Hub : Traits :

Heart disease (siblings)

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 12595275 13990267 1 1 2.5e-07 2.0e-06 1.0e+00 100 RP1-257A7.5
2 6 160071844 161571560 1 1 6.4e-08 3.3e-08 3.8e-08 1 SLC22A3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder 3.37 1 0 0.0 0 1 RP1-257A7.5
Body Mass Index (BMI) (2010) 2.66 1 0 0.0 0 1 SLC22A3
Coronary Artery Disease (CAD) 25.97 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
LDL Cholesterol 7.32 1 0 0.0 0 1 SLC22A3
Triglycerides 9.03 1 1 3.0 0 1 SLC22A3
Blood Platelet Count 0.30 1 0 0.0 0 1 RP1-257A7.5
Blood Red Count 0.80 1 0 0.0 0 1 RP1-257A7.5
Blood White Count 0.47 1 0 0.0 0 1 RP1-257A7.5
BMI 2.53 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Height 1.82 1 1 3.0 0 1 SLC22A3
Waist Hip Ratio (WHR) 8.20 1 1 3.0 0 1 SLC22A3
Systolic Blood Pressure 3.21 1 1 3.0 0 1 RP1-257A7.5
Cardiovascular Disease 2.98 1 0 0.0 0 1 SLC22A3
Type 2 Diabetes (T2D) 1.69 1 0 0.0 0 1 SLC22A3
Lung FEV1/FVC ratio 0.89 1 0 0.0 0 1 SLC22A3
Lung FVC 0.68 1 0 0.0 0 1 SLC22A3
Chronotype (morning person) 1.78 1 0 0.0 0 1 RP1-257A7.5
Hand grip strength (left) 5.56 1 1 3.0 0 1 RP1-257A7.5
Number of treatments/medications taken 4.16 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Ever had hysterectomy (womb removed) 2.65 1 0 0.0 0 1 SLC22A3
Systolic blood pressure, automated reading 3.70 1 0 0.0 0 1 RP1-257A7.5
Angina 20.15 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Diabetes (father) 3.93 1 0 0.0 0 1 RP1-257A7.5
Impedance of leg (right) 0.53 1 0 0.0 0 1 SLC22A3
Leg fat-free mass (left) 3.67 1 1 3.0 0 1 SLC22A3
Trunk fat percentage 3.04 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Hand grip strength (right) 4.32 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
High blood pressure 1.73 1 0 0.0 0 1 RP1-257A7.5
Multivitamins +/- minerals 2.10 1 0 0.0 0 1 SLC22A3
Sitting height 1.78 1 0 0.0 0 1 SLC22A3
Chronic bronchitis/emphysema (father) 3.99 1 0 0.0 0 1 SLC22A3
High blood pressure (mother) 5.41 1 0 0.0 0 1 RP1-257A7.5
Body mass index (BMI) 1.96 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Leg predicted mass (left) 3.77 1 1 3.0 0 1 SLC22A3
Trunk fat mass 3.82 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Past tobacco smoking 1.73 1 0 0.0 0 1 RP1-257A7.5
Alcohol usually taken with meals 1.88 1 0 0.0 0 1 RP1-257A7.5
Frequency of tenseness / restlessness in last 2 weeks 3.26 1 0 0.0 0 1 SLC22A3
Hair/balding pattern: Pattern 2 3.07 1 0 0.0 0 1 SLC22A3
Had other major operations 2.21 1 0 0.0 0 1 RP1-257A7.5
Heart attack 33.17 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Medication: Ramipril 6.42 1 0 0.0 0 1 SLC22A3
Medication: Simvastatin 6.65 1 0 0.0 0 1 SLC22A3
Illnesses of siblings 4.21 1 0 0.0 0 1 SLC22A3
Weight 3.90 1 1 3.0 0 1 SLC22A3
Arm fat percentage (right) 2.21 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Trunk fat-free mass 2.95 1 1 3.0 0 1 SLC22A3
Hip circumference 4.41 1 1 3.0 0 1 SLC22A3
Alcohol intake versus 10 years previously 2.84 1 0 0.0 0 1 RP1-257A7.5
