Hub : Traits :

Rheumatoid Arthritis

63 significantly associated models · 24 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 1829482 3261925 1 1 1.1e-07 4.6e-08 1.4e-04 52 MMEL1
2 1 37628741 39108725 2 1 1.9e-08 7.6e-08 9.0e-07 16 INPP5B
3 1 113236087 115222434 10 10 1.4e-45 1.7e-102 NaN NaN AP4B1 AP4B1-AS1 DCLRE1B HIPK1 OLFML3 PHTF1
4 2 60422555 61938725 2 1 9.7e-08 5.4e-08 1.1e-01 91 PUS10
5 2 99468341 101456989 1 1 3.9e-08 7.4e-09 2.1e-02 84 AFF3
6 3 11900101 13321852 1 1 1.3e-07 1.2e-06 4.6e-01 98 MKRN2
7 5 54699883 56226605 1 1 1.1e-12 2.7e-14 5.1e-03 86 ANKRD55
8 5 101392473 103061825 1 1 2.3e-09 1.0e-09 2.6e-02 87 PAM
9 7 127878155 129284182 1 1 2.4e-10 8.5e-10 9.2e-05 59 IRF5
10 8 10654161 11891593 1 1 3.7e-07 4.5e-06 6.6e-01 99 BLK
11 12 111522000 112941571 1 1 2.4e-07 6.8e-07 5.7e-04 52 ALDH2
12 19 9968139 11372077 1 1 4.9e-08 3.7e-07 1.2e-05 26 KRI1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.62 4 0 0.0 0.60 2.8e-01 ANKRD55 AP4B1-AS1 DCLRE1B HIPK1
Irritable Bowel Disease (IBD) 1.75 2 0 0.0 0.00 1.0e+00 ANKRD55 IRF5
Ulcerative Colitis (UC) 2.17 2 2 6.1 0.00 1.0e+00 IRF5 MMEL1
Reaction Time 2.18 2 0 0.0 0.00 1.0e+00 ALDH2 DCLRE1B
Verbal and Numeric Reasoning (VNR) 1.29 1 0 0.0 0.00 1.0e+00 PAM
Breast Cancer 2.98 3 1 3.0 -0.90 3.8e-02 AP4B1 DCLRE1B PHTF1
Age at First Birth 1.43 1 0 0.0 0.00 1.0e+00 AFF3
Coronary Artery Disease (CAD) 2.24 1 0 0.0 0.00 1.0e+00 ALDH2
Crohns Disease (2012) 2.70 2 0 0.0 0.00 1.0e+00 AP4B1-AS1 HIPK1
LDL Cholesterol 1.45 1 0 0.0 0.00 1.0e+00 ALDH2
Lupus 10.25 5 2 6.1 0.77 1.2e-01 ANKRD55 BLK DCLRE1B IRF5 KRI1
Primary Biliary Cirrhosis 4.45 3 1 3.0 0.00 1.0e+00 IRF5 MMEL1 PAM
Ulcerative Colitis 2.52 2 0 0.0 0.00 1.0e+00 IRF5 MMEL1
Blood Eosinophil Count 3.55 8 4 12.1 0.06 8.8e-01 ALDH2 AP4B1 DCLRE1B INPP5B IRF5 MKRN2 MMEL1 PUS10
Blood Platelet Count 0.90 4 3 9.1 0.41 5.9e-01 ALDH2 IRF5 KRI1 PAM
Blood Red Count 0.98 5 4 12.1 0.37 5.4e-01 AFF3 ALDH2 ANKRD55 PAM PUS10
Blood White Count 4.26 8 7 21.2 -0.36 2.8e-01 ALDH2 AP4B1 DCLRE1B KRI1 MKRN2 OLFML3 PAM PHTF1
Heel T-Score 1.06 6 0 0.0 -0.17 7.5e-01 AFF3 ANKRD55 DCLRE1B INPP5B IRF5 PHTF1
BMI 0.48 2 0 0.0 0.00 1.0e+00 MKRN2 MMEL1
Height 0.52 6 4 12.1 -0.18 7.3e-01 ALDH2 INPP5B IRF5 MKRN2 PAM PUS10
Waist Hip Ratio (WHR) 1.17 1 1 3.0 0.00 1.0e+00 PAM
Systolic Blood Pressure 1.29 2 1 3.0 0.00 1.0e+00 ALDH2 IRF5
Smoking Status 1.62 2 0 0.0 0.00 1.0e+00 DCLRE1B PHTF1
Allergy or Eczema 2.25 3 0 0.0 0.00 1.0e+00 ANKRD55 BLK PUS10
Cardiovascular Disease 0.84 1 1 3.0 0.00 1.0e+00 ALDH2
