Hub : Genes

GOLGA3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0230	9.0e-04	0.005	0.017	0.001	0.016	0.008	7.0e-02	3.0e-03	2.2e-01	4.1e-03	2.9e-02
2	GTEx	Brain Cortex	0.2740	0.0980	9.8e-04	-0.005	NA	0.039	NA	0.014	4.6e-01	NA	3.1e-02	NA	1.3e-01
3	GTEx	Cells Transformed fibroblasts	0.3120	0.0770	4.2e-07	0.163	NA	0.139	NA	0.154	2.7e-12	NA	1.5e-10	NA	1.3e-11
4	GTEx	Esophagus Muscularis	0.2210	0.0860	7.4e-04	0.064	NA	0.099	NA	0.103	9.8e-05	NA	1.4e-06	NA	8.2e-07
5	METSIM	Adipose	0.1652	0.0407	6.7e-13	0.099	0.107	0.095	0.111	0.101	1.3e-14	9.5e-16	5.1e-14	3.3e-16	6.6e-15
6	YFS	Blood	0.1948	0.0429	0.0e+00	0.050	0.072	0.082	0.081	0.057	4.2e-16	2.1e-22	1.7e-25	3.1e-25	4.1e-18
7	TCGA	Prostate Adenocarcinoma	0.0584	0.0307	7.6e-03	-0.003	0.002	0.011	NA	0.001	8.5e-01	1.9e-01	2.4e-02	NA	2.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.6	1.7	0.6	0.2	-0.1	-0.9	1.3	-0.9	-0.2
Bipolar Disorder or Schizophrenia	0.5	1.3	2.6	1.6	0.5	-1.2	-1.2	1.2	-1.4	-0.0
Depressed Affect (Nagel 2018)	0.4	0.9	2.7	0.4	1.7	0.1	-0.0	-0.0	1.6	-1.0
Depression (Nagel 2018)	0.3	0.5	1.4	1.2	0.9	-0.6	-0.4	0.4	0.5	-0.4
Intelligence (Savage-Jansen 2018)	1.0	3.0	7.7	1.7	2.8	1.2	1.8	0.6	-1.6	1.6
Neuroticism (Nagel 2018)	0.6	1.3	5.3	1.7	2.3	-0.0	-0.2	0.0	0.7	-0.7
Schizophrenia (2018)	0.5	1.0	2.3	1.5	0.0	-1.3	-0.6	0.8	-1.2	0.4
Schizophrenia vs Biploar Disorder	0.4	0.6	2.3	0.6	-0.5	-1.5	-1.0	-0.2	-0.3	0.0
Worry (Nagel 2018)	0.6	1.3	5.1	2.3	1.0	-0.9	-1.2	0.2	0.5	-0.8
Alzheimer’s Disease (in mother)	0.2	0.3	1.3	-0.5	1.1	0.0	-0.4	0.1	0.1	0.4
Alzheimer’s Disease (in father)	1.6	1.7	4.2	1.6	-1.3	-1.1	-0.8	-0.5	-1.3	-2.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.7	-0.3	-0.7	-0.9	0.1	-0.5	-1.0
Crohns Disease (2017)	0.4	0.9	3.2	0.7	-1.2	-0.4	-0.2	0.1	-1.8	-1.1
Irritable Bowel Disease (IBD)	0.4	0.9	4.5	-0.7	-0.7	-0.6	0.2	-0.3	-2.1	-0.2
Ulcerative Colitis (UC)	0.5	0.9	2.5	-1.6	0.1	-0.3	0.6	-0.3	-1.6	1.0
Major Depression (MDD)	0.5	0.6	3.0	1.7	0.0	0.4	0.5	0.6	0.0	0.6
Reaction Time	1.7	3.2	8.3	-1.2	-1.3	-1.4	-0.7	-2.3	-1.9	-2.9
Verbal and Numeric Reasoning (VNR)	1.5	3.5	8.4	1.7	2.9	1.4	1.9	1.2	-1.6	2.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.9	1.1	3.5	-0.8	-1.9	-0.2	-1.2	-0.6	0.4	-1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.0	1.5	2.8	-0.1	1.5	-1.5	-1.3	-1.7	1.2	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.7	4.7	-1.1	-0.6	-0.9	-1.6	-2.2	-0.2	-1.5
Coronary Artery Disease (CAD)	2.0	2.4	7.1	-0.4	-0.6	2.7	1.8	1.4	0.9	1.8
Crohns Disease (2012)	0.3	0.5	2.3	-0.3	-1.5	0.8	0.6	0.1	0.1	-0.1
Mean Putamen Volume	0.3	0.4	1.4	-1.2	-0.7	0.2	0.2	0.4	-0.7	0.0
Fasting Glucose	3.0	3.6	11.2	-3.3	-3.3	0.9	1.1	-1.0	-0.8	0.0
HbA1C	0.5	0.5	1.3	-1.1	-0.9	-0.6	0.4	-0.7	0.7	-0.1
HDL Cholesterol	0.3	0.6	1.4	0.7	1.2	-0.9	-0.3	0.0	-0.9	-0.6
LDL Cholesterol	0.2	0.3	0.6	-0.4	0.2	0.8	0.3	-0.7	-0.4	0.7
Lupus	1.1	1.7	3.8	1.9	1.0	1.1	1.0	1.9	-0.7	0.9
Neuroticism (2016)	1.4	2.0	7.7	2.8	2.2	-0.3	-0.4	-0.6	0.5	0.4
Primary Biliary Cirrhosis	0.3	0.5	2.1	-0.4	1.4	-0.6	-0.5	0.6	-0.1	0.1
Rheumatoid Arthritis	0.5	0.6	1.4	0.4	-0.9	0.3	0.6	1.2	0.9	0.9
Schizophrenia (2014)	0.7	1.4	3.3	1.3	0.3	-1.8	-1.7	0.8	-1.2	-0.1