Medication: Ibuprofen (e.g. Nurofen) 16.85 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Medication: Cholesterol lowering 6.75 1 0 0.0 0 1 SLC22A3
Medication: Lansoprazole 4.05 1 0 0.0 0 1 SLC22A3
Lung cancer (father) 3.98 1 0 0.0 0 1 SLC22A3
Pulse wave Arterial Stiffness index 7.58 1 0 0.0 0 1 RP1-257A7.5
Arm fat mass (right) 3.43 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Trunk predicted mass 2.86 1 1 3.0 0 1 SLC22A3
Standing height 2.18 1 1 3.0 0 1 SLC22A3
Breastfed as a baby 4.58 1 0 0.0 0 1 SLC22A3
Peak expiratory flow (PEF) 1.42 1 0 0.0 0 1 RP1-257A7.5
Pulse wave reflection index 4.67 1 0 0.0 0 1 SLC22A3
Medication: Paracetamol 9.32 1 1 3.0 0 1 RP1-257A7.5
Headache pain in last month 17.08 1 1 3.0 0 1 RP1-257A7.5
Birth weight 2.07 1 0 0.0 0 1 RP1-257A7.5
Body fat percentage 2.58 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Leg fat percentage (right) 1.64 1 0 0.0 0 1 RP1-257A7.5
Arm fat-free mass (right) 2.93 1 1 3.0 0 1 SLC22A3
Pulse wave peak to peak time 7.01 1 0 0.0 0 1 RP1-257A7.5
Health satisfaction 2.29 1 0 0.0 0 1 SLC22A3
Medication for pain relief, constipation, heartburn 5.37 1 0 0.0 0 1 RP1-257A7.5
Angina (self-reported) 21.56 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Migraine (self-reported) 26.61 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Medication: Ibuprofen 15.47 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Heart disease (mother) 17.19 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Whole body fat mass 3.76 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Leg fat mass (right) 3.07 1 0 0.0 0 1 SLC22A3
Arm predicted mass (right) 3.17 1 1 3.0 0 1 SLC22A3
Pulse rate, automated reading 2.41 1 0 0.0 0 1 RP1-257A7.5
Alcohol intake frequency. 7.11 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Comparative height size at age 10 2.05 1 0 0.0 0 1 SLC22A3
Had major operations 4.74 1 0 0.0 0 1 RP1-257A7.5
Leg pain on walking 3.26 1 0 0.0 0 1 SLC22A3
Medication: Aspirin 10.18 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Knee pain experienced in last month 2.56 1 0 0.0 0 1 RP1-257A7.5
Hypertension (Self-reported) 1.95 1 0 0.0 0 1 RP1-257A7.5
Illnesses of father: Heart disease 25.60 2 2 6.1 0 1 RP1-257A7.5 SLC22A3
Illnesses of siblings: Diabetes 3.43 1 0 0.0 0 1 SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted 2.04 1 0 0.0 0 1 SLC22A3
Whole body fat-free mass 3.26 1 1 3.0 0 1 SLC22A3
Leg fat-free mass (right) 3.64 1 1 3.0 0 1 SLC22A3
Arm fat percentage (left) 2.22 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Medication for cholesterol 5.56 1 0 0.0 0 1 SLC22A3
Mineral and other dietary supplements 5.05 1 0 0.0 0 1 SLC22A3
Medication: Aspirin 9.07 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Illnesses of father: None of the above (group 1) 6.68 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Whole body water mass 3.15 1 1 3.0 0 1 SLC22A3
Leg predicted mass (right) 3.65 1 1 3.0 0 1 SLC22A3
Arm fat mass (left) 3.36 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Number of self-reported non-cancer illnesses 2.74 1 0 0.0 0 1 SLC22A3
