TWAS hub - C11orf80

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0950	0.0370	4.5e-05	0.043	0.042	0.044	0.041	0.044	5.7e-06	7.2e-06	4.1e-06	8.0e-06	3.8e-06
2	GTEx	Cells Transformed fibroblasts	0.3270	0.1280	3.3e-04	0.007	NA	0.101	NA	0.072	8.6e-02	NA	5.8e-08	NA	4.2e-06
3	GTEx	Esophagus Mucosa	0.2730	0.1120	9.0e-03	0.070	NA	0.073	NA	0.064	2.0e-05	NA	1.2e-05	NA	4.7e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.3594	0.0701	0.0e+00	0.126	0.154	0.196	0.157	0.150	7.2e-16	2.4e-19	1.3e-24	1.2e-19	7.7e-19
5	TCGA	Brain Lower Grade Glioma	0.0487	0.0286	3.2e-05	0.037	0.027	0.023	NA	0.027	3.8e-05	4.6e-04	1.0e-03	NA	4.6e-04
6	TCGA	Lung Squamous Cell Carcinoma	0.0266	0.0226	6.0e-03	0.011	0.007	-0.002	NA	0.002	1.8e-02	4.8e-02	7.1e-01	NA	1.7e-01
7	TCGA	Prostate Adenocarcinoma	0.1184	0.0580	1.3e-05	0.028	0.053	0.065	NA	0.064	6.4e-04	2.8e-06	2.4e-07	NA	2.9e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Supplements: Fish oil (including cod liver oil)	14.6	19.1	28.4	4.9	2.8	5.3	4.6	4.1	4.4	4.0
Average weekly red wine intake	10.9	16.1	25.4	5.0	1.1	3.3	4.6	4.2	4.5	4.0
Mineral and other dietary supplements	9.3	12.5	17.7	-3.8	-2.1	-3.9	-3.4	-3.7	-4.2	-3.3
Alcohol usually taken with meals	7.7	12.5	25.5	5.0	1.9	3.7	3.6	3.1	3.3	3.2
Bipolar Disorder (2011)	7.6	7.4	18.8	3.8	1.5	2.2	3.3	0.0	4.3	0.0
Medication: Co-codamol	6.3	7.3	17.8	-4.2	-2.2	-3.3	-3.6	-1.1	-1.3	-1.3
Commuting to job workplace: Cycle	6.3	7.7	13.0	3.5	0.3	1.1	2.6	3.3	3.6	3.0
Breast Cancer	6.2	15.0	26.7	5.0	0.8	4.2	5.2	3.9	4.0	1.6
Fed-up feelings	6.0	10.9	22.7	-3.3	-0.6	-4.8	-3.6	-3.3	-3.6	-2.2
Mean time to correctly identify matches	5.9	11.2	24.4	-2.9	0.0	-1.0	-2.9	-4.5	-4.9	-4.1
Reaction Time	5.8	11.1	24.1	-2.4	-0.5	-1.2	-2.7	-4.3	-4.5	-4.9
Medication: Seretide 50 evohaler	5.8	6.7	10.6	-3.0	-1.0	-1.7	-3.2	-3.0	-3.1	-2.0
Qualifications: College or University degree	5.6	17.6	32.2	4.6	-0.6	2.7	3.7	5.4	5.7	4.5
Chronotype (morning person)	4.9	11.4	20.2	-2.8	-1.5	-3.1	-2.1	-4.4	-4.5	-4.0
Pain all over the body in last month	4.8	5.1	17.0	-2.4	-1.1	-4.1	-2.9	-1.1	-1.1	-0.9
Qualifications: None of the above	4.6	9.9	19.2	-3.3	0.4	-2.1	-2.7	-4.4	-4.2	-3.1
Number of full brothers	4.4	5.5	7.9	1.8	2.5	2.8	2.4	2.4	2.3	2.1
Unable to work because of sickness or disability	4.4	5.8	9.4	-2.8	-1.1	-3.1	-2.5	-2.5	-2.5	-1.9
Lung FVC	4.3	21.7	51.6	4.2	2.4	3.9	4.5	5.2	7.2	3.8
Vitamin and mineral supplements	4.0	5.5	9.5	-3.1	-0.7	-1.7	-2.6	-2.9	-2.8	-1.5
Primary Biliary Cirrhosis	3.8	5.4	10.7	-2.5	-2.0	-2.1	-3.3	-1.7	-1.6	-2.7
Supplements: Glucosamine	3.7	4.9	10.4	2.2	0.6	1.2	1.3	2.7	3.2	2.9
Allergy or Eczema	3.6	9.5	15.1	3.3	0.8	3.4	3.3	3.7	3.9	2.2
Lung cancer (father)	3.6	4.2	6.9	-1.4	-1.6	-1.1	-2.6	-2.2	-2.4	-2.5
Hearing difficulty/problems with background noise	3.5	5.6	12.2	2.1	0.4	1.6	1.6	3.3	3.5	2.5
Impedance of leg (right)	3.4	16.7	35.6	-2.9	0.5	-0.9	-3.6	-6.0	-5.0	-5.9
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	10.3	1.5	-0.2	0.6	1.4	3.2	2.9	2.4
Schizophrenia vs Biploar Disorder	3.3	4.3	11.6	-2.7	-0.4	-3.4	-2.4	0.0	-2.4	0.0
Health satisfaction	3.3	4.3	14.1	-2.4	-1.4	-3.8	-2.7	-0.3	-0.9	-0.3
Qualifications: nursing, teaching	3.3	5.2	8.8	3.0	-0.5	1.3	2.9	2.4	2.9	1.9
