Hub : Traits :

Pack years of smoking

58 significantly associated models · 16 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 64531160 65911294 1 1 1.2e-07 2.8e-07 0.22 94 JMJD1C-AS1
2 14 103398706 104866687 1 1 8.3e-08 4.8e-07 0.88 100 KLC1
3 15 77589535 79886142 13 4 2.1e-65 1.1e-65 NaN NaN ADAMTS7 CHRNA5 HYKK PSMA4
4 17 35152143 36441093 1 1 1.4e-07 9.4e-07 0.46 98 DUSP14

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Reaction Time 3.14 2 0 0.0 0.00 1.0e+00 CHRNA5 HYKK
Verbal and Numeric Reasoning (VNR) 2.37 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Breast Cancer 1.18 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Schizophrenia 4.31 2 2 6.1 0.00 1.0e+00 KLC1 PSMA4
Triglycerides 1.88 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Blood Eosinophil Count 0.73 1 0 0.0 0.00 1.0e+00 KLC1
Blood Platelet Count 1.68 3 2 6.1 0.00 1.0e+00 ADAMTS7 DUSP14 JMJD1C-AS1
Blood Red Count 1.54 3 1 3.0 0.00 1.0e+00 DUSP14 JMJD1C-AS1 KLC1
Blood White Count 1.99 3 1 3.0 0.00 1.0e+00 DUSP14 JMJD1C-AS1 KLC1
Heel T-Score 4.24 2 1 3.0 0.00 1.0e+00 DUSP14 KLC1
BMI 2.35 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Height 0.72 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Waist Hip Ratio (WHR) 0.72 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Smoking Status 4.19 3 0 0.0 0.00 1.0e+00 CHRNA5 HYKK KLC1
Allergy or Eczema 1.19 1 0 0.0 0.00 1.0e+00 PSMA4
Cardiovascular Disease 1.56 1 1 3.0 0.00 1.0e+00 KLC1
Type 2 Diabetes (T2D) 1.28 1 0 0.0 0.00 1.0e+00 KLC1
Lung FEV1/FVC ratio 2.82 4 1 3.0 0.81 1.9e-01 DUSP14 HYKK JMJD1C-AS1 PSMA4
Lung FVC 2.79 4 2 6.1 0.85 1.5e-01 CHRNA5 HYKK JMJD1C-AS1 PSMA4
Hair Pigment 0.44 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Frequency of depressed mood in last 2 weeks 3.58 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Hearing difficulty/problems: Yes 2.15 1 0 0.0 0.00 1.0e+00 KLC1
Pack years adult smoking proportion 66.95 7 7 21.2 1.00 1.5e-09 ADAMTS7 CHRNA5 DUSP14 HYKK JMJD1C-AS1 KLC1 PSMA4
Impedance of leg (right) 1.92 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Leg fat-free mass (left) 0.99 1 0 0.0 0.00 1.0e+00 KLC1
Trunk fat percentage 0.88 1 0 0.0 0.00 1.0e+00 KLC1
Current tobacco smoking 4.57 3 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1 PSMA4
Maternal smoking around birth 5.40 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Frequency of unenthusiasm / disinterest in last 2 weeks 4.74 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Age when periods started (menarche) 1.94 1 0 0.0 0.00 1.0e+00 PSMA4
Heel bone mineral density (BMD) T-score, automated (left) 2.57 1 1 3.0 0.00 1.0e+00 KLC1
Qualifications: CSEs or equivalent 3.89 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
High blood pressure 1.07 1 0 0.0 0.00 1.0e+00 KLC1
Chronic bronchitis/emphysema (father) 10.30 2 1 3.0 0.00 1.0e+00 HYKK PSMA4
Body mass index (BMI) 2.24 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Impedance of leg (left) 1.97 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Leg predicted mass (left) 0.93 1 0 0.0 0.00 1.0e+00 KLC1
Trunk fat mass 0.89 1 0 0.0 0.00 1.0e+00 KLC1
Waist circumference 1.72 1 1 3.0 0.00 1.0e+00 KLC1
Past tobacco smoking 2.41 1 0 0.0 0.00 1.0e+00 KLC1
Frequency of tenseness / restlessness in last 2 weeks 2.13 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Hearing difficulty/problems with background noise 3.33 1 0 0.0 0.00 1.0e+00 KLC1
