TWAS hub - GOLGA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0230	9.0e-04	0.005	0.017	0.001	0.016	0.008	7.0e-02	3.0e-03	2.2e-01	4.1e-03	2.9e-02
2	GTEx	Brain Cortex	0.2740	0.0980	9.8e-04	-0.005	NA	0.039	NA	0.014	4.6e-01	NA	3.1e-02	NA	1.3e-01
3	GTEx	Cells Transformed fibroblasts	0.3120	0.0770	4.2e-07	0.163	NA	0.139	NA	0.154	2.7e-12	NA	1.5e-10	NA	1.3e-11
4	GTEx	Esophagus Muscularis	0.2210	0.0860	7.4e-04	0.064	NA	0.099	NA	0.103	9.8e-05	NA	1.4e-06	NA	8.2e-07
5	METSIM	Adipose	0.1652	0.0407	6.7e-13	0.099	0.107	0.095	0.111	0.101	1.3e-14	9.5e-16	5.1e-14	3.3e-16	6.6e-15
6	YFS	Blood	0.1948	0.0429	0.0e+00	0.050	0.072	0.082	0.081	0.057	4.2e-16	2.1e-22	1.7e-25	3.1e-25	4.1e-18
7	TCGA	Prostate Adenocarcinoma	0.0584	0.0307	7.6e-03	-0.003	0.002	0.011	NA	0.001	8.5e-01	1.9e-01	2.4e-02	NA	2.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Medication: Ramipril	4.2	5.4	28.6	-5.3	-2.6	0.8	0.4	-0.8	1.1	-0.1
Fasting Glucose	3.0	3.6	11.2	-3.3	-3.3	0.9	1.1	-1.0	-0.8	0.0
Average weekly spirits intake	3.0	3.7	7.1	-2.1	-1.6	-1.9	-1.5	-2.7	-0.7	-2.4
Qualifications: nursing, teaching	2.7	4.1	11.0	0.5	3.3	1.2	1.9	1.7	-1.0	2.9
Number of live births	2.6	3.6	7.5	-1.0	-1.1	2.7	2.3	2.0	2.3	1.0
Number of incorrect matches in round	2.5	4.2	8.8	0.2	-2.5	-2.3	-2.5	-1.5	-0.5	-3.0
Mouth/teeth dental problems: Loose teeth	2.5	3.0	9.6	-0.4	-0.9	3.1	2.1	1.2	-2.0	0.8
Multivitamins +/- minerals	2.4	3.1	4.5	2.1	0.8	-1.9	-2.0	-1.2	-1.9	-2.0
Smoking status: Previous	2.4	3.6	11.3	0.7	-1.6	3.4	2.9	1.6	0.0	0.1
Angina	2.3	3.0	12.0	-0.5	-3.5	2.2	1.0	0.3	1.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	10.9	-1.0	-0.8	-3.3	-3.3	-2.0	-0.4	-2.9
Medication for pain relief, constipation, heartburn	2.2	3.8	7.7	2.6	2.8	-0.9	-0.1	-0.3	-2.0	2.7
Angina (self-reported)	2.2	2.9	11.1	-0.5	-3.3	2.3	1.2	0.5	1.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	5.2	-2.3	-1.9	0.7	0.6	-2.1	1.9	-0.3
Coronary Artery Disease (CAD)	2.0	2.4	7.1	-0.4	-0.6	2.7	1.8	1.4	0.9	1.8
Cardiovascular Disease	2.0	6.6	22.0	-4.7	-4.4	0.4	-0.2	-0.3	0.2	-2.1
Noisy workplace	2.0	2.5	10.0	1.2	-0.7	-1.4	-1.0	-1.0	-1.2	-3.2
Exposure to tobacco smoke at home	2.0	2.2	6.1	-2.5	-0.7	-1.0	-1.9	-1.3	0.3	-1.5
Commuting to job workplace: Cycle	2.0	2.4	4.6	1.1	-0.2	2.1	1.9	1.5	-0.4	2.1
Supplements: Zinc	1.9	2.1	5.6	-0.3	-2.4	-1.1	-1.6	-1.6	0.6	-1.6
Past tobacco smoking	1.9	3.5	10.7	-1.1	1.9	-3.3	-2.4	-1.8	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	9.6	-1.1	-0.9	-2.9	-3.1	-1.6	-0.6	-2.8
Medication: Bendroflumethiazide	1.9	2.9	10.3	-3.2	-2.3	0.4	0.1	-1.4	-1.0	-1.2
Diabetes (self-reported)	1.8	2.8	5.9	-2.4	-1.5	-1.6	-2.4	-1.6	-0.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	6.6	2.6	2.4	1.0	1.3	0.8	-0.3	-0.1
Health satisfaction	1.8	2.3	6.4	-1.5	0.2	2.5	1.9	-0.0	0.4	1.8
Illnesses of father: Heart disease	1.8	2.4	4.7	-2.1	-0.2	2.2	1.3	0.3	2.2	1.2
Mineral and other dietary supplements	1.8	2.4	5.8	-1.1	-0.9	2.4	1.6	0.9	0.2	2.3
Reaction Time	1.7	3.2	8.3	-1.2	-1.3	-1.4	-0.7	-2.3	-1.9	-2.9
High blood pressure (siblings)	1.7	2.5	9.4	-3.1	-1.6	0.0	-1.2	-1.2	0.7	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	5.7	0.6	-0.9	2.4	1.6	0.6	1.2	1.3
Alzheimer’s Disease (in father)	1.6	1.7	4.2	1.6	-1.3	-1.1	-0.8	-0.5	-1.3	-2.0