Hypothyroidism (self reported) 28.72 11 10 30.3 0.98 7.0e-11 ALDH2 AP4B1 AP4B1-AS1 DCLRE1B HIPK1 INPP5B IRF5 MMEL1 OLFML3 PAM PHTF1
Type 2 Diabetes (T2D) 1.09 1 0 0.0 0.00 1.0e+00 PAM
Lung FEV1/FVC ratio 0.73 1 0 0.0 0.00 1.0e+00 MMEL1
Lung FVC 1.11 5 0 0.0 0.85 7.1e-02 AFF3 AP4B1 DCLRE1B KRI1 PAM
Chronotype (morning person) 1.23 1 0 0.0 0.00 1.0e+00 PHTF1
Hair Pigment 0.08 1 0 0.0 0.00 1.0e+00 KRI1
Number of treatments/medications taken 2.39 2 0 0.0 0.00 1.0e+00 DCLRE1B HIPK1
Systolic blood pressure, automated reading 1.16 2 1 3.0 0.00 1.0e+00 ALDH2 BLK
Impedance of leg (right) 0.87 1 0 0.0 0.00 1.0e+00 PAM
Leg fat-free mass (left) 0.59 1 0 0.0 0.00 1.0e+00 MKRN2
Trunk fat percentage 0.51 1 0 0.0 0.00 1.0e+00 MKRN2
Hand grip strength (right) 0.62 1 0 0.0 0.00 1.0e+00 IRF5
Current tobacco smoking 1.84 1 0 0.0 0.00 1.0e+00 PHTF1
Fed-up feelings 1.02 1 0 0.0 0.00 1.0e+00 ALDH2
Taking other prescription medications 4.77 2 1 3.0 0.00 1.0e+00 DCLRE1B HIPK1
Age when periods started (menarche) 2.14 3 0 0.0 0.00 1.0e+00 DCLRE1B OLFML3 PUS10
Heel bone mineral density (BMD) T-score, automated (left) 0.99 1 0 0.0 0.00 1.0e+00 BLK
Serious illness, injury or assault to yourself 1.40 2 0 0.0 0.00 1.0e+00 DCLRE1B HIPK1
High blood pressure 1.23 1 1 3.0 0.00 1.0e+00 ALDH2
Hayfever, allergic rhinitis or eczema 1.88 1 0 0.0 0.00 1.0e+00 PUS10
Medication: Levothyroxine sodium 18.56 10 8 24.2 -0.99 6.4e-11 ALDH2 AP4B1 AP4B1-AS1 DCLRE1B HIPK1 INPP5B MMEL1 OLFML3 PAM PHTF1
Sitting height 0.51 1 0 0.0 0.00 1.0e+00 PUS10
Impedance of leg (left) 0.82 2 0 0.0 0.00 1.0e+00 BLK PAM
Leg predicted mass (left) 0.60 1 0 0.0 0.00 1.0e+00 MKRN2
Trunk fat mass 0.58 1 0 0.0 0.00 1.0e+00 MKRN2
Waist circumference 0.43 1 0 0.0 0.00 1.0e+00 MKRN2
Past tobacco smoking 2.00 2 0 0.0 0.00 1.0e+00 DCLRE1B PHTF1
Alcohol usually taken with meals 1.80 1 0 0.0 0.00 1.0e+00 AFF3
Heel bone mineral density (BMD) T-score, automated (right) 1.08 1 0 0.0 0.00 1.0e+00 BLK
Mouth/teeth dental problems 1.64 1 0 0.0 0.00 1.0e+00 IRF5
Diabetes (self-reported) 2.01 1 0 0.0 0.00 1.0e+00 DCLRE1B
Fluid intelligence score 1.38 1 0 0.0 0.00 1.0e+00 PAM
Neuroticism score 0.84 1 0 0.0 0.00 1.0e+00 BLK
Weight 0.62 2 0 0.0 0.00 1.0e+00 ALDH2 MKRN2
Arm fat percentage (right) 0.47 1 0 0.0 0.00 1.0e+00 MKRN2
Trunk fat-free mass 0.62 1 0 0.0 0.00 1.0e+00 ALDH2
Hip circumference 0.80 1 0 0.0 0.00 1.0e+00 MKRN2
Father's age at death 1.23 1 0 0.0 0.00 1.0e+00 ALDH2
Worrier / anxious feelings 1.17 1 0 0.0 0.00 1.0e+00 PAM
Forced expiratory volume in 1-second (FEV1) 0.95 1 0 0.0 0.00 1.0e+00 AFF3
Asthma 1.53 1 0 0.0 0.00 1.0e+00 INPP5B
