Hub : Traits :

Falls in the last year

3 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49615624 50998816 1 1 1.4e-08 5.4e-04 0.00049 -1 SEMA3B-AS1
2 16 69586228 70978362 1 1 5.2e-08 2.1e-06 0.00217 58 EXOSC6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 7.83 1 0 0.0 0 1 EXOSC6
Crohns Disease (2017) 3.02 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Irritable Bowel Disease (IBD) 2.75 1 0 0.0 0 1 EXOSC6
Breast Cancer 2.22 1 0 0.0 0 1 EXOSC6
Body Mass Index (BMI) (2010) 5.62 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Neuroticism 4.62 1 0 0.0 0 1 SEMA3B-AS1
Blood Eosinophil Count 1.00 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Blood Platelet Count 0.35 1 0 0.0 0 1 SEMA3B-AS1
Blood Red Count 0.75 1 0 0.0 0 1 SEMA3B-AS1
Blood White Count 1.12 1 0 0.0 0 1 EXOSC6
Heel T-Score 0.99 1 0 0.0 0 1 SEMA3B-AS1
BMI 10.86 1 1 3.0 0 1 EXOSC6
Height 3.39 2 2 6.1 0 1 EXOSC6 SEMA3B-AS1
Systolic Blood Pressure 1.07 1 0 0.0 0 1 EXOSC6
Smoking Status 2.55 1 0 0.0 0 1 SEMA3B-AS1
Cardiovascular Disease 3.49 1 0 0.0 0 1 EXOSC6
Type 2 Diabetes (T2D) 2.58 1 0 0.0 0 1 SEMA3B-AS1
Lung FVC 2.94 1 1 3.0 0 1 SEMA3B-AS1
Neuroticism 4.36 1 0 0.0 0 1 SEMA3B-AS1
Number of treatments/medications taken 3.97 1 0 0.0 0 1 EXOSC6
Sensitivity / hurt feelings 4.32 1 0 0.0 0 1 SEMA3B-AS1
Frequency of depressed mood in last 2 weeks 2.71 1 0 0.0 0 1 SEMA3B-AS1
Ever used hormone-replacement therapy (HRT) 5.11 1 0 0.0 0 1 SEMA3B-AS1
Systolic blood pressure, automated reading 2.59 1 0 0.0 0 1 EXOSC6
Diabetes (mother) 2.40 1 0 0.0 0 1 EXOSC6
Pack years adult smoking proportion 3.02 1 0 0.0 0 1 EXOSC6
Impedance of leg (right) 7.40 2 2 6.1 0 1 EXOSC6 SEMA3B-AS1
Leg fat-free mass (left) 1.53 1 0 0.0 0 1 EXOSC6
Trunk fat percentage 6.64 1 1 3.0 0 1 EXOSC6
Hand grip strength (right) 2.19 1 0 0.0 0 1 SEMA3B-AS1
Current tobacco smoking 2.08 1 0 0.0 0 1 SEMA3B-AS1
Maternal smoking around birth 2.82 1 0 0.0 0 1 EXOSC6
Fed-up feelings 2.06 1 0 0.0 0 1 SEMA3B-AS1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.39 1 0 0.0 0 1 SEMA3B-AS1
Relative age voice broke 2.83 1 0 0.0 0 1 EXOSC6
Taking other prescription medications 2.44 1 0 0.0 0 1 EXOSC6
Age when periods started (menarche) 1.63 1 0 0.0 0 1 EXOSC6
Heel bone mineral density (BMD) T-score, automated (left) 2.35 1 0 0.0 0 1 SEMA3B-AS1
Serious illness, injury or assault to yourself 7.08 1 0 0.0 0 1 EXOSC6
High blood pressure 3.00 1 0 0.0 0 1 EXOSC6
Stomach or abdominal pain in last month 3.83 1 0 0.0 0 1 EXOSC6
Medication: Atenolol 4.71 1 0 0.0 0 1 EXOSC6
Body mass index (BMI) 9.41 1 1 3.0 0 1 EXOSC6
Impedance of leg (left) 7.29 2 2 6.1 0 1 EXOSC6 SEMA3B-AS1
Leg predicted mass (left) 1.51 1 0 0.0 0 1 EXOSC6
Trunk fat mass 5.97 1 1 3.0 0 1 EXOSC6
Waist circumference 6.35 1 1 3.0 0 1 EXOSC6
Past tobacco smoking 2.32 1 0 0.0 0 1 SEMA3B-AS1
Nervous feelings 6.24 1 0 0.0 0 1 SEMA3B-AS1
