Hub : Traits :

Medication: Ibuprofen

4 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 12020241 13990267 2 1 1.1e-07 2.7e-08 1 100 RP1-257A7.5
2 12 56805309 58303535 2 2 7.6e-11 6.9e-11 1 100 LRP1 STAT6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 1.50 1 0 0.0 0 1 STAT6
Coronary Artery Disease (CAD) 12.65 1 1 3.0 0 1 RP1-257A7.5
Crohns Disease (2012) 1.80 1 0 0.0 0 1 STAT6
Primary Biliary Cirrhosis 5.73 2 0 0.0 0 1 LRP1 STAT6
Schizophrenia 2.70 1 0 0.0 0 1 STAT6
Blood Eosinophil Count 2.19 2 1 3.0 0 1 LRP1 STAT6
Blood Platelet Count 0.55 1 0 0.0 0 1 LRP1
Blood Red Count 0.66 1 0 0.0 0 1 RP1-257A7.5
Blood White Count 0.67 1 0 0.0 0 1 RP1-257A7.5
BMI 1.79 1 0 0.0 0 1 LRP1
Height 1.97 2 2 6.1 0 1 LRP1 STAT6
Systolic Blood Pressure 2.62 1 1 3.0 0 1 RP1-257A7.5
Allergy or Eczema 5.68 2 0 0.0 0 1 LRP1 STAT6
Respiratory disease 15.44 2 2 6.1 0 1 LRP1 STAT6
Lung FEV1/FVC ratio 11.28 2 2 6.1 0 1 LRP1 STAT6
Neuroticism 3.79 2 0 0.0 0 1 LRP1 STAT6
Chronotype (morning person) 1.04 1 0 0.0 0 1 RP1-257A7.5
Hair Pigment 0.27 1 0 0.0 0 1 LRP1
Hand grip strength (left) 4.67 2 1 3.0 0 1 RP1-257A7.5 STAT6
Number of treatments/medications taken 6.65 3 0 0.0 0 1 LRP1 RP1-257A7.5 STAT6
Sensitivity / hurt feelings 3.81 2 0 0.0 0 1 LRP1 STAT6
Systolic blood pressure, automated reading 3.80 2 0 0.0 0 1 LRP1 RP1-257A7.5
Angina 8.37 1 1 3.0 0 1 RP1-257A7.5
Vitamin and mineral supplements 11.74 2 1 3.0 0 1 LRP1 STAT6
Supplements: Zinc 4.33 2 0 0.0 0 1 LRP1 STAT6
Pack years adult smoking proportion 1.98 1 0 0.0 0 1 LRP1
Leg fat-free mass (left) 1.15 1 0 0.0 0 1 STAT6
Trunk fat percentage 2.06 2 0 0.0 0 1 LRP1 RP1-257A7.5
Hand grip strength (right) 5.87 3 0 0.0 0 1 LRP1 RP1-257A7.5 STAT6
Tinnitus: Yes, but not now, but have in the past 4.50 1 0 0.0 0 1 STAT6
High blood pressure 1.05 1 0 0.0 0 1 RP1-257A7.5
Hayfever, allergic rhinitis or eczema 5.69 2 0 0.0 0 1 LRP1 STAT6
Multivitamins +/- minerals 5.96 2 0 0.0 0 1 LRP1 STAT6
Supplements: Glucosamine 2.00 1 0 0.0 0 1 LRP1
Sitting height 4.35 2 2 6.1 0 1 LRP1 STAT6
High blood pressure (mother) 3.32 1 0 0.0 0 1 RP1-257A7.5
Body mass index (BMI) 1.29 1 0 0.0 0 1 LRP1
Leg predicted mass (left) 1.17 1 0 0.0 0 1 STAT6
Alcohol usually taken with meals 2.96 1 0 0.0 0 1 LRP1
Hearing difficulty/problems with background noise 2.12 1 0 0.0 0 1 STAT6
Hair/balding pattern: Pattern 2 3.14 1 0 0.0 0 1 LRP1
Forced vital capacity (FVC) 1.70 2 0 0.0 0 1 LRP1 STAT6
Qualifications: None of the above 1.32 1 0 0.0 0 1 LRP1
Heart attack 15.92 1 1 3.0 0 1 RP1-257A7.5
Allergy 9.51 2 1 3.0 0 1 LRP1 STAT6
Hayfever/allergic rhinitis (self-reported) 8.26 2 0 0.0 0 1 LRP1 STAT6
Fluid intelligence score 3.34 2 0 0.0 0 1 LRP1 STAT6
Arm fat percentage (right) 2.08 2 0 0.0 0 1 LRP1 RP1-257A7.5
Trunk fat-free mass 2.97 2 1 3.0 0 1 LRP1 STAT6
Worrier / anxious feelings 2.30 1 0 0.0 0 1 STAT6
Asthma 12.46 2 1 3.0 0 1 LRP1 STAT6
Medication: Ibuprofen (e.g. Nurofen) 35.31 3 3 9.1 0 1 LRP1 RP1-257A7.5 STAT6
