Hub : Genes

ANK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.166	0.0540	6.5e-04	0.074	NA	0.047	NA	0.057	1.3e-06	NA	9.3e-05	NA	2.0e-05
2	GTEx	Esophagus Mucosa	0.130	0.0420	2.4e-04	0.109	NA	0.107	NA	0.104	1.1e-07	NA	1.3e-07	NA	1.9e-07
3	METSIM	Adipose	0.160	0.0332	3.1e-09	0.022	0.057	0.101	0.088	0.102	2.3e-04	6.5e-09	6.7e-15	3.9e-13	5.1e-15
4	NTR	Blood	0.135	0.0212	0.0e+00	0.106	0.097	0.120	0.122	0.121	2.3e-32	1.1e-29	1.6e-36	3.8e-37	4.5e-37
5	YFS	Blood	0.109	0.0184	0.0e+00	0.134	0.102	0.127	0.127	0.135	1.0e-41	1.4e-31	1.8e-39	2.7e-39	1.0e-41

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.9	4.5	14.6	-3.8	-0.9	-1.9	-1.6	-1.1
Bipolar Disorder or Schizophrenia	2.4	5.8	12.1	-3.5	0.5	-2.4	-2.8	-1.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.5	-0.4	0.4	1.1	0.2
Depression (Nagel 2018)	0.4	0.7	1.6	-1.2	-0.3	0.3	-0.8	-0.9
Intelligence (Savage-Jansen 2018)	0.8	2.5	7.5	-1.3	1.1	-2.7	-0.6	-1.4
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.5	0.6	0.4	0.5
Schizophrenia (2018)	1.3	2.8	5.4	-1.4	1.3	-1.7	-2.3	-1.3
Schizophrenia vs Biploar Disorder	0.8	1.0	4.8	2.2	0.1	-0.2	-0.7	0.0
Worry (Nagel 2018)	0.5	1.0	1.7	-0.8	-1.3	1.0	0.4	1.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.5	-1.2	0.3	-0.4	-1.6	-1.5
Alzheimer’s Disease (in father)	2.0	2.2	5.4	0.5	0.5	-0.8	-2.3	-2.1
Alzheimer’s Disease (including proxy)	2.0	2.9	6.5	-0.8	1.5	-0.9	-2.5	-2.1
Crohns Disease (2017)	0.8	1.8	5.4	-0.9	0.9	-2.3	-0.8	-1.1
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	0.7	-0.8	-0.5	0.6	0.6
Ulcerative Colitis (UC)	1.2	2.2	3.7	1.9	-1.7	0.7	1.3	1.6
Major Depression (MDD)	1.1	1.4	5.3	-2.3	-1.2	-0.3	-0.0	-0.1
Reaction Time	0.8	1.6	4.5	1.4	-2.1	-0.2	-1.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	0.1	0.3	-1.5	-1.3	-1.1
Breast Cancer	0.2	0.5	2.3	-1.5	0.0	0.2	-0.5	0.0
Ovarian Cancer	1.5	2.0	3.5	-1.2	-1.9	1.1	1.4	1.3
Prostate Cancer	0.5	0.7	2.8	-0.7	-1.7	-0.3	0.4	0.2
Age at First Birth	1.3	1.8	5.8	-0.3	0.1	-2.4	-1.5	-0.9
Bipolar Disorder (2011)	8.1	7.8	28.1	-5.3	0.7	-2.2	-1.5	-1.8
Body Mass Index (BMI) (2010)	1.5	2.1	5.1	-1.0	2.3	0.1	-1.4	-1.6
Coronary Artery Disease (CAD)	0.5	0.6	1.3	0.1	-0.1	-0.8	1.0	1.1
Crohns Disease (2012)	0.3	0.4	1.1	0.2	0.5	-0.4	-0.8	-1.1
Mean Putamen Volume	0.2	0.3	0.6	0.6	0.3	-0.5	0.7	-0.4
Fasting Glucose	3.7	4.4	9.2	-1.5	1.4	-0.5	-2.9	-3.0
HbA1C	0.3	0.3	0.5	0.2	0.5	0.6	-0.7	-0.6
HDL Cholesterol	0.4	0.6	1.3	0.0	-0.3	-1.0	-1.1	-0.9
LDL Cholesterol	0.8	1.3	2.6	1.0	-1.3	0.2	1.0	1.6
Lupus	0.3	0.5	1.4	1.2	-0.7	0.3	0.2	0.7
Neuroticism (2016)	0.7	1.0	1.7	0.1	-1.0	1.1	0.9	1.3
Primary Biliary Cirrhosis	0.6	0.8	2.5	-0.2	-0.2	1.6	-1.1	-0.6
Rheumatoid Arthritis	1.0	1.4	3.8	-1.0	-0.7	-0.1	-2.0	-1.2
Schizophrenia (2014)	1.2	2.6	4.8	-1.6	0.8	-1.7	-2.2	-1.4