Frequency of tenseness / restlessness in last 2 weeks 2.62 1 0 0.0 0 1 SEMA3B-AS1
Had menopause 8.33 1 0 0.0 0 1 SEMA3B-AS1
Forced vital capacity (FVC) 1.21 1 0 0.0 0 1 EXOSC6
Heel bone mineral density (BMD) T-score, automated (right) 1.62 1 0 0.0 0 1 SEMA3B-AS1
Diabetes (self-reported) 3.40 1 0 0.0 0 1 EXOSC6
Medication: Simvastatin 2.51 1 0 0.0 0 1 EXOSC6
Neuroticism score 7.22 1 1 3.0 0 1 SEMA3B-AS1
Weight 3.47 1 1 3.0 0 1 EXOSC6
Impedance of arm (right) 3.14 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Arm fat percentage (right) 9.52 1 1 3.0 0 1 EXOSC6
Hip circumference 6.34 1 1 3.0 0 1 EXOSC6
Worrier / anxious feelings 15.38 2 1 3.0 0 1 EXOSC6 SEMA3B-AS1
Pulse rate 2.16 1 0 0.0 0 1 EXOSC6
Happiness 5.71 1 0 0.0 0 1 SEMA3B-AS1
Medication: Cholesterol lowering 3.68 1 0 0.0 0 1 EXOSC6
Forced expiratory volume in 1-second (FEV1), Best measure 1.21 1 0 0.0 0 1 EXOSC6
Impedance of arm (left) 2.75 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Arm fat mass (right) 7.52 1 1 3.0 0 1 EXOSC6
Standing height 2.92 2 2 6.1 0 1 EXOSC6 SEMA3B-AS1
Breastfed as a baby 4.23 1 0 0.0 0 1 SEMA3B-AS1
Tense / 'highly strung' 6.59 1 0 0.0 0 1 SEMA3B-AS1
Ever highly irritable/argumentative for 2 days 4.30 1 0 0.0 0 1 SEMA3B-AS1
Medication for cholesterol, blood pressure or diabetes 6.20 1 0 0.0 0 1 EXOSC6
Medication: Amlodipine 3.04 1 0 0.0 0 1 EXOSC6
High blood pressure (siblings) 2.37 1 0 0.0 0 1 EXOSC6
Forced vital capacity (FVC), Best measure 1.77 1 0 0.0 0 1 EXOSC6
Body fat percentage 7.68 1 1 3.0 0 1 EXOSC6
Leg fat percentage (right) 7.09 1 1 3.0 0 1 EXOSC6
Comparative body size at age 10 4.61 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Wheeze or whistling in the chest in last year 2.25 1 0 0.0 0 1 EXOSC6
Health satisfaction 3.55 1 0 0.0 0 1 SEMA3B-AS1
Shortness of breath walking on level ground 4.70 1 0 0.0 0 1 SEMA3B-AS1
Medication: Blood pressure 3.47 1 0 0.0 0 1 EXOSC6
Whole body fat mass 6.98 1 1 3.0 0 1 EXOSC6
Leg fat mass (right) 7.03 1 1 3.0 0 1 EXOSC6
Pulse rate, automated reading 3.65 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Overall health rating 3.50 1 0 0.0 0 1 SEMA3B-AS1
Commuting to job workplace: Car/motor vehicle 6.76 1 0 0.0 0 1 SEMA3B-AS1
Knee pain experienced in last month 2.00 1 0 0.0 0 1 EXOSC6
Hypertension (Self-reported) 2.92 1 0 0.0 0 1 EXOSC6
Forced expiratory volume in 1-second (FEV1), predicted 2.75 1 0 0.0 0 1 SEMA3B-AS1
Whole body fat-free mass 0.54 1 0 0.0 0 1 EXOSC6
Leg fat-free mass (right) 1.16 1 0 0.0 0 1 EXOSC6
Arm fat percentage (left) 9.71 1 1 3.0 0 1 EXOSC6
Mood swings 3.89 1 0 0.0 0 1 SEMA3B-AS1
Diabetes diagnosed by doctor 3.48 1 0 0.0 0 1 EXOSC6
Eye problems/disorders: Cataract 3.54 1 0 0.0 0 1 EXOSC6
Whole body water mass 0.52 1 0 0.0 0 1 EXOSC6
Leg predicted mass (right) 1.25 1 0 0.0 0 1 EXOSC6
Arm fat mass (left) 7.46 1 1 3.0 0 1 EXOSC6
