Hub : Traits :

Type 2 Diabetes (T2D)

14 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 97351840 98736225 1 1 2.2e-16 8.7e-03 0.0014 -47 IGKV2OR2-8
2 4 5575751 7002344 1 1 5.7e-08 1.1e-07 1.0000 100 WFS1
3 10 93657148 95151622 3 1 1.7e-15 2.2e-16 1.0000 100 EIF2S2P3
4 10 113511441 115622375 2 1 4.3e-10 1.9e-10 0.0036 79 TCF7L2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.31 1 0 0.0 0 1 EIF2S2P3
Irritable Bowel Disease (IBD) 2.17 1 0 0.0 0 1 EIF2S2P3
Ulcerative Colitis (UC) 1.98 1 0 0.0 0 1 EIF2S2P3
Breast Cancer 5.72 1 1 3.0 0 1 TCF7L2
Age at First Birth 12.93 1 1 3.0 0 1 IGKV2OR2-8
Body Mass Index (BMI) (2010) 2.85 1 0 0.0 0 1 TCF7L2
Fasting Glucose 5.51 1 0 0.0 0 1 TCF7L2
HDL Cholesterol 2.60 1 0 0.0 0 1 IGKV2OR2-8
Blood Eosinophil Count 4.72 2 1 3.0 0 1 EIF2S2P3 IGKV2OR2-8
Blood Platelet Count 1.11 1 1 3.0 0 1 IGKV2OR2-8
Blood Red Count 1.04 1 0 0.0 0 1 EIF2S2P3
Blood White Count 0.38 1 0 0.0 0 1 IGKV2OR2-8
Heel T-Score 0.46 1 0 0.0 0 1 TCF7L2
BMI 2.20 1 1 3.0 0 1 TCF7L2
Height 0.32 1 0 0.0 0 1 TCF7L2
Waist Hip Ratio (WHR) 5.79 2 2 6.1 0 1 EIF2S2P3 TCF7L2
Systolic Blood Pressure 1.88 1 1 3.0 0 1 TCF7L2
Respiratory disease 3.79 1 1 3.0 0 1 EIF2S2P3
Type 2 Diabetes (T2D) 58.81 3 3 9.1 0 1 EIF2S2P3 TCF7L2 WFS1
Neuroticism 1.20 1 0 0.0 0 1 IGKV2OR2-8
Hair Pigment 0.22 1 0 0.0 0 1 IGKV2OR2-8
Number of treatments/medications taken 2.22 1 0 0.0 0 1 WFS1
Eye problems/disorders: Diabetes related eye disease 9.29 2 0 0.0 0 1 TCF7L2 WFS1
Medication: Metformin 39.15 3 3 9.1 0 1 EIF2S2P3 TCF7L2 WFS1
Diabetes (father) 32.67 3 2 6.1 0 1 EIF2S2P3 TCF7L2 WFS1
Diabetes (mother) 25.75 3 1 3.0 0 1 EIF2S2P3 TCF7L2 WFS1
Impedance of leg (right) 0.79 1 0 0.0 0 1 TCF7L2
Leg fat-free mass (left) 0.98 2 0 0.0 0 1 TCF7L2 WFS1
Trunk fat percentage 0.98 1 0 0.0 0 1 TCF7L2
Body mass index (BMI) 2.62 2 1 3.0 0 1 TCF7L2 WFS1
Leg predicted mass (left) 1.01 2 0 0.0 0 1 TCF7L2 WFS1
Trunk fat mass 1.31 1 0 0.0 0 1 TCF7L2
Waist circumference 1.72 2 0 0.0 0 1 TCF7L2 WFS1
Forced vital capacity (FVC) 0.67 1 0 0.0 0 1 IGKV2OR2-8
Diabetes (self-reported) 45.50 3 3 9.1 0 1 EIF2S2P3 TCF7L2 WFS1
Medication: Simvastatin 3.21 1 0 0.0 0 1 TCF7L2
Neuroticism score 1.38 1 0 0.0 0 1 IGKV2OR2-8
Weight 1.65 2 0 0.0 0 1 TCF7L2 WFS1
Impedance of arm (right) 1.40 1 0 0.0 0 1 TCF7L2
Arm fat percentage (right) 1.67 1 0 0.0 0 1 TCF7L2
Hip circumference 4.09 1 1 3.0 0 1 TCF7L2
