Hub : Traits :

Bipolar Disorder

14 significantly associated models · 12 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 84849386 86253581 1 1 4.1e-07 6.1e-04 0.2620 89 TGOLN2
2 2 96675166 98024837 1 1 2.2e-07 4.2e-07 0.6110 99 LMAN2L
3 3 52020411 53623102 3 1 1.1e-07 5.4e-07 0.2540 95 ITIH4-AS1
4 10 61089040 63192846 1 1 1.1e-07 3.8e-09 0.0099 81 ANK3
5 12 48512331 50199949 6 2 1.7e-08 9.4e-09 0.0206 84 CACNB3 LMBR1L

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 3.11 1 0 0.0 0 1 ITIH4-AS1
Reaction Time 3.97 1 1 3.0 0 1 LMBR1L
Verbal and Numeric Reasoning (VNR) 4.56 2 2 6.1 0 1 ITIH4-AS1 LMBR1L
Prostate Cancer 3.21 1 0 0.0 0 1 TGOLN2
Age at First Birth 1.27 1 0 0.0 0 1 ITIH4-AS1
Neuroticism 2.88 1 0 0.0 0 1 ITIH4-AS1
Schizophrenia 6.11 3 2 6.1 0 1 CACNB3 ITIH4-AS1 LMAN2L
Blood Eosinophil Count 5.03 2 2 6.1 0 1 ITIH4-AS1 LMAN2L
Blood Platelet Count 0.67 2 0 0.0 0 1 ITIH4-AS1 LMAN2L
Blood Red Count 1.24 1 1 3.0 0 1 ITIH4-AS1
Blood White Count 0.49 1 0 0.0 0 1 TGOLN2
Heel T-Score 1.27 2 1 3.0 0 1 ITIH4-AS1 LMBR1L
BMI 2.79 2 1 3.0 0 1 ITIH4-AS1 LMBR1L
Height 1.59 2 2 6.1 0 1 ITIH4-AS1 LMAN2L
Waist Hip Ratio (WHR) 2.39 1 1 3.0 0 1 ITIH4-AS1
Systolic Blood Pressure 0.64 1 0 0.0 0 1 ITIH4-AS1
Smoking Status 2.30 2 0 0.0 0 1 CACNB3 ITIH4-AS1
Cardiovascular Disease 1.78 3 0 0.0 0 1 ITIH4-AS1 LMAN2L LMBR1L
Hypothyroidism (self reported) 1.90 2 0 0.0 0 1 CACNB3 LMBR1L
Type 2 Diabetes (T2D) 1.25 1 0 0.0 0 1 ITIH4-AS1
Lung FEV1/FVC ratio 1.20 2 0 0.0 0 1 LMBR1L TGOLN2
Neuroticism 2.19 1 0 0.0 0 1 ITIH4-AS1
Chronotype (morning person) 2.40 1 0 0.0 0 1 CACNB3
Hair Pigment 0.54 2 1 3.0 0 1 CACNB3 LMBR1L
Tanning 0.36 1 0 0.0 0 1 ITIH4-AS1
Hand grip strength (left) 2.03 2 0 0.0 0 1 ITIH4-AS1 LMBR1L
Average weekly spirits intake 3.73 1 0 0.0 0 1 ANK3
Frequency of depressed mood in last 2 weeks 1.58 1 0 0.0 0 1 ITIH4-AS1
Impedance of leg (right) 4.21 3 2 6.1 0 1 CACNB3 ITIH4-AS1 LMBR1L
Leg fat-free mass (left) 0.89 1 0 0.0 0 1 LMBR1L
Age when periods started (menarche) 2.07 2 0 0.0 0 1 ITIH4-AS1 LMBR1L
High blood pressure 1.46 1 0 0.0 0 1 LMBR1L
Medication: Levothyroxine sodium 3.11 1 0 0.0 0 1 CACNB3
Sitting height 1.08 1 1 3.0 0 1 ITIH4-AS1
Body mass index (BMI) 1.75 2 1 3.0 0 1 ITIH4-AS1 LMBR1L
Impedance of leg (left) 3.61 3 2 6.1 0 1 CACNB3 ITIH4-AS1 LMBR1L
Leg predicted mass (left) 0.91 1 0 0.0 0 1 LMBR1L
Number of incorrect matches in round 2.10 1 0 0.0 0 1 ITIH4-AS1
Past tobacco smoking 1.88 1 0 0.0 0 1 ITIH4-AS1
Nervous feelings 2.71 1 1 3.0 0 1 ITIH4-AS1
Frequency of tenseness / restlessness in last 2 weeks 2.34 1 0 0.0 0 1 ITIH4-AS1
Forced vital capacity (FVC) 0.87 1 0 0.0 0 1 ITIH4-AS1
Qualifications: None of the above 1.59 1 0 0.0 0 1 LMBR1L
Diabetes (self-reported) 2.33 1 0 0.0 0 1 ITIH4-AS1
Fluid intelligence score 3.03 2 0 0.0 0 1 ITIH4-AS1 LMBR1L