Number of treatments/medications taken	1.6	2.8	14.6	-3.8	-1.1	0.9	1.4	-0.6	1.0	-0.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.4	-2.1	-2.1	-1.0	-0.6	-1.6	1.0	-1.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.7	1.0	-1.9	1.2	0.9	2.2	0.6	0.3
Had other major operations	1.6	1.9	6.7	-2.2	-2.6	-0.1	-0.9	0.1	1.0	-0.6
Fluid intelligence score	1.6	3.3	9.9	1.1	3.1	1.4	1.8	1.0	-0.8	2.2
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	10.1	-0.4	1.8	0.6	0.0	-0.9	-3.2	0.1
Medication: Paracetamol	1.6	2.6	7.4	-2.0	-2.7	1.5	0.7	0.8	1.2	-1.5
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	10.4	3.2	2.2	-0.2	0.2	0.3	-1.5	0.8
Neck or shoulder pain in last month	1.6	2.2	4.4	-1.7	-1.0	1.8	2.1	1.8	0.9	0.2
Medication: Ibuprofen	1.6	2.0	7.3	2.7	2.0	0.9	1.2	0.2	-0.1	-0.2
Overall health rating	1.6	3.5	13.3	-3.6	-2.0	2.3	1.0	0.1	0.7	0.4
Medication: Aspirin	1.6	2.1	7.9	-2.8	-2.1	0.6	-0.1	-0.4	1.4	-0.4
Ever taken oral contraceptive pill	1.6	1.8	4.4	2.1	1.5	-1.6	-1.4	-0.1	0.1	-1.2
Verbal and Numeric Reasoning (VNR)	1.5	3.5	8.4	1.7	2.9	1.4	1.9	1.2	-1.6	2.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.8	-1.7	-0.2	1.9	1.1	0.7	-0.8	1.6
Financial difficulties in last 2 years	1.5	2.0	3.7	1.3	0.6	1.9	1.9	1.6	-1.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	4.2	1.0	-1.9	-0.9	-1.3	-0.7	-0.1	-2.0
Loud music exposure frequency	1.5	1.7	4.6	2.1	0.2	0.0	-0.6	0.5	-2.2	-1.4
Number of full brothers	1.5	1.8	4.3	1.6	-0.8	2.1	1.8	1.2	-0.9	0.2
Diabetes diagnosed by doctor	1.5	2.5	6.9	-2.6	-1.5	-1.3	-2.1	-1.2	-0.3	-0.8
Medication: Aspirin	1.5	2.0	5.9	-2.4	-2.1	0.5	-0.4	-0.4	1.4	-1.1
Supplements: Fish oil (including cod liver oil)	1.5	1.9	4.6	-0.4	-0.0	-2.1	-1.5	-1.4	0.4	-2.1
Medication: Paracetamol	1.5	2.3	5.0	-2.2	-2.2	1.6	1.1	0.0	1.3	-1.2
Average weekly beer plus cider intake	1.5	2.2	5.4	-1.4	-2.3	1.8	1.8	0.8	-0.9	0.3
Neuroticism (2016)	1.4	2.0	7.7	2.8	2.2	-0.3	-0.4	-0.6	0.5	0.4
Severe depression (siblings)	1.4	1.6	3.8	1.2	0.7	1.4	0.9	2.0	-0.7	1.5
Medication: Simvastatin	1.4	2.1	7.4	-2.0	-2.7	0.2	-0.2	-1.3	-0.4	-1.2
Shortness of breath walking on level ground	1.4	1.7	5.3	0.4	-0.5	2.3	1.6	0.4	-1.3	1.2
Hypertension (Self-reported)	1.4	3.9	16.3	-4.0	-2.9	0.3	-0.2	-0.8	0.3	-1.4
Average weekly champagne plus white wine intake	1.4	1.9	6.2	0.5	2.5	0.7	1.5	1.4	-0.6	1.4
Vascular/heart problems diagnosed by doctor	1.4	3.8	15.5	3.9	3.0	-1.0	-0.4	0.3	-0.2	0.8
Cholesterol lowering medication	1.4	2.1	8.6	-1.4	-2.9	-0.3	-0.5	-1.5	0.2	-1.2
Medication: Metformin	1.3	1.9	3.2	-1.5	-1.4	-0.9	-1.7	-1.8	1.1	-0.9
Taking other prescription medications	1.3	2.0	7.7	-2.8	-0.2	1.3	2.0	0.3	0.6	0.7
High blood pressure	1.3	3.7	17.2	-4.2	-2.6	0.3	-0.1	-0.8	0.2	-1.2
Alcohol usually taken with meals	1.3	2.2	4.2	-1.3	0.9	-2.1	-1.6	-0.9	1.9	-1.2
Happiness	1.3	1.6	3.1	-1.3	0.3	1.8	1.8	0.3	-0.9	1.4
Illnesses of mother	1.3	1.7	4.2	1.1	2.0	-1.2	-0.7	-1.3	-1.3	-0.9
Chest pain or discomfort	1.3	1.9	6.9	1.3	-1.5	0.3	-1.0	1.0	0.6	-2.6
Medication: Gliclazide	1.3	1.4	3.2	-0.8	-0.8	-1.3	-1.6	-0.6	-1.0	-1.8
Number of self-reported non-cancer illnesses	1.3	2.3	9.7	-3.1	-1.8	1.0	0.7	-0.6	-0.1	-1.0
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.8	-1.7	1.1	-1.4	-1.2	-1.6	-0.3	-0.5