Triglycerides	0.4	0.6	2.3	-0.3	-1.3	-0.6	0.3	-0.1	0.3	1.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.9	-1.7	-0.1	1.0	0.4	-1.0	1.2	0.6
Ulcerative Colitis	0.4	0.6	1.6	-1.0	0.2	-0.4	0.5	-0.4	-1.3	0.9
Blood Eosinophil Count	0.4	3.3	12.2	-3.5	-1.4	1.6	1.8	-1.4	0.4	0.9
Blood Platelet Count	0.4	4.9	25.1	5.0	0.1	0.6	1.9	1.9	-1.0	0.6
Blood Red Count	0.6	5.8	20.1	-4.2	-4.5	0.5	1.0	-0.2	1.0	1.0
Blood White Count	0.1	0.7	1.7	-1.3	-1.2	-0.1	-0.7	-0.2	-0.7	-0.8
Heel T-Score	0.5	4.0	9.2	-2.6	-1.0	-2.9	-3.0	-0.3	1.5	-0.7
BMI	0.7	3.9	7.4	-1.1	-1.4	-0.1	-2.4	-2.6	-2.0	-2.7
Height	0.3	5.2	15.6	4.0	-1.6	3.1	2.0	0.4	0.3	2.1
Waist Hip Ratio (WHR)	0.5	2.2	4.2	0.9	-1.3	2.0	2.0	1.0	1.9	0.7
Systolic Blood Pressure	0.9	4.5	20.7	-4.5	-2.9	-0.1	0.9	-0.9	0.8	-0.4
Smoking Status	0.8	1.9	3.0	0.5	-1.7	1.7	1.6	1.6	-0.9	-1.1
Allergy or Eczema	0.2	0.5	1.5	0.3	1.2	0.5	0.4	-0.4	-0.9	0.7
Cardiovascular Disease	2.0	6.6	22.0	-4.7	-4.4	0.4	-0.2	-0.3	0.2	-2.1
Hypothyroidism (self reported)	0.6	1.5	3.2	-1.6	-0.9	-1.0	-0.8	-1.8	-1.0	-1.1
Respiratory disease	1.0	2.3	5.7	0.4	2.0	1.6	1.6	0.3	-1.1	2.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.7	-1.6	-1.4	0.2	-0.4	-0.4	-0.3	-0.1
Lung FEV1/FVC ratio	0.4	2.2	5.8	-2.4	0.2	-1.9	-2.2	-0.7	0.6	0.1
Lung FVC	0.5	2.5	5.3	2.3	2.0	0.4	2.1	-0.3	-0.8	1.7
Neuroticism	0.3	0.8	3.2	1.1	1.8	-0.1	-0.7	0.1	0.3	-0.8
Chronotype (morning person)	0.4	0.8	2.2	-1.5	-0.2	-0.5	-0.6	0.2	1.2	1.1
Hair Pigment	0.0	0.6	1.8	1.4	-0.6	0.8	0.7	0.4	-0.4	-0.8
Tanning	0.1	1.4	3.0	-0.8	-1.7	0.7	0.5	1.7	1.2	-1.2
Hand grip strength (left)	0.4	1.0	2.3	1.5	0.1	1.2	0.8	0.9	-1.3	0.1
Number of treatments/medications taken	1.6	2.8	14.6	-3.8	-1.1	0.9	1.4	-0.6	1.0	-0.0
Average weekly spirits intake	3.0	3.7	7.1	-2.1	-1.6	-1.9	-1.5	-2.7	-0.7	-2.4
Sensitivity / hurt feelings	0.3	0.5	2.0	0.7	-0.1	1.0	-0.1	-1.4	0.0	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	1.6	1.0	-0.6	-0.5	0.4	0.2	-0.8
Hearing difficulty/problems: Yes	0.3	0.4	1.4	-0.1	1.2	-0.5	-0.4	-0.7	0.3	0.5
Relative age of first facial hair	0.4	0.9	3.8	0.9	2.0	-0.4	-0.9	-0.1	-0.7	-0.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.4	-2.1	-2.1	-1.0	-0.6	-1.6	1.0	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	0.8	0.5	0.6	0.8	0.9	-0.5	0.4
Ever had hysterectomy (womb removed)	0.9	1.0	3.1	-1.8	-1.3	0.6	0.9	0.3	0.9	0.3
Systolic blood pressure, automated reading	0.6	1.8	10.4	-3.2	-1.3	-0.5	0.1	-0.3	-0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.8	-1.7	-0.2	1.9	1.1	0.7	-0.8	1.6
Angina	2.3	3.0	12.0	-0.5	-3.5	2.2	1.0	0.3	1.5	-0.7
Medication for hormone replacement therapy	1.2	1.3	4.1	2.0	1.9	0.3	0.3	0.1	-1.0	-0.8
Vitamin and mineral supplements	0.7	1.0	4.3	-2.1	-1.0	0.5	0.4	-0.5	0.7	0.6
Supplements: Zinc	1.9	2.1	5.6	-0.3	-2.4	-1.1	-1.6	-1.6	0.6	-1.6
Medication: Co-codamol	1.1	1.3	2.5	-1.5	-1.5	1.6	1.3	-0.3	0.6	-0.1
Medication: Metformin	1.3	1.9	3.2	-1.5	-1.4	-0.9	-1.7	-1.8	1.1	-0.9
Diabetes (father)	0.2	0.2	0.6	-0.8	0.0	0.2	0.2	-0.5	0.8	0.1
Diabetes (mother)	0.2	0.2	1.1	-0.3	-1.0	-0.2	-0.3	-0.0	-0.1	-0.2
Severe depression (siblings)	1.4	1.6	3.8	1.2	0.7	1.4	0.9	2.0	-0.7	1.5
Pack years adult smoking proportion	0.6	0.9	2.2	-1.5	-1.5	-0.4	-0.5	-1.1	-0.5	-0.1
Impedance of leg (right)	0.6	2.9	9.4	1.1	1.1	0.9	2.4	0.9	1.1	3.1
