Hub : Traits :

Financial difficulties in last 2 years

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 14 103398706 105007585 3 1 1e-07 7.4e-07 0.98 100 PPP1R13B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Prostate Cancer 7.7 1 0 0 0 1 PPP1R13B
Age at First Birth 6.8 1 0 0 0 1 PPP1R13B
Schizophrenia 18.9 1 1 3 0 1 PPP1R13B
Blood Eosinophil Count 2.0 1 0 0 0 1 PPP1R13B
Blood Red Count 1.3 1 0 0 0 1 PPP1R13B
Blood White Count 4.0 1 1 3 0 1 PPP1R13B
Heel T-Score 5.0 1 1 3 0 1 PPP1R13B
BMI 6.3 1 1 3 0 1 PPP1R13B
Height 2.2 1 1 3 0 1 PPP1R13B
Smoking Status 13.5 1 1 3 0 1 PPP1R13B
Cardiovascular Disease 7.2 1 0 0 0 1 PPP1R13B
Lung FEV1/FVC ratio 1.4 1 0 0 0 1 PPP1R13B
Hair Pigment 1.7 1 1 3 0 1 PPP1R13B
Frequency of depressed mood in last 2 weeks 5.4 1 0 0 0 1 PPP1R13B
Hearing difficulty/problems: Yes 9.5 1 0 0 0 1 PPP1R13B
Relative age of first facial hair 4.3 1 0 0 0 1 PPP1R13B
Other serious medical condition/disability diagnosed by doctor 7.2 1 0 0 0 1 PPP1R13B
Pack years adult smoking proportion 11.5 1 0 0 0 1 PPP1R13B
Impedance of leg (right) 5.2 1 1 3 0 1 PPP1R13B
Leg fat-free mass (left) 1.7 1 0 0 0 1 PPP1R13B
Trunk fat percentage 1.8 1 0 0 0 1 PPP1R13B
Townsend deprivation index at recruitment 5.5 1 0 0 0 1 PPP1R13B
Current tobacco smoking 15.0 1 0 0 0 1 PPP1R13B
Maternal smoking around birth 12.1 1 0 0 0 1 PPP1R13B
Heel bone mineral density (BMD) T-score, automated (left) 4.2 1 0 0 0 1 PPP1R13B
High blood pressure 4.1 1 0 0 0 1 PPP1R13B
Stomach or abdominal pain in last month 6.1 1 0 0 0 1 PPP1R13B
Body mass index (BMI) 6.0 1 1 3 0 1 PPP1R13B
Impedance of leg (left) 4.8 1 0 0 0 1 PPP1R13B
Leg predicted mass (left) 1.6 1 0 0 0 1 PPP1R13B
Trunk fat mass 1.8 1 0 0 0 1 PPP1R13B
Waist circumference 5.1 1 0 0 0 1 PPP1R13B
Past tobacco smoking 7.3 1 0 0 0 1 PPP1R13B
Hearing difficulty/problems with background noise 9.4 1 0 0 0 1 PPP1R13B
Mouth/teeth dental problems 12.6 1 0 0 0 1 PPP1R13B
Fluid intelligence score 3.8 1 0 0 0 1 PPP1R13B
Weight 2.1 1 0 0 0 1 PPP1R13B
Impedance of arm (right) 1.8 1 0 0 0 1 PPP1R13B
Arm fat percentage (right) 5.8 1 0 0 0 1 PPP1R13B
Hip circumference 3.3 1 0 0 0 1 PPP1R13B
Frequency of tiredness / lethargy in last 2 weeks 10.6 1 0 0 0 1 PPP1R13B
Qualifications: A levels/AS levels or equivalent 3.0 1 0 0 0 1 PPP1R13B
Impedance of arm (left) 2.5 1 0 0 0 1 PPP1R13B
Arm fat mass (right) 4.9 1 0 0 0 1 PPP1R13B
Standing height 1.1 1 0 0 0 1 PPP1R13B
Exposure to tobacco smoke at home 6.9 1 0 0 0 1 PPP1R13B
Seen doctor (GP) for nerves, anxiety, tension or depression 6.5 1 0 0 0 1 PPP1R13B
Mouth/teeth dental problems: Bleeding gums 4.9 1 0 0 0 1 PPP1R13B
Medication: Paracetamol 5.5 1 0 0 0 1 PPP1R13B
Body fat percentage 2.1 1 0 0 0 1 PPP1R13B
Seen a psychiatrist for nerves, anxiety, tension or depression 8.4 1 0 0 0 1 PPP1R13B
Health satisfaction 6.3 1 0 0 0 1 PPP1R13B
Qualifications: College or University degree 4.1 1 0 0 0 1 PPP1R13B
Mouth/teeth dental problems: Loose teeth 9.1 1 0 0 0 1 PPP1R13B
Emphysema/chronic bronchitis 7.4 1 0 0 0 1 PPP1R13B
Medication for pain relief, constipation, heartburn 4.2 1 0 0 0 1 PPP1R13B
Neck or shoulder pain in last month 4.6 1 0 0 0 1 PPP1R13B
Whole body fat mass 2.5 1 0 0 0 1 PPP1R13B
Leg fat mass (right) 2.3 1 0 0 0 1 PPP1R13B
Pulse rate, automated reading 3.9 1 0 0 0 1 PPP1R13B
Comparative height size at age 10 2.2 1 0 0 0 1 PPP1R13B
Overall health rating 6.8 1 0 0 0 1 PPP1R13B
Illness, injury, bereavement, stress in last 2 years 13.1 1 0 0 0 1 PPP1R13B
Hypertension (Self-reported) 4.3 1 0 0 0 1 PPP1R13B
Leg fat-free mass (right) 1.7 1 0 0 0 1 PPP1R13B
Arm fat percentage (left) 4.6 1 0 0 0 1 PPP1R13B
Long-standing illness, disability or infirmity 9.9 1 0 0 0 1 PPP1R13B
Back pain experienced in last month 4.6 1 0 0 0 1 PPP1R13B
Smoking status: Current 13.0 1 0 0 0 1 PPP1R13B
Leg predicted mass (right) 1.7 1 0 0 0 1 PPP1R13B
Arm fat mass (left) 4.5 1 0 0 0 1 PPP1R13B
Number of self-reported non-cancer illnesses 5.8 1 0 0 0 1 PPP1R13B
Mother's age at death 7.4 1 0 0 0 1 PPP1R13B
Financial situation satisfaction 6.1 1 0 0 0 1 PPP1R13B
Pain type(s) experienced in last month: Hip pain 10.6 1 0 0 0 1 PPP1R13B
Ever smoked 4.3 1 0 0 0 1 PPP1R13B
Leg fat percentage (left) 2.0 1 0 0 0 1 PPP1R13B
Risk taking 16.0 1 0 0 0 1 PPP1R13B
Diastolic blood pressure, automated reading 5.0 1 0 0 0 1 PPP1R13B
Ever depressed for a whole week 6.8 1 0 0 0 1 PPP1R13B
Vascular/heart problems diagnosed by doctor 5.8 1 0 0 0 1 PPP1R13B
Alcohol drinker status: Previous 15.6 1 0 0 0 1 PPP1R13B
Pack years of smoking 10.5 1 0 0 0 1 PPP1R13B
Impedance of whole body 3.2 1 0 0 0 1 PPP1R13B
Leg fat mass (left) 2.8 1 0 0 0 1 PPP1R13B

