Hub : Traits :

Hayfever/allergic rhinitis (self-reported)

113 significantly associated models · 33 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 160458610 161863585 1 1 3.2e-07 3.8e-07 4.7e-01 98 ADAMTS4
2 1 166702558 168182443 1 1 8.4e-09 3.2e-09 1.5e-01 94 CD247
3 2 102118712 104027106 3 2 3.2e-12 3.0e-17 9.9e-06 73 IL18R1 IL1RL2
4 2 197745121 200117777 2 1 2.2e-07 1.0e-07 1.0e+00 100 PLCL1
5 2 241978472 243048760 6 1 2.4e-12 3.9e-11 6.6e-01 100 D2HGDH
6 4 38097478 39643536 3 1 1.2e-15 1.4e-17 1.9e-03 87 TLR1
7 4 122377715 123976639 1 1 1.6e-08 2.4e-10 8.4e-07 40 KIAA1109
8 5 35157236 36571519 1 1 1.7e-07 9.3e-14 6.3e-08 47 IL7R
9 5 109381583 111527482 4 4 3.2e-15 8.3e-18 4.6e-18 -2 CAMK4 SLC25A46 TSLP
10 7 98404438 100026292 2 1 2.6e-07 4.1e-07 3.5e-01 97 CYP3A5
11 9 5317534 7345304 2 2 2.0e-08 2.5e-13 1.9e-07 49 GLDC RANBP6
12 11 75678647 77069746 1 1 2.2e-13 3.6e-18 1.2e-07 63 LRRC32
13 12 55694116 57125879 2 1 3.3e-07 6.5e-07 4.6e-01 98 SUOX
14 14 102118619 103520762 1 1 3.7e-07 3.8e-06 9.3e-04 49 CINP
15 15 90233553 91744509 1 1 9.0e-09 4.2e-07 7.4e-01 100 IQGAP1
16 17 37363793 38783469 2 1 1.7e-09 2.3e-09 5.8e-02 90 ORMDL3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.27 1 0 0.0 0.00 1.0e+00 ADAMTS4
Crohns Disease (2017) 3.57 4 2 6.1 0.65 3.5e-01 KIAA1109 LRRC32 ORMDL3 PLCL1
Irritable Bowel Disease (IBD) 3.00 3 3 9.1 0.00 1.0e+00 KIAA1109 LRRC32 ORMDL3
Ulcerative Colitis (UC) 2.26 3 0 0.0 0.00 1.0e+00 KIAA1109 LRRC32 ORMDL3
Verbal and Numeric Reasoning (VNR) 1.35 2 0 0.0 0.00 1.0e+00 PLCL1 SUOX
Breast Cancer 1.55 1 1 3.0 0.00 1.0e+00 TLR1
Age at First Birth 0.94 1 0 0.0 0.00 1.0e+00 SUOX
Crohns Disease (2012) 2.70 2 0 0.0 0.00 1.0e+00 LRRC32 PLCL1
HbA1C 1.24 1 0 0.0 0.00 1.0e+00 CYP3A5
HDL Cholesterol 1.85 1 1 3.0 0.00 1.0e+00 ORMDL3
Lupus 2.41 1 1 3.0 0.00 1.0e+00 ORMDL3
Primary Biliary Cirrhosis 3.07 1 1 3.0 0.00 1.0e+00 ORMDL3
Rheumatoid Arthritis 2.58 1 0 0.0 0.00 1.0e+00 PLCL1
Schizophrenia 1.38 1 0 0.0 0.00 1.0e+00 PLCL1
Blood Eosinophil Count 20.50 15 14 42.4 -0.93 1.6e-07 ADAMTS4 CAMK4 CD247 D2HGDH GLDC IL18R1 IL1RL2 IL7R KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SUOX TSLP
Blood Platelet Count 1.56 4 2 6.1 -0.45 5.5e-01 ADAMTS4 CINP CYP3A5 ORMDL3
Blood Red Count 0.66 3 2 6.1 0.00 1.0e+00 ORMDL3 PLCL1 SUOX
Blood White Count 5.00 4 1 3.0 -0.24 7.6e-01 ADAMTS4 IQGAP1 ORMDL3 PLCL1
Heel T-Score 1.21 3 1 3.0 0.00 1.0e+00 GLDC IQGAP1 SUOX
BMI 1.59 3 2 6.1 0.00 1.0e+00 PLCL1 SUOX TLR1
Height 0.42 4 1 3.0 0.73 2.7e-01 CINP CYP3A5 IL7R IQGAP1
Waist Hip Ratio (WHR) 0.54 1 0 0.0 0.00 1.0e+00 PLCL1
Smoking Status 1.21 1 0 0.0 0.00 1.0e+00 SUOX
Allergy or Eczema 46.67 20 18 54.5 -0.98 6.1e-15 ADAMTS4 CAMK4 CD247 CINP CYP3A5 D2HGDH GLDC IL18R1 IL1RL2 IL7R IQGAP1 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SUOX TLR1 TSLP
Cardiovascular Disease 1.05 2 0 0.0 0.00 1.0e+00 PLCL1 SUOX
Hypothyroidism (self reported) 3.62 4 2 6.1 -0.12 8.8e-01 CD247 IL7R SUOX TLR1
