Hub : Traits :

Medication: Ramipril

8 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 99859184 101559718 2 1 8.8e-09 9.9e-09 1.0000 100 ARHGAP42
2 12 132663423 133778796 1 1 9.0e-08 2.2e-06 0.0089 69 GOLGA3
3 15 74402161 75930199 2 1 6.3e-08 2.0e-08 0.1170 92 CSK

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Breast Cancer 4.46 1 0 0.0 0 1 CSK
Fasting Glucose 5.91 2 0 0.0 0 1 CSK GOLGA3
LDL Cholesterol 3.41 1 0 0.0 0 1 CSK
Lupus 4.61 1 0 0.0 0 1 CSK
Neuroticism 2.77 1 0 0.0 0 1 GOLGA3
Schizophrenia 1.54 1 0 0.0 0 1 CSK
Blood Eosinophil Count 0.77 1 0 0.0 0 1 GOLGA3
Blood Platelet Count 1.73 3 0 0.0 0 1 ARHGAP42 CSK GOLGA3
Blood Red Count 3.80 2 1 3.0 0 1 CSK GOLGA3
Blood White Count 1.39 1 0 0.0 0 1 ARHGAP42
Heel T-Score 1.52 1 1 3.0 0 1 ARHGAP42
BMI 0.94 1 0 0.0 0 1 CSK
Height 0.62 2 0 0.0 0 1 ARHGAP42 GOLGA3
Waist Hip Ratio (WHR) 1.36 1 0 0.0 0 1 CSK
Systolic Blood Pressure 38.67 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Allergy or Eczema 3.14 2 0 0.0 0 1 ARHGAP42 CSK
Cardiovascular Disease 30.95 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Lung FEV1/FVC ratio 3.71 2 1 3.0 0 1 ARHGAP42 CSK
Hair Pigment 0.22 1 0 0.0 0 1 ARHGAP42
Tanning 0.60 2 0 0.0 0 1 ARHGAP42 CSK
Number of treatments/medications taken 7.59 2 0 0.0 0 1 ARHGAP42 GOLGA3
Hearing difficulty/problems: Yes 2.24 1 0 0.0 0 1 CSK
Other serious medical condition/disability diagnosed by doctor 4.41 1 0 0.0 0 1 CSK
Systolic blood pressure, automated reading 25.04 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Angina 3.07 1 0 0.0 0 1 ARHGAP42
Impedance of leg (right) 1.60 1 0 0.0 0 1 ARHGAP42
Leg fat-free mass (left) 1.44 1 0 0.0 0 1 ARHGAP42
Taking other prescription medications 2.52 1 0 0.0 0 1 GOLGA3
Heel bone mineral density (BMD) T-score, automated (left) 2.36 1 0 0.0 0 1 ARHGAP42
High blood pressure 31.18 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Hayfever, allergic rhinitis or eczema 2.97 1 0 0.0 0 1 CSK
Supplements: Glucosamine 5.28 1 0 0.0 0 1 CSK
Medication: Atenolol 9.76 2 0 0.0 0 1 ARHGAP42 CSK
Sitting height 0.51 1 0 0.0 0 1 ARHGAP42
High blood pressure (mother) 8.22 2 0 0.0 0 1 ARHGAP42 CSK
Body mass index (BMI) 0.81 1 0 0.0 0 1 CSK
Impedance of leg (left) 1.54 1 0 0.0 0 1 ARHGAP42
Leg predicted mass (left) 1.45 1 0 0.0 0 1 ARHGAP42
Waist circumference 1.54 1 0 0.0 0 1 CSK
Hearing difficulty/problems with background noise 5.03 1 0 0.0 0 1 CSK
Had other major operations 3.64 1 0 0.0 0 1 ARHGAP42
Forced vital capacity (FVC) 2.36 2 0 0.0 0 1 ARHGAP42 GOLGA3
Heel bone mineral density (BMD) T-score, automated (right) 2.32 1 0 0.0 0 1 ARHGAP42
Financial difficulties in last 2 years 2.79 1 0 0.0 0 1 CSK
Mouth/teeth dental problems 3.13 1 0 0.0 0 1 CSK
Allergy 1.99 1 0 0.0 0 1 CSK
Medication: Simvastatin 5.20 1 0 0.0 0 1 ARHGAP42
Illnesses of siblings 6.41 1 0 0.0 0 1 ARHGAP42
