Hub : Traits :

Eye problems/disorders: Glaucoma

25 significantly associated models · 9 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 164933115 166462417 2 1 2.6e-30 1.4e-32 1.0e+00 100 TMCO1
2 4 7060959 8640389 2 1 9.3e-11 1.1e-13 5.8e-08 47 AFAP1-AS1
3 9 21303958 22819407 2 1 5.3e-16 8.5e-18 1.2e-03 86 CDKN2B
4 11 46891901 48287931 1 1 2.2e-08 5.5e-07 5.4e-02 85 PTPMT1
5 14 60168943 61664530 1 1 4.5e-10 2.9e-09 4.2e-02 88 C14orf39
6 17 9114358 10799013 1 1 1.2e-08 1.9e-13 3.2e-06 60 GAS7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 1.14 1 0 0.0 0.00 1.0e+00 PTPMT1
Breast Cancer 1.93 1 0 0.0 0.00 1.0e+00 CDKN2B
Coronary Artery Disease (CAD) 13.09 1 1 3.0 0.00 1.0e+00 CDKN2B
HDL Cholesterol 3.41 1 1 3.0 0.00 1.0e+00 PTPMT1
Type 2 Diabetes (T2D) 2.79 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Platelet Count 0.43 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Red Count 0.42 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood White Count 1.59 2 1 3.0 0.00 1.0e+00 CDKN2B PTPMT1
Heel T-Score 2.77 2 2 6.1 0.00 1.0e+00 C14orf39 GAS7
BMI 0.86 1 0 0.0 0.00 1.0e+00 C14orf39
Height 5.72 4 4 12.1 -0.28 7.2e-01 AFAP1-AS1 C14orf39 GAS7 PTPMT1
Waist Hip Ratio (WHR) 2.52 3 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1 TMCO1
Systolic Blood Pressure 2.53 2 2 6.1 0.00 1.0e+00 AFAP1-AS1 PTPMT1
Cardiovascular Disease 1.55 1 0 0.0 0.00 1.0e+00 TMCO1
Respiratory disease 1.54 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Lung FEV1/FVC ratio 1.93 1 1 3.0 0.00 1.0e+00 AFAP1-AS1
Neuroticism 1.52 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Chronotype (morning person) 1.70 1 0 0.0 0.00 1.0e+00 C14orf39
Hair Pigment 0.52 2 1 3.0 0.00 1.0e+00 CDKN2B PTPMT1
Tanning 0.14 1 0 0.0 0.00 1.0e+00 GAS7
Hand grip strength (left) 2.36 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 C14orf39
Average weekly spirits intake 2.46 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Hearing difficulty/problems: Yes 2.41 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Systolic blood pressure, automated reading 1.99 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 PTPMT1
Angina 12.70 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Metformin 2.79 1 0 0.0 0.00 1.0e+00 CDKN2B
Severe depression (siblings) 2.02 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Impedance of leg (right) 1.22 1 0 0.0 0.00 1.0e+00 C14orf39
Leg fat-free mass (left) 3.10 1 1 3.0 0.00 1.0e+00 C14orf39
Trunk fat percentage 1.09 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Hand grip strength (right) 2.44 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 C14orf39
Fed-up feelings 1.53 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Age when periods started (menarche) 3.59 1 1 3.0 0.00 1.0e+00 C14orf39
Heel bone mineral density (BMD) T-score, automated (left) 3.45 2 1 3.0 0.00 1.0e+00 C14orf39 GAS7
High blood pressure 1.43 1 0 0.0 0.00 1.0e+00 PTPMT1
Medication: Atenolol 2.41 1 0 0.0 0.00 1.0e+00 CDKN2B
Sitting height 4.39 3 3 9.1 0.00 1.0e+00 AFAP1-AS1 C14orf39 GAS7
Body mass index (BMI) 1.07 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Impedance of leg (left) 1.04 1 0 0.0 0.00 1.0e+00 C14orf39
Leg predicted mass (left) 3.04 1 1 3.0 0.00 1.0e+00 C14orf39
Trunk fat mass 1.41 1 0 0.0 0.00 1.0e+00 C14orf39
Waist circumference 1.17 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Nervous feelings 1.39 1 0 0.0 0.00 1.0e+00 C14orf39
Forced vital capacity (FVC) 2.07 2 0 0.0 0.00 1.0e+00 C14orf39 GAS7
Heel bone mineral density (BMD) T-score, automated (right) 3.06 1 1 3.0 0.00 1.0e+00 C14orf39
