Hub : Traits :

Blood clot in the leg (DVT)

36 significantly associated models · 23 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 167970917 170514229 5 6 2.7e-15 1.1e-172 3.1e-124 28 AL021068.1 ATP1B1 C1orf112 DPT NME7
2 4 154758667 156166231 1 1 4.4e-16 2.2e-17 8.8e-04 85 PLRG1
3 4 186328499 187829016 2 2 1.5e-12 1.8e-22 3.5e-11 54 CYP4V2 FAM149A
4 9 134907263 137552398 10 8 5.1e-40 3.7e-65 5.2e-02 99 ABO AK8 AL590710.1 C9orf7 GBGT1 SARDH SURF1 VAV2
5 10 70516744 71966819 1 1 5.9e-11 6.0e-11 1.0e+00 100 TSPAN15
6 17 6652789 8057572 1 1 3.0e-07 2.9e-05 3.7e-03 52 CHRNB1
7 20 32898339 34562581 3 1 1.4e-08 1.4e-08 2.4e-02 84 EIF6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 0.90 1 0 0.0 0.00 1.0e+00 ABO
Irritable Bowel Disease (IBD) 1.13 2 0 0.0 0.00 1.0e+00 ABO EIF6
Ulcerative Colitis (UC) 1.41 1 0 0.0 0.00 1.0e+00 EIF6
Major Depression (MDD) 1.75 1 0 0.0 0.00 1.0e+00 CHRNB1
Reaction Time 1.15 1 0 0.0 0.00 1.0e+00 EIF6
Ovarian Cancer 1.67 1 0 0.0 0.00 1.0e+00 SURF1
LDL Cholesterol 1.88 2 0 0.0 0.00 1.0e+00 AK8 SURF1
Primary Biliary Cirrhosis 1.82 1 0 0.0 0.00 1.0e+00 ATP1B1
Ulcerative Colitis 1.38 1 0 0.0 0.00 1.0e+00 EIF6
Blood Eosinophil Count 0.75 4 2 6.1 0.98 2.2e-02 ABO GBGT1 SARDH VAV2
Blood Platelet Count 1.22 11 4 12.1 0.19 5.7e-01 ABO AK8 AL590710.1 ATP1B1 C9orf7 CHRNB1 CYP4V2 EIF6 GBGT1 SURF1 TSPAN15
Blood Red Count 2.51 7 4 12.1 0.34 4.6e-01 ABO AL590710.1 ATP1B1 CHRNB1 GBGT1 SARDH SURF1
Blood White Count 1.51 6 4 12.1 0.96 2.9e-03 ABO AK8 AL590710.1 GBGT1 SARDH SURF1
Heel T-Score 0.75 3 1 3.0 0.00 1.0e+00 C9orf7 CYP4V2 SURF1
BMI 0.61 2 0 0.0 0.00 1.0e+00 AK8 CHRNB1
Height 2.30 6 4 12.1 0.11 8.4e-01 AK8 AL590710.1 CHRNB1 EIF6 PLRG1 SURF1
Waist Hip Ratio (WHR) 0.54 1 0 0.0 0.00 1.0e+00 CHRNB1
Systolic Blood Pressure 1.29 3 1 3.0 0.00 1.0e+00 ATP1B1 C9orf7 CHRNB1
Allergy or Eczema 1.30 1 0 0.0 0.00 1.0e+00 AL590710.1
Respiratory disease 1.20 1 0 0.0 0.00 1.0e+00 CHRNB1
Lung FEV1/FVC ratio 1.08 2 2 6.1 0.00 1.0e+00 EIF6 NME7
Lung FVC 0.92 3 1 3.0 0.00 1.0e+00 AL590710.1 CHRNB1 EIF6
Hair Pigment 0.31 1 1 3.0 0.00 1.0e+00 EIF6
Tanning 0.91 1 1 3.0 0.00 1.0e+00 EIF6
Hand grip strength (left) 1.81 4 1 3.0 -0.44 5.6e-01 AL590710.1 CHRNB1 EIF6 SARDH
Number of treatments/medications taken 0.89 1 0 0.0 0.00 1.0e+00 DPT
Frequency of depressed mood in last 2 weeks 0.91 1 0 0.0 0.00 1.0e+00 NME7
Ever used hormone-replacement therapy (HRT) 1.33 1 0 0.0 0.00 1.0e+00 C1orf112
Systolic blood pressure, automated reading 1.03 1 0 0.0 0.00 1.0e+00 ATP1B1
Angina 1.46 1 0 0.0 0.00 1.0e+00 ATP1B1
