Hub : Traits :

Noisy workplace

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 135874930 137261517 1 1 8.1e-08 3.4e-06 0.22 93 RP11-85F14.5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 2.10 1 0 0 0 1 RP11-85F14.5
Verbal and Numeric Reasoning (VNR) 4.10 1 0 0 0 1 RP11-85F14.5
Age at First Birth 2.88 1 0 0 0 1 RP11-85F14.5
Body Mass Index (BMI) (2010) 7.49 1 0 0 0 1 RP11-85F14.5
HDL Cholesterol 11.70 1 0 0 0 1 RP11-85F14.5
Schizophrenia 2.88 1 0 0 0 1 RP11-85F14.5
Triglycerides 9.85 1 0 0 0 1 RP11-85F14.5
Blood Eosinophil Count 1.70 1 0 0 0 1 RP11-85F14.5
Blood Platelet Count 2.72 1 1 3 0 1 RP11-85F14.5
Blood Red Count 0.54 1 0 0 0 1 RP11-85F14.5
Blood White Count 3.09 1 0 0 0 1 RP11-85F14.5
BMI 13.30 1 1 3 0 1 RP11-85F14.5
Height 7.44 1 1 3 0 1 RP11-85F14.5
Allergy or Eczema 1.55 1 0 0 0 1 RP11-85F14.5
Cardiovascular Disease 13.00 1 1 3 0 1 RP11-85F14.5
Type 2 Diabetes (T2D) 4.25 1 0 0 0 1 RP11-85F14.5
Number of treatments/medications taken 4.39 1 0 0 0 1 RP11-85F14.5
Average weekly spirits intake 4.13 1 0 0 0 1 RP11-85F14.5
Relative age of first facial hair 5.17 1 0 0 0 1 RP11-85F14.5
Ever used hormone-replacement therapy (HRT) 4.60 1 0 0 0 1 RP11-85F14.5
Angina 6.23 1 0 0 0 1 RP11-85F14.5
Medication: Co-codamol 6.23 1 0 0 0 1 RP11-85F14.5
Medication: Metformin 3.41 1 0 0 0 1 RP11-85F14.5
Pack years adult smoking proportion 3.14 1 0 0 0 1 RP11-85F14.5
Impedance of leg (right) 5.87 1 1 3 0 1 RP11-85F14.5
Leg fat-free mass (left) 1.43 1 0 0 0 1 RP11-85F14.5
Trunk fat percentage 2.09 1 0 0 0 1 RP11-85F14.5
Townsend deprivation index at recruitment 3.93 1 0 0 0 1 RP11-85F14.5
Relative age voice broke 4.28 1 0 0 0 1 RP11-85F14.5
Qualifications: CSEs or equivalent 3.49 1 0 0 0 1 RP11-85F14.5
High blood pressure 4.27 1 0 0 0 1 RP11-85F14.5
Hayfever, allergic rhinitis or eczema 2.40 1 0 0 0 1 RP11-85F14.5
High blood pressure (mother) 5.60 1 0 0 0 1 RP11-85F14.5
Body mass index (BMI) 14.63 1 1 3 0 1 RP11-85F14.5
Impedance of leg (left) 6.73 1 1 3 0 1 RP11-85F14.5
Leg predicted mass (left) 1.46 1 0 0 0 1 RP11-85F14.5
Trunk fat mass 2.62 1 0 0 0 1 RP11-85F14.5
Waist circumference 10.49 1 1 3 0 1 RP11-85F14.5
Number of incorrect matches in round 4.53 1 0 0 0 1 RP11-85F14.5
Alcohol usually taken with meals 7.91 1 0 0 0 1 RP11-85F14.5
Nervous feelings 2.12 1 0 0 0 1 RP11-85F14.5
Qualifications: None of the above 3.37 1 0 0 0 1 RP11-85F14.5
Mouth/teeth dental problems 5.20 1 0 0 0 1 RP11-85F14.5
Heart attack 12.53 1 0 0 0 1 RP11-85F14.5
Diabetes (self-reported) 3.25 1 0 0 0 1 RP11-85F14.5
Medication: Simvastatin 7.95 1 0 0 0 1 RP11-85F14.5
Fluid intelligence score 5.20 1 0 0 0 1 RP11-85F14.5
Illnesses of siblings 6.09 1 0 0 0 1 RP11-85F14.5
Weight 2.89 1 0 0 0 1 RP11-85F14.5
Impedance of arm (right) 17.59 1 1 3 0 1 RP11-85F14.5
Arm fat percentage (right) 5.61 1 0 0 0 1 RP11-85F14.5
Hip circumference 5.07 1 0 0 0 1 RP11-85F14.5
Frequency of tiredness / lethargy in last 2 weeks 2.57 1 0 0 0 1 RP11-85F14.5
Falls in the last year 13.78 1 0 0 0 1 RP11-85F14.5
Number of live births 2.91 1 0 0 0 1 RP11-85F14.5
Qualifications: A levels/AS levels or equivalent 2.02 1 0 0 0 1 RP11-85F14.5