Mouth/teeth dental problems 2.54 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack 9.84 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Simvastatin 2.24 1 0 0.0 0.00 1.0e+00 CDKN2B
Fluid intelligence score 1.20 1 0 0.0 0.00 1.0e+00 PTPMT1
Neuroticism score 1.85 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Weight 2.53 1 1 3.0 0.00 1.0e+00 C14orf39
Impedance of arm (right) 0.72 1 0 0.0 0.00 1.0e+00 CDKN2B
Arm fat percentage (right) 1.37 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Trunk fat-free mass 5.06 3 1 3.0 0.00 1.0e+00 C14orf39 GAS7 PTPMT1
Hip circumference 1.61 1 1 3.0 0.00 1.0e+00 C14orf39
Father's age at death 3.77 1 0 0.0 0.00 1.0e+00 CDKN2B
Forced expiratory volume in 1-second (FEV1) 1.63 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Asthma 1.48 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Medication: Cholesterol lowering 2.78 1 0 0.0 0.00 1.0e+00 CDKN2B
Illnesses of mother 1.98 1 0 0.0 0.00 1.0e+00 CDKN2B
Forced expiratory volume in 1-second (FEV1), Best measure 1.50 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Impedance of arm (left) 0.71 1 0 0.0 0.00 1.0e+00 C14orf39
Arm fat mass (right) 1.30 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 C14orf39
Trunk predicted mass 5.13 3 1 3.0 0.00 1.0e+00 C14orf39 GAS7 PTPMT1
Standing height 5.81 4 4 12.1 0.22 7.8e-01 AFAP1-AS1 C14orf39 GAS7 PTPMT1
Birth weight of first child 1.00 1 0 0.0 0.00 1.0e+00 PTPMT1
Glaucoma (self-reported) 40.16 6 5 15.2 1.00 1.6e-05 AFAP1-AS1 C14orf39 CDKN2B GAS7 PTPMT1 TMCO1
Forced vital capacity (FVC), Best measure 1.63 1 0 0.0 0.00 1.0e+00 C14orf39
Body fat percentage 0.99 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Leg fat percentage (right) 0.81 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Arm fat-free mass (right) 4.02 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1
Wheeze or whistling in the chest in last year 1.19 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Age at first live birth 2.74 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 GAS7
Shortness of breath walking on level ground 2.48 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Qualifications: College or University degree 1.32 1 0 0.0 0.00 1.0e+00 C14orf39
Eye problems/disorders: None of the above 6.38 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 TMCO1
Angina (self-reported) 12.55 1 1 3.0 0.00 1.0e+00 CDKN2B
Heart disease (mother) 6.29 1 1 3.0 0.00 1.0e+00 CDKN2B
Whole body fat mass 1.13 1 0 0.0 0.00 1.0e+00 C14orf39
Leg fat mass (right) 0.83 1 0 0.0 0.00 1.0e+00 C14orf39
Arm predicted mass (right) 4.18 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1
Comparative height size at age 10 3.07 3 1 3.0 0.00 1.0e+00 C14orf39 GAS7 PTPMT1
Chest pain or discomfort 1.79 1 0 0.0 0.00 1.0e+00 CDKN2B
Had major operations 3.79 1 0 0.0 0.00 1.0e+00 C14orf39
Age at last live birth 2.72 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Medication: Aspirin 5.54 1 1 3.0 0.00 1.0e+00 CDKN2B
Hypertension (Self-reported) 1.50 1 0 0.0 0.00 1.0e+00 PTPMT1
Illnesses of father: Heart disease 11.98 1 1 3.0 0.00 1.0e+00 CDKN2B
Forced expiratory volume in 1-second (FEV1), predicted 3.87 3 0 0.0 0.00 1.0e+00 AFAP1-AS1 C14orf39 GAS7
Whole body fat-free mass 4.43 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1
Leg fat-free mass (right) 3.29 1 1 3.0 0.00 1.0e+00 C14orf39
Arm fat percentage (left) 1.35 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Long-standing illness, disability or infirmity 2.76 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication for cholesterol 2.97 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Breast cancer (self-reported) 2.29 1 0 0.0 0.00 1.0e+00 CDKN2B