Weight 0.88 1 0 0.0 0 1 CSK
Impedance of arm (right) 1.25 1 0 0.0 0 1 CSK
Trunk fat-free mass 1.27 1 0 0.0 0 1 ARHGAP42
Father's age at death 4.97 1 0 0.0 0 1 CSK
Hair/balding pattern: Pattern 3 2.98 1 0 0.0 0 1 CSK
Forced expiratory volume in 1-second (FEV1) 2.93 2 0 0.0 0 1 ARHGAP42 GOLGA3
Qualifications: A levels/AS levels or equivalent 2.58 1 0 0.0 0 1 CSK
Medication: Ibuprofen (e.g. Nurofen) 5.30 1 0 0.0 0 1 CSK
Medication: Cholesterol lowering 9.58 2 0 0.0 0 1 ARHGAP42 CSK
Illnesses of mother 7.00 2 0 0.0 0 1 ARHGAP42 CSK
Forced expiratory volume in 1-second (FEV1), Best measure 2.01 1 0 0.0 0 1 ARHGAP42
Impedance of arm (left) 1.18 1 0 0.0 0 1 CSK
Arm fat mass (right) 0.61 1 0 0.0 0 1 CSK
Trunk predicted mass 1.21 1 0 0.0 0 1 ARHGAP42
Standing height 0.41 1 0 0.0 0 1 ARHGAP42
Birth weight of first child 4.29 1 0 0.0 0 1 CSK
Peak expiratory flow (PEF) 2.73 1 0 0.0 0 1 CSK
Qualifications: O levels/GCSEs or equivalent 3.26 1 0 0.0 0 1 CSK
Medication: Paracetamol 2.58 1 0 0.0 0 1 CSK
Medication for cholesterol, blood pressure or diabetes 19.21 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Medication: Amlodipine 11.51 2 1 3.0 0 1 ARHGAP42 CSK
Birth weight 2.19 1 0 0.0 0 1 ARHGAP42
High blood pressure (siblings) 9.17 3 0 0.0 0 1 ARHGAP42 CSK GOLGA3
Forced vital capacity (FVC), Best measure 1.58 1 0 0.0 0 1 GOLGA3
Arm fat-free mass (right) 1.36 2 0 0.0 0 1 ARHGAP42 CSK
Comparative body size at age 10 0.95 1 0 0.0 0 1 CSK
Wheeze or whistling in the chest in last year 1.89 1 0 0.0 0 1 CSK
Mouth/teeth dental problems: Loose teeth 2.72 1 0 0.0 0 1 CSK
Medication: Blood pressure 23.37 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Angina (self-reported) 2.84 1 0 0.0 0 1 ARHGAP42
Medication: Ibuprofen 5.03 1 0 0.0 0 1 CSK
Leg fat mass (right) 0.72 1 0 0.0 0 1 CSK
Arm predicted mass (right) 1.29 2 0 0.0 0 1 ARHGAP42 CSK
Alcohol intake frequency. 1.91 1 0 0.0 0 1 CSK
Overall health rating 2.35 1 0 0.0 0 1 GOLGA3
Medication: Aspirin 4.58 1 0 0.0 0 1 GOLGA3
Hypertension (Self-reported) 31.24 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Illnesses of father: Heart disease 4.53 1 0 0.0 0 1 ARHGAP42
Whole body fat-free mass 1.40 2 0 0.0 0 1 ARHGAP42 CSK
Leg fat-free mass (right) 1.59 2 0 0.0 0 1 ARHGAP42 CSK
Average weekly red wine intake 3.21 1 0 0.0 0 1 CSK
Medication for cholesterol 8.17 2 1 3.0 0 1 ARHGAP42 CSK
Osteoarthritis (self-reported) 4.70 1 0 0.0 0 1 CSK
Medication: Aspirin 5.03 1 0 0.0 0 1 CSK
Illnesses of father: None of the above (group 1) 2.77 1 0 0.0 0 1 ARHGAP42
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.93 1 0 0.0 0 1 ARHGAP42
Whole body water mass 1.37 1 0 0.0 0 1 ARHGAP42
Leg predicted mass (right) 1.52 1 0 0.0 0 1 ARHGAP42
Number of self-reported non-cancer illnesses 5.57 3 0 0.0 0 1 ARHGAP42 CSK GOLGA3
