Hub : Genes

CD247

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1460	0.0470	2.3e-03	0.016	0.021	0.050	0.042	0.031	4.2e-03	1.0e-03	1.0e-06	6.9e-06	9.1e-05
2	GTEx	Brain Cortex	0.3810	0.1180	4.7e-03	0.023	NA	-0.001	NA	0.015	7.6e-02	NA	3.5e-01	NA	1.2e-01
3	YFS	Blood	0.0704	0.0192	1.5e-06	0.043	0.015	0.025	0.035	0.039	7.8e-14	5.6e-06	1.3e-08	9.0e-12	1.2e-12
4	TCGA	Breast Invasive Carcinoma	0.0377	0.0148	2.4e-03	0.000	0.002	0.008	NA	-0.001	3.6e-01	1.1e-01	7.9e-03	NA	9.8e-01
5	TCGA	Thyroid Carcinoma	0.0960	0.0320	4.5e-04	-0.002	0.025	0.011	NA	-0.001	6.7e-01	1.5e-03	2.7e-02	NA	4.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.8	-0.1	-0.1	0.0	0.4
Bipolar Disorder or Schizophrenia	0.2	0.6	2.4	-0.3	0.2	0.3	1.5	-0.5
Depressed Affect (Nagel 2018)	0.9	2.0	4.0	1.6	-2.0	0.1	-1.3	1.3
Depression (Nagel 2018)	0.5	0.7	1.9	0.6	-1.4	-0.9	-0.7	0.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.0	-1.4	-1.4	-2.0	0.1	0.1
Neuroticism (Nagel 2018)	0.6	1.4	4.4	0.6	-2.1	0.3	-1.0	1.2
Schizophrenia (2018)	0.9	1.8	8.2	-0.1	0.1	0.5	2.9	-0.9
Schizophrenia vs Biploar Disorder	0.9	1.2	3.1	0.2	-1.8	0.6	0.0	-1.5
Worry (Nagel 2018)	0.3	0.5	1.7	-0.4	-0.4	-0.4	-0.8	1.3
Alzheimer’s Disease (in mother)	1.3	1.5	5.3	-0.6	0.1	-1.4	-2.3	-0.4
Alzheimer’s Disease (in father)	1.2	1.3	4.0	-0.4	-2.0	-0.4	0.6	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.5	-0.5	-0.1	-0.7	-1.2	-1.2
Crohns Disease (2017)	0.8	1.8	3.1	-1.5	-0.5	1.8	1.1	1.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.8	0.3	0.4	0.9	0.2
Ulcerative Colitis (UC)	0.4	0.7	1.0	0.5	1.0	-1.0	0.5	-1.0
Major Depression (MDD)	0.5	0.6	1.3	0.7	1.1	0.9	0.6	-0.1
Reaction Time	1.6	3.0	4.9	2.0	2.0	-1.0	-2.2	0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.7	-1.7	-0.7	-1.3	-0.5	0.4
Breast Cancer	1.0	2.5	6.2	-2.1	-2.5	0.7	0.2	1.2
Ovarian Cancer	1.0	1.4	2.6	-0.3	1.4	-1.4	-1.6	-0.4
Prostate Cancer	1.9	2.6	6.7	2.1	1.2	-0.5	-0.4	-2.6
Age at First Birth	1.7	2.5	5.4	-2.3	0.7	0.8	1.9	1.5
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.4	-0.1	-0.6	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.7	0.7	0.1	1.6	1.5	-0.5
Coronary Artery Disease (CAD)	0.4	0.4	1.8	0.3	0.4	-1.3	-0.0	-0.3
Crohns Disease (2012)	0.7	1.2	2.2	-0.9	-1.1	1.5	0.0	1.3
Mean Putamen Volume	0.4	0.5	1.7	-0.1	0.0	-1.3	-0.6	-0.6
Fasting Glucose	0.9	1.1	3.4	-1.9	-1.2	-0.4	-0.6	0.1
HbA1C	1.5	1.7	3.4	-1.6	-1.9	0.9	-1.2	0.2
HDL Cholesterol	0.6	1.0	2.7	-1.3	-1.6	-0.6	-0.5	0.5
LDL Cholesterol	0.6	1.0	4.5	-0.4	-2.1	0.6	-0.0	-0.0
Lupus	2.3	3.4	9.4	0.8	1.4	-3.1	-2.2	-0.2
Neuroticism (2016)	0.2	0.3	0.9	0.9	0.0	0.3	0.5	-0.6
Primary Biliary Cirrhosis	1.2	1.7	6.1	0.6	-0.7	-1.2	-2.5	-0.3
Rheumatoid Arthritis	3.3	4.6	15.1	0.3	-0.5	-2.5	-3.9	-1.1
Schizophrenia (2014)	0.8	1.8	6.3	0.7	-0.9	0.1	2.5	-1.2