Osteoarthritis (self-reported) 1.57 1 0 0.0 0.00 1.0e+00 GAS7
Medication: Aspirin 5.34 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Gliclazide 1.97 1 0 0.0 0.00 1.0e+00 CDKN2B
Illnesses of father: None of the above (group 1) 5.14 1 1 3.0 0.00 1.0e+00 CDKN2B
Whole body water mass 4.37 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1
Leg predicted mass (right) 3.30 1 1 3.0 0.00 1.0e+00 C14orf39
Arm fat mass (left) 1.12 2 0 0.0 0.00 1.0e+00 AFAP1-AS1 C14orf39
Miserableness 1.79 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Medication: Atorvastatin 3.90 1 1 3.0 0.00 1.0e+00 CDKN2B
Basal metabolic rate 3.99 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1
Leg fat percentage (left) 0.77 1 0 0.0 0.00 1.0e+00 AFAP1-AS1
Arm fat-free mass (left) 4.65 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1
Number of operations (self-reported) 2.63 1 0 0.0 0.00 1.0e+00 C14orf39
Diastolic blood pressure, automated reading 1.86 2 0 0.0 0.00 1.0e+00 CDKN2B PTPMT1
Myopia 4.07 2 0 0.0 0.00 1.0e+00 C14orf39 TMCO1
Vascular/heart problems diagnosed by doctor 1.74 2 0 0.0 0.00 1.0e+00 CDKN2B PTPMT1
Cholesterol lowering medication 1.52 1 0 0.0 0.00 1.0e+00 CDKN2B
Basal cell carcinoma (self-reported) 3.60 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 10.08 1 1 3.0 0.00 1.0e+00 CDKN2B
Heart disease (siblings) 1.74 1 0 0.0 0.00 1.0e+00 CDKN2B
Impedance of whole body 0.86 1 0 0.0 0.00 1.0e+00 C14orf39
Leg fat mass (left) 0.87 1 0 0.0 0.00 1.0e+00 C14orf39
Arm predicted mass (left) 4.75 2 1 3.0 0.00 1.0e+00 C14orf39 PTPMT1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.20
GTEx Adipose Visceral Omentum 0 0.0000 1.21
GTEx Adrenal Gland 0 0.0000 1.18
GTEx Artery Aorta 1 0.0336 1.23
GTEx Artery Coronary 0 0.0000 1.24
GTEx Artery Tibial 2 0.0532 1.22
GTEx Brain Caudate basal ganglia 0 0.0000 1.23
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.22
GTEx Brain Cerebellum 1 0.0505 1.14
GTEx Brain Cortex 0 0.0000 1.18
GTEx Brain Frontal Cortex BA9 0 0.0000 1.15
GTEx Brain Hippocampus 0 0.0000 1.26
GTEx Brain Hypothalamus 0 0.0000 1.23
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.16
GTEx Brain Putamen basal ganglia 0 0.0000 1.06
GTEx Breast Mammary Tissue 0 0.0000 1.22
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.26
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.26
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.19
GTEx Cells Transformed fibroblasts 1 0.0238 1.21
GTEx Colon Sigmoid 1 0.0684 1.21
GTEx Colon Transverse 0 0.0000 1.19
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.18
GTEx Esophagus Mucosa 2 0.0602 1.20
GTEx Esophagus Muscularis 0 0.0000 1.18
GTEx Heart Atrial Appendage 0 0.0000 1.20
GTEx Heart Left Ventricle 0 0.0000 1.23
GTEx Liver 0 0.0000 1.25
GTEx Lung 1 0.0348 1.20
GTEx Muscle Skeletal 1 0.0346 1.18
GTEx Nerve Tibial 0 0.0000 1.18
GTEx Ovary 0 0.0000 1.24
GTEx Pancreas 0 0.0000 1.25
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.21
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.28
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.22
GTEx Small Intestine Terminal Ileum 0 0.0000 1.24
GTEx Spleen 0 0.0000 1.16
GTEx Stomach 0 0.0000 1.26
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 0 0.0000 1.14
GTEx Uterus 0 0.0000 1.28
GTEx Vagina 0 0.0000 1.22
GTEx Whole Blood 2 0.1004 1.20
METSIM Adipose 1 0.0217 1.13
NTR Blood 1 0.0416 1.21
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.21
YFS Blood 0 0.0000 1.14
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.21
TCGA Breast Tumor 0 0.0000 1.18
TCGA Breast Normal 0 0.0000 1.14
TCGA Ovarian Tumor 0 0.0000 1.18
TCGA Prostate Tumor 1 0.0289 1.19