Neuroticism score 1.37 1 0 0.0 0 1 ITIH4-AS1
Impedance of arm (right) 3.20 3 2 6.1 0 1 CACNB3 ITIH4-AS1 LMBR1L
Arm fat percentage (right) 0.44 1 0 0.0 0 1 ITIH4-AS1
Trunk fat-free mass 0.76 1 0 0.0 0 1 LMAN2L
Worrier / anxious feelings 4.21 1 1 3.0 0 1 ITIH4-AS1
Pulse rate 1.79 1 0 0.0 0 1 ITIH4-AS1
Mouth/teeth dental problems: Dentures 1.70 1 0 0.0 0 1 LMAN2L
Medication: Cholesterol lowering 1.85 1 0 0.0 0 1 LMAN2L
Prospective memory result 1.92 1 0 0.0 0 1 ITIH4-AS1
Impedance of arm (left) 2.38 2 1 3.0 0 1 ITIH4-AS1 LMBR1L
Trunk predicted mass 0.80 1 0 0.0 0 1 LMAN2L
Standing height 1.34 2 1 3.0 0 1 ITIH4-AS1 LMAN2L
Tense / 'highly strung' 2.36 1 0 0.0 0 1 ITIH4-AS1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.90 1 0 0.0 0 1 ITIH4-AS1
Ever highly irritable/argumentative for 2 days 1.47 1 0 0.0 0 1 ITIH4-AS1
Headache pain in last month 1.91 1 0 0.0 0 1 ITIH4-AS1
Medication for cholesterol, blood pressure or diabetes 1.97 1 0 0.0 0 1 LMAN2L
Hypothyroidism/myxoedema (self-reported) 2.64 2 0 0.0 0 1 CACNB3 LMBR1L
Birth weight 2.11 1 0 0.0 0 1 LMBR1L
Forced vital capacity (FVC), Best measure 0.90 1 0 0.0 0 1 ITIH4-AS1
Leg fat percentage (right) 0.64 1 0 0.0 0 1 ITIH4-AS1
Arm fat-free mass (right) 0.84 1 0 0.0 0 1 LMBR1L
Comparative body size at age 10 5.65 3 1 3.0 0 1 CACNB3 ITIH4-AS1 LMBR1L
Worry too long after embarrassment 2.18 1 0 0.0 0 1 ITIH4-AS1
Wheeze or whistling in the chest in last year 1.62 1 0 0.0 0 1 CACNB3
Qualifications: College or University degree 1.72 2 0 0.0 0 1 CACNB3 LMBR1L
Mean time to correctly identify matches 4.09 1 1 3.0 0 1 LMBR1L
Leg fat mass (right) 0.49 1 0 0.0 0 1 ITIH4-AS1
Arm predicted mass (right) 0.79 1 0 0.0 0 1 LMBR1L
Pulse rate, automated reading 2.43 2 1 3.0 0 1 CACNB3 LMBR1L
Comparative height size at age 10 1.34 1 1 3.0 0 1 ITIH4-AS1
Suffer from 'nerves' 2.06 1 0 0.0 0 1 ITIH4-AS1
Family relationship satisfaction 2.31 1 0 0.0 0 1 ITIH4-AS1
Hypertension (Self-reported) 1.51 1 0 0.0 0 1 LMBR1L
Illnesses of father: Heart disease 1.44 1 0 0.0 0 1 TGOLN2
Forced expiratory volume in 1-second (FEV1), predicted 1.26 1 0 0.0 0 1 ITIH4-AS1
Whole body fat-free mass 0.85 2 0 0.0 0 1 LMAN2L LMBR1L
Leg fat-free mass (right) 1.18 2 0 0.0 0 1 LMAN2L LMBR1L
Handedness (chirality/laterality): Left-handed 2.89 2 0 0.0 0 1 CACNB3 LMBR1L
Ever had bowel cancer screening 2.82 1 0 0.0 0 1 CACNB3
Diabetes diagnosed by doctor 2.24 2 0 0.0 0 1 ITIH4-AS1 LMAN2L
Eye problems/disorders: Cataract 3.88 1 0 0.0 0 1 ANK3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.92 1 0 0.0 0 1 CACNB3
Osteoporosis (self-reported) 2.34 1 0 0.0 0 1 LMBR1L
Whole body water mass 0.88 2 0 0.0 0 1 LMAN2L LMBR1L
Leg predicted mass (right) 1.17 2 0 0.0 0 1 LMAN2L LMBR1L
Arm fat mass (left) 0.72 1 0 0.0 0 1 ITIH4-AS1
Guilty feelings 1.95 1 0 0.0 0 1 ITIH4-AS1