Triglycerides	0.3	0.4	1.2	-0.8	-1.1	-0.5	-0.2	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.6	-1.3	-0.5	-0.1	-0.2	-0.3
Ulcerative Colitis	2.2	3.2	4.0	1.8	-1.8	1.9	1.3	2.0
Blood Eosinophil Count	0.0	0.3	0.7	0.7	-0.0	0.9	0.4	0.6
Blood Platelet Count	0.1	0.7	3.0	0.8	-1.7	0.1	-0.1	0.4
Blood Red Count	1.5	14.5	26.1	2.0	-2.6	3.9	4.5	5.1
Blood White Count	0.1	1.0	2.5	0.4	-1.5	1.6	-0.4	-0.2
Heel T-Score	1.9	15.1	24.1	-2.7	3.9	-2.9	-4.9	-4.5
BMI	0.1	0.8	1.4	0.2	-1.0	1.2	1.0	-0.6
Height	0.2	3.5	13.6	-1.2	3.7	-1.2	0.4	0.7
Waist Hip Ratio (WHR)	0.3	1.3	4.2	2.0	-0.6	1.2	0.1	0.3
Systolic Blood Pressure	0.2	0.9	3.4	1.8	0.1	0.9	0.5	-0.4
Smoking Status	0.7	1.8	5.1	0.3	1.6	2.3	1.0	-0.3
Allergy or Eczema	0.4	1.0	2.7	-1.1	-1.6	0.3	0.2	1.0
Cardiovascular Disease	0.7	2.3	9.8	1.0	-0.7	3.1	-0.2	-0.5
Hypothyroidism (self reported)	0.5	1.3	2.7	-1.6	1.5	-1.0	0.3	0.4
Respiratory disease	0.4	0.9	2.5	0.5	0.5	1.1	1.6	0.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.3	-1.1	-1.1	0.8	1.1	0.8
Lung FEV1/FVC ratio	0.3	1.3	3.3	-1.3	-1.8	0.9	-0.3	-0.9
Lung FVC	0.4	1.9	5.6	2.0	2.4	0.3	-0.1	0.4
Neuroticism	0.2	0.6	1.0	-0.5	-0.8	0.9	0.5	1.0
Chronotype (morning person)	0.8	1.9	7.4	2.7	-1.1	0.5	-0.5	0.4
Hair Pigment	0.0	0.8	2.5	-1.6	-0.6	0.7	-0.5	-0.7
Tanning	0.1	0.7	1.7	-0.9	-0.7	0.2	0.7	1.3
Hand grip strength (left)	0.3	0.7	2.4	-0.7	-0.2	-0.5	-1.5	-0.3
Number of treatments/medications taken	0.6	1.0	2.2	-0.2	1.4	1.5	-0.5	-0.9
Average weekly spirits intake	2.6	3.2	13.4	-3.7	1.1	0.1	0.3	-1.1
Sensitivity / hurt feelings	0.5	0.9	1.7	-0.8	0.1	-1.3	-1.2	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.7	-0.1	-0.2	-0.6	-0.6
Hearing difficulty/problems: Yes	0.6	0.9	2.1	-0.1	-0.4	-1.4	-1.2	-0.8
Relative age of first facial hair	0.5	1.0	2.7	0.1	-1.6	0.3	1.1	1.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.7	-1.9	1.4	-0.8	0.4	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	1.2	-0.5	0.0	-0.6	-0.6
Ever had hysterectomy (womb removed)	0.1	0.2	0.7	-0.1	-0.1	0.8	0.2	-0.2
Systolic blood pressure, automated reading	0.6	1.7	3.8	1.9	-0.9	1.1	1.6	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.6	-1.0	-0.4	0.1	0.3
Angina	0.3	0.3	1.3	0.0	0.5	0.4	0.1	-1.1
Medication for hormone replacement therapy	1.8	2.0	4.5	-0.4	1.7	-1.0	-1.2	-2.1
Vitamin and mineral supplements	1.7	2.3	4.6	1.9	-0.7	2.1	1.5	0.8
Supplements: Zinc	0.9	1.0	4.0	-0.5	0.5	-2.0	-0.3	-0.6
Medication: Co-codamol	0.1	0.2	0.3	0.0	0.4	0.4	-0.5	-0.5
Medication: Metformin	0.5	0.7	2.1	0.2	-1.4	1.0	0.6	0.3
Diabetes (father)	0.2	0.2	0.4	-0.6	0.5	-0.3	-0.1	0.5
Diabetes (mother)	0.3	0.3	0.6	-0.2	0.4	-0.8	0.8	-0.4
Severe depression (siblings)	1.0	1.2	3.4	-0.0	-1.8	-0.0	0.7	1.4
Pack years adult smoking proportion	2.4	3.6	7.5	0.2	-2.7	2.2	1.9	1.5
Impedance of leg (right)	0.7	3.2	5.0	1.4	-0.7	2.1	2.0	2.2
Leg fat-free mass (left)	0.6	3.1	7.6	-1.8	1.3	-2.8	-0.8	-1.6
