Hub : Traits :

Medication: Gliclazide

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 113511441 115622375 2 1 2e-16 1e-53 2.8e-41 24 TCF7L2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 2.55 1 0 0 0 1 TCF7L2
Breast Cancer 22.77 1 1 3 0 1 TCF7L2
Body Mass Index (BMI) (2010) 7.96 1 0 0 0 1 TCF7L2
Fasting Glucose 8.73 1 0 0 0 1 TCF7L2
Type 2 Diabetes (T2D) 33.13 1 1 3 0 1 TCF7L2
Blood Platelet Count 0.67 1 0 0 0 1 TCF7L2
Blood Red Count 0.72 1 0 0 0 1 TCF7L2
Heel T-Score 1.29 1 0 0 0 1 TCF7L2
BMI 7.25 1 1 3 0 1 TCF7L2
Height 0.47 1 0 0 0 1 TCF7L2
Waist Hip Ratio (WHR) 16.78 1 1 3 0 1 TCF7L2
Systolic Blood Pressure 5.37 1 1 3 0 1 TCF7L2
Type 2 Diabetes (T2D) 141.28 1 1 3 0 1 TCF7L2
Lung FEV1/FVC ratio 1.00 1 0 0 0 1 TCF7L2
Chronotype (morning person) 2.78 1 0 0 0 1 TCF7L2
Eye problems/disorders: Diabetes related eye disease 18.82 1 0 0 0 1 TCF7L2
Medication: Metformin 92.37 1 1 3 0 1 TCF7L2
Diabetes (father) 91.58 1 1 3 0 1 TCF7L2
Diabetes (mother) 66.88 1 1 3 0 1 TCF7L2
Impedance of leg (right) 1.90 1 0 0 0 1 TCF7L2
Leg fat-free mass (left) 1.99 1 0 0 0 1 TCF7L2
Trunk fat percentage 2.70 1 0 0 0 1 TCF7L2
Hand grip strength (right) 2.57 1 0 0 0 1 TCF7L2
Heel bone mineral density (BMD) T-score, automated (left) 3.72 1 0 0 0 1 TCF7L2
Body mass index (BMI) 7.72 1 1 3 0 1 TCF7L2
Impedance of leg (left) 1.39 1 0 0 0 1 TCF7L2
Leg predicted mass (left) 2.02 1 0 0 0 1 TCF7L2
Trunk fat mass 3.68 1 0 0 0 1 TCF7L2
Waist circumference 4.40 1 0 0 0 1 TCF7L2
Alcohol usually taken with meals 4.61 1 0 0 0 1 TCF7L2
Heel bone mineral density (BMD) T-score, automated (right) 3.33 1 0 0 0 1 TCF7L2
Diabetes (self-reported) 102.78 1 1 3 0 1 TCF7L2
Medication: Simvastatin 11.21 1 0 0 0 1 TCF7L2
Weight 4.44 1 0 0 0 1 TCF7L2
Impedance of arm (right) 3.65 1 0 0 0 1 TCF7L2
Arm fat percentage (right) 5.25 1 0 0 0 1 TCF7L2
Trunk fat-free mass 0.95 1 0 0 0 1 TCF7L2
Hip circumference 14.20 1 1 3 0 1 TCF7L2
Worrier / anxious feelings 6.34 1 0 0 0 1 TCF7L2
Falls in the last year 4.08 1 0 0 0 1 TCF7L2
Medication: Cholesterol lowering 11.00 1 0 0 0 1 TCF7L2
Illnesses of mother 4.66 1 0 0 0 1 TCF7L2
Impedance of arm (left) 3.77 1 0 0 0 1 TCF7L2
Arm fat mass (right) 6.07 1 1 3 0 1 TCF7L2
Trunk predicted mass 0.99 1 0 0 0 1 TCF7L2
Standing height 0.58 1 0 0 0 1 TCF7L2
Birth weight of first child 3.43 1 0 0 0 1 TCF7L2
Medication for cholesterol, blood pressure or diabetes 5.25 1 0 0 0 1 TCF7L2
Birth weight 4.70 1 0 0 0 1 TCF7L2
Body fat percentage 5.17 1 0 0 0 1 TCF7L2
Leg fat percentage (right) 9.02 1 1 3 0 1 TCF7L2
Arm fat-free mass (right) 1.73 1 0 0 0 1 TCF7L2
Comparative body size at age 10 1.87 1 0 0 0 1 TCF7L2
Reproduciblity of spirometry measurement using ERS/ATS criteria 9.90 1 0 0 0 1 TCF7L2
Whole body fat mass 5.67 1 0 0 0 1 TCF7L2
Leg fat mass (right) 8.30 1 1 3 0 1 TCF7L2
Arm predicted mass (right) 1.58 1 0 0 0 1 TCF7L2
Pulse rate, automated reading 3.30 1 0 0 0 1 TCF7L2
Medication: Aspirin 4.01 1 0 0 0 1 TCF7L2
Illnesses of siblings: Diabetes 38.60 1 1 3 0 1 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted 3.03 1 0 0 0 1 TCF7L2
Whole body fat-free mass 1.51 1 0 0 0 1 TCF7L2
Leg fat-free mass (right) 1.73 1 0 0 0 1 TCF7L2
Arm fat percentage (left) 5.51 1 0 0 0 1 TCF7L2