Leg fat-free mass (left)	0.5	2.4	6.9	0.7	-0.6	0.8	-1.4	-1.7	-2.6	-2.0
Trunk fat percentage	0.4	1.5	3.8	-0.0	0.6	1.9	0.4	-1.8	-1.6	0.2
Hand grip strength (right)	0.8	2.3	4.8	2.2	0.0	1.6	1.6	1.5	-1.7	0.9
Townsend deprivation index at recruitment	1.0	1.4	5.3	-1.2	0.5	1.1	1.1	-0.8	-2.3	0.3
Current tobacco smoking	0.6	0.9	3.1	-0.1	-1.8	0.0	-0.0	0.5	-1.6	-0.6
Average weekly fortified wine intake	0.6	0.7	2.8	-1.7	0.3	-1.1	-0.5	-0.4	0.8	0.3
Maternal smoking around birth	0.2	0.3	1.0	0.4	0.4	1.0	0.8	0.0	-0.2	0.5
Fed-up feelings	0.5	0.9	1.7	-1.0	0.6	-0.8	-1.3	-0.6	1.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.2	0.5	-0.4	-0.4	-0.4	0.7	-0.6
Relative age voice broke	1.1	1.7	3.2	1.3	1.8	-1.7	-1.7	-0.2	0.1	-0.9
Taking other prescription medications	1.3	2.0	7.7	-2.8	-0.2	1.3	2.0	0.3	0.6	0.7
Age when periods started (menarche)	0.5	1.2	4.3	0.5	2.1	-1.0	-0.8	-0.8	-0.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.0	-1.7	-0.4	0.6	0.8	-0.6	-1.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	10.9	-1.0	-0.8	-3.3	-3.3	-2.0	-0.4	-2.9
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.7	1.0	-1.9	1.2	0.9	2.2	0.6	0.3
Qualifications: CSEs or equivalent	0.7	1.0	2.3	0.0	-0.7	0.6	-0.0	-1.3	-1.5	-1.4
Serious illness, injury or assault to yourself	0.8	0.9	2.6	-1.2	-1.6	1.2	0.6	-0.8	0.3	0.1
High blood pressure	1.3	3.7	17.2	-4.2	-2.6	0.3	-0.1	-0.8	0.2	-1.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.4	-0.2	0.6	0.5	-0.8	-0.4	0.1
Multivitamins +/- minerals	2.4	3.1	4.5	2.1	0.8	-1.9	-2.0	-1.2	-1.9	-2.0
Stomach or abdominal pain in last month	1.2	1.5	4.9	-0.8	-1.0	0.8	0.7	1.7	2.2	-0.5
Supplements: Glucosamine	0.7	0.9	2.5	0.8	1.1	-1.6	-1.1	0.4	0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	5.0	-2.2	-1.1	-1.0	-0.4	-0.4	-0.2	-0.5
Medication: Atenolol	1.1	1.3	3.2	-1.8	-1.4	-0.2	-0.1	-1.3	1.3	-0.8
Medication: Levothyroxine sodium	0.5	0.8	2.4	-1.6	-0.9	-0.5	-0.4	-1.2	-0.4	-0.5
Sitting height	0.3	2.3	7.1	0.6	0.5	1.9	1.9	1.2	0.3	2.7
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	0.5	1.2	-0.4	0.2	-1.4	-1.5	-0.3
High blood pressure (mother)	1.1	1.6	9.1	-0.8	-3.0	0.7	-0.1	0.0	0.7	-0.4
Body mass index (BMI)	0.6	2.5	4.9	-0.7	-0.5	0.4	-1.6	-2.2	-2.1	-2.1
Impedance of leg (left)	0.6	3.0	9.4	1.1	1.1	0.8	2.4	1.3	1.2	3.1
Leg predicted mass (left)	0.4	2.4	6.6	0.6	-0.7	0.8	-1.4	-1.6	-2.6	-2.0
Trunk fat mass	0.3	1.5	3.6	0.2	-0.1	1.8	-0.2	-1.8	-1.9	-0.4
Waist circumference	0.6	2.3	5.1	0.2	-1.5	1.1	-1.2	-2.3	-1.3	-2.0
Number of incorrect matches in round	2.5	4.2	8.8	0.2	-2.5	-2.3	-2.5	-1.5	-0.5	-3.0
Past tobacco smoking	1.9	3.5	10.7	-1.1	1.9	-3.3	-2.4	-1.8	0.3	0.2
Alcohol usually taken with meals	1.3	2.2	4.2	-1.3	0.9	-2.1	-1.6	-0.9	1.9	-1.2
Nervous feelings	0.2	0.3	1.5	1.2	-0.1	-0.1	0.1	0.2	0.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.2	1.5	1.2	-1.2	-1.2	0.7	1.4	-0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.7	0.6	0.4	0.1	0.5	-0.2	0.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.8	0.7	1.7	0.7	0.4	1.1	0.7	1.1
Had menopause	0.5	0.6	2.0	-1.0	-0.3	-0.9	-0.7	0.1	1.4	0.5
Had other major operations	1.6	1.9	6.7	-2.2	-2.6	-0.1	-0.9	0.1	1.0	-0.6