Financial situation satisfaction 3.75 2 0 0.0 0 1 LMBR1L TGOLN2
Medication: Blood pressure 1.83 1 0 0.0 0 1 LMBR1L
High cholesterol (Self-reported) 2.65 1 0 0.0 0 1 LMAN2L
Medication: Atorvastatin 1.93 1 0 0.0 0 1 LMAN2L
Ever smoked 2.30 1 0 0.0 0 1 ITIH4-AS1
Basal metabolic rate 0.80 1 0 0.0 0 1 LMBR1L
Leg fat percentage (left) 0.60 1 0 0.0 0 1 ITIH4-AS1
Arm fat-free mass (left) 0.81 1 0 0.0 0 1 LMAN2L
Fractured/broken bones in last 5 years 2.54 1 0 0.0 0 1 LMBR1L
Diastolic blood pressure, automated reading 1.41 1 0 0.0 0 1 LMAN2L
Vascular/heart problems diagnosed by doctor 1.56 1 0 0.0 0 1 LMBR1L
Cholesterol lowering medication 1.52 1 0 0.0 0 1 TGOLN2
Impedance of whole body 3.39 3 2 6.1 0 1 CACNB3 ITIH4-AS1 LMBR1L
Leg fat mass (left) 0.54 1 0 0.0 0 1 ITIH4-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0402 1.36
GTEx Adipose Visceral Omentum 0 0.0000 1.35
GTEx Adrenal Gland 0 0.0000 1.41
GTEx Artery Aorta 2 0.0939 1.41
GTEx Artery Coronary 0 0.0000 1.34
GTEx Artery Tibial 0 0.0000 1.32
GTEx Brain Caudate basal ganglia 0 0.0000 1.29
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.36
GTEx Brain Cerebellum 2 0.1398 1.50
GTEx Brain Cortex 0 0.0000 1.37
GTEx Brain Frontal Cortex BA9 0 0.0000 1.31
GTEx Brain Hippocampus 0 0.0000 1.47
GTEx Brain Hypothalamus 0 0.0000 1.25
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.49
GTEx Brain Putamen basal ganglia 0 0.0000 1.20
GTEx Breast Mammary Tissue 0 0.0000 1.41
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.36
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.35
GTEx Cells EBV-transformed lymphocytes 1 0.0950 1.44
GTEx Cells Transformed fibroblasts 0 0.0000 1.40
GTEx Colon Sigmoid 0 0.0000 1.41
GTEx Colon Transverse 0 0.0000 1.37
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.35
GTEx Esophagus Mucosa 1 0.0425 1.38
GTEx Esophagus Muscularis 1 0.0435 1.40
GTEx Heart Atrial Appendage 0 0.0000 1.37
GTEx Heart Left Ventricle 0 0.0000 1.37
GTEx Liver 0 0.0000 1.27
GTEx Lung 1 0.0494 1.48
GTEx Muscle Skeletal 2 0.0963 1.35
GTEx Nerve Tibial 1 0.0325 1.39
GTEx Ovary 0 0.0000 1.40
GTEx Pancreas 0 0.0000 1.40
GTEx Pituitary 0 0.0000 1.37
GTEx Prostate 0 0.0000 1.39
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.36
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.36
GTEx Small Intestine Terminal Ileum 0 0.0000 1.51
GTEx Spleen 0 0.0000 1.50
GTEx Stomach 0 0.0000 1.34
GTEx Testis 1 0.0433 1.41
GTEx Thyroid 0 0.0000 1.40
GTEx Uterus 0 0.0000 1.19
GTEx Vagina 0 0.0000 1.41
GTEx Whole Blood 0 0.0000 1.33
METSIM Adipose 0 0.0000 1.34
NTR Blood 0 0.0000 1.31
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.42
YFS Blood 0 0.0000 1.35
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.36
TCGA Breast Tumor 0 0.0000 1.26
TCGA Breast Normal 1 0.0337 1.31
TCGA Ovarian Tumor 0 0.0000 1.27
TCGA Prostate Tumor 0 0.0000 1.38