Number of self-reported non-cancer illnesses 3.58 1 0 0.0 0 1 EXOSC6
Commuting to job workplace: Public transport 5.09 1 0 0.0 0 1 SEMA3B-AS1
High cholesterol (Self-reported) 3.38 1 0 0.0 0 1 EXOSC6
Ever smoked 1.88 1 0 0.0 0 1 SEMA3B-AS1
Basal metabolic rate 1.06 1 0 0.0 0 1 EXOSC6
Leg fat percentage (left) 6.98 1 1 3.0 0 1 EXOSC6
Ever had prostate specific antigen (PSA) test 3.44 1 0 0.0 0 1 SEMA3B-AS1
Fractured/broken bones in last 5 years 9.98 1 0 0.0 0 1 SEMA3B-AS1
Diastolic blood pressure, automated reading 3.96 1 0 0.0 0 1 EXOSC6
Vascular/heart problems diagnosed by doctor 2.38 1 0 0.0 0 1 EXOSC6
Alcohol drinker status: Previous 6.76 1 0 0.0 0 1 SEMA3B-AS1
Pack years of smoking 3.36 1 0 0.0 0 1 EXOSC6
Impedance of whole body 4.97 2 1 3.0 0 1 EXOSC6 SEMA3B-AS1
Leg fat mass (left) 6.69 1 1 3.0 0 1 EXOSC6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.33
GTEx Adipose Visceral Omentum 0 0.0000 1.38
GTEx Adrenal Gland 0 0.0000 1.33
GTEx Artery Aorta 1 0.0336 1.40
GTEx Artery Coronary 0 0.0000 1.47
GTEx Artery Tibial 1 0.0266 1.37
GTEx Brain Caudate basal ganglia 0 0.0000 1.36
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.40
GTEx Brain Cerebellum 0 0.0000 1.47
GTEx Brain Cortex 0 0.0000 1.40
GTEx Brain Frontal Cortex BA9 0 0.0000 1.38
GTEx Brain Hippocampus 0 0.0000 1.44
GTEx Brain Hypothalamus 0 0.0000 1.26
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.32
GTEx Brain Putamen basal ganglia 0 0.0000 1.34
GTEx Breast Mammary Tissue 0 0.0000 1.35
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.32
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.29
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.41
GTEx Cells Transformed fibroblasts 0 0.0000 1.38
GTEx Colon Sigmoid 0 0.0000 1.45
GTEx Colon Transverse 0 0.0000 1.37
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.42
GTEx Esophagus Mucosa 0 0.0000 1.38
GTEx Esophagus Muscularis 0 0.0000 1.41
GTEx Heart Atrial Appendage 0 0.0000 1.37
GTEx Heart Left Ventricle 0 0.0000 1.41
GTEx Liver 0 0.0000 1.49
GTEx Lung 0 0.0000 1.34
GTEx Muscle Skeletal 0 0.0000 1.36
GTEx Nerve Tibial 0 0.0000 1.36
GTEx Ovary 0 0.0000 1.55
GTEx Pancreas 0 0.0000 1.36
GTEx Pituitary 0 0.0000 1.38
GTEx Prostate 0 0.0000 1.54
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.40
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.36
GTEx Small Intestine Terminal Ileum 0 0.0000 1.48
GTEx Spleen 0 0.0000 1.46
GTEx Stomach 0 0.0000 1.49
GTEx Testis 0 0.0000 1.38
GTEx Thyroid 0 0.0000 1.41
GTEx Uterus 0 0.0000 1.50
GTEx Vagina 0 0.0000 1.43
GTEx Whole Blood 0 0.0000 1.35
METSIM Adipose 0 0.0000 1.32
NTR Blood 0 0.0000 1.36
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.35
YFS Blood 0 0.0000 1.33
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.33
TCGA Breast Tumor 0 0.0000 1.44
TCGA Breast Normal 0 0.0000 1.30
TCGA Ovarian Tumor 0 0.0000 1.21
TCGA Prostate Tumor 0 0.0000 1.29