Impedance of leg (right) 0.78 3 0 0.0 0.00 1.0e+00 AK8 EIF6 SARDH
Leg fat-free mass (left) 1.31 1 1 3.0 0.00 1.0e+00 EIF6
Trunk fat percentage 0.78 3 0 0.0 0.00 1.0e+00 ABO AK8 CHRNB1
Hand grip strength (right) 2.45 3 1 3.0 0.00 1.0e+00 AL590710.1 CHRNB1 EIF6
Age when periods started (menarche) 0.88 1 0 0.0 0.00 1.0e+00 EIF6
High blood pressure 1.35 2 0 0.0 0.00 1.0e+00 ABO C9orf7
Hayfever, allergic rhinitis or eczema 1.09 1 0 0.0 0.00 1.0e+00 AL590710.1
Diverticular disease/diverticulitis (self-reported) 1.64 1 0 0.0 0.00 1.0e+00 TSPAN15
Sitting height 2.52 3 1 3.0 0.00 1.0e+00 CHRNB1 EIF6 SURF1
Body mass index (BMI) 0.72 2 0 0.0 0.00 1.0e+00 AK8 CHRNB1
Impedance of leg (left) 0.76 4 0 0.0 -1.00 4.8e-03 AK8 EIF6 SARDH SURF1
Leg predicted mass (left) 1.31 1 1 3.0 0.00 1.0e+00 EIF6
Trunk fat mass 0.50 1 0 0.0 0.00 1.0e+00 AK8
Waist circumference 0.46 1 0 0.0 0.00 1.0e+00 AK8
Hearing difficulty/problems with background noise 1.16 1 0 0.0 0.00 1.0e+00 ABO
Forced vital capacity (FVC) 1.00 3 0 0.0 0.00 1.0e+00 AL590710.1 EIF6 SURF1
Allergy 3.11 4 1 3.0 -0.69 3.1e-01 ABO AL590710.1 EIF6 SARDH
Fluid intelligence score 0.98 1 0 0.0 0.00 1.0e+00 AK8
Neuroticism score 0.73 1 0 0.0 0.00 1.0e+00 ATP1B1
Weight 0.76 1 1 3.0 0.00 1.0e+00 EIF6
Impedance of arm (right) 1.72 5 1 3.0 1.00 1.4e-04 ABO AL590710.1 C9orf7 GBGT1 VAV2
Arm fat percentage (right) 1.03 3 0 0.0 0.00 1.0e+00 ABO AK8 CHRNB1
Trunk fat-free mass 2.33 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Father's age at death 1.82 1 0 0.0 0.00 1.0e+00 NME7
Frequency of tiredness / lethargy in last 2 weeks 1.20 1 0 0.0 0.00 1.0e+00 NME7
Forced expiratory volume in 1-second (FEV1) 1.01 2 0 0.0 0.00 1.0e+00 AL590710.1 EIF6
Qualifications: A levels/AS levels or equivalent 0.85 1 0 0.0 0.00 1.0e+00 CHRNB1
Prospective memory result 1.68 2 0 0.0 0.00 1.0e+00 AK8 CHRNB1
Forced expiratory volume in 1-second (FEV1), Best measure 1.10 2 0 0.0 0.00 1.0e+00 AL590710.1 EIF6
Impedance of arm (left) 1.74 5 1 3.0 1.00 8.1e-05 ABO AL590710.1 C9orf7 GBGT1 VAV2
Arm fat mass (right) 0.56 1 0 0.0 0.00 1.0e+00 AK8
Trunk predicted mass 2.35 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Standing height 2.18 5 2 6.1 0.12 8.5e-01 AL590710.1 CHRNB1 EIF6 PLRG1 SURF1
Length of working week for main job 1.64 1 0 0.0 0.00 1.0e+00 SURF1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.04 1 0 0.0 0.00 1.0e+00 NME7
Birth weight of first child 0.79 1 0 0.0 0.00 1.0e+00 ATP1B1
Peak expiratory flow (PEF) 1.88 2 0 0.0 0.00 1.0e+00 ABO EIF6
Mouth/teeth dental problems: Bleeding gums 0.98 1 0 0.0 0.00 1.0e+00 EIF6