Respiratory disease 27.70 16 14 42.4 -0.97 3.9e-10 ADAMTS4 CAMK4 CD247 D2HGDH GLDC IL18R1 IL1RL2 IL7R KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SUOX TLR1 TSLP
Lung FEV1/FVC ratio 2.38 6 1 3.0 0.97 1.7e-03 D2HGDH GLDC IL18R1 IL1RL2 ORMDL3 SUOX
Lung FVC 0.55 2 0 0.0 0.00 1.0e+00 ORMDL3 SUOX
Chronotype (morning person) 1.94 1 1 3.0 0.00 1.0e+00 PLCL1
Hair Pigment 0.10 1 0 0.0 0.00 1.0e+00 SUOX
Number of treatments/medications taken 1.53 1 0 0.0 0.00 1.0e+00 IL1RL2
Impedance of leg (right) 1.85 3 2 6.1 0.00 1.0e+00 PLCL1 RANBP6 SUOX
Leg fat-free mass (left) 1.08 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Taking other prescription medications 4.01 3 0 0.0 0.00 1.0e+00 D2HGDH IL1RL2 ORMDL3
Age when periods started (menarche) 1.17 2 0 0.0 0.00 1.0e+00 CAMK4 SUOX
Heel bone mineral density (BMD) T-score, automated (left) 1.20 1 1 3.0 0.00 1.0e+00 IQGAP1
Tinnitus: Yes, but not now, but have in the past 1.66 1 0 0.0 0.00 1.0e+00 IL18R1
High blood pressure 0.96 1 0 0.0 0.00 1.0e+00 SUOX
Hayfever, allergic rhinitis or eczema 43.43 19 19 57.6 0.99 1.8e-15 ADAMTS4 CAMK4 CD247 CINP D2HGDH GLDC IL18R1 IL1RL2 IL7R IQGAP1 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SUOX TLR1 TSLP
Supplements: Glucosamine 1.53 1 0 0.0 0.00 1.0e+00 GLDC
Medication: Levothyroxine sodium 2.82 2 1 3.0 0.00 1.0e+00 CD247 SUOX
Body mass index (BMI) 1.42 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Impedance of leg (left) 1.66 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Leg predicted mass (left) 1.08 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Trunk fat mass 0.57 1 0 0.0 0.00 1.0e+00 SUOX
Waist circumference 1.07 2 1 3.0 0.00 1.0e+00 CINP SUOX
Past tobacco smoking 1.36 1 0 0.0 0.00 1.0e+00 GLDC
Heel bone mineral density (BMD) T-score, automated (right) 1.07 1 1 3.0 0.00 1.0e+00 IQGAP1
Qualifications: None of the above 1.61 1 1 3.0 0.00 1.0e+00 SUOX
Allergy 46.73 19 18 54.5 -0.99 2.7e-15 ADAMTS4 CAMK4 CD247 CINP D2HGDH GLDC IL18R1 IL1RL2 IL7R IQGAP1 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SUOX TLR1 TSLP
Fluid intelligence score 1.66 1 0 0.0 0.00 1.0e+00 SUOX
Weight 1.03 3 1 3.0 0.00 1.0e+00 CINP PLCL1 SUOX
Impedance of arm (right) 2.77 5 3 9.1 0.88 4.7e-02 KIAA1109 LRRC32 ORMDL3 PLCL1 SUOX
Arm fat percentage (right) 0.72 1 0 0.0 0.00 1.0e+00 SUOX
Trunk fat-free mass 1.16 3 2 6.1 0.00 1.0e+00 IQGAP1 PLCL1 SUOX
Hip circumference 0.91 2 0 0.0 0.00 1.0e+00 CINP SUOX
Forced expiratory volume in 1-second (FEV1) 0.82 1 0 0.0 0.00 1.0e+00 SUOX
Qualifications: A levels/AS levels or equivalent 0.88 1 0 0.0 0.00 1.0e+00 SUOX
Mouth/teeth dental problems: Dentures 1.40 1 0 0.0 0.00 1.0e+00 ADAMTS4
Asthma 30.26 17 14 42.4 0.97 3.9e-11 ADAMTS4 CAMK4 CD247 D2HGDH GLDC IL18R1 IL1RL2 IL7R KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SUOX TLR1 TSLP
Forced expiratory volume in 1-second (FEV1), Best measure 0.76 1 1 3.0 0.00 1.0e+00 SUOX
Impedance of arm (left) 2.68 4 2 6.1 0.88 1.2e-01 LRRC32 ORMDL3 PLCL1 SUOX
Arm fat mass (right) 0.95 2 1 3.0 0.00 1.0e+00 PLCL1 SUOX