Prospective memory result 2.72 1 0 0.0 0 1 LRP1
Pulse wave Arterial Stiffness index 6.83 1 0 0.0 0 1 RP1-257A7.5
Impedance of arm (left) 0.70 1 0 0.0 0 1 STAT6
Trunk predicted mass 3.06 2 1 3.0 0 1 LRP1 STAT6
Standing height 2.59 2 2 6.1 0 1 LRP1 STAT6
Birth weight of first child 2.48 1 0 0.0 0 1 STAT6
Peak expiratory flow (PEF) 1.73 1 0 0.0 0 1 RP1-257A7.5
Pulse wave reflection index 3.57 1 0 0.0 0 1 LRP1
Medication: Paracetamol 25.33 3 2 6.1 0 1 LRP1 RP1-257A7.5 STAT6
Headache pain in last month 58.54 3 3 9.1 0 1 LRP1 RP1-257A7.5 STAT6
Gout (self-reported) 3.09 1 0 0.0 0 1 LRP1
Medication: Ventolin 100micrograms inhaler 6.73 2 0 0.0 0 1 LRP1 STAT6
Birth weight 4.99 3 0 0.0 0 1 LRP1 RP1-257A7.5 STAT6
High blood pressure (siblings) 3.48 1 0 0.0 0 1 LRP1
Forced vital capacity (FVC), Best measure 1.47 1 0 0.0 0 1 STAT6
Body fat percentage 2.47 2 0 0.0 0 1 LRP1 RP1-257A7.5
Leg fat percentage (right) 3.11 2 0 0.0 0 1 LRP1 RP1-257A7.5
Arm fat-free mass (right) 1.83 2 0 0.0 0 1 LRP1 STAT6
Wheeze or whistling in the chest in last year 2.44 1 0 0.0 0 1 STAT6
Pulse wave peak to peak time 5.78 1 0 0.0 0 1 RP1-257A7.5
Medication for pain relief, constipation, heartburn 24.63 3 2 6.1 0 1 LRP1 RP1-257A7.5 STAT6
Neck or shoulder pain in last month 2.74 1 0 0.0 0 1 LRP1
Angina (self-reported) 8.42 1 1 3.0 0 1 RP1-257A7.5
Migraine (self-reported) 57.41 3 3 9.1 0 1 LRP1 RP1-257A7.5 STAT6
Medication: Seretide 50 evohaler 5.15 2 0 0.0 0 1 LRP1 STAT6
Heart disease (mother) 5.43 1 0 0.0 0 1 RP1-257A7.5
Leg fat mass (right) 1.19 1 0 0.0 0 1 LRP1
Arm predicted mass (right) 1.78 2 0 0.0 0 1 LRP1 STAT6
Pulse rate, automated reading 1.66 1 0 0.0 0 1 RP1-257A7.5
Alcohol intake frequency. 8.96 3 0 0.0 0 1 LRP1 RP1-257A7.5 STAT6
Had major operations 4.44 1 0 0.0 0 1 RP1-257A7.5
Medication: Aspirin 2.31 1 0 0.0 0 1 RP1-257A7.5
Knee pain experienced in last month 3.02 1 0 0.0 0 1 RP1-257A7.5
Hypertension (Self-reported) 1.22 1 0 0.0 0 1 RP1-257A7.5
Illnesses of father: Heart disease 10.67 1 1 3.0 0 1 RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted 2.00 1 0 0.0 0 1 STAT6
Whole body fat-free mass 2.18 2 1 3.0 0 1 LRP1 STAT6
Leg fat-free mass (right) 1.34 1 0 0.0 0 1 STAT6
Arm fat percentage (left) 2.24 2 0 0.0 0 1 LRP1 RP1-257A7.5
Mood swings 2.97 2 0 0.0 0 1 LRP1 STAT6
Back pain experienced in last month 3.55 1 0 0.0 0 1 LRP1
Mineral and other dietary supplements 6.83 2 0 0.0 0 1 LRP1 STAT6
Asthma (self-reported) 13.12 2 1 3.0 0 1 LRP1 STAT6
Medication: Aspirin 2.61 1 0 0.0 0 1 RP1-257A7.5
Illnesses of father: None of the above (group 1) 2.36 1 0 0.0 0 1 RP1-257A7.5
Whole body water mass 2.20 2 1 3.0 0 1 LRP1 STAT6
Leg predicted mass (right) 1.32 1 0 0.0 0 1 STAT6
Miserableness 4.27 2 0 0.0 0 1 LRP1 STAT6
Guilty feelings 1.48 1 0 0.0 0 1 RP1-257A7.5
Supplements: Fish oil (including cod liver oil) 6.22 2 0 0.0 0 1 LRP1 STAT6
Medication: Bendroflumethiazide 2.67 1 0 0.0 0 1 RP1-257A7.5
Medication: Paracetamol 19.57 3 1 3.0 0 1 LRP1 RP1-257A7.5 STAT6