Trunk fat percentage	0.1	0.5	1.8	-0.2	-0.8	-0.3	0.3	-1.3
Hand grip strength (right)	0.1	0.4	1.2	-0.5	-0.3	-0.7	-1.1	-0.2
Townsend deprivation index at recruitment	0.9	1.2	3.4	0.1	1.1	-0.6	-1.0	-1.8
Current tobacco smoking	1.0	1.6	6.7	0.7	-0.1	2.6	0.8	-0.1
Average weekly fortified wine intake	0.5	0.6	1.9	-0.2	-1.4	0.5	0.4	0.9
Maternal smoking around birth	0.5	0.7	1.5	1.0	1.2	0.8	0.4	0.2
Fed-up feelings	0.5	1.0	1.5	1.2	-0.6	0.7	1.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.7	-0.9	0.1	-0.6	-0.6
Relative age voice broke	0.4	0.6	1.0	-1.0	-0.9	-0.2	-0.5	-0.9
Taking other prescription medications	1.1	1.6	2.6	0.2	-1.2	1.5	1.6	1.3
Age when periods started (menarche)	0.4	0.9	3.6	-0.1	-0.2	-1.9	0.6	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-1.0	0.7	0.7	-1.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	10.4	-1.0	1.9	-1.1	-3.2	-2.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.6	1.2	-1.6	-0.6	0.6	1.1
Qualifications: CSEs or equivalent	0.5	0.6	1.8	1.3	-0.9	-0.4	0.4	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.7	-0.5	-0.2	0.4	-0.1
High blood pressure	0.4	1.0	2.8	1.0	-0.4	1.7	-0.8	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.4	-2.1	-1.0	-0.1	-0.1	0.3
Multivitamins +/- minerals	1.4	1.8	3.5	-0.5	0.4	-1.8	-1.9	-1.3
Stomach or abdominal pain in last month	1.1	1.4	2.6	-0.7	-1.1	1.0	1.6	1.4
Supplements: Glucosamine	1.0	1.3	3.6	-0.2	1.3	-1.9	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	7.3	0.1	-0.2	-0.9	-2.7	-2.1
Medication: Atenolol	0.4	0.5	1.5	1.2	-0.5	0.6	-0.2	-0.5
Medication: Levothyroxine sodium	0.6	1.1	3.3	-1.8	1.1	-1.0	0.1	-0.0
Sitting height	0.3	2.2	5.9	-2.4	1.3	-1.9	-0.1	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.4	0.7	0.5	-0.1	-0.8
High blood pressure (mother)	0.7	0.9	2.0	0.1	0.9	-1.2	-0.7	-1.4
Body mass index (BMI)	0.1	0.5	1.6	0.0	-0.8	0.1	0.3	-1.3
Impedance of leg (left)	0.6	2.7	4.0	1.4	-0.8	1.8	1.9	2.0
Leg predicted mass (left)	0.6	3.1	7.5	-1.7	1.3	-2.7	-0.9	-1.7
Trunk fat mass	0.2	0.7	2.4	-0.8	-0.2	-0.8	0.1	-1.6
Waist circumference	0.1	0.3	0.8	0.3	-0.5	-0.3	0.7	-0.9
Number of incorrect matches in round	0.8	1.4	3.1	-1.3	-0.8	-1.1	-1.8	-0.5
Past tobacco smoking	0.5	0.9	3.7	-0.0	-1.9	-0.0	-0.1	0.8
Alcohol usually taken with meals	0.2	0.3	0.6	-0.8	0.5	-0.0	-0.6	0.1
Nervous feelings	0.2	0.3	1.1	-0.2	-1.0	-0.2	-0.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	8.3	-0.6	-2.9	0.1	-0.0	1.8
Hearing difficulty/problems with background noise	0.4	0.6	1.8	-0.2	0.0	-1.4	-1.0	-0.0
Hair/balding pattern: Pattern 2	2.0	2.6	4.7	1.4	0.0	-1.2	-2.2	-2.2
Had menopause	1.0	1.3	2.1	0.7	-1.0	0.8	1.4	1.4
Had other major operations	1.9	2.3	5.2	-0.4	1.3	1.1	2.3	1.8
Forced vital capacity (FVC)	0.7	2.7	12.3	0.8	3.5	-0.3	-0.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	6.0	-0.9	1.6	-0.9	-2.4	-1.3