Triglycerides	0.4	0.7	2.9	0.7	0.2	1.7	-0.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.6	0.4	-0.7	-0.0	-0.5
Ulcerative Colitis	0.9	1.3	4.0	-0.1	0.6	-1.4	-0.6	-2.0
Blood Eosinophil Count	2.0	15.1	60.8	-0.2	0.4	-7.8	-2.8	-2.5
Blood Platelet Count	0.1	0.9	3.5	0.1	0.5	1.9	0.5	0.8
Blood Red Count	0.3	3.3	13.8	1.4	3.7	-0.2	0.8	-0.4
Blood White Count	0.7	4.8	13.9	0.6	0.3	2.7	3.7	1.5
Heel T-Score	0.2	1.3	5.3	0.2	2.3	-0.5	-0.6	0.5
BMI	0.5	2.7	6.4	1.9	1.1	2.5	1.4	0.5
Height	0.1	1.7	6.5	-1.2	-2.5	0.0	-0.7	0.1
Waist Hip Ratio (WHR)	0.1	0.3	0.5	0.6	0.7	-0.6	0.5	0.1
Systolic Blood Pressure	0.1	0.6	1.2	-1.1	0.9	-1.0	0.3	-0.5
Smoking Status	0.2	0.5	1.6	0.7	-1.3	0.5	-0.3	-0.3
Allergy or Eczema	10.5	27.7	104.0	0.2	-0.2	-10.2	-3.4	-4.8
Cardiovascular Disease	0.4	1.3	2.8	1.3	1.7	-0.3	-1.1	0.9
Hypothyroidism (self reported)	3.8	8.8	29.1	-0.0	0.9	5.4	1.6	3.4
Respiratory disease	8.0	17.8	71.9	0.5	0.2	-8.5	-3.7	-1.8
Type 2 Diabetes (T2D) (2018)	1.3	2.5	9.9	3.1	0.0	-0.3	-1.4	-0.7
Lung FEV1/FVC ratio	1.0	5.3	12.3	-1.0	1.9	3.1	3.5	0.0
Lung FVC	0.2	1.0	2.6	-1.6	0.0	-1.4	0.1	-0.7
Neuroticism	0.6	1.5	3.5	0.3	-1.9	-0.8	-1.1	1.4
Chronotype (morning person)	0.4	0.9	2.1	-1.5	0.7	-1.2	0.1	-0.6
Hair Pigment	0.1	2.2	5.4	0.7	1.1	2.3	1.5	-1.3
Tanning	0.0	0.2	0.9	-0.9	0.5	-0.2	-0.2	0.2
Hand grip strength (left)	0.2	0.4	1.2	-1.1	0.5	-0.6	-0.5	-0.3
Number of treatments/medications taken	0.5	1.0	2.3	1.5	1.5	-0.4	0.2	-0.0
Average weekly spirits intake	1.7	2.1	4.0	1.4	0.6	1.3	2.0	-1.5
Sensitivity / hurt feelings	1.1	1.9	3.0	-1.4	-1.7	-0.9	-1.1	1.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.9	-0.6	-2.2	-1.2	-0.0	0.7
Hearing difficulty/problems: Yes	0.7	1.0	2.8	1.0	-0.7	-0.7	0.6	-1.7
Relative age of first facial hair	0.1	0.2	0.8	-0.9	0.0	0.3	-0.4	-0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.5	-0.8	-0.5	0.8	-1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	1.0	-0.1	0.7	0.5	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	1.0	-0.5	-0.2	0.4	1.3
Systolic blood pressure, automated reading	0.4	1.2	5.6	0.3	2.4	-0.3	0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.4	0.6	0.8	-0.6	-0.9	-1.6
Angina	1.9	2.5	4.7	1.7	2.2	1.5	-0.7	1.5
Medication for hormone replacement therapy	4.2	4.7	9.3	-1.9	-0.6	2.9	3.0	1.4
Vitamin and mineral supplements	0.8	1.0	3.0	0.7	-1.2	1.7	-0.2	0.6
Supplements: Zinc	0.3	0.3	0.9	-0.5	-0.9	-0.2	-0.5	0.1
Medication: Co-codamol	0.3	0.4	1.1	0.4	-0.3	0.4	-1.0	0.7
Medication: Metformin	3.5	5.0	16.8	4.1	1.8	-1.6	-1.2	-1.1
Diabetes (father)	1.1	1.4	3.1	1.4	0.3	-1.2	-1.8	-0.3
Diabetes (mother)	0.5	0.6	1.7	0.7	-0.4	0.9	1.3	-0.1
Severe depression (siblings)	0.4	0.4	1.2	-0.8	-1.1	0.4	-0.0	0.1
Pack years adult smoking proportion	0.8	1.1	3.6	1.9	0.9	0.9	-0.3	0.7
Impedance of leg (right)	0.3	1.7	4.3	-1.1	-1.5	-2.1	-0.7	0.3