Trunk predicted mass 1.19 3 2 6.1 0.00 1.0e+00 IQGAP1 PLCL1 SUOX
Standing height 0.48 1 1 3.0 0.00 1.0e+00 IQGAP1
Hair/balding pattern: Pattern 4 1.54 1 1 3.0 0.00 1.0e+00 IQGAP1
Birth weight of first child 2.18 3 0 0.0 0.00 1.0e+00 CINP IQGAP1 SUOX
Medication: Paracetamol 1.07 1 0 0.0 0.00 1.0e+00 SUOX
Headache pain in last month 1.45 1 0 0.0 0.00 1.0e+00 SUOX
Gout (self-reported) 1.89 1 0 0.0 0.00 1.0e+00 IL1RL2
Hypothyroidism/myxoedema (self-reported) 3.21 2 1 3.0 0.00 1.0e+00 CD247 SUOX
Medication: Ventolin 100micrograms inhaler 13.41 14 5 15.2 0.97 9.0e-09 ADAMTS4 CD247 D2HGDH GLDC IL18R1 IL1RL2 KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SUOX TLR1 TSLP
Birth weight 1.23 1 0 0.0 0.00 1.0e+00 SUOX
Leg fat percentage (right) 0.74 1 0 0.0 0.00 1.0e+00 SUOX
Arm fat-free mass (right) 1.40 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Comparative body size at age 10 0.88 1 0 0.0 0.00 1.0e+00 PLCL1
Wheeze or whistling in the chest in last year 10.61 11 7 21.2 0.97 8.9e-08 CD247 D2HGDH GLDC IL18R1 IL1RL2 KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 TSLP
Reason for reducing amount of alcohol drunk: Health precaution 1.94 1 0 0.0 0.00 1.0e+00 SUOX
Age at first live birth 1.13 1 0 0.0 0.00 1.0e+00 SUOX
Shortness of breath walking on level ground 2.14 1 0 0.0 0.00 1.0e+00 LRRC32
Qualifications: College or University degree 1.27 1 1 3.0 0.00 1.0e+00 SUOX
Neck or shoulder pain in last month 1.24 1 0 0.0 0.00 1.0e+00 SUOX
Medication: Seretide 50 evohaler 5.42 2 0 0.0 0.00 1.0e+00 D2HGDH IL18R1
Whole body fat mass 0.70 1 0 0.0 0.00 1.0e+00 SUOX
Leg fat mass (right) 0.91 1 1 3.0 0.00 1.0e+00 SUOX
Arm predicted mass (right) 1.47 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Pulse rate, automated reading 1.05 2 0 0.0 0.00 1.0e+00 CYP3A5 SUOX
Alcohol intake frequency. 1.09 1 0 0.0 0.00 1.0e+00 SUOX
Comparative height size at age 10 0.66 1 1 3.0 0.00 1.0e+00 IQGAP1
Overall health rating 1.73 2 1 3.0 0.00 1.0e+00 PLCL1 SUOX
Chest pain or discomfort 2.20 1 0 0.0 0.00 1.0e+00 ORMDL3
Hypertension (Self-reported) 1.07 1 0 0.0 0.00 1.0e+00 SUOX
Whole body fat-free mass 1.20 3 2 6.1 0.00 1.0e+00 IQGAP1 PLCL1 SUOX
Leg fat-free mass (right) 1.13 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Arm fat percentage (left) 0.65 1 0 0.0 0.00 1.0e+00 SUOX
Mouth/teeth dental problems: Mouth ulcers 2.00 1 0 0.0 0.00 1.0e+00 IL7R
Asthma (self-reported) 29.51 16 14 42.4 0.97 9.6e-11 ADAMTS4 CAMK4 CD247 D2HGDH GLDC IL18R1 IL1RL2 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SUOX TLR1 TSLP
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.41 2 0 0.0 0.00 1.0e+00 ORMDL3 SUOX
Whole body water mass 1.20 3 2 6.1 0.00 1.0e+00 IQGAP1 PLCL1 SUOX
Leg predicted mass (right) 1.13 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Arm fat mass (left) 0.92 2 1 3.0 0.00 1.0e+00 PLCL1 SUOX
Number of self-reported non-cancer illnesses 4.03 4 2 6.1 0.99 1.5e-02 D2HGDH IL1RL2 LRRC32 ORMDL3