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.4	-2.1	1.0	-1.9	-1.2	-1.1
Qualifications: None of the above	0.7	1.5	4.3	2.1	-1.6	0.6	0.6	0.2
Financial difficulties in last 2 years	0.4	0.6	1.1	1.1	-0.3	0.7	-0.8	-0.6
Mouth/teeth dental problems	1.8	2.8	4.7	1.1	0.8	-2.2	-2.1	-1.8
Heart attack	0.4	0.5	1.2	0.6	-0.1	0.9	0.5	1.1
Allergy	0.2	0.4	1.7	1.3	0.3	-0.5	-0.2	0.1
Pain all over the body in last month	1.1	1.2	5.1	-0.0	2.3	-0.6	0.4	-0.6
Diabetes (self-reported)	1.5	2.3	5.6	-1.2	-2.4	1.4	1.4	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.2	0.9	-1.5	0.1	-0.2	-0.1
Medication: Ramipril	0.6	0.8	2.3	0.9	-0.6	1.5	0.5	-0.0
Medication: Simvastatin	0.1	0.2	0.6	0.3	0.2	0.7	0.3	-0.6
Fluid intelligence score	0.4	0.7	1.8	0.7	0.5	-1.1	-1.3	-0.2
Illnesses of siblings	0.4	0.6	1.0	-0.9	-0.5	-0.5	0.7	1.0
Neuroticism score	0.1	0.2	0.5	-0.4	-0.4	0.2	-0.1	0.7
Weight	0.1	0.7	1.2	-1.1	0.1	-1.0	0.4	-1.0
Impedance of arm (right)	0.0	0.1	0.3	0.2	0.1	-0.6	-0.1	0.2
Arm fat percentage (right)	0.2	0.8	4.0	-0.2	-0.1	-0.1	-0.2	-2.0
Trunk fat-free mass	0.2	1.4	3.2	-1.8	1.2	-1.5	0.0	-0.4
Hip circumference	0.2	0.7	1.2	-0.8	-1.0	-0.6	1.1	-0.3
Time employed in main current job	0.4	0.5	0.9	1.0	-0.8	0.5	-0.7	0.2
Alcohol intake versus 10 years previously	1.3	1.9	3.5	1.1	-0.1	1.4	1.7	1.9
Father’s age at death	1.4	1.9	4.5	-2.1	-0.1	-1.1	-2.0	-0.2
Worrier / anxious feelings	0.5	0.9	2.7	0.1	-1.6	0.6	-0.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.8	-0.3	0.6	1.3	-1.0	-0.9
Falls in the last year	0.6	0.8	1.9	-1.4	-0.7	-1.2	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.6	0.8	1.5	-1.0	1.0	1.2	0.5	0.5
Number of live births	1.4	2.0	4.7	0.5	0.8	0.8	2.2	2.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.3	0.7	2.3	-0.3	-0.4	-0.0
Pulse rate	1.4	2.4	7.2	-0.9	1.1	-1.5	-0.8	-2.7
Happiness	3.6	4.3	10.9	0.7	-1.2	1.6	2.5	3.3
Noisy workplace	1.7	2.2	4.8	0.9	0.8	-0.8	-1.9	-2.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.0	-1.2	0.7	-2.5	-1.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.8	-1.3	0.2	-1.3	-0.5	-0.8
Mouth/teeth dental problems: Dentures	1.9	3.2	8.4	-0.5	-1.4	2.9	1.8	1.5
Asthma	0.5	1.0	3.0	0.0	0.2	1.0	1.7	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	3.5	-0.9	1.8	-0.5	-1.7	-1.9
Medication: Cholesterol lowering	0.3	0.5	2.3	0.3	-0.1	1.5	0.3	-0.0
Depression (self-reported)	2.2	2.7	6.6	-2.6	0.5	-1.8	-1.4	-1.2
Medication: Lansoprazole	0.8	0.9	1.3	0.5	0.8	1.1	1.0	1.1
Prospective memory result	0.2	0.2	0.4	-0.6	-0.7	-0.4	0.1	0.3
Lung cancer (father)	0.8	0.9	2.9	-1.7	-0.2	0.5	0.9	-0.8
Illnesses of mother	1.0	1.3	2.7	-0.9	-0.9	0.7	1.3	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.7	0.6	1.9	-0.8	-0.3	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-0.1	0.9	-1.1	-0.5	-0.9