Forced vital capacity (FVC) 1.81 2 1 3.0 0.00 1.0e+00 HYKK PSMA4
Heel bone mineral density (BMD) T-score, automated (right) 1.75 1 0 0.0 0.00 1.0e+00 KLC1
Qualifications: None of the above 3.83 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Financial difficulties in last 2 years 4.77 1 0 0.0 0.00 1.0e+00 KLC1
Mouth/teeth dental problems 2.40 1 0 0.0 0.00 1.0e+00 KLC1
Diabetes (self-reported) 1.10 1 0 0.0 0.00 1.0e+00 KLC1
Fluid intelligence score 2.39 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Weight 1.05 1 0 0.0 0.00 1.0e+00 KLC1
Impedance of arm (right) 1.43 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Arm fat percentage (right) 1.80 1 1 3.0 0.00 1.0e+00 KLC1
Hip circumference 1.27 1 0 0.0 0.00 1.0e+00 KLC1
Father's age at death 8.53 2 2 6.1 0.00 1.0e+00 HYKK PSMA4
Frequency of tiredness / lethargy in last 2 weeks 3.18 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Falls in the last year 3.23 2 0 0.0 0.00 1.0e+00 CHRNA5 HYKK
Forced expiratory volume in 1-second (FEV1) 3.51 2 1 3.0 0.00 1.0e+00 HYKK PSMA4
Qualifications: A levels/AS levels or equivalent 2.40 2 0 0.0 0.00 1.0e+00 DUSP14 JMJD1C-AS1
Mouth/teeth dental problems: Dentures 3.79 1 0 0.0 0.00 1.0e+00 PSMA4
Lung cancer (father) 13.22 2 1 3.0 0.00 1.0e+00 HYKK PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure 4.30 3 2 6.1 0.00 1.0e+00 CHRNA5 HYKK PSMA4
Impedance of arm (left) 1.70 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Arm fat mass (right) 1.64 1 1 3.0 0.00 1.0e+00 KLC1
Standing height 0.55 1 0 0.0 0.00 1.0e+00 KLC1
Peak expiratory flow (PEF) 1.75 1 0 0.0 0.00 1.0e+00 PSMA4
Medication: Paracetamol 2.08 1 0 0.0 0.00 1.0e+00 KLC1
Chronic bronchitis/emphysema (mother) 8.65 2 1 3.0 0.00 1.0e+00 HYKK PSMA4
Forced vital capacity (FVC), Best measure 2.35 3 0 0.0 0.00 1.0e+00 CHRNA5 HYKK PSMA4
Body fat percentage 0.99 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat percentage (right) 0.93 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat-free mass (right) 0.62 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Exposure to tobacco smoke outside home 2.49 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Wheeze or whistling in the chest in last year 3.42 1 0 0.0 0.00 1.0e+00 PSMA4
Age at first live birth 2.23 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Qualifications: College or University degree 2.96 2 1 3.0 0.00 1.0e+00 DUSP14 JMJD1C-AS1
Emphysema/chronic bronchitis 5.15 1 0 0.0 0.00 1.0e+00 PSMA4
Medication for pain relief, constipation, heartburn 2.01 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Angina (self-reported) 3.42 1 0 0.0 0.00 1.0e+00 HYKK
Heart disease (mother) 3.02 1 0 0.0 0.00 1.0e+00 PSMA4
Whole body fat mass 1.10 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat mass (right) 1.15 1 0 0.0 0.00 1.0e+00 KLC1
Pulse rate, automated reading 1.01 1 0 0.0 0.00 1.0e+00 KLC1
Comparative height size at age 10 1.05 2 0 0.0 0.00 1.0e+00 DUSP14 KLC1
Overall health rating 3.92 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Hypertension (Self-reported) 1.11 1 0 0.0 0.00 1.0e+00 KLC1
Smoking status: Previous 3.73 1 0 0.0 0.00 1.0e+00 HYKK
Leg fat-free mass (right) 0.88 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat percentage (left) 1.55 1 1 3.0 0.00 1.0e+00 KLC1
Mood swings 1.27 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Loneliness, isolation 3.39 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Long-standing illness, disability or infirmity 4.09 1 0 0.0 0.00 1.0e+00 KLC1