Leg fat-free mass (left)	0.1	0.7	2.1	0.5	0.6	1.5	0.8	-0.1
Trunk fat percentage	0.6	2.2	3.7	1.9	1.5	1.4	1.8	-0.2
Hand grip strength (right)	0.3	0.8	1.7	-1.3	-0.7	-1.0	-0.0	-1.0
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.7	0.3	1.0	0.3	-0.2
Current tobacco smoking	0.4	0.6	1.5	0.5	-1.2	1.0	0.2	-0.3
Average weekly fortified wine intake	0.8	0.9	2.6	0.5	1.0	-0.7	0.6	-1.6
Maternal smoking around birth	0.9	1.3	3.5	0.1	-0.7	1.5	0.2	1.9
Fed-up feelings	0.6	1.2	2.0	1.3	-1.4	0.6	-0.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.5	0.2	-1.8	-1.9	-1.9	-0.4
Relative age voice broke	0.6	0.9	2.4	-1.1	-0.1	0.5	-0.9	1.6
Taking other prescription medications	0.8	1.3	2.0	1.1	1.4	-0.8	1.0	-1.2
Age when periods started (menarche)	0.6	1.4	3.3	-1.8	-1.7	-1.0	0.1	-0.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	0.7	0.7	-0.8	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.6	-1.0	-0.7	-0.9	-1.2	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.4	0.6	-0.1	-0.1	-0.4
Qualifications: CSEs or equivalent	1.8	2.4	7.9	0.7	-2.8	1.7	-0.3	0.9
Serious illness, injury or assault to yourself	0.4	0.5	0.8	0.8	-0.3	-0.9	-0.0	-0.9
High blood pressure	0.2	0.4	0.9	0.7	0.9	-0.6	0.2	-0.8
Hayfever, allergic rhinitis or eczema	9.0	19.5	71.7	0.8	-1.1	-8.5	-2.6	-4.1
Multivitamins +/- minerals	0.3	0.3	0.7	-0.3	0.8	-0.8	0.2	0.4
Stomach or abdominal pain in last month	0.6	0.8	1.4	-0.4	-0.8	-1.2	0.8	-1.1
Supplements: Glucosamine	0.5	0.7	2.1	0.5	0.7	-1.5	0.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.9	1.7	-0.6	-1.0	0.4	-0.4
Medication: Atenolol	0.3	0.4	1.1	0.2	1.0	0.8	0.4	0.4
Medication: Levothyroxine sodium	2.7	4.5	15.2	-0.8	0.3	3.9	1.2	2.3
Sitting height	0.0	0.3	1.2	-1.1	-0.4	0.3	-0.1	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	0.5	0.1	-0.5	-1.1	-0.6
High blood pressure (mother)	1.2	1.7	6.8	0.1	-2.6	-0.5	-0.9	0.8
Body mass index (BMI)	0.8	3.6	6.0	2.2	1.5	2.5	2.2	-0.1
Impedance of leg (left)	0.4	2.1	3.8	-1.6	-1.9	-2.0	-0.7	0.5
Leg predicted mass (left)	0.1	0.6	2.0	0.4	0.5	1.4	0.7	-0.1
Trunk fat mass	0.4	1.7	2.3	1.5	1.4	1.5	1.5	-0.2
Waist circumference	0.6	2.4	5.1	2.2	1.9	0.9	1.4	-0.5
Number of incorrect matches in round	0.7	1.2	2.9	1.2	1.7	0.8	-0.9	-0.2
Past tobacco smoking	0.3	0.6	2.1	-1.5	-0.3	-0.8	0.0	-0.1
Alcohol usually taken with meals	0.4	0.6	1.4	-0.8	0.7	-1.2	0.5	0.4
Nervous feelings	0.3	0.6	2.2	0.4	0.2	-0.1	-1.5	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.7	0.2	-1.3	-1.1	-0.7	0.0
Hearing difficulty/problems with background noise	1.7	2.7	5.8	2.4	1.3	-0.8	-0.2	-2.4
Hair/balding pattern: Pattern 2	0.9	1.2	2.4	1.4	1.6	0.6	1.1	-0.2
Had menopause	1.2	1.5	3.1	1.2	1.8	0.7	1.4	0.4
Had other major operations	1.0	1.3	3.7	-1.1	-0.8	-0.1	1.9	-0.8