Impedance of arm (left)	0.1	0.3	1.1	0.3	-0.4	-0.4	0.5	1.0
Arm fat mass (right)	0.1	0.6	2.6	-0.3	-0.2	-0.2	0.1	-1.6
Trunk predicted mass	0.2	1.4	3.3	-1.8	1.1	-1.5	0.0	-0.4
Standing height	0.3	3.2	6.4	-2.5	2.0	-2.3	0.3	0.6
Length of working week for main job	0.5	0.6	1.5	-1.2	1.1	0.1	-0.2	0.3
Exposure to tobacco smoke at home	1.7	1.9	3.9	-2.0	-2.0	0.5	1.0	0.8
Breastfed as a baby	0.3	0.4	0.6	-0.8	0.4	0.8	-0.8	0.2
Tense / ‘highly strung’	0.3	0.6	1.0	-1.0	-0.8	0.0	0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.7	8.4	-1.8	0.5	-2.9	-2.2	-2.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	-0.1	0.5	-0.1	-0.4	-0.2
Birth weight of first child	0.6	1.1	3.6	-1.2	0.7	-1.9	-0.2	-0.2
Peak expiratory flow (PEF)	0.3	0.7	1.8	-0.5	1.3	-0.2	-1.1	-0.6
Pulse wave reflection index	0.1	0.2	0.4	-0.4	0.3	-0.2	0.5	0.6
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.6	-0.4	0.1	-0.5	-0.2
Loud music exposure frequency	0.3	0.3	0.7	-0.2	-0.9	0.6	-0.2	0.5
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	6.2	0.8	0.0	-2.2	-2.5	-1.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.1	-1.6	0.0	1.4	2.0	1.3
Blood clot in the leg (DVT)	0.4	0.5	1.6	0.2	-0.4	1.3	-0.0	-0.8
Medication: Paracetamol	0.3	0.4	1.4	0.3	0.1	-1.2	-0.4	-0.6
Headache pain in last month	1.1	1.8	3.3	0.1	-0.9	1.4	1.8	1.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	0.3	0.3	-1.4	1.0	1.0
Glaucoma (self-reported)	0.4	0.5	1.7	0.8	0.2	0.3	-1.3	-0.2
Gout (self-reported)	0.7	0.9	1.7	1.3	-1.1	-0.2	-0.6	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	-1.5	0.8	-0.9	0.4	0.5
Medication: Amlodipine	0.3	0.4	1.0	0.5	1.0	0.2	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.9	-0.9	-0.4	-0.6	0.9	0.9
Birth weight	1.0	2.1	3.8	-1.3	0.6	-1.2	1.8	1.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.6	1.9	0.5	0.2	-0.1	0.4
High blood pressure (siblings)	0.8	1.2	2.1	1.3	1.4	-0.1	-0.9	-1.2
Forced vital capacity (FVC), Best measure	0.5	1.8	7.8	0.6	2.8	-0.8	-0.3	0.3
Body fat percentage	0.1	0.6	2.2	-0.2	-0.6	0.1	0.4	-1.5
Leg fat percentage (right)	0.3	0.9	2.3	0.2	-0.6	1.5	1.3	-0.5
Arm fat-free mass (right)	0.2	0.9	2.2	-1.1	0.8	-1.5	0.1	-0.5
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-0.5	-1.2	0.8	1.0	0.2
Comparative body size at age 10	0.6	1.8	4.3	-0.8	1.7	0.3	-2.1	-1.0
Number of full brothers	0.3	0.4	0.5	0.7	-0.6	0.7	0.5	-0.3
Worry too long after embarrassment	0.4	0.6	1.7	0.3	0.9	-0.2	0.5	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.1	-1.8	0.5	-1.8	-0.0	-0.6
Wheeze or whistling in the chest in last year	2.4	4.3	8.8	0.6	-1.7	1.8	3.0	2.5
Number of children fathered	1.6	1.8	3.8	1.9	-2.0	0.9	0.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.6	-0.0	1.0	-2.1	-0.6	-1.4
Age at first live birth	0.4	0.7	1.6	0.1	1.3	-1.1	-0.9	0.1
Pulse wave peak to peak time	0.4	0.5	0.9	-0.1	-0.7	1.0	0.4	0.9