Forced vital capacity (FVC)	1.2	4.5	14.7	3.8	1.7	1.1	2.4	1.4	-1.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	9.6	-1.1	-0.9	-2.9	-3.1	-1.6	-0.6	-2.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.5	0.7	0.6	-0.2	1.1	-0.1	1.0	1.2
Qualifications: None of the above	0.4	0.9	2.8	-0.8	-1.7	0.2	-0.6	-1.2	-0.5	-1.0
Financial difficulties in last 2 years	1.5	2.0	3.7	1.3	0.6	1.9	1.9	1.6	-1.4	0.6
Mouth/teeth dental problems	0.8	1.3	6.8	1.2	-0.3	-0.7	-0.4	0.2	2.6	-0.2
Heart attack	0.5	0.6	1.2	1.1	-1.0	-0.6	-0.9	0.4	-0.4	-0.7
Allergy	0.3	0.6	1.3	-0.5	-0.8	-1.0	-1.1	0.0	-0.2	-1.2
Pain all over the body in last month	0.7	0.7	2.2	-0.5	-0.3	-1.0	-0.9	-0.9	0.0	-1.5
Diabetes (self-reported)	1.8	2.8	5.9	-2.4	-1.5	-1.6	-2.4	-1.6	-0.1	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	3.6	-0.6	0.1	-0.5	0.1	-0.3	-1.9	-0.4
Medication: Ramipril	4.2	5.4	28.6	-5.3	-2.6	0.8	0.4	-0.8	1.1	-0.1
Medication: Simvastatin	1.4	2.1	7.4	-2.0	-2.7	0.2	-0.2	-1.3	-0.4	-1.2
Fluid intelligence score	1.6	3.3	9.9	1.1	3.1	1.4	1.8	1.0	-0.8	2.2
Illnesses of siblings	0.8	1.2	6.1	2.5	0.6	-0.4	0.1	1.2	-0.3	-0.2
Neuroticism score	0.5	1.1	4.6	1.6	2.1	-0.3	-0.6	0.1	0.2	-0.5
Weight	0.4	2.1	5.0	0.3	-0.8	1.1	-1.2	-1.9	-2.2	-1.6
Impedance of arm (right)	0.6	2.9	9.5	0.5	1.4	0.9	2.2	0.4	1.6	3.1
Arm fat percentage (right)	0.3	1.3	3.2	-0.2	0.2	1.6	-0.1	-1.8	-1.7	-0.5
Trunk fat-free mass	0.3	1.5	2.9	0.6	-1.2	0.2	-1.5	-0.9	-1.7	-1.7
Hip circumference	0.7	3.1	6.7	-0.8	-1.1	0.2	-1.9	-2.6	-2.4	-1.9
Time employed in main current job	1.2	1.4	4.1	-2.0	1.2	0.4	0.8	-0.4	1.2	1.2
Alcohol intake versus 10 years previously	0.3	0.5	2.4	0.2	-0.9	0.3	0.4	0.1	-1.5	-0.1
Father’s age at death	0.9	1.2	3.5	1.9	0.5	-1.6	-1.2	0.5	-0.7	-0.2
Worrier / anxious feelings	0.6	1.1	2.9	1.2	1.7	-1.4	-1.1	-0.4	0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.6	1.6	1.2	0.6	-0.3	0.6	0.1	-0.5
Falls in the last year	0.9	1.3	6.9	-0.2	0.7	0.5	0.8	0.6	0.6	2.6
Hair/balding pattern: Pattern 3	1.2	1.8	4.1	-1.8	-0.6	-1.5	-2.0	-1.3	0.8	-0.8
Number of live births	2.6	3.6	7.5	-1.0	-1.1	2.7	2.3	2.0	2.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	8.9	3.0	1.4	0.3	1.4	1.1	-1.4	1.1
Pulse rate	0.5	0.9	1.3	1.0	1.1	1.1	1.0	0.6	-0.8	0.8
Happiness	1.3	1.6	3.1	-1.3	0.3	1.8	1.8	0.3	-0.9	1.4
Noisy workplace	2.0	2.5	10.0	1.2	-0.7	-1.4	-1.0	-1.0	-1.2	-3.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.4	2.1	2.1	0.1	0.8	0.6	0.8	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	4.2	1.0	-1.9	-0.9	-1.3	-0.7	-0.1	-2.0
Mouth/teeth dental problems: Dentures	0.8	1.3	2.2	-1.2	-1.4	1.5	1.2	0.4	-1.3	0.3
Asthma	1.0	1.9	3.2	1.3	1.3	1.8	1.7	0.7	-0.6	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	6.6	2.6	2.4	1.0	1.3	0.8	-0.3	-0.1
Medication: Cholesterol lowering	1.0	1.5	5.5	-2.4	-1.7	0.8	0.3	-0.3	1.0	0.4
Depression (self-reported)	0.7	0.8	2.4	1.6	0.2	1.1	0.9	-0.6	-0.9	0.2
Medication: Lansoprazole	1.0	1.1	4.0	-0.5	-2.0	1.0	1.4	-0.8	-0.5	0.3
Prospective memory result	0.1	0.1	0.4	-0.7	-0.2	0.5	0.3	-0.0	0.1	0.2
Lung cancer (father)	0.8	1.0	2.1	-0.8	-1.5	-0.9	-1.5	0.2	-0.7	-0.8
Illnesses of mother	1.3	1.7	4.2	1.1	2.0	-1.2	-0.7	-1.3	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.5	2.3	0.9	0.7	1.4	1.1	-1.1	0.8
Pulse wave Arterial Stiffness index	1.1	1.3	3.9	0.1	-1.6	-0.1	-0.9	-0.6	2.0	-1.1