Mouth/teeth dental problems: Dentures 6.37 1 0 0 0 1 RP11-85F14.5
Medication: Ibuprofen (e.g. Nurofen) 11.74 1 0 0 0 1 RP11-85F14.5
Medication: Cholesterol lowering 9.49 1 0 0 0 1 RP11-85F14.5
Impedance of arm (left) 15.68 1 1 3 0 1 RP11-85F14.5
Arm fat mass (right) 5.82 1 0 0 0 1 RP11-85F14.5
Standing height 7.85 1 1 3 0 1 RP11-85F14.5
Hair/balding pattern: Pattern 4 1.69 1 0 0 0 1 RP11-85F14.5
Birth weight of first child 3.81 1 0 0 0 1 RP11-85F14.5
Qualifications: O levels/GCSEs or equivalent 4.71 1 0 0 0 1 RP11-85F14.5
Medication: Paracetamol 4.61 1 0 0 0 1 RP11-85F14.5
Medication for cholesterol, blood pressure or diabetes 5.52 1 0 0 0 1 RP11-85F14.5
Hypothyroidism/myxoedema (self-reported) 2.44 1 0 0 0 1 RP11-85F14.5
Body fat percentage 5.21 1 0 0 0 1 RP11-85F14.5
Leg fat percentage (right) 11.88 1 1 3 0 1 RP11-85F14.5
Arm fat-free mass (right) 2.30 1 0 0 0 1 RP11-85F14.5
Exposure to tobacco smoke outside home 5.32 1 0 0 0 1 RP11-85F14.5
Seen a psychiatrist for nerves, anxiety, tension or depression 4.81 1 0 0 0 1 RP11-85F14.5
Wheeze or whistling in the chest in last year 3.91 1 0 0 0 1 RP11-85F14.5
Pulse wave peak to peak time 3.33 1 0 0 0 1 RP11-85F14.5
Health satisfaction 4.55 1 0 0 0 1 RP11-85F14.5
Qualifications: College or University degree 3.10 1 0 0 0 1 RP11-85F14.5
Medication for pain relief, constipation, heartburn 7.05 1 0 0 0 1 RP11-85F14.5
Neck or shoulder pain in last month 8.63 1 0 0 0 1 RP11-85F14.5
Angina (self-reported) 6.74 1 0 0 0 1 RP11-85F14.5
Medication: Ibuprofen 12.61 1 0 0 0 1 RP11-85F14.5
Heart disease (mother) 5.19 1 0 0 0 1 RP11-85F14.5
Whole body fat mass 5.15 1 0 0 0 1 RP11-85F14.5
Leg fat mass (right) 9.51 1 1 3 0 1 RP11-85F14.5
Arm predicted mass (right) 2.23 1 0 0 0 1 RP11-85F14.5
Pulse rate, automated reading 2.50 1 0 0 0 1 RP11-85F14.5
Comparative height size at age 10 5.02 1 1 3 0 1 RP11-85F14.5
Overall health rating 6.33 1 0 0 0 1 RP11-85F14.5
Chest pain or discomfort 5.03 1 0 0 0 1 RP11-85F14.5
Qualifications: NVQ or HND or HNC or equivalent 6.24 1 0 0 0 1 RP11-85F14.5
Medication: Aspirin 6.78 1 0 0 0 1 RP11-85F14.5
Knee pain experienced in last month 2.86 1 0 0 0 1 RP11-85F14.5
Hypertension (Self-reported) 4.58 1 0 0 0 1 RP11-85F14.5
Illnesses of father: Heart disease 12.11 1 0 0 0 1 RP11-85F14.5
Illnesses of siblings: Diabetes 10.07 1 0 0 0 1 RP11-85F14.5
Forced expiratory volume in 1-second (FEV1), predicted 2.15 1 0 0 0 1 RP11-85F14.5
Whole body fat-free mass 0.88 1 0 0 0 1 RP11-85F14.5
Leg fat-free mass (right) 1.14 1 0 0 0 1 RP11-85F14.5
Arm fat percentage (left) 6.64 1 1 3 0 1 RP11-85F14.5
Average weekly red wine intake 6.82 1 0 0 0 1 RP11-85F14.5
Handedness (chirality/laterality): Left-handed 6.91 1 0 0 0 1 RP11-85F14.5
Long-standing illness, disability or infirmity 8.31 1 0 0 0 1 RP11-85F14.5
Diabetes diagnosed by doctor 4.50 1 0 0 0 1 RP11-85F14.5
Medication for cholesterol 3.31 1 0 0 0 1 RP11-85F14.5
Medication: Aspirin 7.64 1 0 0 0 1 RP11-85F14.5
Illnesses of father: None of the above (group 1) 4.55 1 0 0 0 1 RP11-85F14.5
Whole body water mass 0.77 1 0 0 0 1 RP11-85F14.5
Leg predicted mass (right) 1.09 1 0 0 0 1 RP11-85F14.5