Health satisfaction	0.1	0.2	0.7	-0.1	0.4	0.4	-0.1	0.8
Shortness of breath walking on level ground	0.4	0.4	1.3	-0.6	-1.1	-0.1	-0.7	-0.1
Qualifications: College or University degree	0.5	1.7	4.8	-2.2	1.5	-0.8	-0.9	0.0
Eye problems/disorders: None of the above	0.4	0.5	1.3	1.2	-0.9	-0.5	0.2	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.6	0.6	0.4	0.6	0.8
Emphysema/chronic bronchitis	1.2	1.3	3.7	-0.9	-0.0	0.9	1.9	1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.3	-0.9	-0.6	0.3	0.1
Neck or shoulder pain in last month	0.3	0.4	1.0	0.2	0.1	1.0	-0.4	0.9
Medication: Blood pressure	0.3	0.5	1.2	-0.1	0.8	0.6	-0.4	-1.1
Angina (self-reported)	0.3	0.3	1.2	-0.3	0.6	0.3	0.2	-1.1
Migraine (self-reported)	0.4	0.5	1.3	0.3	0.4	1.1	-0.3	0.9
Medication: Ibuprofen	1.4	1.7	3.0	-1.5	1.7	-0.3	-1.0	-1.5
Medication: Allopurinol	0.4	0.6	1.4	0.5	-1.0	-0.3	-0.6	-1.2
Medication: Omeprazole	0.3	0.3	0.8	-0.3	0.6	-0.9	0.4	0.2
Medication: Seretide 50 evohaler	0.8	0.9	3.7	-1.9	0.6	0.4	0.1	-0.7
Mean time to correctly identify matches	0.7	1.4	3.9	1.0	-2.0	-0.1	-1.2	-0.8
Heart disease (mother)	0.7	0.9	1.8	0.9	1.4	-0.3	-0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	4.0	2.0	-0.2	0.9	0.6	0.2
Whole body fat mass	0.2	0.7	2.5	-0.7	-0.2	-0.6	0.0	-1.6
Leg fat mass (right)	0.1	0.4	1.4	-0.4	0.0	0.1	0.5	-1.2
Arm predicted mass (right)	0.2	1.0	2.4	-1.2	0.8	-1.6	0.0	-0.5
Pulse rate, automated reading	0.3	0.9	2.9	0.4	0.1	1.1	0.5	-1.7
Alcohol intake frequency.	1.1	2.6	5.3	1.3	-1.0	1.1	2.3	1.9
Comparative height size at age 10	0.5	2.9	7.4	-0.8	2.7	-0.4	1.8	1.8
Number of full sisters	0.1	0.1	0.2	-0.3	0.4	0.2	0.4	0.3
Suffer from ‘nerves’	0.3	0.5	1.1	-0.8	-0.7	0.6	-0.2	1.1
Overall health rating	0.7	1.5	6.5	0.2	-0.7	2.5	0.4	-0.2
Chest pain or discomfort	0.3	0.4	1.3	0.1	-0.2	0.8	1.1	0.0
Had major operations	0.6	0.7	2.3	-1.5	0.6	0.7	0.6	0.2
Age at last live birth	0.8	1.2	3.9	0.4	2.0	-0.7	-1.2	-0.1
Family relationship satisfaction	0.8	1.0	3.4	-0.0	-0.9	-0.1	0.8	1.8
Leg pain on walking	0.5	0.6	1.3	1.1	-0.7	-0.3	0.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.3	0.7	1.5	0.2	0.2	-1.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	-0.5	-0.6	-0.4	-1.5	-1.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.4	-0.0	-0.7	-0.1	1.1	2.1
Medication: Aspirin	1.0	1.3	4.5	-0.6	-0.7	2.1	0.4	1.0
Supplements: Vitamin C	1.1	1.3	2.7	-1.6	1.1	-1.5	-0.1	0.3
Knee pain experienced in last month	0.8	1.2	5.9	2.4	-0.3	-0.1	0.3	0.3
Hypertension (Self-reported)	0.4	1.2	4.8	0.8	-0.8	2.2	-0.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.8	-0.3	-0.7	-1.7	-0.0	-0.2
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.1	0.5	0.3	-0.7	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.7	-0.3	-0.5	-0.8	-0.2	-0.3