Bilateral oophorectomy (both ovaries removed)	3.2	3.7	6.5	-2.5	-0.8	-2.2	-2.5	-1.5	-1.7	-1.6
Multivitamins +/- minerals	3.2	4.1	9.1	3.0	0.9	1.6	2.3	2.2	2.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	13.6	-1.2	-0.8	-1.0	-3.7	-3.0	-3.3	-3.2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	9.5	2.4	0.2	-0.3	1.5	3.1	3.0	1.1
Mouth/teeth dental problems: Loose teeth	3.0	3.6	7.0	2.0	0.9	2.7	2.4	1.7	2.0	0.8
Supplements: Calcium	3.0	3.3	6.5	1.6	0.7	1.4	1.9	2.1	2.5	2.0
Hearing difficulty/problems: Yes	2.7	4.1	10.0	1.5	-1.2	0.1	0.8	3.2	2.9	2.5
Past tobacco smoking	2.7	5.0	10.3	-1.8	-1.4	-2.2	-1.7	-2.5	-2.4	-3.2
Number of operations (self-reported)	2.7	4.1	8.7	-2.4	-1.1	-2.7	-2.9	-1.2	-1.7	-1.1
Qualifications: CSEs or equivalent	2.6	3.5	5.1	-1.9	0.9	-2.1	-1.4	-2.2	-2.2	-1.9
Impedance of leg (left)	2.6	12.4	27.0	-2.3	1.0	-0.7	-3.1	-5.2	-4.2	-5.1
Comparative body size at age 10	2.6	7.2	25.9	-3.3	-1.1	-5.1	-2.4	-1.4	-1.9	-1.2
Pain experienced in last month	2.6	4.3	14.5	1.1	0.9	3.8	2.8	0.1	0.9	2.1
Noisy workplace	2.4	2.9	5.1	-2.1	-0.7	-1.8	-1.4	-1.7	-2.3	-1.6
Ever smoked	2.4	4.2	6.9	1.7	0.9	2.0	1.4	2.5	2.5	2.6
Impedance of whole body	2.4	12.0	26.0	-2.0	-0.8	-0.2	-2.8	-5.1	-4.5	-5.1
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	8.6	1.0	-0.7	-0.8	0.7	2.4	2.9	1.2
Mother’s age at death	2.3	2.9	7.4	1.2	-0.3	2.3	1.6	1.5	1.2	2.7
Risk taking	2.3	3.4	6.4	2.3	0.8	2.1	0.8	2.4	2.5	0.9
Qualifications: A levels/AS levels or equivalent	2.2	4.8	8.8	2.3	0.2	1.5	3.0	2.3	2.8	2.0
Alcohol intake frequency.	2.2	5.1	9.1	-2.4	-0.9	-2.2	-3.0	-2.1	-2.8	-1.7
Tense / ‘highly strung’	2.1	3.5	7.0	2.2	1.0	0.3	1.1	2.5	2.6	1.9
Medication: Omeprazole	2.1	2.5	6.2	0.4	-1.0	0.3	0.9	2.5	2.2	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	13.3	1.3	0.4	1.5	1.5	2.5	3.6	2.1
Ever had hysterectomy (womb removed)	2.0	2.3	4.7	-1.6	-1.6	-1.2	-2.2	-1.4	-1.3	-1.2
Eye problems/disorders: None of the above	2.0	2.3	3.8	-1.3	-1.8	-1.1	-0.8	-2.0	-1.5	-1.7
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	4.1	1.4	1.2	0.3	1.5	1.7	1.4	2.0
Hair/balding pattern: Pattern 3	1.9	2.9	7.1	1.3	-1.0	-0.2	1.7	2.7	2.2	1.4
Heart disease (siblings)	1.9	2.3	7.0	-2.6	-1.1	-1.4	-1.5	-0.9	-0.9	-1.5
Ulcerative Colitis (UC)	1.8	3.4	11.5	-2.6	-3.4	-1.5	-1.6	0.4	1.0	-0.4
Triglycerides	1.8	3.0	8.1	-2.3	0.1	-1.9	-2.8	0.0	-1.9	0.0
Father’s age at death	1.8	2.4	5.3	1.2	-1.5	1.6	1.1	1.5	1.3	2.3
Long-standing illness, disability or infirmity	1.8	2.8	7.3	-2.1	-1.0	-2.7	-2.5	-0.2	-0.8	-0.1
Irritability	1.8	3.0	5.4	2.3	1.6	0.3	1.1	2.3	2.1	1.4
Blood Red Count	1.7	16.9	33.1	4.1	0.0	1.3	5.8	5.1	5.2	3.7
Exposure to tobacco smoke at home	1.7	1.9	3.6	-1.8	0.3	-1.9	-1.4	-1.0	-1.5	-0.8
Age at last live birth	1.7	2.4	6.2	2.5	0.1	2.0	1.8	1.2	0.9	1.3
Smoking status: Previous	1.7	2.5	5.2	1.3	1.3	2.2	1.1	1.2	1.2	2.3
Commuting to job workplace: Public transport	1.7	2.1	4.0	1.7	-0.3	0.5	1.4	1.8	1.4	2.0
Bipolar Disorder or Schizophrenia	1.6	4.0	21.6	1.9	0.4	1.0	1.4	0.0	4.6	0.0
Smoking Status	1.6	3.7	6.2	1.4	1.7	1.6	0.8	2.5	2.4	2.5
Serious illness, injury or assault to yourself	1.6	1.9	4.5	-2.1	0.9	-2.1	-1.2	-0.5	-0.8	-1.0
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.5	1.1	0.8	-0.6	1.2	1.8	1.8	1.9
Medication: Atenolol	1.6	2.0	3.7	1.7	1.2	1.3	1.6	1.1	0.8	1.9