Impedance of arm (left)	0.6	2.9	9.1	0.5	2.1	0.9	2.2	0.2	0.8	3.0
Arm fat mass (right)	0.4	1.6	3.9	-0.2	-0.4	1.4	-0.6	-1.8	-2.0	-1.3
Trunk predicted mass	0.3	1.5	2.8	0.6	-1.1	0.2	-1.5	-0.9	-1.7	-1.7
Standing height	0.1	1.3	3.1	1.8	-0.7	1.6	0.9	0.3	-0.3	1.3
Length of working week for main job	1.0	1.1	3.5	-1.9	0.4	-0.8	-0.8	-1.6	-0.2	-0.6
Exposure to tobacco smoke at home	2.0	2.2	6.1	-2.5	-0.7	-1.0	-1.9	-1.3	0.3	-1.5
Breastfed as a baby	0.9	1.1	2.8	0.4	0.2	-1.7	-1.5	-0.4	1.4	0.5
Tense / ‘highly strung’	0.3	0.5	1.0	0.8	0.1	-0.3	-0.7	-0.9	-0.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	4.4	2.1	0.9	-0.3	-0.4	-0.3	0.2	-0.6
Hair/balding pattern: Pattern 4	0.4	0.8	3.6	-0.6	-1.9	-0.7	-0.2	-0.5	-0.0	-1.1
Birth weight of first child	0.6	1.1	4.1	-0.0	0.4	1.6	0.6	0.7	0.7	2.0
Peak expiratory flow (PEF)	0.3	0.7	2.9	1.7	0.7	-0.2	0.4	0.6	-0.1	1.0
Pulse wave reflection index	1.1	1.3	4.0	0.1	-2.0	-0.7	-1.2	-0.5	1.2	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	-0.1	0.7	0.9	0.8	0.7	0.2	-0.0
Loud music exposure frequency	1.5	1.7	4.6	2.1	0.2	0.0	-0.6	0.5	-2.2	-1.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.3	0.3	0.5	0.8	0.6	0.8	0.4
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	10.1	-0.4	1.8	0.6	0.0	-0.9	-3.2	0.1
Blood clot in the leg (DVT)	1.1	1.4	3.3	0.7	0.3	1.8	1.5	1.4	0.7	1.0
Medication: Paracetamol	1.6	2.6	7.4	-2.0	-2.7	1.5	0.7	0.8	1.2	-1.5
Headache pain in last month	0.4	0.7	1.5	1.2	-0.2	0.8	0.6	0.6	-0.5	-1.2
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	10.4	3.2	2.2	-0.2	0.2	0.3	-1.5	0.8
Glaucoma (self-reported)	1.0	1.1	2.4	-0.7	1.3	-0.9	-0.6	-1.4	1.6	-0.1
Gout (self-reported)	0.7	0.9	3.2	-1.8	-1.2	0.2	0.9	-0.9	0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.9	-1.0	-1.0	-0.9	-0.6	-1.7	-1.1	-1.1
Medication: Amlodipine	1.0	1.4	4.0	-2.0	-1.2	1.0	1.0	0.7	1.2	0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-0.9	-0.3	0.3	0.1	0.1	0.8	1.3
Birth weight	0.7	1.4	4.6	-2.1	-0.8	-0.6	-0.3	-1.9	0.7	0.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	0.5	0.5	1.3	1.4	-0.0	-0.3	0.2
High blood pressure (siblings)	1.7	2.5	9.4	-3.1	-1.6	0.0	-1.2	-1.2	0.7	-1.4
Forced vital capacity (FVC), Best measure	1.0	3.5	10.6	3.2	0.8	1.6	2.3	1.6	-1.4	1.2
Body fat percentage	0.4	1.5	3.9	0.3	0.5	2.0	0.2	-1.7	-1.8	-0.0
Leg fat percentage (right)	0.5	1.8	5.9	0.5	-0.0	1.4	-0.3	-2.0	-2.4	-0.7
Arm fat-free mass (right)	0.4	2.1	7.6	0.9	-0.6	0.5	-1.2	-0.9	-2.8	-1.8
Exposure to tobacco smoke outside home	0.8	1.1	3.7	-0.8	1.9	0.8	1.0	0.5	0.1	1.2
Comparative body size at age 10	1.0	2.9	6.2	0.3	-2.5	-1.5	-1.9	-0.8	0.9	-2.5
Number of full brothers	1.5	1.8	4.3	1.6	-0.8	2.1	1.8	1.2	-0.9	0.2
Worry too long after embarrassment	1.0	1.7	8.5	0.1	2.9	-0.3	0.3	-0.2	-1.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.9	1.2	2.2	-0.1	0.0	-0.7	-1.5	0.3
Wheeze or whistling in the chest in last year	0.4	0.8	2.8	0.8	-0.0	0.9	0.7	0.5	-1.7	0.7
Number of children fathered	0.9	1.0	2.1	1.4	1.2	0.9	-0.0	-0.8	-1.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.7	0.1	-0.8	-0.7	-0.8	1.2	-1.2
Age at first live birth	0.4	0.7	2.3	-0.0	1.5	-1.2	-0.5	-0.4	0.0	0.9
Pulse wave peak to peak time	1.0	1.2	3.8	0.2	1.4	0.3	1.0	0.7	-2.0	1.1