Smoking status: Previous	0.5	0.7	2.8	0.4	1.7	-0.3	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	0.0	1.0	-0.7	0.5	0.8
Whole body fat-free mass	0.3	2.0	4.3	-1.8	1.2	-2.1	-0.3	-1.0
Leg fat-free mass (right)	0.7	3.7	9.2	-1.9	1.3	-3.0	-1.0	-1.8
Arm fat percentage (left)	0.1	0.5	2.3	-0.3	-0.4	-0.0	0.3	-1.5
Average weekly red wine intake	2.3	3.4	4.9	-1.6	2.2	-2.0	-1.9	-1.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.2	-0.2	1.5	-0.5	-0.7	-1.0
Mood swings	0.2	0.4	1.2	0.7	-0.3	1.1	0.4	0.6
Loneliness, isolation	0.4	0.6	2.1	-0.7	-1.4	-0.0	-0.3	-0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-1.1	0.5	0.1	0.0	-1.2
Ever had bowel cancer screening	0.4	0.4	1.8	-1.4	0.4	0.0	-0.3	0.1
Diabetes diagnosed by doctor	0.9	1.6	3.0	-0.6	-1.7	1.6	1.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.1	-1.5	1.4	-1.0	1.3	0.0
Friendships satisfaction	1.1	1.4	4.0	-1.1	-0.2	-0.2	1.3	2.0
Qualifications: nursing, teaching	0.5	0.8	1.6	-1.3	1.1	0.8	-0.7	-0.4
Commuting to job workplace: Walk	4.5	4.9	9.8	1.8	-2.0	0.7	2.6	3.1
Eye problems/disorders: Cataract	2.1	2.4	9.4	-3.1	0.5	-1.0	-0.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	5.1	1.3	-1.3	-0.3	2.2	2.2
Medication for cholesterol	0.7	1.1	2.7	-0.2	1.0	-0.9	1.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	5.1	-2.3	0.8	1.0	-0.2	-0.2
Back pain experienced in last month	0.4	0.6	1.9	1.4	-0.4	0.8	0.1	-0.4
Mineral and other dietary supplements	0.9	1.3	2.6	0.2	-1.5	1.6	1.1	0.3
Breast cancer (self-reported)	0.9	1.1	3.4	-1.4	-0.2	0.0	1.9	0.2
Asthma (self-reported)	0.4	0.9	2.7	0.1	0.2	1.0	1.6	0.8
Osteoporosis (self-reported)	0.8	1.0	2.6	0.3	-0.7	-0.3	1.4	1.6
Osteoarthritis (self-reported)	0.5	0.6	2.1	1.5	-0.1	-0.7	-0.5	-0.2
Medication: Aspirin	1.5	2.0	5.3	-0.9	-1.0	2.3	0.9	1.4
Medication: Gliclazide	0.9	1.0	2.4	0.3	-1.6	1.0	0.6	1.1
Illnesses of father: None of the above (group 1)	1.1	1.3	3.6	-0.2	-1.6	0.3	1.9	0.6
Smoking status: Current	0.8	1.3	5.7	0.4	0.0	2.4	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.8	0.8	1.0	-1.7	-1.4	-0.7
Whole body water mass	0.4	2.0	4.4	-1.7	1.3	-2.1	-0.5	-1.1
Leg predicted mass (right)	0.7	3.6	8.9	-1.8	1.4	-3.0	-1.0	-1.8
Arm fat mass (left)	0.1	0.4	1.4	-0.4	-0.4	-0.2	0.6	-1.2
Number of self-reported non-cancer illnesses	0.7	1.2	3.3	1.8	-1.4	1.0	-0.1	-0.0
Average weekly champagne plus white wine intake	1.2	1.7	5.1	-0.5	1.2	-2.3	-0.7	-1.1
Miserableness	0.3	0.5	1.0	-1.0	-0.3	-0.1	0.9	0.8
Guilty feelings	0.2	0.2	1.0	0.4	-0.1	0.1	-1.0	0.2
Wears glasses or contact lenses	1.4	1.6	4.4	0.3	0.7	-0.3	-2.1	-1.7
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.9	-0.1	-0.5	-0.2	-0.1
Hearing aid user	0.8	0.9	1.9	-0.6	1.4	-0.8	-0.5	-1.2
Mother’s age at death	0.2	0.3	1.0	-0.3	-0.0	-0.4	-1.0	-0.2
Financial situation satisfaction	1.4	1.7	5.1	1.5	-2.3	0.5	0.1	0.9
Tinnitus: Yes, now most or all of the time	1.9	2.3	3.9	0.7	-0.6	-1.8	-2.0	-1.8