Alcohol intake versus 10 years previously 2.82 1 0 0.0 0 1 IGKV2OR2-8
Worrier / anxious feelings 3.57 2 0 0.0 0 1 IGKV2OR2-8 TCF7L2
Pulse rate 2.52 1 0 0.0 0 1 WFS1
Asthma 3.24 1 0 0.0 0 1 EIF2S2P3
Medication: Cholesterol lowering 4.19 1 0 0.0 0 1 TCF7L2
Impedance of arm (left) 1.58 2 0 0.0 0 1 TCF7L2 WFS1
Arm fat mass (right) 2.06 2 1 3.0 0 1 TCF7L2 WFS1
Birth weight of first child 2.80 1 0 0.0 0 1 IGKV2OR2-8
Mouth/teeth dental problems: Bleeding gums 1.74 1 0 0.0 0 1 WFS1
Medication for cholesterol, blood pressure or diabetes 2.14 1 0 0.0 0 1 TCF7L2
Birth weight 6.86 2 1 3.0 0 1 EIF2S2P3 TCF7L2
Body fat percentage 1.66 1 0 0.0 0 1 TCF7L2
Leg fat percentage (right) 2.69 1 1 3.0 0 1 TCF7L2
Arm fat-free mass (right) 0.90 1 0 0.0 0 1 TCF7L2
Comparative body size at age 10 1.65 1 0 0.0 0 1 WFS1
Age at first live birth 3.09 1 0 0.0 0 1 EIF2S2P3
Qualifications: College or University degree 1.21 1 0 0.0 0 1 IGKV2OR2-8
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.83 2 0 0.0 0 1 EIF2S2P3 TCF7L2
Whole body fat mass 1.97 2 0 0.0 0 1 TCF7L2 WFS1
Leg fat mass (right) 2.73 2 1 3.0 0 1 TCF7L2 WFS1
Arm predicted mass (right) 0.90 1 0 0.0 0 1 WFS1
Pulse rate, automated reading 3.72 3 1 3.0 0 1 EIF2S2P3 TCF7L2 WFS1
Alcohol intake frequency. 2.12 1 0 0.0 0 1 WFS1
Comparative height size at age 10 1.02 1 0 0.0 0 1 EIF2S2P3
Had major operations 3.73 1 0 0.0 0 1 IGKV2OR2-8
Age at last live birth 3.18 1 0 0.0 0 1 EIF2S2P3
Illnesses of siblings: Diabetes 16.10 3 1 3.0 0 1 EIF2S2P3 TCF7L2 WFS1
Whole body fat-free mass 0.87 2 0 0.0 0 1 TCF7L2 WFS1
Leg fat-free mass (right) 0.90 2 0 0.0 0 1 TCF7L2 WFS1
Arm fat percentage (left) 1.69 1 0 0.0 0 1 TCF7L2
Diabetes diagnosed by doctor 50.70 3 3 9.1 0 1 EIF2S2P3 TCF7L2 WFS1
Ever had stillbirth, spontaneous miscarriage or termination 2.87 1 0 0.0 0 1 TCF7L2
Qualifications: nursing, teaching 2.82 1 0 0.0 0 1 TCF7L2
Breast cancer (self-reported) 2.78 1 0 0.0 0 1 TCF7L2
Asthma (self-reported) 2.96 1 0 0.0 0 1 EIF2S2P3
Medication: Aspirin 2.78 1 0 0.0 0 1 TCF7L2
Medication: Gliclazide 20.51 2 1 3.0 0 1 TCF7L2 WFS1
Whole body water mass 0.86 2 0 0.0 0 1 TCF7L2 WFS1
Leg predicted mass (right) 0.90 2 0 0.0 0 1 TCF7L2 WFS1
Arm fat mass (left) 1.91 1 0 0.0 0 1 TCF7L2
Guilty feelings 4.66 1 1 3.0 0 1 IGKV2OR2-8
High cholesterol (Self-reported) 1.48 1 0 0.0 0 1 TCF7L2
Medication: Atorvastatin 4.98 1 0 0.0 0 1 TCF7L2
Basal metabolic rate 1.04 2 0 0.0 0 1 TCF7L2 WFS1