Medication: Cholesterol lowering 1.29 1 0 0.0 0.00 1.0e+00 DCLRE1B
Impedance of arm (left) 0.31 1 0 0.0 0.00 1.0e+00 ALDH2
Arm fat mass (right) 0.46 1 0 0.0 0.00 1.0e+00 MKRN2
Trunk predicted mass 0.62 1 0 0.0 0.00 1.0e+00 ALDH2
Standing height 0.57 4 0 0.0 0.61 3.9e-01 ALDH2 INPP5B IRF5 MKRN2
Peak expiratory flow (PEF) 0.85 1 0 0.0 0.00 1.0e+00 BLK
Hypothyroidism/myxoedema (self-reported) 24.09 11 8 24.2 -0.98 5.8e-11 ALDH2 AP4B1 AP4B1-AS1 DCLRE1B HIPK1 INPP5B IRF5 MMEL1 OLFML3 PAM PHTF1
Birth weight 1.56 1 0 0.0 0.00 1.0e+00 DCLRE1B
Body fat percentage 0.56 1 0 0.0 0.00 1.0e+00 MKRN2
Arm fat-free mass (right) 0.53 1 0 0.0 0.00 1.0e+00 ALDH2
Qualifications: College or University degree 1.26 3 0 0.0 0.00 1.0e+00 AFF3 HIPK1 PAM
Emphysema/chronic bronchitis 1.42 1 0 0.0 0.00 1.0e+00 HIPK1
Medication for pain relief, constipation, heartburn 1.11 1 0 0.0 0.00 1.0e+00 PAM
Mean time to correctly identify matches 2.17 1 0 0.0 0.00 1.0e+00 ALDH2
Whole body fat mass 0.60 1 0 0.0 0.00 1.0e+00 MKRN2
Leg fat mass (right) 0.63 1 0 0.0 0.00 1.0e+00 MKRN2
Arm predicted mass (right) 0.51 1 0 0.0 0.00 1.0e+00 ALDH2
Alcohol intake frequency. 1.91 3 0 0.0 0.00 1.0e+00 AP4B1 DCLRE1B PUS10
Comparative height size at age 10 0.67 1 0 0.0 0.00 1.0e+00 ALDH2
Suffer from 'nerves' 1.39 1 0 0.0 0.00 1.0e+00 PAM
Overall health rating 1.32 2 0 0.0 0.00 1.0e+00 DCLRE1B PAM
Hypertension (Self-reported) 1.08 1 1 3.0 0.00 1.0e+00 ALDH2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.31 1 0 0.0 0.00 1.0e+00 HIPK1
Whole body fat-free mass 0.59 1 0 0.0 0.00 1.0e+00 ALDH2
Leg fat-free mass (right) 0.65 1 0 0.0 0.00 1.0e+00 MKRN2
Arm fat percentage (left) 0.52 1 0 0.0 0.00 1.0e+00 MKRN2
Long-standing illness, disability or infirmity 3.45 1 1 3.0 0.00 1.0e+00 DCLRE1B
Diabetes diagnosed by doctor 1.91 1 0 0.0 0.00 1.0e+00 DCLRE1B
Mouth/teeth dental problems: Mouth ulcers 3.26 3 1 3.0 0.00 1.0e+00 AFF3 IRF5 PAM
Medication for cholesterol 1.16 1 0 0.0 0.00 1.0e+00 ALDH2
Asthma (self-reported) 1.58 1 0 0.0 0.00 1.0e+00 INPP5B
Smoking status: Current 1.84 1 0 0.0 0.00 1.0e+00 PHTF1
Whole body water mass 0.59 1 0 0.0 0.00 1.0e+00 ALDH2
Leg predicted mass (right) 0.65 1 0 0.0 0.00 1.0e+00 MKRN2
Arm fat mass (left) 0.49 1 0 0.0 0.00 1.0e+00 MKRN2
Number of self-reported non-cancer illnesses 1.58 1 0 0.0 0.00 1.0e+00 ALDH2
Medication: Blood pressure 1.30 1 1 3.0 0.00 1.0e+00 ALDH2
Illnesses of father: High blood pressure 1.42 1 0 0.0 0.00 1.0e+00 ALDH2
Ever smoked 1.91 2 0 0.0 0.00 1.0e+00 DCLRE1B PHTF1
Basal metabolic rate 0.60 2 0 0.0 0.00 1.0e+00 ALDH2 MKRN2