Arm fat mass (left) 5.85 1 0 0 0 1 RP11-85F14.5
Miserableness 2.97 1 0 0 0 1 RP11-85F14.5
Mother's age at death 4.03 1 0 0 0 1 RP11-85F14.5
High cholesterol (Self-reported) 9.08 1 0 0 0 1 RP11-85F14.5
Medication: Paracetamol 4.20 1 0 0 0 1 RP11-85F14.5
Medication: Atorvastatin 6.88 1 0 0 0 1 RP11-85F14.5
Basal metabolic rate 1.37 1 0 0 0 1 RP11-85F14.5
Leg fat percentage (left) 11.85 1 1 3 0 1 RP11-85F14.5
Arm fat-free mass (left) 1.53 1 0 0 0 1 RP11-85F14.5
Average weekly beer plus cider intake 9.39 1 0 0 0 1 RP11-85F14.5
Risk taking 3.38 1 0 0 0 1 RP11-85F14.5
Age started oral contraceptive pill 11.98 1 0 0 0 1 RP11-85F14.5
Commuting to job workplace: Cycle 3.81 1 0 0 0 1 RP11-85F14.5
Vascular/heart problems diagnosed by doctor 7.30 1 0 0 0 1 RP11-85F14.5
Cholesterol lowering medication 6.77 1 0 0 0 1 RP11-85F14.5
Pain experienced in last month 7.34 1 0 0 0 1 RP11-85F14.5
Heart attack/myocardial infarction (self-reported) 12.15 1 0 0 0 1 RP11-85F14.5
Heart disease (siblings) 4.26 1 0 0 0 1 RP11-85F14.5
Impedance of whole body 12.32 1 1 3 0 1 RP11-85F14.5
Leg fat mass (left) 8.98 1 1 3 0 1 RP11-85F14.5
Arm predicted mass (left) 1.72 1 0 0 0 1 RP11-85F14.5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.22
GTEx Adipose Visceral Omentum 0 0.000 1.31
GTEx Adrenal Gland 0 0.000 1.18
GTEx Artery Aorta 0 0.000 1.27
GTEx Artery Coronary 0 0.000 1.23
GTEx Artery Tibial 0 0.000 1.24
GTEx Brain Caudate basal ganglia 0 0.000 1.31
GTEx Brain Cerebellar Hemisphere 0 0.000 1.30
GTEx Brain Cerebellum 0 0.000 1.23
GTEx Brain Cortex 0 0.000 1.38
GTEx Brain Frontal Cortex BA9 0 0.000 1.30
GTEx Brain Hippocampus 0 0.000 1.39
GTEx Brain Hypothalamus 0 0.000 1.36
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.32
GTEx Brain Putamen basal ganglia 0 0.000 1.25
GTEx Breast Mammary Tissue 0 0.000 1.25
GTEx Breast Mammary Tissue (Male) 0 0.000 1.17
GTEx Breast Mammary Tissue (Female) 0 0.000 1.26
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.34
GTEx Cells Transformed fibroblasts 0 0.000 1.25
GTEx Colon Sigmoid 0 0.000 1.22
GTEx Colon Transverse 0 0.000 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.23
GTEx Esophagus Mucosa 0 0.000 1.25
GTEx Esophagus Muscularis 0 0.000 1.25
GTEx Heart Atrial Appendage 0 0.000 1.24
GTEx Heart Left Ventricle 0 0.000 1.33
GTEx Liver 0 0.000 1.26
GTEx Lung 0 0.000 1.22
GTEx Muscle Skeletal 0 0.000 1.28
GTEx Nerve Tibial 0 0.000 1.20
GTEx Ovary 0 0.000 1.23
GTEx Pancreas 0 0.000 1.31
GTEx Pituitary 0 0.000 1.22
GTEx Prostate 0 0.000 1.17
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.27
GTEx Skin Sun Exposed Lower leg 0 0.000 1.26
GTEx Small Intestine Terminal Ileum 0 0.000 1.25
GTEx Spleen 0 0.000 1.24
GTEx Stomach 0 0.000 1.25
GTEx Testis 0 0.000 1.27
GTEx Thyroid 1 0.025 1.25
GTEx Uterus 0 0.000 1.27
GTEx Vagina 0 0.000 1.28
GTEx Whole Blood 0 0.000 1.27
METSIM Adipose 0 0.000 1.24
NTR Blood 0 0.000 1.25
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.21
YFS Blood 0 0.000 1.18
CommonMind Brain Pre-frontal Cortex 0 0.000 1.23
TCGA Breast Tumor 0 0.000 1.27
TCGA Breast Normal 0 0.000 1.19
TCGA Ovarian Tumor 0 0.000 1.23
TCGA Prostate Tumor 0 0.000 1.26