Leg fat percentage (left) 2.81 1 1 3.0 0 1 TCF7L2
Arm fat-free mass (left) 1.19 2 0 0.0 0 1 TCF7L2 WFS1
Diastolic blood pressure, automated reading 1.55 1 0 0.0 0 1 TCF7L2
Cholesterol lowering medication 4.13 1 0 0.0 0 1 TCF7L2
Impedance of whole body 1.16 1 0 0.0 0 1 TCF7L2
Leg fat mass (left) 2.73 1 1 3.0 0 1 TCF7L2
Arm predicted mass (left) 1.18 2 0 0.0 0 1 TCF7L2 WFS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.32
GTEx Adipose Visceral Omentum 0 0.0000 1.27
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 1 0.0364 1.34
GTEx Artery Coronary 0 0.0000 1.33
GTEx Artery Tibial 0 0.0000 1.27
GTEx Brain Caudate basal ganglia 0 0.0000 1.34
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.32
GTEx Brain Cerebellum 1 0.0545 1.30
GTEx Brain Cortex 0 0.0000 1.35
GTEx Brain Frontal Cortex BA9 0 0.0000 1.30
GTEx Brain Hippocampus 0 0.0000 1.44
GTEx Brain Hypothalamus 0 0.0000 1.26
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.30
GTEx Breast Mammary Tissue 0 0.0000 1.24
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.23
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.30
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.26
GTEx Cells Transformed fibroblasts 0 0.0000 1.26
GTEx Colon Sigmoid 0 0.0000 1.34
GTEx Colon Transverse 0 0.0000 1.25
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.24
GTEx Esophagus Mucosa 0 0.0000 1.25
GTEx Esophagus Muscularis 1 0.0335 1.25
GTEx Heart Atrial Appendage 0 0.0000 1.32
GTEx Heart Left Ventricle 0 0.0000 1.28
GTEx Liver 0 0.0000 1.24
GTEx Lung 0 0.0000 1.25
GTEx Muscle Skeletal 0 0.0000 1.30
GTEx Nerve Tibial 0 0.0000 1.32
GTEx Ovary 0 0.0000 1.31
GTEx Pancreas 0 0.0000 1.31
GTEx Pituitary 0 0.0000 1.31
GTEx Prostate 1 0.1311 1.36
GTEx Skin Not Sun Exposed Suprapubic 1 0.0433 1.27
GTEx Skin Sun Exposed Lower leg 1 0.0299 1.27
GTEx Small Intestine Terminal Ileum 0 0.0000 1.25
GTEx Spleen 1 0.0760 1.37
GTEx Stomach 0 0.0000 1.28
GTEx Testis 1 0.0341 1.26
GTEx Thyroid 2 0.0542 1.29
GTEx Uterus 0 0.0000 1.34
GTEx Vagina 0 0.0000 1.32
GTEx Whole Blood 0 0.0000 1.27
METSIM Adipose 0 0.0000 1.27
NTR Blood 2 0.0860 1.22
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 0 0.0000 1.23
CommonMind Brain Pre-frontal Cortex 1 0.0196 1.21
TCGA Breast Tumor 0 0.0000 1.40
TCGA Breast Normal 0 0.0000 1.25
TCGA Ovarian Tumor 1 0.0353 1.17
TCGA Prostate Tumor 0 0.0000 1.24