Average weekly champagne plus white wine intake 0.75 1 0 0.0 0.00 1.0e+00 SUOX
Miserableness 1.24 1 0 0.0 0.00 1.0e+00 ORMDL3
Medication: Paracetamol 1.04 1 0 0.0 0.00 1.0e+00 SUOX
Basal metabolic rate 1.17 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Leg fat percentage (left) 0.78 1 0 0.0 0.00 1.0e+00 SUOX
Arm fat-free mass (left) 1.41 2 2 6.1 0.00 1.0e+00 PLCL1 SUOX
Age started oral contraceptive pill 1.12 1 0 0.0 0.00 1.0e+00 SUOX
Diastolic blood pressure, automated reading 1.02 1 0 0.0 0.00 1.0e+00 SUOX
Ever depressed for a whole week 1.19 1 0 0.0 0.00 1.0e+00 ORMDL3
Myopia 1.44 1 0 0.0 0.00 1.0e+00 ORMDL3
Vascular/heart problems diagnosed by doctor 0.98 1 0 0.0 0.00 1.0e+00 SUOX
Pain experienced in last month 1.77 1 1 3.0 0.00 1.0e+00 SUOX
Impedance of whole body 2.35 3 2 6.1 0.00 1.0e+00 LRRC32 PLCL1 SUOX
Leg fat mass (left) 0.97 2 1 3.0 0.00 1.0e+00 PLCL1 SUOX
Arm predicted mass (left) 1.53 3 2 6.1 0.00 1.0e+00 CINP PLCL1 SUOX

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.0859 1.32
GTEx Adipose Visceral Omentum 3 0.1473 1.34
GTEx Adrenal Gland 2 0.1373 1.31
GTEx Artery Aorta 2 0.0672 1.27
GTEx Artery Coronary 0 0.0000 1.32
GTEx Artery Tibial 4 0.1064 1.34
GTEx Brain Caudate basal ganglia 0 0.0000 1.30
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.31
GTEx Brain Cerebellum 2 0.1009 1.30
GTEx Brain Cortex 0 0.0000 1.42
GTEx Brain Frontal Cortex BA9 2 0.2165 1.33
GTEx Brain Hippocampus 0 0.0000 1.31
GTEx Brain Hypothalamus 2 0.3390 1.35
GTEx Brain Nucleus accumbens basal ganglia 2 0.2312 1.39
GTEx Brain Putamen basal ganglia 2 0.3205 1.46
GTEx Breast Mammary Tissue 2 0.1013 1.33
GTEx Breast Mammary Tissue (Male) 2 0.1676 1.32
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.33
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.33
GTEx Cells Transformed fibroblasts 6 0.1429 1.39
GTEx Colon Sigmoid 0 0.0000 1.30
GTEx Colon Transverse 4 0.1938 1.37
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.31
GTEx Esophagus Mucosa 4 0.1205 1.37
GTEx Esophagus Muscularis 2 0.0619 1.31
GTEx Heart Atrial Appendage 0 0.0000 1.34
GTEx Heart Left Ventricle 1 0.0654 1.28
GTEx Liver 1 0.1395 1.36
GTEx Lung 2 0.0696 1.29
GTEx Muscle Skeletal 2 0.0692 1.31
GTEx Nerve Tibial 1 0.0231 1.26
GTEx Ovary 0 0.0000 1.26
GTEx Pancreas 3 0.1838 1.38
GTEx Pituitary 2 0.1794 1.30
GTEx Prostate 1 0.1198 1.26
GTEx Skin Not Sun Exposed Suprapubic 3 0.1220 1.35
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.32
GTEx Small Intestine Terminal Ileum 0 0.0000 1.26
GTEx Spleen 4 0.2835 1.43
GTEx Stomach 0 0.0000 1.25
GTEx Testis 4 0.1268 1.33
GTEx Thyroid 4 0.1000 1.30
GTEx Uterus 1 0.1764 1.36
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 5 0.2509 1.41
METSIM Adipose 4 0.0868 1.33
NTR Blood 1 0.0416 1.36
ROSMAP Brain Pre-frontal Cortex 9 0.2050 1.41
YFS Blood 5 0.1083 1.41
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.30
TCGA Breast Tumor 1 0.1304 1.40
TCGA Breast Normal 3 0.0713 1.24
TCGA Ovarian Tumor 0 0.0000 1.25
TCGA Prostate Tumor 4 0.1156 1.35