Chronic bronchitis/emphysema (mother) 1.76 2 0 0.0 0.00 1.0e+00 GBGT1 VAV2
Forced vital capacity (FVC), Best measure 0.97 2 0 0.0 0.00 1.0e+00 AL590710.1 EIF6
Body fat percentage 0.84 3 0 0.0 0.00 1.0e+00 ABO AK8 CHRNB1
Leg fat percentage (right) 0.90 2 0 0.0 0.00 1.0e+00 CHRNB1 EIF6
Arm fat-free mass (right) 2.12 4 1 3.0 -0.44 5.6e-01 ABO AL590710.1 EIF6 GBGT1
Qualifications: College or University degree 1.25 2 0 0.0 0.00 1.0e+00 CHRNB1 EIF6
Medication for pain relief, constipation, heartburn 1.38 1 0 0.0 0.00 1.0e+00 NME7
Whole body fat mass 0.52 1 0 0.0 0.00 1.0e+00 AK8
Leg fat mass (right) 0.56 1 0 0.0 0.00 1.0e+00 AK8
Arm predicted mass (right) 2.09 4 1 3.0 -0.46 5.4e-01 ABO AL590710.1 EIF6 GBGT1
Pulse rate, automated reading 0.70 1 0 0.0 0.00 1.0e+00 GBGT1
Alcohol intake frequency. 1.10 1 0 0.0 0.00 1.0e+00 NME7
Comparative height size at age 10 1.21 1 1 3.0 0.00 1.0e+00 EIF6
Age at last live birth 1.41 1 0 0.0 0.00 1.0e+00 VAV2
Medication: Aspirin 2.16 1 0 0.0 0.00 1.0e+00 NME7
Hypertension (Self-reported) 1.35 2 0 0.0 0.00 1.0e+00 ABO C9orf7
Forced expiratory volume in 1-second (FEV1), predicted 1.26 1 1 3.0 0.00 1.0e+00 EIF6
Whole body fat-free mass 1.91 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Leg fat-free mass (right) 1.39 1 1 3.0 0.00 1.0e+00 EIF6
Arm fat percentage (left) 1.13 4 0 0.0 0.73 2.7e-01 ABO AK8 CHRNB1 EIF6
Ever had bowel cancer screening 1.52 1 0 0.0 0.00 1.0e+00 ABO
Ever had stillbirth, spontaneous miscarriage or termination 1.52 1 0 0.0 0.00 1.0e+00 C9orf7
Medication: Aspirin 2.13 1 0 0.0 0.00 1.0e+00 NME7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.69 1 0 0.0 0.00 1.0e+00 CHRNB1
Whole body water mass 1.89 3 1 3.0 0.00 1.0e+00 ABO AL590710.1 EIF6
Leg predicted mass (right) 1.38 1 1 3.0 0.00 1.0e+00 EIF6
Arm fat mass (left) 0.60 1 0 0.0 0.00 1.0e+00 AK8
Number of self-reported non-cancer illnesses 1.10 1 0 0.0 0.00 1.0e+00 ATP1B1
Medication: Blood pressure 1.51 2 0 0.0 0.00 1.0e+00 ATP1B1 CHRNB1
High cholesterol (Self-reported) 1.16 1 0 0.0 0.00 1.0e+00 SURF1
Medication: Bendroflumethiazide 1.62 1 0 0.0 0.00 1.0e+00 ABO
Basal metabolic rate 1.60 2 1 3.0 0.00 1.0e+00 AL590710.1 EIF6
Leg fat percentage (left) 0.92 2 0 0.0 0.00 1.0e+00 CHRNB1 EIF6
Arm fat-free mass (left) 2.01 4 1 3.0 -0.45 5.5e-01 ABO AL590710.1 EIF6 GBGT1
Risk taking 1.10 1 0 0.0 0.00 1.0e+00 PLRG1
Diastolic blood pressure, automated reading 1.20 2 0 0.0 0.00 1.0e+00 ABO C9orf7
Myopia 1.87 2 0 0.0 0.00 1.0e+00 ATP1B1 VAV2