Medication: Allopurinol	1.6	2.1	5.5	-1.6	2.4	-0.5	-0.1	-1.6	-1.6	-0.8
Bipolar Disorder (2018)	1.5	2.3	10.2	2.1	0.3	1.1	0.6	0.0	3.2	0.0
Average weekly fortified wine intake	1.5	1.8	5.9	-0.1	-2.4	-2.1	-0.6	0.8	0.3	1.0
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.4	1.5	0.1	2.3	1.7	2.3	2.5	0.8
Number of incorrect matches in round	1.5	2.5	7.3	1.1	0.1	0.4	1.2	2.4	2.7	1.4
Allergy	1.5	3.4	6.5	-1.7	0.4	-1.7	-1.8	-2.5	-2.4	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	5.5	1.8	-1.7	-1.4	0.7	2.4	1.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.0	-0.9	-2.2	-0.9	-0.8	-1.2	-1.4	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.9	1.7	-1.4	1.2	0.3	1.4	1.1	1.2
Myopia	1.5	2.2	3.7	1.4	0.5	1.6	1.9	1.6	1.9	1.1
Depressed Affect (Nagel 2018)	1.4	3.0	13.5	-1.6	-0.9	-3.7	-2.0	-0.4	-0.4	-0.0
Major Depression (MDD)	1.4	1.8	4.6	-2.1	-1.9	-0.9	-1.7	-0.2	-0.0	-0.2
Diabetes (mother)	1.4	1.8	8.5	1.4	2.9	0.3	1.2	0.6	0.3	0.5
Breast cancer (self-reported)	1.4	1.6	3.0	-1.7	-0.8	-1.7	-1.4	-1.0	-0.6	-1.2
Osteoarthritis (self-reported)	1.4	1.8	6.1	-1.2	0.2	-2.1	-2.5	-0.4	-0.3	0.5
Alcohol drinker status: Never	1.4	1.7	2.5	-1.6	-1.5	-1.3	-1.3	-1.0	-1.4	-0.9
Medication: Simvastatin	1.3	1.9	5.5	-2.4	0.1	-1.6	-1.6	-1.2	-0.9	-0.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	3.9	2.0	0.0	1.5	1.2	0.7	0.8	1.5
Average weekly champagne plus white wine intake	1.3	1.8	4.2	2.0	-1.0	0.5	-0.4	1.7	1.9	0.8
LDL Cholesterol	1.2	1.9	5.4	-1.7	0.0	-2.3	-2.1	0.0	-0.8	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	6.9	-1.5	0.1	-2.6	-1.4	-0.1	-0.0	-0.2
Impedance of arm (right)	1.2	5.6	13.7	-0.7	-2.5	0.5	-1.2	-3.2	-2.7	-3.7
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	8.4	-1.1	-0.4	-2.9	-1.0	-0.4	-1.1	-1.0
Impedance of arm (left)	1.2	5.6	12.7	-0.8	-1.8	0.9	-1.6	-3.3	-3.0	-3.6
Length of working week for main job	1.2	1.3	4.1	-0.5	-1.5	-2.0	-1.2	-0.3	-0.9	0.4
Peak expiratory flow (PEF)	1.2	2.7	6.8	1.1	1.4	2.2	0.0	1.5	2.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.7	1.4	1.5	0.5	1.6	1.3	1.2	0.4
Overall health rating	1.2	2.5	10.7	-1.7	-0.3	-3.3	-1.7	0.6	-0.4	-0.5
Mood swings	1.2	2.2	11.8	-0.8	-1.2	-3.4	-1.1	-0.2	-0.2	-0.2
Loneliness, isolation	1.2	1.7	5.2	-0.5	-1.9	-2.3	-1.3	0.1	-0.0	1.0
Eye problems/disorders: Cataract	1.2	1.3	3.7	0.6	1.2	1.9	0.5	1.3	1.1	0.7
Vascular/heart problems diagnosed by doctor	1.2	3.4	6.3	-2.1	-2.3	-1.9	-2.5	-1.2	-0.8	-1.3
Alzheimer’s Disease (in father)	1.1	1.2	3.9	-0.4	0.8	-0.1	-0.8	-1.7	-2.0	-0.4
Irritable Bowel Disease (IBD)	1.1	2.7	7.4	-2.7	-2.3	-1.2	-1.8	0.1	0.5	-0.9
Ulcerative Colitis	1.1	1.6	5.9	-1.0	-2.4	0.3	-0.3	0.0	2.0	0.0
Supplements: Zinc	1.1	1.2	3.2	1.7	-0.2	0.4	0.8	0.9	0.9	1.8
Medication: Levothyroxine sodium	1.1	1.8	7.7	-0.4	-0.9	-2.8	-1.3	-0.9	-1.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	3.8	0.3	-1.0	-0.1	-0.3	1.9	1.8	1.4
Medication: Amlodipine	1.1	1.6	3.5	1.8	0.7	1.8	1.9	0.5	0.7	0.3
Medication: Blood pressure	1.1	1.9	5.8	1.5	1.2	1.2	2.4	1.0	1.0	0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.3	0.7	-1.2	0.9	0.6	1.2	1.4	1.5
Back pain experienced in last month	1.1	1.6	5.6	-0.7	-0.5	-2.4	-2.1	0.5	0.1	0.2
Schizophrenia (2018)	1.0	2.0	11.5	0.7	0.3	0.7	1.3	0.0	3.4	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	8.8	1.5	1.2	1.8	-0.3	2.0	3.0	1.6