Body Mass Index (BMI) (2010)	1.2	1.7	4.7	-1.1	-0.6	-0.9	-1.6	-2.2	-0.2	-1.5
Medication for hormone replacement therapy	1.2	1.3	4.1	2.0	1.9	0.3	0.3	0.1	-1.0	-0.8
Stomach or abdominal pain in last month	1.2	1.5	4.9	-0.8	-1.0	0.8	0.7	1.7	2.2	-0.5
Forced vital capacity (FVC)	1.2	4.5	14.7	3.8	1.7	1.1	2.4	1.4	-1.6	1.6
Time employed in main current job	1.2	1.4	4.1	-2.0	1.2	0.4	0.8	-0.4	1.2	1.2
Hair/balding pattern: Pattern 3	1.2	1.8	4.1	-1.8	-0.6	-1.5	-2.0	-1.3	0.8	-0.8
Average weekly red wine intake	1.2	1.8	4.4	-0.1	-0.5	-1.9	-2.1	-0.5	1.8	-0.9
Guilty feelings	1.2	1.8	6.8	2.1	2.6	-0.5	-1.0	0.2	0.0	-0.4
Fractured/broken bones in last 5 years	1.2	1.6	7.3	-2.7	-0.8	-0.9	-1.0	-1.1	0.2	0.1
Lupus	1.1	1.7	3.8	1.9	1.0	1.1	1.0	1.9	-0.7	0.9
Medication: Co-codamol	1.1	1.3	2.5	-1.5	-1.5	1.6	1.3	-0.3	0.6	-0.1
Relative age voice broke	1.1	1.7	3.2	1.3	1.8	-1.7	-1.7	-0.2	0.1	-0.9
Medication: Atenolol	1.1	1.3	3.2	-1.8	-1.4	-0.2	-0.1	-1.3	1.3	-0.8
High blood pressure (mother)	1.1	1.6	9.1	-0.8	-3.0	0.7	-0.1	0.0	0.7	-0.4
Pulse wave Arterial Stiffness index	1.1	1.3	3.9	0.1	-1.6	-0.1	-0.9	-0.6	2.0	-1.1
Pulse wave reflection index	1.1	1.3	4.0	0.1	-2.0	-0.7	-1.2	-0.5	1.2	-1.2
Blood clot in the leg (DVT)	1.1	1.4	3.3	0.7	0.3	1.8	1.5	1.4	0.7	1.0
Medication: Blood pressure	1.1	2.0	8.5	-2.9	-1.6	0.3	-0.6	-0.2	0.9	-1.3
Heart disease (mother)	1.1	1.3	5.2	-1.2	-2.3	0.7	0.0	1.4	0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	4.6	2.1	-1.0	0.5	0.9	1.7	0.5	0.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.0	-2.2	-1.4	-0.4	-0.4	-0.2	-0.5	-1.2
Commuting to job workplace: Public transport	1.1	1.3	3.7	-0.4	0.6	1.2	1.3	0.8	-1.9	1.1
Heart disease (siblings)	1.1	1.3	3.6	-0.4	0.2	1.9	1.2	1.0	-0.9	1.5
Alcohol drinker status: Previous	1.1	1.3	5.2	-2.3	-0.2	0.6	0.8	-1.1	-0.2	1.1
Intelligence (Savage-Jansen 2018)	1.0	3.0	7.7	1.7	2.8	1.2	1.8	0.6	-1.6	1.6
Age at First Birth	1.0	1.5	2.8	-0.1	1.5	-1.5	-1.3	-1.7	1.2	-0.5
Respiratory disease	1.0	2.3	5.7	0.4	2.0	1.6	1.6	0.3	-1.1	2.4
Townsend deprivation index at recruitment	1.0	1.4	5.3	-1.2	0.5	1.1	1.1	-0.8	-2.3	0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	5.0	-2.2	-1.1	-1.0	-0.4	-0.4	-0.2	-0.5
Asthma	1.0	1.9	3.2	1.3	1.3	1.8	1.7	0.7	-0.6	1.8
Medication: Cholesterol lowering	1.0	1.5	5.5	-2.4	-1.7	0.8	0.3	-0.3	1.0	0.4
Medication: Lansoprazole	1.0	1.1	4.0	-0.5	-2.0	1.0	1.4	-0.8	-0.5	0.3
Length of working week for main job	1.0	1.1	3.5	-1.9	0.4	-0.8	-0.8	-1.6	-0.2	-0.6
Glaucoma (self-reported)	1.0	1.1	2.4	-0.7	1.3	-0.9	-0.6	-1.4	1.6	-0.1
Medication: Amlodipine	1.0	1.4	4.0	-2.0	-1.2	1.0	1.0	0.7	1.2	0.5
Forced vital capacity (FVC), Best measure	1.0	3.5	10.6	3.2	0.8	1.6	2.3	1.6	-1.4	1.2
Comparative body size at age 10	1.0	2.9	6.2	0.3	-2.5	-1.5	-1.9	-0.8	0.9	-2.5
Worry too long after embarrassment	1.0	1.7	8.5	0.1	2.9	-0.3	0.3	-0.2	-1.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.9	1.2	2.2	-0.1	0.0	-0.7	-1.5	0.3
Pulse wave peak to peak time	1.0	1.2	3.8	0.2	1.4	0.3	1.0	0.7	-2.0	1.1
Suffer from ‘nerves’	1.0	1.5	5.2	2.3	1.8	-1.0	-0.9	-0.1	-0.3	-0.5
Ever had bowel cancer screening	1.0	1.2	3.6	-0.0	-1.7	-0.6	-0.6	-0.7	-0.6	-1.9
Ever smoked	1.0	1.7	5.0	0.8	-2.2	1.6	0.9	1.2	-0.7	-1.2