Diabetes diagnosed by doctor 1.52 1 0 0.0 0.00 1.0e+00 KLC1
Qualifications: nursing, teaching 2.92 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Smoking status: Current 4.09 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.94 4 2 6.1 -0.91 9.2e-02 CHRNA5 HYKK JMJD1C-AS1 PSMA4
Leg predicted mass (right) 0.92 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat mass (left) 1.53 1 1 3.0 0.00 1.0e+00 KLC1
Number of self-reported non-cancer illnesses 2.90 1 0 0.0 0.00 1.0e+00 KLC1
Mother's age at death 4.65 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Supplements: Fish oil (including cod liver oil) 2.45 1 0 0.0 0.00 1.0e+00 KLC1
Ever smoked 3.96 2 0 0.0 0.00 1.0e+00 HYKK PSMA4
Leg fat percentage (left) 0.97 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat-free mass (left) 0.94 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Risk taking 4.47 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Diastolic blood pressure, automated reading 1.21 1 0 0.0 0.00 1.0e+00 KLC1
Vascular/heart problems diagnosed by doctor 1.23 1 0 0.0 0.00 1.0e+00 KLC1
Pain experienced in last month 3.30 2 0 0.0 0.00 1.0e+00 CHRNA5 HYKK
Impedance of whole body 1.84 2 1 3.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Leg fat mass (left) 1.21 1 0 0.0 0.00 1.0e+00 KLC1
Arm predicted mass (left) 1.00 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.55
GTEx Adipose Visceral Omentum 0 0.0000 1.49
GTEx Adrenal Gland 1 0.0686 1.41
GTEx Artery Aorta 1 0.0336 1.50
GTEx Artery Coronary 1 0.0845 1.50
GTEx Artery Tibial 2 0.0532 1.50
GTEx Brain Caudate basal ganglia 1 0.1087 1.61
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.55
GTEx Brain Cerebellum 1 0.0505 1.53
GTEx Brain Cortex 2 0.1932 1.69
GTEx Brain Frontal Cortex BA9 1 0.1082 1.62
GTEx Brain Hippocampus 1 0.1908 1.59
GTEx Brain Hypothalamus 1 0.1695 1.58
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.64
GTEx Brain Putamen basal ganglia 2 0.3205 1.66
GTEx Breast Mammary Tissue 1 0.0507 1.57
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.51
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.51
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.49
GTEx Cells Transformed fibroblasts 1 0.0238 1.43
GTEx Colon Sigmoid 1 0.0684 1.52
GTEx Colon Transverse 1 0.0484 1.51
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.56
GTEx Esophagus Mucosa 1 0.0301 1.45
GTEx Esophagus Muscularis 0 0.0000 1.46
GTEx Heart Atrial Appendage 0 0.0000 1.45
GTEx Heart Left Ventricle 2 0.1307 1.56
GTEx Liver 1 0.1395 1.79
GTEx Lung 1 0.0348 1.48
GTEx Muscle Skeletal 1 0.0346 1.53
GTEx Nerve Tibial 3 0.0694 1.46
GTEx Ovary 1 0.1101 1.64
GTEx Pancreas 0 0.0000 1.45
GTEx Pituitary 0 0.0000 1.45
GTEx Prostate 0 0.0000 1.46
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.50
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.54
GTEx Small Intestine Terminal Ileum 0 0.0000 1.39
GTEx Spleen 1 0.0709 1.52
GTEx Stomach 0 0.0000 1.51
GTEx Testis 2 0.0634 1.51
GTEx Thyroid 0 0.0000 1.46
GTEx Uterus 0 0.0000 1.36
GTEx Vagina 0 0.0000 1.40
GTEx Whole Blood 0 0.0000 1.46
METSIM Adipose 2 0.0434 1.43
NTR Blood 0 0.0000 1.35
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.44
YFS Blood 2 0.0433 1.48
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.46
TCGA Breast Tumor 3 0.3911 1.73
TCGA Breast Normal 1 0.0238 1.33
TCGA Ovarian Tumor 1 0.0342 1.36
TCGA Prostate Tumor 2 0.0578 1.55