Guilty feelings 2.16 1 0 0.0 0 1 RP1-257A7.5
Supplements: Fish oil (including cod liver oil) 5.32 1 0 0.0 0 1 SLC22A3
High cholesterol (Self-reported) 16.26 1 1 3.0 0 1 SLC22A3
Medication: Bendroflumethiazide 3.42 1 0 0.0 0 1 RP1-257A7.5
Medication: Paracetamol 7.09 1 0 0.0 0 1 RP1-257A7.5
Medication: Atorvastatin 8.71 1 0 0.0 0 1 SLC22A3
Alcohol drinker status: Never 3.22 1 0 0.0 0 1 RP1-257A7.5
Ever smoked 2.00 1 0 0.0 0 1 RP1-257A7.5
Basal metabolic rate 3.60 1 1 3.0 0 1 SLC22A3
Leg fat percentage (left) 1.60 1 0 0.0 0 1 RP1-257A7.5
Arm fat-free mass (left) 3.07 1 1 3.0 0 1 SLC22A3
Irritability 3.00 1 0 0.0 0 1 SLC22A3
Diastolic blood pressure, automated reading 3.07 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Cholesterol lowering medication 16.57 1 1 3.0 0 1 SLC22A3
Pain experienced in last month 4.04 1 0 0.0 0 1 RP1-257A7.5
Heart attack/myocardial infarction (self-reported) 34.24 2 1 3.0 0 1 RP1-257A7.5 SLC22A3
Leg fat mass (left) 2.98 1 0 0.0 0 1 SLC22A3
Arm predicted mass (left) 3.30 1 1 3.0 0 1 SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.27
GTEx Adipose Visceral Omentum 0 0.0000 1.26
GTEx Adrenal Gland 0 0.0000 1.22
GTEx Artery Aorta 1 0.0336 1.31
GTEx Artery Coronary 0 0.0000 1.35
GTEx Artery Tibial 0 0.0000 1.27
GTEx Brain Caudate basal ganglia 0 0.0000 1.27
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.26
GTEx Brain Cerebellum 0 0.0000 1.30
GTEx Brain Cortex 0 0.0000 1.40
GTEx Brain Frontal Cortex BA9 1 0.1082 1.38
GTEx Brain Hippocampus 0 0.0000 1.41
GTEx Brain Hypothalamus 0 0.0000 1.27
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.32
GTEx Brain Putamen basal ganglia 0 0.0000 1.39
GTEx Breast Mammary Tissue 0 0.0000 1.32
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.21
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.28
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.26
GTEx Cells Transformed fibroblasts 0 0.0000 1.24
GTEx Colon Sigmoid 0 0.0000 1.30
GTEx Colon Transverse 0 0.0000 1.25
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 0 0.0000 1.23
GTEx Esophagus Muscularis 0 0.0000 1.23
GTEx Heart Atrial Appendage 0 0.0000 1.29
GTEx Heart Left Ventricle 0 0.0000 1.31
GTEx Liver 0 0.0000 1.30
GTEx Lung 0 0.0000 1.29
GTEx Muscle Skeletal 0 0.0000 1.26
GTEx Nerve Tibial 0 0.0000 1.25
GTEx Ovary 0 0.0000 1.38
GTEx Pancreas 0 0.0000 1.31
GTEx Pituitary 0 0.0000 1.32
GTEx Prostate 0 0.0000 1.33
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.28
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.37
GTEx Spleen 0 0.0000 1.23
GTEx Stomach 0 0.0000 1.24
GTEx Testis 0 0.0000 1.28
GTEx Thyroid 0 0.0000 1.28
GTEx Uterus 0 0.0000 1.36
GTEx Vagina 0 0.0000 1.32
GTEx Whole Blood 0 0.0000 1.23
METSIM Adipose 0 0.0000 1.19
NTR Blood 0 0.0000 1.15
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.23
YFS Blood 0 0.0000 1.17
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.17
TCGA Breast Tumor 0 0.0000 1.12
TCGA Breast Normal 0 0.0000 1.11
TCGA Ovarian Tumor 0 0.0000 1.21
TCGA Prostate Tumor 0 0.0000 1.16