Ovarian Cancer	0.9	1.1	3.5	-0.8	-1.9	-0.2	-1.2	-0.6	0.4	-1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.9	-1.7	-0.1	1.0	0.4	-1.0	1.2	0.6
Systolic Blood Pressure	0.9	4.5	20.7	-4.5	-2.9	-0.1	0.9	-0.9	0.8	-0.4
Ever had hysterectomy (womb removed)	0.9	1.0	3.1	-1.8	-1.3	0.6	0.9	0.3	0.9	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.2	1.5	1.2	-1.2	-1.2	0.7	1.4	-0.6
Father’s age at death	0.9	1.2	3.5	1.9	0.5	-1.6	-1.2	0.5	-0.7	-0.2
Falls in the last year	0.9	1.3	6.9	-0.2	0.7	0.5	0.8	0.6	0.6	2.6
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.4	2.1	2.1	0.1	0.8	0.6	0.8	2.0
Breastfed as a baby	0.9	1.1	2.8	0.4	0.2	-1.7	-1.5	-0.4	1.4	0.5
Number of children fathered	0.9	1.0	2.1	1.4	1.2	0.9	-0.0	-0.8	-1.4	0.5
Mean time to correctly identify matches	0.9	1.7	3.8	-1.9	-1.1	-0.9	-0.1	-1.6	-1.1	-1.6
Medication for cholesterol	0.9	1.3	3.3	0.7	1.8	0.2	0.2	1.1	1.0	1.8
Back pain experienced in last month	0.9	1.3	4.7	-0.5	-0.8	2.2	1.4	-0.3	1.3	0.2
Asthma (self-reported)	0.9	1.8	3.2	1.2	1.1	1.8	1.6	0.7	-0.6	1.7
Miserableness	0.9	1.6	6.6	2.6	1.6	0.9	0.6	0.3	-0.2	-0.9
Financial situation satisfaction	0.9	1.1	3.2	0.4	0.1	1.8	1.1	0.2	-1.7	0.6
High cholesterol (Self-reported)	0.9	1.6	4.6	-2.1	-2.1	0.4	-0.3	-1.1	0.5	-0.7
Smoking Status	0.8	1.9	3.0	0.5	-1.7	1.7	1.6	1.6	-0.9	-1.1
Hand grip strength (right)	0.8	2.3	4.8	2.2	0.0	1.6	1.6	1.5	-1.7	0.9
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.0	-1.7	-0.4	0.6	0.8	-0.6	-1.2	0.8
Serious illness, injury or assault to yourself	0.8	0.9	2.6	-1.2	-1.6	1.2	0.6	-0.8	0.3	0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	0.5	1.2	-0.4	0.2	-1.4	-1.5	-0.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.8	0.7	1.7	0.7	0.4	1.1	0.7	1.1
Mouth/teeth dental problems	0.8	1.3	6.8	1.2	-0.3	-0.7	-0.4	0.2	2.6	-0.2
Illnesses of siblings	0.8	1.2	6.1	2.5	0.6	-0.4	0.1	1.2	-0.3	-0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	2.2	-1.2	-1.4	1.5	1.2	0.4	-1.3	0.3
Lung cancer (father)	0.8	1.0	2.1	-0.8	-1.5	-0.9	-1.5	0.2	-0.7	-0.8
Exposure to tobacco smoke outside home	0.8	1.1	3.7	-0.8	1.9	0.8	1.0	0.5	0.1	1.2
Medication: Allopurinol	0.8	1.1	3.0	-1.7	-1.2	0.3	0.7	-1.6	0.2	0.1
Pulse rate, automated reading	0.8	2.6	5.3	0.7	0.2	1.8	2.1	2.3	-1.5	1.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.9	-0.7	1.7	0.2	0.9	0.5	0.1	1.5
Knee pain experienced in last month	0.8	1.2	3.3	1.6	0.3	1.1	0.3	0.7	1.8	0.8
Medication: Atorvastatin	0.8	1.0	3.5	-1.9	-0.8	-0.3	-0.8	-1.3	0.5	-0.6
Ever depressed for a whole week	0.8	1.0	2.6	1.2	1.0	0.6	1.2	0.7	0.0	1.6
Pain experienced in last month	0.8	1.4	4.8	0.1	1.4	-2.2	-1.2	-0.6	-1.0	0.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.3	1.1	1.5	1.5	0.4	-0.3	-1.0	0.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	0.3	0.1	1.5	1.3	1.3	0.5	0.9
Pack years of smoking	0.8	1.2	3.5	-1.9	-1.4	-0.6	-0.8	-1.3	0.0	0.3
Impedance of whole body	0.8	4.3	13.3	1.0	1.9	1.1	2.9	0.9	1.2	3.6
Schizophrenia (2014)	0.7	1.4	3.3	1.3	0.3	-1.8	-1.7	0.8	-1.2	-0.1
BMI	0.7	3.9	7.4	-1.1	-1.4	-0.1	-2.4	-2.6	-2.0	-2.7
Vitamin and mineral supplements	0.7	1.0	4.3	-2.1	-1.0	0.5	0.4	-0.5	0.7	0.6
Qualifications: CSEs or equivalent	0.7	1.0	2.3	0.0	-0.7	0.6	-0.0	-1.3	-1.5	-1.4