Forced vital capacity (FVC)	0.8	3.0	4.3	-1.9	-1.8	-2.1	-1.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	0.2	0.2	-1.2	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.4	0.5	-0.6	-0.3	-0.1
Qualifications: None of the above	1.0	2.2	5.4	0.9	2.1	2.3	0.4	0.0
Financial difficulties in last 2 years	2.3	3.1	6.2	-0.7	-2.3	-1.9	-2.5	-0.4
Mouth/teeth dental problems	0.8	1.2	5.1	-2.3	-0.8	0.1	0.6	0.2
Heart attack	0.2	0.3	0.8	0.6	0.5	-0.1	0.9	0.1
Allergy	9.7	22.2	83.2	-0.8	0.0	9.1	2.7	4.5
Pain all over the body in last month	0.3	0.3	0.7	0.7	0.1	0.9	-0.4	0.6
Diabetes (self-reported)	1.8	2.7	6.4	2.5	0.5	-1.2	-2.0	-1.3
Hayfever/allergic rhinitis (self-reported)	7.4	9.8	33.2	0.7	-1.9	-5.8	-1.1	-3.2
Medication: Ramipril	0.3	0.4	0.9	1.0	0.0	-0.9	0.1	0.3
Medication: Simvastatin	1.2	1.7	5.0	1.4	2.2	-0.7	-1.0	0.3
Fluid intelligence score	0.8	1.7	3.0	-1.7	-1.5	-1.5	-0.8	-0.2
Illnesses of siblings	0.8	1.1	3.1	-0.9	-1.8	-0.9	-0.2	-0.6
Neuroticism score	1.0	2.0	4.5	0.2	-2.1	-0.6	-2.1	1.0
Weight	0.3	1.4	2.9	1.1	1.0	1.7	1.4	-0.1
Impedance of arm (right)	0.4	2.0	6.3	-0.6	-0.6	-2.5	-1.6	0.7
Arm fat percentage (right)	0.9	3.5	6.6	2.6	2.1	1.8	1.8	0.2
Trunk fat-free mass	0.1	0.3	0.9	-0.8	-0.0	0.9	0.5	0.0
Hip circumference	0.3	1.2	2.2	1.0	1.5	1.2	1.1	-0.6
Time employed in main current job	2.0	2.3	3.2	1.6	1.8	0.8	1.4	-1.7
Alcohol intake versus 10 years previously	1.6	2.3	5.2	1.2	0.6	2.3	2.1	0.5
Father’s age at death	0.1	0.2	0.7	-0.4	-0.1	-0.8	0.3	-0.0
Worrier / anxious feelings	0.1	0.2	0.5	-0.7	-0.4	-0.2	0.1	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.8	1.4	0.2	-0.9	-0.0	-0.3
Falls in the last year	0.3	0.4	1.4	1.2	0.6	0.4	0.4	-0.1
Hair/balding pattern: Pattern 3	1.4	2.1	4.0	-0.9	-1.7	2.0	0.3	1.6
Number of live births	0.5	0.7	1.8	-0.9	-0.2	0.8	1.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	2.6	-1.6	-1.1	-1.2	-0.7	0.1
Pulse rate	0.4	0.6	0.9	-0.7	-0.9	-0.9	1.0	-0.3
Happiness	0.3	0.3	1.5	-0.2	-0.0	0.2	-0.1	1.2
Noisy workplace	0.3	0.4	0.9	0.0	-0.8	0.9	-0.2	0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.9	-1.2	-0.1	-2.0	-0.8	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.6	-0.8	-0.8	0.8	1.3	0.9
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	1.4	-0.2	0.8	-1.4	-0.3
Asthma	6.4	12.7	52.3	0.1	0.2	-7.2	-2.3	-2.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	7.2	-1.1	-0.6	0.1	-1.0	2.7
Medication: Cholesterol lowering	2.0	3.1	7.4	2.5	2.7	-0.3	-1.4	-0.2
Depression (self-reported)	0.4	0.5	1.3	-0.2	-1.1	0.9	0.5	0.4
Medication: Lansoprazole	1.2	1.3	3.5	1.6	1.9	-0.2	-0.2	0.9
Prospective memory result	0.3	0.4	1.4	-0.5	0.1	0.7	1.2	0.2
Lung cancer (father)	0.7	0.8	3.1	-0.1	-0.1	1.8	0.3	1.0
Illnesses of mother	0.4	0.5	2.1	0.6	0.4	-0.2	1.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.8	-1.7	-1.0	-0.8	-0.1	-0.6
Pulse wave Arterial Stiffness index	1.1	1.3	3.9	0.1	-0.2	-2.0	-1.6	-0.4