Standing height	1.0	10.4	43.4	-0.9	-1.7	1.1	-6.6	-3.1	-3.1	-2.4
Birth weight	1.0	2.2	8.8	-1.3	-3.0	-1.7	-0.7	0.1	-0.6	0.8
High blood pressure (siblings)	1.0	1.5	2.2	1.4	-1.0	-1.5	0.2	1.4	1.2	1.3
Worry too long after embarrassment	1.0	1.7	3.5	0.1	-1.9	-0.2	-0.2	-1.6	-1.6	-1.9
Medication for pain relief, constipation, heartburn	1.0	1.7	6.2	-0.3	0.3	0.5	0.0	-2.5	-2.0	-1.3
Migraine (self-reported)	1.0	1.2	4.2	-0.1	-2.0	-1.2	-1.1	-0.3	-1.0	-0.7
Medication: Aspirin	1.0	1.4	3.1	0.3	1.8	1.4	1.0	1.1	1.0	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.6	0.4	-0.6	-0.2	0.1	1.4	1.9	1.4
Hearing aid user	1.0	1.1	2.3	-1.5	-1.0	-1.2	-0.9	0.8	0.7	0.9
Neuroticism (Nagel 2018)	0.9	2.1	9.8	0.0	-1.0	-3.1	-0.9	1.2	0.9	0.8
Blood White Count	0.9	6.5	13.3	2.6	1.4	0.6	2.5	3.6	3.6	2.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.7	-1.1	-0.8	-1.2	-1.3	-1.1	-1.1	-1.3
Angina	0.9	1.1	2.0	0.8	1.2	0.1	1.0	1.4	1.4	1.0
High blood pressure (mother)	0.9	1.3	2.7	1.4	-0.7	1.4	1.7	0.8	0.9	0.6
Body mass index (BMI)	0.9	3.6	7.7	-0.7	0.2	-2.5	-0.5	2.7	1.8	2.8
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	7.6	1.5	1.4	2.2	0.1	1.6	2.8	1.3
Prospective memory result	0.9	1.1	2.1	-1.4	-0.4	-1.5	-1.4	-0.7	0.1	-1.1
Hair/balding pattern: Pattern 4	0.9	2.3	7.6	1.6	1.1	2.8	2.0	-0.3	-0.4	-0.7
Medication: Ventolin 100micrograms inhaler	0.9	1.1	4.0	-1.2	-0.6	0.2	-1.2	-0.5	-0.4	-2.0
Leg fat mass (right)	0.9	3.3	10.6	-1.8	0.2	-3.3	-2.8	0.7	-0.1	0.8
Medication: Aspirin	0.9	1.2	2.0	0.2	1.4	1.3	1.0	1.1	0.9	1.2
Financial situation satisfaction	0.9	1.1	2.2	-0.6	0.7	-1.5	-1.4	-0.8	-1.1	-0.9
Worry (Nagel 2018)	0.8	1.8	3.0	1.5	-0.4	-0.8	0.9	1.6	1.7	1.7
Age at First Birth	0.8	1.1	6.9	0.6	0.3	-0.6	-0.3	0.0	-2.6	0.0
BMI	0.8	4.8	9.1	-1.0	-0.1	-3.0	-0.8	3.0	2.3	3.0
Severe depression (siblings)	0.8	0.9	2.1	1.1	-0.3	1.0	0.9	0.9	1.4	0.5
Stomach or abdominal pain in last month	0.8	1.0	2.0	0.6	-1.4	-1.2	0.6	1.3	1.0	-0.4
Trunk fat mass	0.8	3.3	12.2	-1.6	-0.4	-2.7	-3.5	0.6	-0.4	0.9
Waist circumference	0.8	3.0	6.2	0.1	0.3	-1.9	-2.0	2.3	1.4	2.5
Nervous feelings	0.8	1.4	3.3	-0.1	0.1	-0.4	-0.5	-1.8	-1.7	-1.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.1	-1.3	0.3	-1.4	-1.2	-1.0	-1.0	-0.2
Leg fat percentage (right)	0.8	2.9	9.8	-2.2	1.0	-3.1	-2.2	0.2	-0.4	0.3
Exposure to tobacco smoke outside home	0.8	1.1	5.9	0.5	2.4	0.1	0.1	-0.3	-0.6	-0.9
Angina (self-reported)	0.8	1.1	2.0	0.8	1.1	0.1	1.0	1.4	1.4	0.9
Medication: Ibuprofen	0.8	0.9	1.8	0.1	-0.9	-0.6	-1.0	1.4	1.2	1.0
Whole body fat mass	0.8	3.5	10.8	-1.7	-0.5	-3.0	-3.3	0.7	-0.3	0.8
Suffer from ‘nerves’	0.8	1.3	3.1	1.8	0.7	0.0	1.6	1.1	1.2	0.2
Hypertension (Self-reported)	0.8	2.2	4.5	1.5	1.8	2.1	2.1	0.4	-0.0	1.1
Leg fat mass (left)	0.8	3.1	9.5	-1.6	0.3	-3.1	-2.7	1.0	0.2	1.1
Depression (Nagel 2018)	0.7	1.0	2.8	-0.1	0.0	-1.7	-0.8	1.0	1.0	1.4
Prostate Cancer	0.7	1.0	3.1	-0.5	-0.8	0.0	0.9	1.1	1.8	1.0
Height	0.7	13.7	69.2	-0.9	-2.0	2.0	-8.3	-2.9	-2.9	-1.1
Sensitivity / hurt feelings	0.7	1.1	5.8	1.1	0.3	-2.4	-0.3	0.7	0.3	-0.4
Pack years adult smoking proportion	0.7	1.1	2.5	-0.5	1.1	-1.6	-0.5	-0.7	-1.2	-1.3
Trunk fat percentage	0.7	2.8	8.9	-1.8	-0.5	-2.5	-3.0	0.1	-0.8	0.3
High blood pressure	0.7	1.9	4.0	1.3	2.0	1.8	1.9	0.4	0.1	0.8
