Hub : Traits :

Supplements: Fish oil (including cod liver oil)

5 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 203692179 205160074 1 1 5.8e-08 5.8e-10 0.0014 73 PIK3C2B
2 11 65636509 67294308 2 1 9.9e-08 2.0e-07 0.0508 86 C11orf80
3 11 88900816 90296673 1 1 2.5e-07 8.1e-06 0.2910 94 RP11-81M19.3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Breast Cancer 2.83 1 0 0 0 1 C11orf80
Prostate Cancer 2.49 1 0 0 0 1 PIK3C2B
Schizophrenia 1.37 1 0 0 0 1 PIK3C2B
Blood Eosinophil Count 0.42 1 0 0 0 1 PIK3C2B
Blood Platelet Count 0.66 1 0 0 0 1 PIK3C2B
BMI 1.81 2 0 0 0 1 C11orf80 RP11-81M19.3
Height 0.27 1 0 0 0 1 RP11-81M19.3
Waist Hip Ratio (WHR) 2.11 1 1 3 0 1 PIK3C2B
Allergy or Eczema 1.73 1 0 0 0 1 C11orf80
Cardiovascular Disease 0.80 1 0 0 0 1 RP11-81M19.3
Type 2 Diabetes (T2D) 2.39 1 0 0 0 1 PIK3C2B
Lung FEV1/FVC ratio 0.59 1 0 0 0 1 PIK3C2B
Lung FVC 4.18 2 1 3 0 1 C11orf80 PIK3C2B
Neuroticism 2.56 1 0 0 0 1 PIK3C2B
Chronotype (morning person) 1.77 1 0 0 0 1 C11orf80
Hair Pigment 2.37 1 1 3 0 1 RP11-81M19.3
Tanning 2.22 1 1 3 0 1 RP11-81M19.3
Hand grip strength (left) 0.84 1 0 0 0 1 PIK3C2B
Vitamin and mineral supplements 8.35 2 0 0 0 1 PIK3C2B RP11-81M19.3
Supplements: Zinc 3.18 1 0 0 0 1 PIK3C2B
Medication: Co-codamol 4.40 1 0 0 0 1 C11orf80
Pack years adult smoking proportion 2.57 1 0 0 0 1 PIK3C2B
Trunk fat percentage 1.63 1 0 0 0 1 PIK3C2B
Hand grip strength (right) 0.90 1 0 0 0 1 PIK3C2B
Fed-up feelings 6.72 2 0 0 0 1 C11orf80 PIK3C2B
Frequency of unenthusiasm / disinterest in last 2 weeks 3.00 1 0 0 0 1 C11orf80
Multivitamins +/- minerals 7.87 1 0 0 0 1 RP11-81M19.3
Medication: Levothyroxine sodium 1.98 1 0 0 0 1 C11orf80
Sitting height 0.33 1 0 0 0 1 PIK3C2B
Impedance of leg (left) 0.62 1 0 0 0 1 RP11-81M19.3
Trunk fat mass 1.50 2 0 0 0 1 C11orf80 PIK3C2B
Waist circumference 2.26 2 0 0 0 1 PIK3C2B RP11-81M19.3
Alcohol usually taken with meals 6.17 2 0 0 0 1 C11orf80 PIK3C2B
Hair/balding pattern: Pattern 2 2.29 1 0 0 0 1 PIK3C2B
Forced vital capacity (FVC) 1.37 1 0 0 0 1 PIK3C2B
Qualifications: None of the above 2.74 1 0 0 0 1 PIK3C2B
Pain all over the body in last month 5.66 1 0 0 0 1 C11orf80
Diabetes (self-reported) 2.18 1 0 0 0 1 PIK3C2B
Neuroticism score 2.66 1 0 0 0 1 PIK3C2B
Arm fat percentage (right) 1.48 1 0 0 0 1 PIK3C2B
Frequency of tiredness / lethargy in last 2 weeks 3.19 1 0 0 0 1 C11orf80
Forced expiratory volume in 1-second (FEV1) 1.85 1 0 0 0 1 PIK3C2B
Pulse rate 1.92 1 0 0 0 1 PIK3C2B
Forced expiratory volume in 1-second (FEV1), Best measure 2.01 1 0 0 0 1 PIK3C2B
Impedance of arm (left) 0.79 1 0 0 0 1 RP11-81M19.3
Arm fat mass (right) 1.37 2 0 0 0 1 C11orf80 PIK3C2B
Hair/balding pattern: Pattern 4 1.07 1 0 0 0 1 C11orf80
Peak expiratory flow (PEF) 2.50 1 0 0 0 1 PIK3C2B
Medication: Amlodipine 2.66 1 0 0 0 1 RP11-81M19.3
Birth weight 2.56 1 0 0 0 1 PIK3C2B
Forced vital capacity (FVC), Best measure 1.57 1 0 0 0 1 PIK3C2B
Body fat percentage 1.75 2 0 0 0 1 C11orf80 PIK3C2B
Leg fat percentage (right) 1.89 2 0 0 0 1 C11orf80 PIK3C2B
Comparative body size at age 10 3.57 1 1 3 0 1 C11orf80
Number of full brothers 2.30 1 0 0 0 1 C11orf80
Health satisfaction 4.02 1 0 0 0 1 C11orf80
Qualifications: College or University degree 3.83 2 1 3 0 1 C11orf80 PIK3C2B
Mouth/teeth dental problems: Loose teeth 2.58 1 0 0 0 1 C11orf80
Whole body fat mass 1.65 2 0 0 0 1 C11orf80 PIK3C2B
Leg fat mass (right) 1.89 2 0 0 0 1 C11orf80 PIK3C2B
Overall health rating 2.99 2 0 0 0 1 C11orf80 PIK3C2B
Arm fat percentage (left) 1.39 1 0 0 0 1 PIK3C2B
Average weekly red wine intake 5.91 2 0 0 0 1 C11orf80 PIK3C2B
Mood swings 3.90 2 0 0 0 1 C11orf80 PIK3C2B
Long-standing illness, disability or infirmity 1.68 1 0 0 0 1 C11orf80
Ever had bowel cancer screening 3.59 1 0 0 0 1 RP11-81M19.3
Qualifications: nursing, teaching 2.34 1 0 0 0 1 PIK3C2B
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.21 1 0 0 0 1 RP11-81M19.3
Mineral and other dietary supplements 11.43 3 0 0 0 1 C11orf80 PIK3C2B RP11-81M19.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.67 1 0 0 0 1 PIK3C2B
Arm fat mass (left) 1.42 1 0 0 0 1 PIK3C2B
Miserableness 2.65 1 0 0 0 1 PIK3C2B
Wears glasses or contact lenses 4.24 1 0 0 0 1 PIK3C2B
Leg fat percentage (left) 1.63 1 0 0 0 1 C11orf80
Number of operations (self-reported) 2.02 1 0 0 0 1 C11orf80
Irritability 2.28 1 0 0 0 1 PIK3C2B
Age started oral contraceptive pill 3.47 1 0 0 0 1 RP11-81M19.3
Unable to work because of sickness or disability 2.87 1 0 0 0 1 C11orf80
Pain experienced in last month 5.11 2 0 0 0 1 C11orf80 RP11-81M19.3
Impedance of whole body 0.78 1 0 0 0 1 RP11-81M19.3
Leg fat mass (left) 1.72 2 0 0 0 1 C11orf80 PIK3C2B