Impedance of arm (left)	0.7	3.0	9.2	0.0	-0.2	-3.0	-2.4	-0.1
Arm fat mass (right)	0.6	2.5	4.2	1.6	1.4	1.9	2.0	-0.2
Trunk predicted mass	0.1	0.3	0.8	-0.8	-0.0	0.9	0.4	0.1
Standing height	0.3	2.8	5.9	-2.4	-1.2	-1.7	-1.9	-0.3
Length of working week for main job	2.1	2.4	5.5	0.4	-2.4	-1.9	-0.9	-1.3
Exposure to tobacco smoke at home	0.7	0.8	1.4	-0.6	0.6	-1.2	-1.0	0.9
Breastfed as a baby	0.6	0.7	2.5	0.5	1.6	0.8	0.2	0.2
Tense / ‘highly strung’	0.1	0.2	0.5	0.4	0.4	0.0	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.0	0.2	-2.0	-0.2	-0.4	0.6
Hair/balding pattern: Pattern 4	0.4	0.9	2.1	-0.9	-0.8	-1.0	0.2	-1.4
Birth weight of first child	0.2	0.3	0.9	0.6	0.4	-0.1	-1.0	0.2
Peak expiratory flow (PEF)	0.2	0.5	2.4	-1.6	-0.0	-0.4	0.3	-0.0
Pulse wave reflection index	0.4	0.5	1.1	0.2	1.1	-0.9	-0.7	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.4	1.0	0.1	-0.7	0.4
Loud music exposure frequency	0.6	0.7	1.7	0.6	-0.5	-1.3	0.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.5	-1.6	-1.0	-1.0	-0.4	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	1.8	1.4	0.6	-1.0	0.2	-0.9
Blood clot in the leg (DVT)	1.6	2.1	5.8	-0.4	1.3	1.5	2.4	-0.7
Medication: Paracetamol	1.4	2.3	3.9	-0.5	1.0	2.0	1.8	1.8
Headache pain in last month	1.3	2.2	6.2	-0.3	0.3	-2.5	-1.8	-1.3
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	9.1	-1.6	-3.0	0.1	0.8	0.1
Glaucoma (self-reported)	1.1	1.2	2.6	1.5	1.6	-0.6	0.0	-1.0
Gout (self-reported)	0.6	0.9	3.0	0.9	-0.5	0.3	-1.7	-0.4
Hypothyroidism/myxoedema (self-reported)	3.9	7.6	23.5	-1.0	0.8	4.8	1.8	3.1
Medication: Amlodipine	0.4	0.5	1.6	-0.3	-0.0	-0.1	1.0	-1.3
Medication: Ventolin 100micrograms inhaler	4.2	5.3	20.1	-0.6	-0.8	-4.5	-1.2	-2.0
Birth weight	0.5	1.1	3.1	0.3	0.5	-1.1	-1.8	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.3	0.8	0.2	0.1	0.9
High blood pressure (siblings)	0.6	0.8	2.2	1.5	0.9	0.4	0.9	0.3
Forced vital capacity (FVC), Best measure	0.6	2.1	3.9	-1.3	-0.9	-2.0	-1.4	-1.4
Body fat percentage	0.6	2.5	4.5	2.1	1.7	1.5	1.7	-0.0
Leg fat percentage (right)	0.9	3.4	5.7	2.4	1.6	2.0	2.2	0.1
Arm fat-free mass (right)	0.1	0.7	2.2	-0.4	0.2	1.5	1.1	-0.1
Exposure to tobacco smoke outside home	1.3	1.7	2.7	-1.6	-1.2	-1.3	1.3	-1.2
Comparative body size at age 10	0.5	1.3	2.7	1.6	0.8	0.4	1.2	-1.4
Number of full brothers	1.2	1.5	3.8	-0.2	-1.2	1.9	0.6	1.3
Worry too long after embarrassment	1.0	1.6	2.6	-0.7	-1.4	-1.1	-1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	0.2	-1.1	-0.3	-0.2	1.3
Wheeze or whistling in the chest in last year	4.6	8.2	25.0	1.7	2.0	-5.0	-1.5	-2.7
Number of children fathered	1.1	1.2	5.0	-0.9	-2.2	-0.0	0.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.1	0.1	0.3	-1.8	-1.7	-0.6
Age at first live birth	0.5	0.9	1.7	-0.1	1.1	-1.2	-1.3	0.6
Pulse wave peak to peak time	1.0	1.2	3.8	-0.3	0.0	1.9	1.4	0.6