Forced vital capacity (FVC)	0.7	2.9	7.9	1.2	1.6	1.9	-0.6	1.6	2.8	1.3
Diabetes (self-reported)	0.7	1.0	2.2	-1.0	-0.4	-1.4	-1.0	-0.8	-1.5	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	4.5	0.1	-2.1	-0.7	0.2	0.7	0.7	-0.8
Hip circumference	0.7	3.1	8.0	-1.3	-0.6	-2.5	-2.8	1.4	0.9	1.7
Worrier / anxious feelings	0.7	1.4	6.2	-0.5	-1.6	-2.5	-0.8	0.1	0.2	0.2
Happiness	0.7	0.9	1.6	0.3	-1.3	-1.0	-0.2	1.3	1.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.5	0.8	-0.1	0.3	1.6	1.2	1.2	1.0
Blood clot in the leg (DVT)	0.7	1.0	1.9	-1.3	-0.4	-1.4	-0.9	-1.0	-1.1	-0.0
Gout (self-reported)	0.7	0.9	3.1	-1.2	1.8	-0.6	-0.1	-0.7	-0.8	0.6
Forced vital capacity (FVC), Best measure	0.7	2.7	7.5	1.0	1.3	2.1	-1.0	1.6	2.7	0.8
Body fat percentage	0.7	2.8	8.2	-1.9	-0.2	-2.9	-2.7	0.3	-0.6	0.3
Pulse rate, automated reading	0.7	2.4	6.2	-2.0	-1.0	-2.5	-1.0	-0.9	-1.6	-1.0
Chest pain or discomfort	0.7	1.0	1.9	0.8	-0.5	-0.1	1.2	1.4	1.3	1.1
Knee pain experienced in last month	0.7	1.0	3.4	-0.5	0.4	-1.8	-1.8	0.1	-0.2	-0.3
Illnesses of siblings: Diabetes	0.7	0.9	3.6	0.1	1.9	0.4	0.7	0.9	0.9	-0.0
Illnesses of father: None of the above (group 1)	0.7	0.8	2.8	0.5	1.0	0.1	-0.4	-1.3	-1.7	-0.2
Number of self-reported non-cancer illnesses	0.7	1.2	4.1	-1.4	-0.7	-2.0	-1.0	0.5	-0.3	0.6
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.2	0.8	-0.6	0.3	1.4	1.3	0.8
Medication: Blood pressure	0.7	1.4	4.1	0.5	1.7	2.0	0.2	-1.1	-1.1	-0.3
Leg fat percentage (left)	0.7	2.7	9.1	-1.8	1.3	-3.0	-1.9	0.7	0.1	0.9
Fractured/broken bones in last 5 years	0.7	0.9	3.0	0.5	-1.2	-0.6	-0.2	1.1	0.4	1.7
Alcohol drinker status: Previous	0.7	0.8	2.8	1.7	0.1	1.3	0.5	0.7	0.3	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	3.1	0.3	1.1	-0.2	0.5	-1.1	-1.8	-0.3
Mean Putamen Volume	0.6	0.7	2.8	-0.1	-0.0	-1.7	-0.3	-1.0	-0.8	-0.3
Lupus	0.6	0.9	1.7	1.0	0.3	0.5	0.9	0.7	1.3	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.9	-0.4	-0.8	-0.8	-0.2	1.4	1.3	0.8
Current tobacco smoking	0.6	0.9	2.9	-1.0	0.0	-1.1	-1.7	-0.2	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	-0.2	-1.3	-1.1	-0.6	0.5	0.7	0.7
Weight	0.6	3.2	11.6	-1.1	-0.7	-2.1	-3.4	1.3	0.4	1.6
Alcohol intake versus 10 years previously	0.6	1.0	2.7	-1.2	1.2	-1.7	-0.9	-0.1	-0.6	-0.1
Depression (self-reported)	0.6	0.7	2.0	0.7	0.6	0.6	0.3	1.4	0.9	0.7
Arm fat mass (right)	0.6	2.5	6.7	-1.0	-0.8	-2.6	-2.0	1.6	0.6	1.4
Loud music exposure frequency	0.6	0.7	2.4	-0.8	-1.2	-0.1	-0.5	-0.0	0.1	-1.5
Arm fat-free mass (right)	0.6	2.9	13.0	-0.6	-0.1	-1.9	-3.6	0.8	0.2	1.6
Number of children fathered	0.6	0.6	1.4	0.8	1.0	1.2	1.0	0.5	0.4	0.0
Neck or shoulder pain in last month	0.6	0.9	3.4	-0.6	1.8	-1.4	-0.8	0.3	-0.1	0.3
Heart disease (mother)	0.6	0.7	1.8	0.1	0.7	-0.6	0.4	1.2	1.3	0.6
Arm predicted mass (right)	0.6	2.9	12.5	-0.5	-0.2	-1.8	-3.5	1.1	0.5	1.6
Leg fat-free mass (right)	0.6	3.4	7.3	0.9	-1.1	-0.7	-1.8	2.7	1.8	2.7
Ever had bowel cancer screening	0.6	0.7	1.3	-0.6	-0.6	0.1	-1.1	1.1	1.1	0.9
Friendships satisfaction	0.6	0.8	1.9	0.7	-0.8	0.5	0.8	1.2	1.4	-0.2
Medication for cholesterol	0.6	0.8	2.9	0.1	-1.7	-1.2	0.4	0.9	0.7	0.4
Leg predicted mass (right)	0.6	3.4	7.3	0.9	-1.2	-0.7	-1.9	2.7	1.8	2.7