Supplements: Glucosamine	0.7	0.9	2.5	0.8	1.1	-1.6	-1.1	0.4	0.3	-0.8
Pain all over the body in last month	0.7	0.7	2.2	-0.5	-0.3	-1.0	-0.9	-0.9	0.0	-1.5
Hip circumference	0.7	3.1	6.7	-0.8	-1.1	0.2	-1.9	-2.6	-2.4	-1.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	8.9	3.0	1.4	0.3	1.4	1.1	-1.4	1.1
Depression (self-reported)	0.7	0.8	2.4	1.6	0.2	1.1	0.9	-0.6	-0.9	0.2
Gout (self-reported)	0.7	0.9	3.2	-1.8	-1.2	0.2	0.9	-0.9	0.6	-0.3
Birth weight	0.7	1.4	4.6	-2.1	-0.8	-0.6	-0.3	-1.9	0.7	0.2
Migraine (self-reported)	0.7	0.9	3.4	0.6	-0.3	1.1	0.8	1.9	-0.5	0.1
Medication: Seretide 50 evohaler	0.7	0.8	1.8	0.1	0.4	1.0	0.9	1.2	-1.3	0.7
Number of full sisters	0.7	0.8	2.9	-0.2	-0.3	0.5	0.2	0.4	1.6	1.7
Age at last live birth	0.7	1.0	2.1	-1.4	0.2	-1.4	-0.7	-1.4	0.9	0.1
Long-standing illness, disability or infirmity	0.7	1.1	2.3	-0.9	-1.5	1.4	0.6	0.6	1.3	0.6
Breast cancer (self-reported)	0.7	0.9	2.8	-0.5	-0.7	0.9	1.7	0.3	-0.8	1.0
Hearing aid user	0.7	0.8	3.2	-0.1	1.6	0.3	-0.3	-0.1	-0.0	1.8
Eye problems/disorders: Glaucoma	0.7	0.9	2.3	-0.9	1.0	-0.9	-0.3	-0.7	1.5	-0.7
Medication: Blood pressure	0.7	1.4	5.2	-2.3	-1.9	0.3	0.4	-0.7	-0.0	-0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.2	1.8	-0.2	0.3	0.8	0.8	0.0	-1.0
Age started oral contraceptive pill	0.7	0.8	2.2	-0.2	1.5	-0.5	0.2	1.0	0.8	1.3
Neuroticism (Nagel 2018)	0.6	1.3	5.3	1.7	2.3	-0.0	-0.2	0.0	0.7	-0.7
Worry (Nagel 2018)	0.6	1.3	5.1	2.3	1.0	-0.9	-1.2	0.2	0.5	-0.8
Blood Red Count	0.6	5.8	20.1	-4.2	-4.5	0.5	1.0	-0.2	1.0	1.0
Hypothyroidism (self reported)	0.6	1.5	3.2	-1.6	-0.9	-1.0	-0.8	-1.8	-1.0	-1.1
Systolic blood pressure, automated reading	0.6	1.8	10.4	-3.2	-1.3	-0.5	0.1	-0.3	-0.2	-0.2
Pack years adult smoking proportion	0.6	0.9	2.2	-1.5	-1.5	-0.4	-0.5	-1.1	-0.5	-0.1
Impedance of leg (right)	0.6	2.9	9.4	1.1	1.1	0.9	2.4	0.9	1.1	3.1
Current tobacco smoking	0.6	0.9	3.1	-0.1	-1.8	0.0	-0.0	0.5	-1.6	-0.6
Average weekly fortified wine intake	0.6	0.7	2.8	-1.7	0.3	-1.1	-0.5	-0.4	0.8	0.3
Body mass index (BMI)	0.6	2.5	4.9	-0.7	-0.5	0.4	-1.6	-2.2	-2.1	-2.1
Impedance of leg (left)	0.6	3.0	9.4	1.1	1.1	0.8	2.4	1.3	1.2	3.1
Waist circumference	0.6	2.3	5.1	0.2	-1.5	1.1	-1.2	-2.3	-1.3	-2.0
Impedance of arm (right)	0.6	2.9	9.5	0.5	1.4	0.9	2.2	0.4	1.6	3.1
Worrier / anxious feelings	0.6	1.1	2.9	1.2	1.7	-1.4	-1.1	-0.4	0.2	-0.0
Impedance of arm (left)	0.6	2.9	9.1	0.5	2.1	0.9	2.2	0.2	0.8	3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	4.4	2.1	0.9	-0.3	-0.4	-0.3	0.2	-0.6
Birth weight of first child	0.6	1.1	4.1	-0.0	0.4	1.6	0.6	0.7	0.7	2.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.9	-1.0	-1.0	-0.9	-0.6	-1.7	-1.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.7	0.1	-0.8	-0.7	-0.8	1.2	-1.2
Medication: Omeprazole	0.6	0.7	3.3	-1.8	-0.6	-0.3	-0.5	0.7	0.5	-0.3
Comparative height size at age 10	0.6	3.4	8.0	1.2	-2.2	2.8	2.3	1.0	0.0	1.7
Illnesses of father: High blood pressure	0.6	0.7	2.2	-0.8	-1.5	0.4	0.1	-0.4	-0.0	-1.3
Number of operations (self-reported)	0.6	0.9	2.3	-1.5	-1.2	0.6	0.3	-1.1	-0.6	-0.9
Risk taking	0.6	0.9	4.3	-2.1	0.3	0.1	-0.1	-0.1	1.0	1.0
Diastolic blood pressure, automated reading	0.6	1.9	6.2	-2.5	-1.2	1.0	1.9	-0.4	-0.3	0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.2	1.1	-1.5	-0.5	-0.8	0.5	-0.2	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	2.6	1.6	0.5	-1.2	-1.2	1.2	-1.4	-0.0