Health satisfaction	0.3	0.4	0.8	0.8	-0.9	-0.7	-0.3	-0.3
Shortness of breath walking on level ground	1.3	1.6	3.3	1.4	-0.6	-1.5	-1.8	0.0
Qualifications: College or University degree	0.5	1.7	6.5	0.2	1.1	-2.5	-0.6	0.5
Eye problems/disorders: None of the above	1.1	1.3	2.4	-1.2	-0.6	1.5	0.5	1.4
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.2	-0.6	-0.6	0.5	-0.1
Emphysema/chronic bronchitis	0.3	0.4	1.4	1.2	-0.4	0.1	-0.4	0.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.8	0.2	0.1	-1.6	-1.7	-1.3
Neck or shoulder pain in last month	0.5	0.8	2.6	0.3	-1.6	0.5	0.9	-0.1
Medication: Blood pressure	0.9	1.6	7.2	0.5	2.7	-0.3	0.3	-0.6
Angina (self-reported)	1.6	2.1	4.9	1.8	2.2	0.8	-0.7	1.1
Migraine (self-reported)	0.5	0.6	2.6	0.7	1.6	-0.1	0.1	0.0
Medication: Ibuprofen	0.9	1.0	2.8	-1.3	-0.6	-0.1	-0.5	1.7
Medication: Allopurinol	1.1	1.4	4.0	1.5	-0.8	0.2	-2.0	-0.6
Medication: Omeprazole	0.2	0.2	0.5	-0.3	0.0	0.6	0.5	-0.7
Medication: Seretide 50 evohaler	2.5	2.9	7.4	-2.7	-0.4	-2.4	-1.1	0.5
Mean time to correctly identify matches	1.8	3.5	7.6	1.7	2.6	-0.4	-2.8	0.3
Heart disease (mother)	0.8	1.0	2.2	-1.4	1.5	0.5	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.2	-0.3	-0.5	-1.5	0.0	-1.5
Whole body fat mass	0.5	2.0	2.9	1.7	1.3	1.5	1.7	-0.2
Leg fat mass (right)	0.7	2.7	4.3	1.8	1.4	2.1	2.0	0.0
Arm predicted mass (right)	0.2	0.8	2.2	-0.6	0.1	1.5	1.1	-0.2
Pulse rate, automated reading	0.1	0.3	0.7	-0.2	0.1	-0.7	0.5	0.9
Alcohol intake frequency.	0.2	0.4	1.1	0.1	0.6	1.0	0.7	-0.4
Comparative height size at age 10	0.1	0.8	3.5	-1.9	-0.0	-0.0	-0.8	0.1
Number of full sisters	0.3	0.4	1.0	-0.3	0.0	0.6	-0.6	1.0
Suffer from ‘nerves’	0.4	0.7	1.8	-0.7	-1.4	-0.4	-0.6	0.7
Overall health rating	0.7	1.6	5.2	2.3	1.1	0.7	-0.6	0.9
Chest pain or discomfort	1.0	1.5	5.3	-0.9	0.2	-2.3	-1.2	-0.1
Had major operations	0.4	0.5	1.8	-0.2	0.8	-0.2	0.2	-1.3
Age at last live birth	0.4	0.6	1.5	0.3	0.6	-1.2	-0.9	-0.0
Family relationship satisfaction	0.5	0.7	1.6	0.5	0.7	-1.0	-1.3	-0.3
Leg pain on walking	0.8	1.0	4.1	2.0	0.0	0.6	-0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-0.1	-1.0	-0.2	0.6	0.2
Commuting to job workplace: Car/motor vehicle	1.7	2.0	4.5	-0.3	-1.8	2.1	0.9	1.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.6	1.3	1.9	0.8	0.1	-0.2
Medication: Aspirin	0.4	0.6	1.3	1.1	0.1	0.5	1.2	0.4
Supplements: Vitamin C	2.0	2.4	3.8	-1.8	-0.7	-1.6	1.3	-1.9
Knee pain experienced in last month	0.5	0.8	2.9	1.7	-0.5	-0.5	0.5	-0.6
Hypertension (Self-reported)	0.2	0.5	1.9	0.8	1.4	-0.1	0.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	4.9	0.3	0.4	2.2	1.6	1.6
Illnesses of father: Heart disease	0.5	0.7	2.5	-0.0	0.3	-1.0	-1.6	-0.2
Illnesses of siblings: Diabetes	1.4	1.7	3.9	0.1	1.5	1.6	0.1	2.0