Arm fat mass (left)	0.6	2.5	6.3	-1.0	-0.5	-2.5	-2.0	1.6	0.6	1.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.8	-0.9	-1.1	-1.7	-0.3	-0.0	-0.5	0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	-0.6	-1.1	-1.3	-1.1	-0.2	-0.2	0.3
Cholesterol lowering medication	0.6	0.9	1.9	-1.4	1.2	-0.8	-1.2	-0.5	-0.7	0.1
Basal cell carcinoma (self-reported)	0.6	0.7	3.1	-1.8	-0.9	-0.7	-0.4	-0.1	-0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	-1.2	0.1	-0.9	-0.9	-1.0	-1.0	-0.1
Pack years of smoking	0.6	0.8	2.4	-0.3	1.6	-0.8	-0.3	-0.7	-1.1	-1.0
Arm predicted mass (left)	0.6	2.9	12.1	-0.9	-0.7	-2.0	-3.5	0.9	0.4	1.4
HDL Cholesterol	0.5	0.8	4.5	-0.3	-2.1	-0.7	0.1	0.0	-0.6	0.0
Neuroticism (2016)	0.5	0.7	3.4	-0.3	-0.5	-1.9	-1.0	0.4	0.4	0.1
Rheumatoid Arthritis	0.5	0.6	1.3	-1.1	0.4	0.0	-1.1	-1.1	-0.6	-0.6
Schizophrenia (2014)	0.5	1.2	8.3	0.2	-0.3	-0.3	0.0	0.0	2.9	0.0
Waist Hip Ratio (WHR)	0.5	2.4	10.2	3.2	0.6	0.6	0.1	1.7	1.3	1.4
Systolic Blood Pressure	0.5	2.5	6.0	0.9	1.9	2.5	1.7	-1.4	-1.3	-0.7
Cardiovascular Disease	0.5	1.5	2.8	0.8	1.2	0.6	1.2	1.6	1.2	1.7
Hair Pigment	0.5	15.2	32.0	1.3	0.6	-0.0	3.7	5.4	5.7	5.4
Relative age of first facial hair	0.5	1.0	4.2	-0.9	-2.1	0.7	-1.1	0.4	0.1	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	-1.3	0.1	-0.1	-1.5	-0.4	-0.4	-0.0
Leg fat-free mass (left)	0.5	2.7	5.4	0.4	-1.2	-1.0	-2.3	2.1	1.2	2.2
Townsend deprivation index at recruitment	0.5	0.7	3.2	0.4	0.7	0.0	-0.1	0.8	0.2	1.8
Taking other prescription medications	0.5	0.8	2.1	-0.8	-0.7	-1.2	-1.4	0.4	-0.2	0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	-0.2	-1.0	-0.4	-1.0	-0.3	-0.3	-1.3
Leg predicted mass (left)	0.5	2.6	5.7	0.4	-1.3	-1.1	-2.4	2.0	1.1	2.0
Had other major operations	0.5	0.6	2.3	-0.2	-0.3	-0.7	-1.5	-0.7	-0.8	-0.4
Illnesses of siblings	0.5	0.8	2.8	0.4	1.2	1.7	0.3	-0.6	-0.5	-0.5
Arm fat percentage (right)	0.5	2.1	6.2	-1.0	-1.1	-2.5	-1.0	1.8	0.8	1.3
Time employed in main current job	0.5	0.5	2.3	-0.2	-0.7	-1.5	-0.8	-0.4	-0.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.2	-0.2	-0.2	-0.3	-0.2	1.1	1.5	0.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.1	0.3	1.4	-0.8	-0.8	-0.1	-0.5	1.4
Illnesses of mother	0.5	0.6	2.0	-0.9	-0.2	0.0	-1.4	-0.8	-0.7	0.1
Birth weight of first child	0.5	0.9	2.1	1.4	-0.7	0.8	1.4	0.8	0.8	-0.1
Headache pain in last month	0.5	0.8	2.3	0.1	-1.0	-1.3	-0.1	-0.2	-0.8	-1.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.4	-0.5	-0.1	-1.8	-1.2	-0.7	-0.9	-0.1
Age at first live birth	0.5	0.9	2.9	0.7	-1.7	0.7	1.4	0.4	0.3	0.1
Pulse wave peak to peak time	0.5	0.5	1.9	-1.4	0.5	1.0	-0.4	-0.5	-0.3	0.1
Shortness of breath walking on level ground	0.5	0.6	1.6	1.3	-0.6	-0.1	0.4	1.1	0.3	-0.9
Comparative height size at age 10	0.5	2.8	16.0	-0.8	-0.0	-0.0	-4.0	-1.3	-1.0	-0.1
Number of full sisters	0.5	0.6	1.9	-0.1	0.2	-0.3	-0.8	1.4	1.1	0.6
Family relationship satisfaction	0.5	0.7	1.1	-0.9	-0.8	-0.8	-1.1	-0.7	-0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	0.3	0.7	0.6	0.9	0.7	0.8	1.1
Illnesses of father: Heart disease	0.5	0.7	1.9	0.8	-0.4	-0.3	0.9	1.3	1.4	-0.0
Whole body fat-free mass	0.5	2.7	6.8	0.6	-0.8	-0.7	-2.6	2.0	1.4	2.2
Arm fat percentage (left)	0.5	2.0	5.3	-0.9	-0.7	-2.3	-1.1	1.8	0.8	1.4
Whole body water mass	0.5	2.7	6.8	0.5	-0.9	-0.8	-2.6	2.0	1.3	2.2
Guilty feelings	0.5	0.8	2.0	-0.5	-0.8	-1.4	-0.9	-0.2	0.1	-1.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.6	-0.5	1.6	-0.8	-0.8	0.4	0.3	0.4