Health satisfaction	1.8	2.3	6.4	-1.5	0.2	2.5	1.9	-0.0	0.4	1.8
Shortness of breath walking on level ground	1.4	1.7	5.3	0.4	-0.5	2.3	1.6	0.4	-1.3	1.2
Qualifications: College or University degree	0.5	1.7	5.4	-0.3	2.3	-1.8	-1.0	-0.9	-0.6	0.9
Eye problems/disorders: None of the above	0.3	0.3	1.0	1.0	0.2	-0.5	0.3	0.3	-0.7	0.2
Mouth/teeth dental problems: Loose teeth	2.5	3.0	9.6	-0.4	-0.9	3.1	2.1	1.2	-2.0	0.8
Emphysema/chronic bronchitis	0.4	0.5	1.6	-0.2	1.1	0.6	0.1	0.3	-0.1	1.3
Medication for pain relief, constipation, heartburn	2.2	3.8	7.7	2.6	2.8	-0.9	-0.1	-0.3	-2.0	2.7
Neck or shoulder pain in last month	1.6	2.2	4.4	-1.7	-1.0	1.8	2.1	1.8	0.9	0.2
Medication: Blood pressure	1.1	2.0	8.5	-2.9	-1.6	0.3	-0.6	-0.2	0.9	-1.3
Angina (self-reported)	2.2	2.9	11.1	-0.5	-3.3	2.3	1.2	0.5	1.2	-0.5
Migraine (self-reported)	0.7	0.9	3.4	0.6	-0.3	1.1	0.8	1.9	-0.5	0.1
Medication: Ibuprofen	1.6	2.0	7.3	2.7	2.0	0.9	1.2	0.2	-0.1	-0.2
Medication: Allopurinol	0.8	1.1	3.0	-1.7	-1.2	0.3	0.7	-1.6	0.2	0.1
Medication: Omeprazole	0.6	0.7	3.3	-1.8	-0.6	-0.3	-0.5	0.7	0.5	-0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.8	0.1	0.4	1.0	0.9	1.2	-1.3	0.7
Mean time to correctly identify matches	0.9	1.7	3.8	-1.9	-1.1	-0.9	-0.1	-1.6	-1.1	-1.6
Heart disease (mother)	1.1	1.3	5.2	-1.2	-2.3	0.7	0.0	1.4	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.4	0.6	-0.0	-0.2	-0.4	-0.7	-0.2
Whole body fat mass	0.4	1.6	4.5	0.4	-0.1	1.8	-0.2	-1.7	-2.1	-0.7
Leg fat mass (right)	0.5	2.0	5.8	0.6	-0.2	1.5	-0.7	-1.8	-2.4	-1.2
Arm predicted mass (right)	0.4	1.9	6.6	1.0	-0.5	0.6	-1.2	-1.0	-2.6	-1.7
Pulse rate, automated reading	0.8	2.6	5.3	0.7	0.2	1.8	2.1	2.3	-1.5	1.5
Alcohol intake frequency.	0.4	0.9	4.8	-1.1	-2.2	0.3	-0.2	-0.5	-0.2	0.3
Comparative height size at age 10	0.6	3.4	8.0	1.2	-2.2	2.8	2.3	1.0	0.0	1.7
Number of full sisters	0.7	0.8	2.9	-0.2	-0.3	0.5	0.2	0.4	1.6	1.7
Suffer from ‘nerves’	1.0	1.5	5.2	2.3	1.8	-1.0	-0.9	-0.1	-0.3	-0.5
Overall health rating	1.6	3.5	13.3	-3.6	-2.0	2.3	1.0	0.1	0.7	0.4
Chest pain or discomfort	1.3	1.9	6.9	1.3	-1.5	0.3	-1.0	1.0	0.6	-2.6
Had major operations	0.1	0.1	0.5	-0.1	-0.2	0.2	0.2	0.3	-0.7	-0.2
Age at last live birth	0.7	1.0	2.1	-1.4	0.2	-1.4	-0.7	-1.4	0.9	0.1
Family relationship satisfaction	0.4	0.5	2.5	1.6	1.0	0.1	-0.2	0.1	-0.3	-0.2
Leg pain on walking	0.5	0.6	1.4	-0.2	1.2	0.8	0.9	-0.8	-0.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	4.6	2.1	-1.0	0.5	0.9	1.7	0.5	0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.9	0.6	-0.4	-0.0	-0.3	0.7	1.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.9	-0.7	1.7	0.2	0.9	0.5	0.1	1.5
Medication: Aspirin	1.6	2.1	7.9	-2.8	-2.1	0.6	-0.1	-0.4	1.4	-0.4
Supplements: Vitamin C	0.4	0.5	1.1	0.8	-0.5	0.8	1.0	0.7	0.7	-0.1
Knee pain experienced in last month	0.8	1.2	3.3	1.6	0.3	1.1	0.3	0.7	1.8	0.8
Hypertension (Self-reported)	1.4	3.9	16.3	-4.0	-2.9	0.3	-0.2	-0.8	0.3	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.6	-0.8	0.9	1.1	0.5	-1.0	-0.2
Illnesses of father: Heart disease	1.8	2.4	4.7	-2.1	-0.2	2.2	1.3	0.3	2.2	1.2
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-1.2	-0.6	0.8	0.4	0.1	0.7	1.1