Medication: Blood pressure 21.63 2 2 6.1 0 1 ARHGAP42 CSK
High cholesterol (Self-reported) 6.38 1 0 0.0 0 1 ARHGAP42
Medication: Bendroflumethiazide 14.42 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Medication: Paracetamol 3.29 1 0 0.0 0 1 CSK
Medication: Lisinopril 10.25 2 0 0.0 0 1 ARHGAP42 CSK
Illnesses of father: High blood pressure 5.47 1 0 0.0 0 1 ARHGAP42
Basal metabolic rate 1.29 2 0 0.0 0 1 ARHGAP42 CSK
Arm fat-free mass (left) 1.13 1 0 0.0 0 1 CSK
Diastolic blood pressure, automated reading 29.56 2 2 6.1 0 1 ARHGAP42 CSK
Vascular/heart problems diagnosed by doctor 31.13 3 2 6.1 0 1 ARHGAP42 CSK GOLGA3
Impedance of whole body 1.46 1 0 0.0 0 1 ARHGAP42
Leg fat mass (left) 0.83 1 0 0.0 0 1 CSK
Arm predicted mass (left) 1.33 2 0 0.0 0 1 ARHGAP42 CSK

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.29
GTEx Adipose Visceral Omentum 0 0.0000 1.36
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 1 0.0336 1.35
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 2 0.0532 1.32
GTEx Brain Caudate basal ganglia 0 0.0000 1.23
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.25
GTEx Brain Cerebellum 0 0.0000 1.33
GTEx Brain Cortex 0 0.0000 1.33
GTEx Brain Frontal Cortex BA9 0 0.0000 1.34
GTEx Brain Hippocampus 0 0.0000 1.29
GTEx Brain Hypothalamus 0 0.0000 1.26
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.24
GTEx Brain Putamen basal ganglia 0 0.0000 1.30
GTEx Breast Mammary Tissue 0 0.0000 1.30
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.19
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.29
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.34
GTEx Cells Transformed fibroblasts 0 0.0000 1.30
GTEx Colon Sigmoid 0 0.0000 1.27
GTEx Colon Transverse 0 0.0000 1.36
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.31
GTEx Esophagus Mucosa 0 0.0000 1.32
GTEx Esophagus Muscularis 0 0.0000 1.34
GTEx Heart Atrial Appendage 0 0.0000 1.39
GTEx Heart Left Ventricle 0 0.0000 1.28
GTEx Liver 0 0.0000 1.32
GTEx Lung 1 0.0348 1.33
GTEx Muscle Skeletal 0 0.0000 1.31
GTEx Nerve Tibial 0 0.0000 1.31
GTEx Ovary 0 0.0000 1.32
GTEx Pancreas 0 0.0000 1.37
GTEx Pituitary 0 0.0000 1.20
GTEx Prostate 0 0.0000 1.24
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.36
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.36
GTEx Small Intestine Terminal Ileum 0 0.0000 1.40
GTEx Spleen 0 0.0000 1.34
GTEx Stomach 0 0.0000 1.42
GTEx Testis 0 0.0000 1.32
GTEx Thyroid 0 0.0000 1.35
GTEx Uterus 0 0.0000 1.38
GTEx Vagina 1 0.1575 1.44
GTEx Whole Blood 0 0.0000 1.29
METSIM Adipose 0 0.0000 1.23
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 1 0.0217 1.28
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.30
TCGA Breast Tumor 0 0.0000 1.16
TCGA Breast Normal 0 0.0000 1.22
TCGA Ovarian Tumor 0 0.0000 1.22
TCGA Prostate Tumor 0 0.0000 1.26