Leg fat percentage (left) 0.69 1 0 0.0 0.00 1.0e+00 MMEL1
Arm fat-free mass (left) 0.57 1 0 0.0 0.00 1.0e+00 ALDH2
Irritability 0.93 1 0 0.0 0.00 1.0e+00 BLK
Diastolic blood pressure, automated reading 1.60 2 1 3.0 0.00 1.0e+00 ALDH2 BLK
Ever depressed for a whole week 1.31 1 0 0.0 0.00 1.0e+00 ALDH2
Myopia 1.65 1 0 0.0 0.00 1.0e+00 AP4B1
Vascular/heart problems diagnosed by doctor 0.94 1 1 3.0 0.00 1.0e+00 ALDH2
Leg fat mass (left) 0.61 1 0 0.0 0.00 1.0e+00 MKRN2
Arm predicted mass (left) 0.62 1 0 0.0 0.00 1.0e+00 ALDH2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0590 1.38
GTEx Adipose Visceral Omentum 3 0.1512 1.41
GTEx Adrenal Gland 0 0.0000 1.38
GTEx Artery Aorta 1 0.0346 1.45
GTEx Artery Coronary 0 0.0000 1.37
GTEx Artery Tibial 3 0.0821 1.47
GTEx Brain Caudate basal ganglia 0 0.0000 1.48
GTEx Brain Cerebellar Hemisphere 2 0.1377 1.51
GTEx Brain Cerebellum 0 0.0000 1.44
GTEx Brain Cortex 0 0.0000 1.43
GTEx Brain Frontal Cortex BA9 1 0.1110 1.41
GTEx Brain Hippocampus 0 0.0000 1.45
GTEx Brain Hypothalamus 0 0.0000 1.40
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.37
GTEx Brain Putamen basal ganglia 0 0.0000 1.44
GTEx Breast Mammary Tissue 1 0.0521 1.47
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.38
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.41
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.42
GTEx Cells Transformed fibroblasts 5 0.1223 1.41
GTEx Colon Sigmoid 1 0.0704 1.48
GTEx Colon Transverse 3 0.1497 1.46
GTEx Esophagus Gastroesophageal Junction 1 0.0717 1.40
GTEx Esophagus Mucosa 1 0.0310 1.40
GTEx Esophagus Muscularis 1 0.0318 1.45
GTEx Heart Atrial Appendage 0 0.0000 1.41
GTEx Heart Left Ventricle 0 0.0000 1.36
GTEx Liver 0 0.0000 1.40
GTEx Lung 1 0.0359 1.45
GTEx Muscle Skeletal 1 0.0355 1.39
GTEx Nerve Tibial 4 0.0952 1.39
GTEx Ovary 0 0.0000 1.46
GTEx Pancreas 0 0.0000 1.45
GTEx Pituitary 0 0.0000 1.46
GTEx Prostate 0 0.0000 1.45
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.39
GTEx Skin Sun Exposed Lower leg 1 0.0283 1.45
GTEx Small Intestine Terminal Ileum 0 0.0000 1.38
GTEx Spleen 2 0.1453 1.50
GTEx Stomach 0 0.0000 1.50
GTEx Testis 2 0.0649 1.43
GTEx Thyroid 1 0.0257 1.39
GTEx Uterus 0 0.0000 1.52
GTEx Vagina 0 0.0000 1.46
GTEx Whole Blood 1 0.0517 1.51
METSIM Adipose 7 0.1551 1.40
NTR Blood 1 0.0419 1.50
ROSMAP Brain Pre-frontal Cortex 4 0.0934 1.46
YFS Blood 4 0.0877 1.47
CommonMind Brain Pre-frontal Cortex 3 0.0567 1.38
TCGA Breast Tumor 1 0.1326 1.49
TCGA Breast Normal 2 0.0484 1.38
TCGA Ovarian Tumor 1 0.0347 1.27
TCGA Prostate Tumor 2 0.0592 1.43