Heart Left Ventricle 1 0.0654 1.20
GTEx Liver 0 0.0000 1.22
GTEx Lung 1 0.0348 1.18
GTEx Muscle Skeletal 2 0.0692 1.15
GTEx Nerve Tibial 1 0.0231 1.20
GTEx Ovary 0 0.0000 1.21
GTEx Pancreas 0 0.0000 1.23
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.19
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.24
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.21
GTEx Small Intestine Terminal Ileum 0 0.0000 1.25
GTEx Spleen 0 0.0000 1.21
GTEx Stomach 1 0.0688 1.22
GTEx Testis 0 0.0000 1.23
GTEx Thyroid 0 0.0000 1.16
GTEx Uterus 0 0.0000 1.20
GTEx Vagina 0 0.0000 1.24
GTEx Whole Blood 1 0.0502 1.16
METSIM Adipose 1 0.0217 1.14
NTR Blood 1 0.0416 1.17
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.17
YFS Blood 0 0.0000 1.17
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.20
TCGA Breast Tumor 0 0.0000 1.17
TCGA Breast Normal 0 0.0000 1.09
TCGA Ovarian Tumor 0 0.0000 1.13
TCGA Prostate Tumor 1 0.0289 1.15