Alcohol drinker status: Never 3.38 1 0 0.0 0 1 RP1-257A7.5
Basal metabolic rate 1.53 1 0 0.0 0 1 STAT6
Leg fat percentage (left) 3.03 2 0 0.0 0 1 LRP1 RP1-257A7.5
Arm fat-free mass (left) 1.75 1 0 0.0 0 1 STAT6
Number of operations (self-reported) 4.42 1 0 0.0 0 1 LRP1
Average weekly beer plus cider intake 5.89 2 0 0.0 0 1 LRP1 STAT6
Diastolic blood pressure, automated reading 0.84 1 0 0.0 0 1 RP1-257A7.5
Myopia 7.71 2 0 0.0 0 1 LRP1 STAT6
Pain experienced in last month 13.32 3 1 3.0 0 1 LRP1 RP1-257A7.5 STAT6
Supplements: Calcium 4.75 1 0 0.0 0 1 LRP1
Heart attack/myocardial infarction (self-reported) 16.56 1 1 3.0 0 1 RP1-257A7.5
Heart disease (siblings) 7.36 1 1 3.0 0 1 RP1-257A7.5
Alcohol drinker status: Previous 2.49 1 0 0.0 0 1 LRP1
Impedance of whole body 0.64 1 0 0.0 0 1 STAT6
Leg fat mass (left) 1.13 1 0 0.0 0 1 LRP1
Arm predicted mass (left) 1.71 1 0 0.0 0 1 STAT6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.19
GTEx Adipose Visceral Omentum 0 0.0000 1.33
GTEx Adrenal Gland 0 0.0000 1.28
GTEx Artery Aorta 2 0.0672 1.22
GTEx Artery Coronary 0 0.0000 1.32
GTEx Artery Tibial 2 0.0532 1.26
GTEx Brain Caudate basal ganglia 0 0.0000 1.21
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.31
GTEx Brain Cerebellum 0 0.0000 1.24
GTEx Brain Cortex 0 0.0000 1.30
GTEx Brain Frontal Cortex BA9 0 0.0000 1.30
GTEx Brain Hippocampus 0 0.0000 1.31
GTEx Brain Hypothalamus 0 0.0000 1.26
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.29
GTEx Brain Putamen basal ganglia 0 0.0000 1.24
GTEx Breast Mammary Tissue 0 0.0000 1.25
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.26
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.19
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.32
GTEx Cells Transformed fibroblasts 0 0.0000 1.21
GTEx Colon Sigmoid 0 0.0000 1.23
GTEx Colon Transverse 0 0.0000 1.26
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.25
GTEx Esophagus Mucosa 0 0.0000 1.29
GTEx Esophagus Muscularis 0 0.0000 1.26
GTEx Heart Atrial Appendage 0 0.0000 1.26
GTEx Heart Left Ventricle 0 0.0000 1.27
GTEx Liver 0 0.0000 1.26
GTEx Lung 0 0.0000 1.20
GTEx Muscle Skeletal 0 0.0000 1.22
GTEx Nerve Tibial 0 0.0000 1.21
GTEx Ovary 0 0.0000 1.28
GTEx Pancreas 0 0.0000 1.26
GTEx Pituitary 0 0.0000 1.20
GTEx Prostate 0 0.0000 1.28
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.26
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.24
GTEx Small Intestine Terminal Ileum 0 0.0000 1.37
GTEx Spleen 0 0.0000 1.19
GTEx Stomach 0 0.0000 1.28
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 0 0.0000 1.21
GTEx Uterus 0 0.0000 1.30
GTEx Vagina 0 0.0000 1.21
GTEx Whole Blood 0 0.0000 1.17
METSIM Adipose 0 0.0000 1.12
NTR Blood 0 0.0000 1.20
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.19
YFS Blood 0 0.0000 1.14
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.22
TCGA Breast Tumor 0 0.0000 1.20
TCGA Breast Normal 0 0.0000 1.17
TCGA Ovarian Tumor 0 0.0000 1.16
TCGA Prostate Tumor 0 0.0000 1.15