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.40
GTEx Adipose Visceral Omentum 0 0.0000 1.38
GTEx Adrenal Gland 0 0.0000 1.33
GTEx Artery Aorta 1 0.0336 1.36
GTEx Artery Coronary 0 0.0000 1.36
GTEx Artery Tibial 0 0.0000 1.41
GTEx Brain Caudate basal ganglia 0 0.0000 1.37
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.41
GTEx Brain Cerebellum 0 0.0000 1.41
GTEx Brain Cortex 0 0.0000 1.39
GTEx Brain Frontal Cortex BA9 0 0.0000 1.26
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.43
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.38
GTEx Brain Putamen basal ganglia 0 0.0000 1.38
GTEx Breast Mammary Tissue 1 0.0507 1.41
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.37
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.37
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.40
GTEx Cells Transformed fibroblasts 0 0.0000 1.38
GTEx Colon Sigmoid 0 0.0000 1.33
GTEx Colon Transverse 0 0.0000 1.41
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.45
GTEx Esophagus Mucosa 0 0.0000 1.45
GTEx Esophagus Muscularis 0 0.0000 1.40
GTEx Heart Atrial Appendage 0 0.0000 1.32
GTEx Heart Left Ventricle 0 0.0000 1.28
GTEx Liver 0 0.0000 1.33
GTEx Lung 0 0.0000 1.39
GTEx Muscle Skeletal 0 0.0000 1.39
GTEx Nerve Tibial 0 0.0000 1.40
GTEx Ovary 0 0.0000 1.40
GTEx Pancreas 0 0.0000 1.39
GTEx Pituitary 0 0.0000 1.39
GTEx Prostate 0 0.0000 1.37
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.44
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.39
GTEx Small Intestine Terminal Ileum 0 0.0000 1.53
GTEx Spleen 0 0.0000 1.41
GTEx Stomach 0 0.0000 1.46
GTEx Testis 0 0.0000 1.39
GTEx Thyroid 1 0.0250 1.42
GTEx Uterus 0 0.0000 1.43
GTEx Vagina 0 0.0000 1.39
GTEx Whole Blood 0 0.0000 1.35
METSIM Adipose 0 0.0000 1.30
NTR Blood 0 0.0000 1.29
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.35
YFS Blood 0 0.0000 1.26
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.35
TCGA Breast Tumor 0 0.0000 1.28
TCGA Breast Normal 0 0.0000 1.25
TCGA Ovarian Tumor 0 0.0000 1.31
TCGA Prostate Tumor 0 0.0000 1.35