Schizophrenia (2018)	0.5	1.0	2.3	1.5	0.0	-1.3	-0.6	0.8	-1.2	0.4
Ulcerative Colitis (UC)	0.5	0.9	2.5	-1.6	0.1	-0.3	0.6	-0.3	-1.6	1.0
Major Depression (MDD)	0.5	0.6	3.0	1.7	0.0	0.4	0.5	0.6	0.0	0.6
HbA1C	0.5	0.5	1.3	-1.1	-0.9	-0.6	0.4	-0.7	0.7	-0.1
Rheumatoid Arthritis	0.5	0.6	1.4	0.4	-0.9	0.3	0.6	1.2	0.9	0.9
Heel T-Score	0.5	4.0	9.2	-2.6	-1.0	-2.9	-3.0	-0.3	1.5	-0.7
Waist Hip Ratio (WHR)	0.5	2.2	4.2	0.9	-1.3	2.0	2.0	1.0	1.9	0.7
Lung FVC	0.5	2.5	5.3	2.3	2.0	0.4	2.1	-0.3	-0.8	1.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	1.6	1.0	-0.6	-0.5	0.4	0.2	-0.8
Leg fat-free mass (left)	0.5	2.4	6.9	0.7	-0.6	0.8	-1.4	-1.7	-2.6	-2.0
Fed-up feelings	0.5	0.9	1.7	-1.0	0.6	-0.8	-1.3	-0.6	1.0	-1.1
Age when periods started (menarche)	0.5	1.2	4.3	0.5	2.1	-1.0	-0.8	-0.8	-0.5	1.1
Medication: Levothyroxine sodium	0.5	0.8	2.4	-1.6	-0.9	-0.5	-0.4	-1.2	-0.4	-0.5
Had menopause	0.5	0.6	2.0	-1.0	-0.3	-0.9	-0.7	0.1	1.4	0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.5	0.7	0.6	-0.2	1.1	-0.1	1.0	1.2
Heart attack	0.5	0.6	1.2	1.1	-1.0	-0.6	-0.9	0.4	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	3.6	-0.6	0.1	-0.5	0.1	-0.3	-1.9	-0.4
Neuroticism score	0.5	1.1	4.6	1.6	2.1	-0.3	-0.6	0.1	0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.6	1.6	1.2	0.6	-0.3	0.6	0.1	-0.5
Pulse rate	0.5	0.9	1.3	1.0	1.1	1.1	1.0	0.6	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.5	2.3	0.9	0.7	1.4	1.1	-1.1	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	0.5	0.5	1.3	1.4	-0.0	-0.3	0.2
Leg fat percentage (right)	0.5	1.8	5.9	0.5	-0.0	1.4	-0.3	-2.0	-2.4	-0.7
Qualifications: College or University degree	0.5	1.7	5.4	-0.3	2.3	-1.8	-1.0	-0.9	-0.6	0.9
Leg fat mass (right)	0.5	2.0	5.8	0.6	-0.2	1.5	-0.7	-1.8	-2.4	-1.2
Leg pain on walking	0.5	0.6	1.4	-0.2	1.2	0.8	0.9	-0.8	-0.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.6	-0.8	0.9	1.1	0.5	-1.0	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-1.2	-0.6	0.8	0.4	0.1	0.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.7	-0.4	-0.5	1.9	1.6	-0.0	-0.5	0.5
Friendships satisfaction	0.5	0.6	2.3	-0.2	1.5	0.3	-0.2	-0.7	-0.7	0.7
Osteoporosis (self-reported)	0.5	0.6	1.4	0.0	0.4	0.2	1.2	0.7	0.8	1.1
Medication: Lisinopril	0.5	0.7	2.8	-1.7	-1.1	-0.1	-0.2	-0.1	-0.1	-0.8
Alcohol drinker status: Never	0.5	0.6	1.5	-0.8	-1.1	-0.2	-0.6	-0.2	0.5	1.2
Irritability	0.5	0.8	3.1	0.8	1.8	-0.1	-0.3	-0.7	-1.1	-0.7
Myopia	0.5	0.7	2.6	0.3	-1.6	1.2	0.3	-0.1	-0.8	0.0
Supplements: Calcium	0.5	0.6	1.9	-0.2	0.3	-1.1	-0.4	-0.7	1.4	-0.5
Leg fat mass (left)	0.5	2.0	6.0	0.6	-0.3	1.3	-0.9	-1.7	-2.5	-1.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.7	0.4	1.7	0.1	-0.0	-0.0	1.6	-1.0
Schizophrenia vs Biploar Disorder	0.4	0.6	2.3	0.6	-0.5	-1.5	-1.0	-0.2	-0.3	0.0
Crohns Disease (2017)	0.4	0.9	3.2	0.7	-1.2	-0.4	-0.2	0.1	-1.8	-1.1
Irritable Bowel Disease (IBD)	0.4	0.9	4.5	-0.7	-0.7	-0.6	0.2	-0.3	-2.1	-0.2
Triglycerides	0.4	0.6	2.3	-0.3	-1.3	-0.6	0.3	-0.1	0.3	1.5
Ulcerative Colitis	0.4	0.6	1.6	-1.0	0.2	-0.4	0.5	-0.4	-1.3	0.9
Blood Eosinophil Count	0.4	3.3	12.2	-3.5	-1.4	1.6	1.8	-1.4	0.4	0.9