Medication: Paracetamol	0.5	0.8	3.9	-0.2	-0.2	-2.0	-1.3	0.4	-0.0	0.1
Illnesses of father: High blood pressure	0.5	0.7	2.2	-0.8	-0.5	-0.9	-0.2	0.2	0.8	-1.5
Basal metabolic rate	0.5	2.8	8.4	0.2	-0.8	-1.2	-2.9	1.9	1.1	2.0
Arm fat-free mass (left)	0.5	2.5	10.2	-0.4	-0.4	-1.9	-3.2	1.1	0.5	1.5
Age started oral contraceptive pill	0.5	0.6	2.7	1.1	0.2	-0.3	-0.4	0.4	0.1	1.6
Crohns Disease (2017)	0.4	0.9	4.4	-2.1	-0.2	-0.5	-1.1	-0.2	-0.1	-0.6
HbA1C	0.4	0.4	1.1	-0.4	-0.9	-0.9	-1.1	0.0	-0.1	0.0
Hypothyroidism (self reported)	0.4	0.9	1.6	-0.7	-0.1	-1.0	-1.1	-1.3	-1.3	-0.3
Neuroticism	0.4	1.0	5.1	0.6	-0.6	-2.3	-0.5	0.6	0.6	0.7
Average weekly spirits intake	0.4	0.5	1.1	-0.6	-1.0	-0.7	-0.9	-0.4	-0.8	0.5
Hand grip strength (right)	0.4	1.1	5.0	-0.9	0.9	-0.5	-2.2	-0.6	-0.3	0.3
Age when periods started (menarche)	0.4	0.9	2.5	-0.6	-1.3	-0.7	-1.6	-0.2	-0.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	0.3	0.5	-1.3	-0.1	1.1	1.1	0.1
Heart attack	0.4	0.5	2.2	0.5	1.5	0.0	1.1	-0.0	0.1	-0.3
Neuroticism score	0.4	0.8	5.2	0.4	-0.4	-2.3	-0.4	-0.1	0.0	-0.4
Trunk fat-free mass	0.4	2.2	7.2	0.5	-0.5	-0.4	-2.7	1.6	1.2	1.9
Falls in the last year	0.4	0.5	1.5	0.3	-1.2	-0.6	-0.7	0.7	0.4	0.7
Pulse rate	0.4	0.7	2.6	-0.2	-1.6	-1.1	0.3	0.6	0.2	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	2.4	1.5	-0.6	-0.8	0.1	0.4	0.1	-0.2
Trunk predicted mass	0.4	2.3	7.2	0.5	-0.6	-0.4	-2.7	1.6	1.2	1.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	1.3	0.4	-0.7	0.4	-0.4	-0.7	-0.6
Emphysema/chronic bronchitis	0.4	0.4	1.6	0.0	1.3	0.2	0.7	0.5	0.2	0.8
Commuting to job workplace: Walk	0.4	0.4	1.0	0.7	0.5	-0.0	1.0	0.7	0.4	0.9
Asthma (self-reported)	0.4	0.8	4.4	0.0	-2.1	-0.8	-0.1	0.5	0.4	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	0.0	0.9	-0.4	-0.9	-0.7	-1.0	-0.0
Medication: Atorvastatin	0.4	0.5	2.2	0.5	1.5	0.0	0.8	0.1	0.0	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	0.5	1.3	0.1	1.1	0.1	0.2	-0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.2	0.2	1.5	0.7	0.7	0.9	1.2	1.4
Ovarian Cancer	0.3	0.4	1.0	1.0	0.1	0.3	0.7	0.9	0.7	0.5
Coronary Artery Disease (CAD)	0.3	0.4	1.2	-0.7	-0.2	0.9	-0.1	0.0	1.1	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	-0.7	-0.2	-1.0	-0.6	0.0	-0.5	0.0
Blood Platelet Count	0.3	3.9	10.4	0.3	-1.5	-1.3	0.8	2.4	2.5	3.2
Heel T-Score	0.3	2.0	7.7	-0.9	2.8	1.1	1.0	-1.2	-1.2	-0.5
Lung FEV1/FVC ratio	0.3	1.5	3.3	-0.5	1.0	0.7	-0.5	-1.7	-1.8	-1.5
Hand grip strength (left)	0.3	0.9	2.6	-0.0	1.0	0.2	-0.9	0.7	1.6	1.0
Medication for hormone replacement therapy	0.3	0.3	1.1	0.5	-1.1	0.4	0.5	0.4	0.4	0.1
Diabetes (father)	0.3	0.4	0.8	0.6	0.4	0.7	-0.0	-0.6	-0.6	-0.9
Maternal smoking around birth	0.3	0.5	1.3	-0.7	0.9	0.2	-0.6	-0.4	-0.2	-1.2
Relative age voice broke	0.3	0.5	1.3	-0.4	-1.1	1.1	-0.5	-0.2	-0.4	-0.3
Had menopause	0.3	0.3	0.7	-0.5	-0.1	-0.1	-0.7	-0.4	-0.8	0.8
Financial difficulties in last 2 years	0.3	0.5	0.9	0.1	0.5	-0.7	0.9	1.0	-0.1	0.9
Mouth/teeth dental problems	0.3	0.5	1.8	-0.8	-0.9	1.4	0.4	-0.1	0.2	-0.4
Asthma	0.3	0.6	2.3	0.6	-1.5	-0.7	0.2	0.7	0.5	0.6
Medication: Lansoprazole	0.3	0.3	0.6	-0.6	0.6	-0.6	-0.7	0.4	0.8	0.1
Breastfed as a baby	0.3	0.4	1.2	-0.4	-1.0	1.1	0.4	-0.2	-0.6	0.2