Smoking status: Previous	0.4	0.6	1.5	1.2	1.2	-0.1	0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.6	-1.5	-1.9	-0.6	-1.9	-0.7
Whole body fat-free mass	0.1	0.4	1.4	-0.3	0.2	1.2	0.6	-0.0
Leg fat-free mass (right)	0.1	0.5	2.2	0.2	0.2	1.5	0.6	0.1
Arm fat percentage (left)	0.8	3.4	7.8	2.8	2.2	1.5	1.3	-0.1
Average weekly red wine intake	0.3	0.5	1.2	-1.1	0.2	-1.0	0.0	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.7	0.0	0.0	-1.0	-1.3	0.0
Mood swings	0.9	1.7	3.6	1.1	-1.9	0.5	-1.8	0.5
Loneliness, isolation	0.4	0.5	1.3	0.5	-1.1	-0.9	0.6	0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.5	1.2	0.1	0.8	0.1	0.8
Ever had bowel cancer screening	2.3	2.6	9.1	-1.0	0.2	-1.5	-3.0	-0.8
Diabetes diagnosed by doctor	1.1	1.8	6.9	2.6	0.4	-0.8	-0.8	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.7	-0.7	-0.6	-1.9	0.6	-1.5
Friendships satisfaction	0.3	0.4	1.2	-0.8	-0.1	0.4	-0.0	1.1
Qualifications: nursing, teaching	0.6	1.0	2.5	-1.0	1.1	-1.6	-0.3	0.3
Commuting to job workplace: Walk	1.1	1.1	1.9	1.1	1.2	-1.1	-1.4	0.1
Eye problems/disorders: Cataract	1.8	2.1	5.8	2.4	1.8	-0.3	-1.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.5	1.0	-0.8	-1.2	0.3	0.3
Medication for cholesterol	0.5	0.7	1.4	0.4	0.6	-1.0	-1.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.2	1.1	2.1	1.6	0.9	0.5
Back pain experienced in last month	0.2	0.2	0.4	0.5	-0.6	0.4	-0.6	0.1
Mineral and other dietary supplements	0.9	1.3	3.1	0.2	-0.1	1.7	-0.5	1.8
Breast cancer (self-reported)	1.0	1.1	3.9	0.9	2.0	0.3	0.7	-0.6
Asthma (self-reported)	5.9	11.7	48.7	-0.3	0.5	-7.0	-2.1	-2.2
Osteoporosis (self-reported)	0.2	0.3	1.0	-1.0	0.3	-0.4	-0.2	-0.4
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.3	-0.5	0.6	0.5	0.5
Medication: Aspirin	0.6	0.8	3.1	1.8	0.4	0.3	0.8	0.4
Medication: Gliclazide	1.8	2.0	6.4	2.5	0.9	-0.6	0.2	-1.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.1	-0.2	0.2	0.5	-1.0
Smoking status: Current	0.5	0.8	1.8	0.6	-1.3	1.1	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	-1.1	1.4	-0.4	-0.3	-0.7
Whole body water mass	0.1	0.4	1.6	-0.3	0.2	1.3	0.7	-0.0
Leg predicted mass (right)	0.1	0.5	2.1	0.1	0.2	1.4	0.6	0.1
Arm fat mass (left)	0.6	2.6	3.7	1.9	1.5	1.8	1.9	-0.1
Number of self-reported non-cancer illnesses	1.3	2.2	3.3	1.8	1.6	-1.8	-1.1	-1.0
Average weekly champagne plus white wine intake	0.4	0.6	2.3	-1.5	0.6	-0.0	0.0	0.6
Miserableness	1.9	3.4	5.1	1.5	-2.3	-2.0	-2.2	-0.8
Guilty feelings	1.0	1.5	3.8	1.1	-1.9	1.3	-0.8	0.0
Wears glasses or contact lenses	0.1	0.1	0.4	0.2	-0.6	0.2	0.2	-0.1
Ever taken oral contraceptive pill	0.2	0.3	0.6	0.8	0.1	-0.2	-0.3	-0.8
Hearing aid user	0.7	0.8	2.7	-0.1	0.3	1.6	1.0	0.3
Mother’s age at death	0.4	0.5	1.0	-0.0	0.2	-0.9	-1.0	0.6
Financial situation satisfaction	1.4	1.8	5.4	0.7	-0.6	-1.4	-2.3	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.2	0.8	-1.2	-0.8	0.5	-1.8