Smoking status: Previous	2.4	3.6	11.3	0.7	-1.6	3.4	2.9	1.6	0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.7	-0.4	-0.5	1.9	1.6	-0.0	-0.5	0.5
Whole body fat-free mass	0.3	1.9	4.8	0.7	-0.9	0.4	-1.5	-1.2	-2.2	-1.8
Leg fat-free mass (right)	0.4	2.0	5.7	0.7	-0.6	0.7	-1.4	-1.2	-2.4	-1.9
Arm fat percentage (left)	0.4	1.6	4.2	-0.3	0.3	1.6	-0.2	-2.0	-2.0	-0.7
Average weekly red wine intake	1.2	1.8	4.4	-0.1	-0.5	-1.9	-2.1	-0.5	1.8	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.0	-2.2	-1.4	-0.4	-0.4	-0.2	-0.5	-1.2
Mood swings	0.4	0.6	1.9	0.5	1.2	0.2	0.0	0.1	1.4	-1.0
Loneliness, isolation	0.3	0.4	2.7	-1.6	0.3	-0.3	0.1	0.2	0.2	0.3
Long-standing illness, disability or infirmity	0.7	1.1	2.3	-0.9	-1.5	1.4	0.6	0.6	1.3	0.6
Ever had bowel cancer screening	1.0	1.2	3.6	-0.0	-1.7	-0.6	-0.6	-0.7	-0.6	-1.9
Diabetes diagnosed by doctor	1.5	2.5	6.9	-2.6	-1.5	-1.3	-2.1	-1.2	-0.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	5.7	0.6	-0.9	2.4	1.6	0.6	1.2	1.3
Friendships satisfaction	0.5	0.6	2.3	-0.2	1.5	0.3	-0.2	-0.7	-0.7	0.7
Qualifications: nursing, teaching	2.7	4.1	11.0	0.5	3.3	1.2	1.9	1.7	-1.0	2.9
Commuting to job workplace: Walk	0.3	0.4	1.8	-0.4	-1.3	0.5	0.4	0.4	0.1	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.4	-1.0	0.1	-0.7	0.8	0.6	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.2	0.0	-0.5	-0.5	0.0	-0.7	-0.6
Medication for cholesterol	0.9	1.3	3.3	0.7	1.8	0.2	0.2	1.1	1.0	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	5.2	-2.3	-1.9	0.7	0.6	-2.1	1.9	-0.3
Back pain experienced in last month	0.9	1.3	4.7	-0.5	-0.8	2.2	1.4	-0.3	1.3	0.2
Mineral and other dietary supplements	1.8	2.4	5.8	-1.1	-0.9	2.4	1.6	0.9	0.2	2.3
Breast cancer (self-reported)	0.7	0.9	2.8	-0.5	-0.7	0.9	1.7	0.3	-0.8	1.0
Asthma (self-reported)	0.9	1.8	3.2	1.2	1.1	1.8	1.6	0.7	-0.6	1.7
Osteoporosis (self-reported)	0.5	0.6	1.4	0.0	0.4	0.2	1.2	0.7	0.8	1.1
Osteoarthritis (self-reported)	0.4	0.5	2.4	-0.2	-0.7	-0.1	0.2	1.6	0.3	-0.4
Medication: Aspirin	1.5	2.0	5.9	-2.4	-2.1	0.5	-0.4	-0.4	1.4	-1.1
Medication: Gliclazide	1.3	1.4	3.2	-0.8	-0.8	-1.3	-1.6	-0.6	-1.0	-1.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.6	-0.6	-0.5	-0.3	0.1	-1.1	0.0
Smoking status: Current	0.4	0.7	2.2	-0.3	-1.5	-0.1	-0.1	0.4	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	1.2	1.0	-0.9	0.2	-0.0	-0.9	1.0
Whole body water mass	0.3	1.9	4.9	0.7	-0.9	0.4	-1.5	-1.2	-2.2	-1.8
Leg predicted mass (right)	0.4	2.0	5.8	0.7	-0.6	0.6	-1.4	-1.2	-2.4	-1.9
Arm fat mass (left)	0.4	1.8	4.9	-0.2	-0.3	1.4	-0.4	-2.0	-2.2	-1.1
Number of self-reported non-cancer illnesses	1.3	2.3	9.7	-3.1	-1.8	1.0	0.7	-0.6	-0.1	-1.0
Average weekly champagne plus white wine intake	1.4	1.9	6.2	0.5	2.5	0.7	1.5	1.4	-0.6	1.4
Miserableness	0.9	1.6	6.6	2.6	1.6	0.9	0.6	0.3	-0.2	-0.9
Guilty feelings	1.2	1.8	6.8	2.1	2.6	-0.5	-1.0	0.2	0.0	-0.4
Wears glasses or contact lenses	0.2	0.3	0.6	-0.5	0.6	-0.2	-0.8	0.4	-0.0	0.7
Ever taken oral contraceptive pill	1.6	1.8	4.4	2.1	1.5	-1.6	-1.4	-0.1	0.1	-1.2
Hearing aid user	0.7	0.8	3.2	-0.1	1.6	0.3	-0.3	-0.1	-0.0	1.8
Mother’s age at death	0.2	0.2	0.8	-0.4	-0.7	0.1	0.0	-0.1	0.9	-0.1
Financial situation satisfaction	0.9	1.1	3.2	0.4	0.1	1.8	1.1	0.2	-1.7	0.6
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.8	-1.7	1.1	-1.4	-1.2	-1.6	-0.3	-0.5