Blood Platelet Count	0.4	4.9	25.1	5.0	0.1	0.6	1.9	1.9	-1.0	0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.7	-1.6	-1.4	0.2	-0.4	-0.4	-0.3	-0.1
Lung FEV1/FVC ratio	0.4	2.2	5.8	-2.4	0.2	-1.9	-2.2	-0.7	0.6	0.1
Chronotype (morning person)	0.4	0.8	2.2	-1.5	-0.2	-0.5	-0.6	0.2	1.2	1.1
Hand grip strength (left)	0.4	1.0	2.3	1.5	0.1	1.2	0.8	0.9	-1.3	0.1
Relative age of first facial hair	0.4	0.9	3.8	0.9	2.0	-0.4	-0.9	-0.1	-0.7	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	0.8	0.5	0.6	0.8	0.9	-0.5	0.4
Trunk fat percentage	0.4	1.5	3.8	-0.0	0.6	1.9	0.4	-1.8	-1.6	0.2
Leg predicted mass (left)	0.4	2.4	6.6	0.6	-0.7	0.8	-1.4	-1.6	-2.6	-2.0
Qualifications: None of the above	0.4	0.9	2.8	-0.8	-1.7	0.2	-0.6	-1.2	-0.5	-1.0
Weight	0.4	2.1	5.0	0.3	-0.8	1.1	-1.2	-1.9	-2.2	-1.6
Arm fat mass (right)	0.4	1.6	3.9	-0.2	-0.4	1.4	-0.6	-1.8	-2.0	-1.3
Hair/balding pattern: Pattern 4	0.4	0.8	3.6	-0.6	-1.9	-0.7	-0.2	-0.5	-0.0	-1.1
Headache pain in last month	0.4	0.7	1.5	1.2	-0.2	0.8	0.6	0.6	-0.5	-1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-0.9	-0.3	0.3	0.1	0.1	0.8	1.3
Body fat percentage	0.4	1.5	3.9	0.3	0.5	2.0	0.2	-1.7	-1.8	-0.0
Arm fat-free mass (right)	0.4	2.1	7.6	0.9	-0.6	0.5	-1.2	-0.9	-2.8	-1.8
Wheeze or whistling in the chest in last year	0.4	0.8	2.8	0.8	-0.0	0.9	0.7	0.5	-1.7	0.7
Age at first live birth	0.4	0.7	2.3	-0.0	1.5	-1.2	-0.5	-0.4	0.0	0.9
Emphysema/chronic bronchitis	0.4	0.5	1.6	-0.2	1.1	0.6	0.1	0.3	-0.1	1.3
Whole body fat mass	0.4	1.6	4.5	0.4	-0.1	1.8	-0.2	-1.7	-2.1	-0.7
Arm predicted mass (right)	0.4	1.9	6.6	1.0	-0.5	0.6	-1.2	-1.0	-2.6	-1.7
Alcohol intake frequency.	0.4	0.9	4.8	-1.1	-2.2	0.3	-0.2	-0.5	-0.2	0.3
Family relationship satisfaction	0.4	0.5	2.5	1.6	1.0	0.1	-0.2	0.1	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.9	0.6	-0.4	-0.0	-0.3	0.7	1.4	0.2
Supplements: Vitamin C	0.4	0.5	1.1	0.8	-0.5	0.8	1.0	0.7	0.7	-0.1
Leg fat-free mass (right)	0.4	2.0	5.7	0.7	-0.6	0.7	-1.4	-1.2	-2.4	-1.9
Arm fat percentage (left)	0.4	1.6	4.2	-0.3	0.3	1.6	-0.2	-2.0	-2.0	-0.7
Mood swings	0.4	0.6	1.9	0.5	1.2	0.2	0.0	0.1	1.4	-1.0
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.4	-1.0	0.1	-0.7	0.8	0.6	-0.7
Osteoarthritis (self-reported)	0.4	0.5	2.4	-0.2	-0.7	-0.1	0.2	1.6	0.3	-0.4
Smoking status: Current	0.4	0.7	2.2	-0.3	-1.5	-0.1	-0.1	0.4	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	1.2	1.0	-0.9	0.2	-0.0	-0.9	1.0
Leg predicted mass (right)	0.4	2.0	5.8	0.7	-0.6	0.6	-1.4	-1.2	-2.4	-1.9
Arm fat mass (left)	0.4	1.8	4.9	-0.2	-0.3	1.4	-0.4	-2.0	-2.2	-1.1
Basal metabolic rate	0.4	2.2	5.5	0.7	-0.9	0.5	-1.5	-1.4	-2.3	-2.0
Leg fat percentage (left)	0.4	1.6	5.6	0.4	-0.2	1.1	-0.5	-1.7	-2.4	-1.0
Unable to work because of sickness or disability	0.4	0.5	1.0	-0.9	1.0	-0.7	-1.0	-0.3	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	-1.2	-0.7	0.1	-0.2	0.2	1.1	-0.5
Arm predicted mass (left)	0.4	1.8	4.9	1.1	-0.6	0.3	-1.4	-1.0	-2.2	-1.8
Bipolar Disorder (2018)	0.3	0.6	1.7	0.6	0.2	-0.1	-0.9	1.3	-0.9	-0.2
Depression (Nagel 2018)	0.3	0.5	1.4	1.2	0.9	-0.6	-0.4	0.4	0.5	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.7	-0.3	-0.7	-0.9	0.1	-0.5	-1.0
Crohns Disease (2012)	0.3	0.5	2.3	-0.3	-1.5	0.8	0.6	0.1	0.1	-0.1
Mean Putamen Volume	0.3	0.4	1.4	-1.2	-0.7	0.2	0.2	0.4	-0.7	0.0