Medication: Paracetamol	0.3	0.5	1.7	0.2	-0.3	-1.3	-0.7	0.8	0.4	0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.1	-0.3	-1.0	-0.6	-1.4	-0.1	-0.3	-0.1
Glaucoma (self-reported)	0.3	0.3	0.7	0.6	0.8	-0.1	-0.1	-0.4	-0.9	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	1.0	-0.0	-0.3	0.6	1.3	0.8	0.3
Had major operations	0.3	0.4	1.2	-0.3	1.1	-0.2	-0.2	0.9	0.8	-0.2
Smoking status: Current	0.3	0.4	1.2	-0.5	0.2	-1.0	-1.1	0.2	-0.3	-0.2
Miserableness	0.3	0.5	1.8	0.3	0.9	-1.4	-0.1	0.6	0.8	0.1
Wears glasses or contact lenses	0.3	0.4	1.1	-0.1	0.6	-0.3	-0.3	0.8	0.1	1.1
Medication: Lisinopril	0.3	0.4	0.8	0.6	0.7	0.9	0.8	0.1	0.4	-0.4
Diastolic blood pressure, automated reading	0.3	0.9	1.8	-0.0	1.3	1.4	1.1	0.1	0.2	1.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.1	0.8	-0.8	0.7	0.4	0.0	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-0.1	0.3	0.9	-0.2	0.6	0.9	1.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.8	0.6	-0.6	-0.7	0.0	-0.3	0.0
Crohns Disease (2012)	0.2	0.2	1.3	0.6	0.2	0.1	0.2	0.0	1.2	0.0
Fasting Glucose	0.2	0.3	0.8	0.6	-0.9	0.5	0.6	0.0	0.4	0.0
Blood Eosinophil Count	0.2	1.6	7.3	1.5	2.7	0.9	0.2	0.5	-0.0	0.8
Respiratory disease	0.2	0.4	1.9	-0.2	-1.4	-0.5	0.0	0.4	0.0	0.4
Tanning	0.2	2.5	5.2	-2.0	-0.9	-0.5	-1.9	-1.6	-1.0	-2.3
Number of treatments/medications taken	0.2	0.4	1.5	-0.3	0.0	-0.2	-0.4	1.2	0.4	0.8
Systolic blood pressure, automated reading	0.2	0.6	2.0	0.2	0.9	1.4	0.8	-0.4	-0.1	0.8
Medication: Metformin	0.2	0.3	1.1	0.8	1.0	0.4	0.3	0.3	-0.0	-0.1
Sitting height	0.2	1.5	5.0	-0.4	0.7	-0.4	-2.2	-1.3	-1.3	-1.2
Medication: Ramipril	0.2	0.2	0.5	-0.1	-0.3	0.4	0.6	0.7	0.3	0.6
Fluid intelligence score	0.2	0.4	1.2	0.5	1.0	1.1	0.2	0.3	0.3	0.5
Pulse wave reflection index	0.2	0.3	0.8	0.4	0.1	-0.8	-0.4	0.0	-0.0	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.2	0.4	-0.6	0.0	0.7	0.6	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.3	0.3	-0.3	-0.1	0.2	-0.3	0.3	-1.1
Supplements: Vitamin C	0.2	0.2	0.7	-0.2	-0.1	0.3	-0.4	0.5	0.8	-0.3
Diabetes diagnosed by doctor	0.2	0.4	1.3	-0.3	0.3	-0.8	-0.7	-0.4	-1.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	-0.2	0.2	-1.3	-0.4	-0.4	-0.4	-0.7
Medication: Gliclazide	0.2	0.2	0.5	0.3	0.1	0.7	0.5	0.5	-0.2	0.6
High cholesterol (Self-reported)	0.2	0.4	2.0	-1.4	0.5	-0.6	-0.3	-0.1	0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.8	0.1	0.9	0.0	0.1	0.7	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	-0.1	0.8	0.3	0.5	-0.3	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.0	0.3	0.8	0.6	-0.3	-0.4	-0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.8	-0.0	0.0	-0.1	-0.0	-0.0	0.0	-0.9
Number of live births	0.1	0.1	0.2	0.4	0.3	-0.1	-0.4	0.4	0.4	0.2
Medication: Cholesterol lowering	0.1	0.2	0.8	-0.9	0.4	-0.4	0.4	-0.3	0.2	-0.3
Leg pain on walking	0.1	0.2	0.8	-0.2	0.3	-0.9	-0.3	0.1	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.0	0.4	0.4	0.2	-0.3	0.1	-0.1
Osteoporosis (self-reported)	0.1	0.2	0.9	-0.3	-0.4	-0.1	-1.0	-0.1	0.0	-0.0
Medication: Bendroflumethiazide	0.1	0.2	0.8	0.5	0.9	0.3	-0.2	-0.0	-0.1	0.3
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.0	0.3	0.6	0.5	0.2	-0.2	-0.4
Ever depressed for a whole week	0.1	0.1	0.5	-0.0	-0.7	-0.1	-0.2	-0.3	-0.6	0.0

Hub : Genes

C11orf80

Models

Trait associations