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.35
GTEx Adipose Visceral Omentum 0 0.0000 1.33
GTEx Adrenal Gland 0 0.0000 1.32
GTEx Artery Aorta 0 0.0000 1.34
GTEx Artery Coronary 0 0.0000 1.25
GTEx Artery Tibial 0 0.0000 1.31
GTEx Brain Caudate basal ganglia 0 0.0000 1.31
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.34
GTEx Brain Cerebellum 0 0.0000 1.32
GTEx Brain Cortex 0 0.0000 1.29
GTEx Brain Frontal Cortex BA9 0 0.0000 1.30
GTEx Brain Hippocampus 0 0.0000 1.22
GTEx Brain Hypothalamus 0 0.0000 1.32
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.19
GTEx Brain Putamen basal ganglia 0 0.0000 1.32
GTEx Breast Mammary Tissue 0 0.0000 1.34
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.29
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.31
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.32
GTEx Cells Transformed fibroblasts 0 0.0000 1.29
GTEx Colon Sigmoid 1 0.0684 1.34
GTEx Colon Transverse 0 0.0000 1.35
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.28
GTEx Esophagus Mucosa 2 0.0602 1.30
GTEx Esophagus Muscularis 0 0.0000 1.35
GTEx Heart Atrial Appendage 0 0.0000 1.33
GTEx Heart Left Ventricle 0 0.0000 1.36
GTEx Liver 0 0.0000 1.29
GTEx Lung 0 0.0000 1.34
GTEx Muscle Skeletal 0 0.0000 1.35
GTEx Nerve Tibial 0 0.0000 1.33
GTEx Ovary 0 0.0000 1.35
GTEx Pancreas 0 0.0000 1.32
GTEx Pituitary 0 0.0000 1.38
GTEx Prostate 0 0.0000 1.42
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.33
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.34
GTEx Small Intestine Terminal Ileum 0 0.0000 1.26
GTEx Spleen 0 0.0000 1.35
GTEx Stomach 0 0.0000 1.33
GTEx Testis 0 0.0000 1.36
GTEx Thyroid 0 0.0000 1.28
GTEx Uterus 0 0.0000 1.27
GTEx Vagina 0 0.0000 1.39
GTEx Whole Blood 0 0.0000 1.31
METSIM Adipose 0 0.0000 1.28
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.36
YFS Blood 0 0.0000 1.30
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.30
TCGA Breast Tumor 0 0.0000 1.34
TCGA Breast Normal 0 0.0000 1.26
TCGA Ovarian Tumor 1 0.0342 1.29
TCGA Prostate Tumor 0 0.0000 1.33