HDL Cholesterol	0.3	0.6	1.4	0.7	1.2	-0.9	-0.3	0.0	-0.9	-0.6
Primary Biliary Cirrhosis	0.3	0.5	2.1	-0.4	1.4	-0.6	-0.5	0.6	-0.1	0.1
Height	0.3	5.2	15.6	4.0	-1.6	3.1	2.0	0.4	0.3	2.1
Neuroticism	0.3	0.8	3.2	1.1	1.8	-0.1	-0.7	0.1	0.3	-0.8
Sensitivity / hurt feelings	0.3	0.5	2.0	0.7	-0.1	1.0	-0.1	-1.4	0.0	-0.4
Hearing difficulty/problems: Yes	0.3	0.4	1.4	-0.1	1.2	-0.5	-0.4	-0.7	0.3	0.5
Sitting height	0.3	2.3	7.1	0.6	0.5	1.9	1.9	1.2	0.3	2.7
Trunk fat mass	0.3	1.5	3.6	0.2	-0.1	1.8	-0.2	-1.8	-1.9	-0.4
Allergy	0.3	0.6	1.3	-0.5	-0.8	-1.0	-1.1	0.0	-0.2	-1.2
Arm fat percentage (right)	0.3	1.3	3.2	-0.2	0.2	1.6	-0.1	-1.8	-1.7	-0.5
Trunk fat-free mass	0.3	1.5	2.9	0.6	-1.2	0.2	-1.5	-0.9	-1.7	-1.7
Alcohol intake versus 10 years previously	0.3	0.5	2.4	0.2	-0.9	0.3	0.4	0.1	-1.5	-0.1
Trunk predicted mass	0.3	1.5	2.8	0.6	-1.1	0.2	-1.5	-0.9	-1.7	-1.7
Tense / ‘highly strung’	0.3	0.5	1.0	0.8	0.1	-0.3	-0.7	-0.9	-0.3	-1.0
Peak expiratory flow (PEF)	0.3	0.7	2.9	1.7	0.7	-0.2	0.4	0.6	-0.1	1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	-0.1	0.7	0.9	0.8	0.7	0.2	-0.0
Eye problems/disorders: None of the above	0.3	0.3	1.0	1.0	0.2	-0.5	0.3	0.3	-0.7	0.2
Whole body fat-free mass	0.3	1.9	4.8	0.7	-0.9	0.4	-1.5	-1.2	-2.2	-1.8
Loneliness, isolation	0.3	0.4	2.7	-1.6	0.3	-0.3	0.1	0.2	0.2	0.3
Commuting to job workplace: Walk	0.3	0.4	1.8	-0.4	-1.3	0.5	0.4	0.4	0.1	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.6	-0.6	-0.5	-0.3	0.1	-1.1	0.0
Whole body water mass	0.3	1.9	4.9	0.7	-0.9	0.4	-1.5	-1.2	-2.2	-1.8
Arm fat-free mass (left)	0.3	1.7	5.5	0.8	-0.7	0.5	-1.1	-1.0	-2.4	-1.7
Alzheimer’s Disease (in mother)	0.2	0.3	1.3	-0.5	1.1	0.0	-0.4	0.1	0.1	0.4
LDL Cholesterol	0.2	0.3	0.6	-0.4	0.2	0.8	0.3	-0.7	-0.4	0.7
Allergy or Eczema	0.2	0.5	1.5	0.3	1.2	0.5	0.4	-0.4	-0.9	0.7
Diabetes (father)	0.2	0.2	0.6	-0.8	0.0	0.2	0.2	-0.5	0.8	0.1
Diabetes (mother)	0.2	0.2	1.1	-0.3	-1.0	-0.2	-0.3	-0.0	-0.1	-0.2
Maternal smoking around birth	0.2	0.3	1.0	0.4	0.4	1.0	0.8	0.0	-0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.2	0.5	-0.4	-0.4	-0.4	0.7	-0.6
Nervous feelings	0.2	0.3	1.5	1.2	-0.1	-0.1	0.1	0.2	0.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.3	0.3	0.5	0.8	0.6	0.8	0.4
Wears glasses or contact lenses	0.2	0.3	0.6	-0.5	0.6	-0.2	-0.8	0.4	-0.0	0.7
Mother’s age at death	0.2	0.2	0.8	-0.4	-0.7	0.1	0.0	-0.1	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.3	-0.7	-0.1	-0.7	-0.7	0.4	-0.1
Blood White Count	0.1	0.7	1.7	-1.3	-1.2	-0.1	-0.7	-0.2	-0.7	-0.8
Tanning	0.1	1.4	3.0	-0.8	-1.7	0.7	0.5	1.7	1.2	-1.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.4	-0.2	0.6	0.5	-0.8	-0.4	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.7	0.6	0.4	0.1	0.5	-0.2	0.3
Prospective memory result	0.1	0.1	0.4	-0.7	-0.2	0.5	0.3	-0.0	0.1	0.2
Standing height	0.1	1.3	3.1	1.8	-0.7	1.6	0.9	0.3	-0.3	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.4	0.6	-0.0	-0.2	-0.4	-0.7	-0.2
Had major operations	0.1	0.1	0.5	-0.1	-0.2	0.2	0.2	0.3	-0.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.2	0.0	-0.5	-0.5	0.0	-0.7	-0.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.6	1.8	1.4	-0.6	0.8	0.7	0.4	-0.4	-0.8

Hub : Genes

GOLGA3

Models

Trait associations