Commuting to job workplace: Public transport	2.8	3.3	9.4	2.2	3.1	-1.2	-1.0	0.2
Eye problems/disorders: Glaucoma	0.6	0.8	1.4	1.1	1.2	-0.4	0.4	-0.9
Medication: Blood pressure	0.1	0.1	0.3	0.1	-0.4	0.0	0.5	-0.5
Pain type(s) experienced in last month: Hip pain	1.4	1.8	6.5	2.5	1.1	-0.7	-0.1	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.2	-0.3	0.6	-0.7	0.1	-1.5
High cholesterol (Self-reported)	1.2	2.2	4.2	1.6	1.8	-1.0	-2.0	0.3
Medication: Bendroflumethiazide	0.4	0.6	2.0	0.5	0.3	0.7	-0.2	-1.4
Medication: Paracetamol	1.8	2.8	5.5	-0.6	0.9	2.3	1.5	2.4
Medication: Lisinopril	0.4	0.5	1.2	-0.2	1.1	-0.3	0.0	-1.0
Medication: Atorvastatin	1.0	1.3	3.0	1.7	-0.9	-0.7	-1.2	-0.8
Illnesses of father: High blood pressure	0.9	1.1	1.5	0.2	-1.2	1.2	1.0	1.2
Alcohol drinker status: Never	1.7	2.1	8.2	-1.3	-2.9	0.5	-0.1	-0.3
Ever smoked	0.3	0.5	1.2	0.5	-0.6	1.1	0.8	-0.0
Basal metabolic rate	0.1	0.5	1.7	0.1	0.2	1.3	0.9	-0.0
Leg fat percentage (left)	0.8	2.9	5.0	2.2	1.3	1.9	2.0	-0.1
Arm fat-free mass (left)	0.2	0.9	2.3	-0.5	0.0	1.5	1.4	-0.1
Number of operations (self-reported)	0.4	0.6	2.0	-0.3	0.3	-1.4	0.1	-0.8
Average weekly beer plus cider intake	1.1	1.6	4.2	2.0	-0.3	1.3	-0.0	-1.4
Irritability	1.4	2.4	3.7	1.0	-1.5	-1.2	-1.9	-1.9
Risk taking	1.0	1.4	3.4	0.2	-0.7	1.8	0.8	1.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.2	0.5	0.4	-0.5	-2.1	0.1
Fractured/broken bones in last 5 years	0.9	1.1	3.2	-0.6	-1.4	-0.3	0.2	-1.8
Age started oral contraceptive pill	1.8	2.2	5.2	2.1	2.3	0.4	0.5	-1.0
Diastolic blood pressure, automated reading	0.1	0.4	1.3	-0.2	0.7	-0.3	1.1	0.3
Ever depressed for a whole week	1.3	1.5	3.0	1.7	1.2	-1.3	0.3	-1.2
Unable to work because of sickness or disability	2.0	2.6	7.1	2.7	-0.9	1.0	0.5	1.9
Commuting to job workplace: Cycle	0.7	0.9	3.3	-0.1	-0.0	-1.0	0.2	-1.8
Myopia	1.3	1.8	6.1	1.2	2.5	-0.7	-1.0	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.0	-0.9	-1.0	0.2	-0.1	0.3
Cholesterol lowering medication	0.3	0.4	0.6	-0.0	-0.8	-0.8	-0.6	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.5	-0.0	0.4	0.4	-0.3
Pain experienced in last month	0.6	1.1	2.8	-1.7	0.2	1.4	0.5	0.4
Supplements: Calcium	2.3	2.6	5.9	0.0	0.6	-2.2	-1.3	-2.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	-1.2	-0.5	0.3	0.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.6	0.5	-0.1	0.9	0.1
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	7.3	-0.5	1.2	1.3	2.7	-0.6
Heart disease (siblings)	0.5	0.6	1.7	0.4	1.3	-0.5	-1.0	0.2
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.2	-0.2	0.9	0.1	0.7
Pack years of smoking	0.7	1.0	2.8	1.7	0.9	1.1	-0.0	0.6
Impedance of whole body	0.5	2.7	8.3	-0.9	-1.1	-2.9	-1.7	0.4
Leg fat mass (left)	0.7	2.6	4.5	1.8	1.4	2.1	1.8	0.1
Arm predicted mass (left)	0.2	1.0	2.8	-0.4	-0.0	1.7	1.5	-0.1