Vascular/heart problems diagnosed by doctor 1.13 1 0 0.0 0.00 1.0e+00 ABO
Deep venous thrombosis (DVT) (self-reported) 36.52 19 17 51.5 1.00 1.3e-28 ABO AK8 AL021068.1 AL590710.1 ATP1B1 C1orf112 C9orf7 CHRNB1 CYP4V2 DPT EIF6 FAM149A GBGT1 NME7 PLRG1 SARDH SURF1 TSPAN15 VAV2
Alcohol drinker status: Previous 1.91 1 0 0.0 0.00 1.0e+00 NME7
Impedance of whole body 1.00 2 1 3.0 0.00 1.0e+00 ABO EIF6
Leg fat mass (left) 0.59 1 0 0.0 0.00 1.0e+00 AK8
Arm predicted mass (left) 2.07 4 1 3.0 -0.44 5.6e-01 ABO AL590710.1 EIF6 GBGT1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.30
GTEx Adipose Visceral Omentum 0 0.0000 1.30
GTEx Adrenal Gland 0 0.0000 1.32
GTEx Artery Aorta 1 0.0336 1.27
GTEx Artery Coronary 0 0.0000 1.31
GTEx Artery Tibial 2 0.0532 1.32
GTEx Brain Caudate basal ganglia 1 0.1087 1.36
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.22
GTEx Brain Cerebellum 1 0.0505 1.28
GTEx Brain Cortex 0 0.0000 1.27
GTEx Brain Frontal Cortex BA9 0 0.0000 1.32
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.36
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.34
GTEx Brain Putamen basal ganglia 0 0.0000 1.29
GTEx Breast Mammary Tissue 2 0.1013 1.38
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.15
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.27
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.33
GTEx Cells Transformed fibroblasts 1 0.0238 1.29
GTEx Colon Sigmoid 0 0.0000 1.25
GTEx Colon Transverse 1 0.0484 1.32
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.29
GTEx Esophagus Mucosa 2 0.0602 1.34
GTEx Esophagus Muscularis 0 0.0000 1.27
GTEx Heart Atrial Appendage 1 0.0633 1.30
GTEx Heart Left Ventricle 0 0.0000 1.25
GTEx Liver 0 0.0000 1.22
GTEx Lung 1 0.0348 1.29
GTEx Muscle Skeletal 0 0.0000 1.32
GTEx Nerve Tibial 1 0.0231 1.28
GTEx Ovary 0 0.0000 1.18
GTEx Pancreas 0 0.0000 1.37
GTEx Pituitary 1 0.0897 1.33
GTEx Prostate 0 0.0000 1.28
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.35
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.35
GTEx Small Intestine Terminal Ileum 0 0.0000 1.45
GTEx Spleen 2 0.1417 1.29
GTEx Stomach 1 0.0688 1.34
GTEx Testis 1 0.0317 1.31
GTEx Thyroid 1 0.0250 1.25
GTEx Uterus 1 0.1764 1.40
GTEx Vagina 1 0.1575 1.33
GTEx Whole Blood 1 0.0502 1.26
METSIM Adipose 4 0.0868 1.26
NTR Blood 0 0.0000 1.21
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.24
YFS Blood 0 0.0000 1.20
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.23
TCGA Breast Tumor 0 0.0000 1.32
TCGA Breast Normal 2 0.0475 1.20
TCGA Ovarian Tumor 1 0.0342 1.18
TCGA Prostate Tumor 2 0.0578 1.27