Commuting to job workplace: Public transport	1.1	1.3	3.7	-0.4	0.6	1.2	1.3	0.8	-1.9	1.1
Eye problems/disorders: Glaucoma	0.7	0.9	2.3	-0.9	1.0	-0.9	-0.3	-0.7	1.5	-0.7
Medication: Blood pressure	0.7	1.4	5.2	-2.3	-1.9	0.3	0.4	-0.7	-0.0	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.3	-0.7	-0.1	-0.7	-0.7	0.4	-0.1
Supplements: Fish oil (including cod liver oil)	1.5	1.9	4.6	-0.4	-0.0	-2.1	-1.5	-1.4	0.4	-2.1
High cholesterol (Self-reported)	0.9	1.6	4.6	-2.1	-2.1	0.4	-0.3	-1.1	0.5	-0.7
Medication: Bendroflumethiazide	1.9	2.9	10.3	-3.2	-2.3	0.4	0.1	-1.4	-1.0	-1.2
Medication: Paracetamol	1.5	2.3	5.0	-2.2	-2.2	1.6	1.1	0.0	1.3	-1.2
Medication: Lisinopril	0.5	0.7	2.8	-1.7	-1.1	-0.1	-0.2	-0.1	-0.1	-0.8
Medication: Atorvastatin	0.8	1.0	3.5	-1.9	-0.8	-0.3	-0.8	-1.3	0.5	-0.6
Illnesses of father: High blood pressure	0.6	0.7	2.2	-0.8	-1.5	0.4	0.1	-0.4	-0.0	-1.3
Alcohol drinker status: Never	0.5	0.6	1.5	-0.8	-1.1	-0.2	-0.6	-0.2	0.5	1.2
Ever smoked	1.0	1.7	5.0	0.8	-2.2	1.6	0.9	1.2	-0.7	-1.2
Basal metabolic rate	0.4	2.2	5.5	0.7	-0.9	0.5	-1.5	-1.4	-2.3	-2.0
Leg fat percentage (left)	0.4	1.6	5.6	0.4	-0.2	1.1	-0.5	-1.7	-2.4	-1.0
Arm fat-free mass (left)	0.3	1.7	5.5	0.8	-0.7	0.5	-1.1	-1.0	-2.4	-1.7
Number of operations (self-reported)	0.6	0.9	2.3	-1.5	-1.2	0.6	0.3	-1.1	-0.6	-0.9
Average weekly beer plus cider intake	1.5	2.2	5.4	-1.4	-2.3	1.8	1.8	0.8	-0.9	0.3
Irritability	0.5	0.8	3.1	0.8	1.8	-0.1	-0.3	-0.7	-1.1	-0.7
Risk taking	0.6	0.9	4.3	-2.1	0.3	0.1	-0.1	-0.1	1.0	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.2	1.8	-0.2	0.3	0.8	0.8	0.0	-1.0
Fractured/broken bones in last 5 years	1.2	1.6	7.3	-2.7	-0.8	-0.9	-1.0	-1.1	0.2	0.1
Age started oral contraceptive pill	0.7	0.8	2.2	-0.2	1.5	-0.5	0.2	1.0	0.8	1.3
Diastolic blood pressure, automated reading	0.6	1.9	6.2	-2.5	-1.2	1.0	1.9	-0.4	-0.3	0.6
Ever depressed for a whole week	0.8	1.0	2.6	1.2	1.0	0.6	1.2	0.7	0.0	1.6
Unable to work because of sickness or disability	0.4	0.5	1.0	-0.9	1.0	-0.7	-1.0	-0.3	0.2	0.2
Commuting to job workplace: Cycle	2.0	2.4	4.6	1.1	-0.2	2.1	1.9	1.5	-0.4	2.1
Myopia	0.5	0.7	2.6	0.3	-1.6	1.2	0.3	-0.1	-0.8	0.0
Vascular/heart problems diagnosed by doctor	1.4	3.8	15.5	3.9	3.0	-1.0	-0.4	0.3	-0.2	0.8
Cholesterol lowering medication	1.4	2.1	8.6	-1.4	-2.9	-0.3	-0.5	-1.5	0.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	-1.2	-0.7	0.1	-0.2	0.2	1.1	-0.5
Pain experienced in last month	0.8	1.4	4.8	0.1	1.4	-2.2	-1.2	-0.6	-1.0	0.2
Supplements: Calcium	0.5	0.6	1.9	-0.2	0.3	-1.1	-0.4	-0.7	1.4	-0.5
Basal cell carcinoma (self-reported)	0.8	1.0	2.3	1.1	1.5	1.5	0.4	-0.3	-1.0	0.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.2	1.1	-1.5	-0.5	-0.8	0.5	-0.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	0.3	0.1	1.5	1.3	1.3	0.5	0.9
Heart disease (siblings)	1.1	1.3	3.6	-0.4	0.2	1.9	1.2	1.0	-0.9	1.5
Alcohol drinker status: Previous	1.1	1.3	5.2	-2.3	-0.2	0.6	0.8	-1.1	-0.2	1.1
Pack years of smoking	0.8	1.2	3.5	-1.9	-1.4	-0.6	-0.8	-1.3	0.0	0.3
Impedance of whole body	0.8	4.3	13.3	1.0	1.9	1.1	2.9	0.9	1.2	3.6
Leg fat mass (left)	0.5	2.0	6.0	0.6	-0.3	1.3	-0.9	-1.7	-2.5	-1.4
Arm predicted mass (left)	0.4	1.8	4.9	1.1	-0.6	0.3	-1.4	-1.0	-2.2	-1.8