Commuting to job workplace: Public transport	0.6	0.7	2.5	0.5	1.6	0.3	-0.5	-0.7
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	1.0	-0.4	0.2	-0.7	-0.1
Medication: Blood pressure	0.8	1.5	2.5	1.3	-1.0	1.6	-1.4	-0.4
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.4	0.5	-0.7	1.6	1.5	1.6
Supplements: Fish oil (including cod liver oil)	2.4	3.1	7.5	-0.2	1.6	-1.8	-2.7	-1.5
High cholesterol (Self-reported)	0.7	1.2	1.8	1.4	-1.1	1.1	-0.9	-0.9
Medication: Bendroflumethiazide	0.7	1.1	4.2	0.9	0.1	2.1	-0.6	0.1
Medication: Paracetamol	0.2	0.2	0.6	-0.5	0.4	-0.8	-0.3	-0.5
Medication: Lisinopril	1.6	2.0	3.8	-0.7	1.0	-1.8	-1.2	-2.0
Medication: Atorvastatin	0.7	0.9	3.3	0.3	-0.1	-0.3	-1.8	-1.0
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.3	0.1	0.1	0.1	0.2
Alcohol drinker status: Never	0.1	0.1	0.1	0.3	-0.3	0.3	-0.4	-0.1
Ever smoked	0.4	0.7	2.3	-0.1	1.5	0.4	0.3	-0.9
Basal metabolic rate	0.3	1.6	3.5	-1.6	0.9	-1.9	-0.1	-1.0
Leg fat percentage (left)	0.2	0.9	1.8	-0.0	-0.9	1.4	1.3	-0.5
Arm fat-free mass (left)	0.2	1.2	2.3	-1.5	0.8	-1.5	-0.1	-0.8
Number of operations (self-reported)	1.9	2.8	5.6	-1.2	2.4	1.7	1.8	0.9
Average weekly beer plus cider intake	1.0	1.4	5.2	0.2	-2.3	0.4	0.4	1.2
Irritability	0.3	0.6	1.6	-0.6	-0.7	0.4	0.4	1.3
Risk taking	0.8	1.1	2.0	-1.4	1.3	1.3	0.2	0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.1	-1.8	-0.7	0.2	-0.2	0.6
Fractured/broken bones in last 5 years	1.0	1.3	1.9	1.1	1.0	1.4	1.1	1.2
Age started oral contraceptive pill	0.1	0.2	0.5	-0.2	0.0	-0.7	0.0	0.5
Diastolic blood pressure, automated reading	0.4	1.3	4.1	2.0	-0.3	-0.4	1.2	-1.0
Ever depressed for a whole week	0.6	0.7	2.4	-0.6	0.8	-1.6	0.0	-0.1
Unable to work because of sickness or disability	0.4	0.5	1.9	-0.4	-0.5	0.0	1.4	0.2
Commuting to job workplace: Cycle	1.6	1.9	7.3	-0.3	1.2	-2.7	-0.4	-0.8
Myopia	1.5	2.2	6.8	-0.1	-2.6	0.9	0.8	1.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.3	-1.2	0.6	-2.1	0.3	0.6
Cholesterol lowering medication	0.2	0.4	0.9	-0.5	-0.9	0.7	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.2	0.2	-0.3	0.7	0.7
Pain experienced in last month	0.9	1.6	3.1	-0.8	-0.2	-1.6	-1.8	-1.2
Supplements: Calcium	0.2	0.2	0.6	0.1	0.6	-0.8	0.0	-0.2
Basal cell carcinoma (self-reported)	1.5	1.8	4.4	1.0	1.1	2.1	1.4	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.5	0.3	0.6	0.5	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	0.2	-0.2	1.2	0.3	-0.6
Heart disease (siblings)	0.5	0.7	1.3	0.5	-0.1	1.1	-0.8	-1.0
Alcohol drinker status: Previous	2.1	2.4	6.0	-0.8	-1.3	0.4	2.4	1.8
Pack years of smoking	1.6	2.4	4.8	0.1	-2.2	2.1	1.4	1.1
Impedance of whole body	0.2	1.2	2.7	0.7	-0.8	0.8	1.3	1.6
Leg fat mass (left)	0.1	0.4	1.3	-0.7	-0.2	0.2	0.5	-1.1
Arm predicted mass (left)	0.2	0.8	1.8	-1.3	0.5	-1.3	0.1	-0.6