Long-standing illness, disability or infirmity 3.70 1 0 0 0 1 TCF7L2
Diabetes diagnosed by doctor 120.22 1 1 3 0 1 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 9.12 1 0 0 0 1 TCF7L2
Qualifications: nursing, teaching 8.73 1 0 0 0 1 TCF7L2
Breast cancer (self-reported) 9.53 1 0 0 0 1 TCF7L2
Medication: Aspirin 7.09 1 0 0 0 1 TCF7L2
Illnesses of father: None of the above (group 1) 6.12 1 0 0 0 1 TCF7L2
Whole body water mass 1.46 1 0 0 0 1 TCF7L2
Leg predicted mass (right) 1.76 1 0 0 0 1 TCF7L2
Arm fat mass (left) 5.60 1 0 0 0 1 TCF7L2
Average weekly champagne plus white wine intake 5.94 1 0 0 0 1 TCF7L2
High cholesterol (Self-reported) 5.71 1 0 0 0 1 TCF7L2
Medication: Atorvastatin 15.32 1 0 0 0 1 TCF7L2
Basal metabolic rate 2.15 1 0 0 0 1 TCF7L2
Leg fat percentage (left) 9.60 1 1 3 0 1 TCF7L2
Arm fat-free mass (left) 2.23 1 0 0 0 1 TCF7L2
Diastolic blood pressure, automated reading 3.86 1 0 0 0 1 TCF7L2
Myopia 5.32 1 0 0 0 1 TCF7L2
Cholesterol lowering medication 15.20 1 0 0 0 1 TCF7L2
Heart attack/myocardial infarction (self-reported) 3.96 1 0 0 0 1 TCF7L2
Impedance of whole body 2.75 1 0 0 0 1 TCF7L2
Leg fat mass (left) 8.60 1 1 3 0 1 TCF7L2
Arm predicted mass (left) 1.95 1 0 0 0 1 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.15
GTEx Adipose Visceral Omentum 0 0.0000 1.11
GTEx Adrenal Gland 0 0.0000 1.14
GTEx Artery Aorta 1 0.0336 1.20
GTEx Artery Coronary 0 0.0000 1.07
GTEx Artery Tibial 0 0.0000 1.15
GTEx Brain Caudate basal ganglia 0 0.0000 1.09
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.13
GTEx Brain Cerebellum 0 0.0000 1.15
GTEx Brain Cortex 0 0.0000 1.16
GTEx Brain Frontal Cortex BA9 0 0.0000 1.12
GTEx Brain Hippocampus 0 0.0000 1.04
GTEx Brain Hypothalamus 0 0.0000 1.03
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.08
GTEx Brain Putamen basal ganglia 0 0.0000 1.01
GTEx Breast Mammary Tissue 0 0.0000 1.13
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.12
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.11
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.08
GTEx Cells Transformed fibroblasts 0 0.0000 1.17
GTEx Colon Sigmoid 0 0.0000 1.18
GTEx Colon Transverse 0 0.0000 1.19
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.10
GTEx Esophagus Mucosa 0 0.0000 1.16
GTEx Esophagus Muscularis 0 0.0000 1.15
GTEx Heart Atrial Appendage 0 0.0000 1.13
GTEx Heart Left Ventricle 0 0.0000 1.11
GTEx Liver 0 0.0000 1.08
GTEx Lung 0 0.0000 1.11
GTEx Muscle Skeletal 0 0.0000 1.18
GTEx Nerve Tibial 0 0.0000 1.15
GTEx Ovary 0 0.0000 1.11
GTEx Pancreas 0 0.0000 1.17
GTEx Pituitary 0 0.0000 1.11
GTEx Prostate 0 0.0000 1.14
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.16
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.18
GTEx Small Intestine Terminal Ileum 0 0.0000 1.18
GTEx Spleen 0 0.0000 1.13
GTEx Stomach 0 0.0000 1.12
GTEx Testis 0 0.0000 1.19
GTEx Thyroid 0 0.0000 1.18
GTEx Uterus 0 0.0000 1.05
GTEx Vagina 0 0.0000 1.17
GTEx Whole Blood 0 0.0000 1.14
METSIM Adipose 0 0.0000 1.12
NTR Blood 0 0.0000 1.12
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.12
YFS Blood 0 0.0000 1.15
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.16
TCGA Breast Tumor 0 0.0000 1.14
TCGA Breast Normal 1 0.0238 1.12
TCGA Ovarian Tumor 0 0.0000 1.07
TCGA Prostate Tumor 0 0.0000 1.14